{"id":"https://openalex.org/W2004575181","doi":"https://doi.org/10.1126/science.1604319","title":"Exhaustive Matching of the Entire Protein Sequence Database","display_name":"Exhaustive Matching of the Entire Protein Sequence Database","publication_year":1992,"publication_date":"1992-06-05","ids":{"openalex":"https://openalex.org/W2004575181","doi":"https://doi.org/10.1126/science.1604319","mag":"2004575181","pmid":"https://pubmed.ncbi.nlm.nih.gov/1604319"},"language":"en","primary_location":{"id":"doi:10.1126/science.1604319","doi":"https://doi.org/10.1126/science.1604319","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1604319","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2004575181"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013025384","display_name":"Gast\u00f3n H. Gonnet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255184","display_name":"Laboratory of Organic Chemistry","ror":"https://ror.org/02q73ep21","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255184"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Gaston H. Gonnet","raw_affiliation_strings":["Institute for Scientific Computation and Institute for Organic Chemistry, Swiss Federal Institute of Technology, Universitatstr. 16, 8092 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Scientific Computation and Institute for Organic Chemistry, Swiss Federal Institute of Technology, Universitatstr. 16, 8092 Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046812199","display_name":"Mark A. Cohen","orcid":"https://orcid.org/0000-0002-1548-2773","observed_orcids":["https://orcid.org/0000-0002-1548-2773"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255184","display_name":"Laboratory of Organic Chemistry","ror":"https://ror.org/02q73ep21","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255184"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mark A. Cohen","raw_affiliation_strings":["Institute for Scientific Computation and Institute for Organic Chemistry, Swiss Federal Institute of Technology, Universitatstr. 16, 8092 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Scientific Computation and Institute for Organic Chemistry, Swiss Federal Institute of Technology, Universitatstr. 16, 8092 Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255184"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005259044","display_name":"Steven A. Benner","orcid":"https://orcid.org/0000-0002-3318-9917","observed_orcids":["https://orcid.org/0000-0002-3318-9917"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255184","display_name":"Laboratory of Organic Chemistry","ror":"https://ror.org/02q73ep21","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255184"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Steven A. Benner","raw_affiliation_strings":["Institute for Scientific Computation and Institute for Organic Chemistry, Swiss Federal Institute of Technology, Universitatstr. 16, 8092 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Scientific Computation and Institute for Organic Chemistry, Swiss Federal Institute of Technology, Universitatstr. 16, 8092 Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255184"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.0455,"has_fulltext":false,"cited_by_count":844,"citation_normalized_percentile":{"value":0.98447662,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"256","issue":"5062","first_page":"1443","last_page":"1445"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.019200000911951065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12946","display_name":"Fractal and DNA sequence analysis","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-sequence-databases","display_name":"protein sequence databases","score":0.9259999990463257},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"sequence alignment","score":0.6869999766349792},{"id":"https://openalex.org/keywords/protein-structure-prediction","display_name":"protein structure prediction","score":0.7360000014305115},{"id":"https://openalex.org/keywords/de-novo-structure-prediction","display_name":"de novo structure prediction","score":0.6510000228881836},{"id":"https://openalex.org/keywords/ancestral-protein-reconstruction","display_name":"ancestral protein reconstruction","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.7303539514541626},{"id":"https://openalex.org/C165064840","wikidata":"https://www.wikidata.org/wiki/Q1321061","display_name":"Matching (statistics)","level":2,"score":0.6346234083175659},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6190181970596313},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.5366408824920654},{"id":"https://openalex.org/C41584329","wikidata":"https://www.wikidata.org/wiki/Q175902","display_name":"Sequence database","level":3,"score":0.5004003047943115},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4853188395500183},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4527183473110199},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.44320595264434814},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.4358372688293457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4324067234992981},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.35057443380355835},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34974807500839233},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.3029256761074066},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1943804919719696},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16374805569648743},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12181991338729858},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.1604319","doi":"https://doi.org/10.1126/science.1604319","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1604319","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:1604319","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1604319","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W127396280","https://openalex.org/W1973578915","https://openalex.org/W1978444265","https://openalex.org/W1980038204","https://openalex.org/W1981375932","https://openalex.org/W2005313213","https://openalex.org/W2026185422","https://openalex.org/W2052832659","https://openalex.org/W2054526121","https://openalex.org/W2067405360","https://openalex.org/W2069319961","https://openalex.org/W2074097924","https://openalex.org/W2074231493","https://openalex.org/W2076505328","https://openalex.org/W2086105889","https://openalex.org/W2090493969","https://openalex.org/W2129361631","https://openalex.org/W2163892779","https://openalex.org/W2254458779","https://openalex.org/W2278218567","https://openalex.org/W2332674222","https://openalex.org/W4242745500"],"related_works":["https://openalex.org/W2082440408","https://openalex.org/W2130101420","https://openalex.org/W2026936692","https://openalex.org/W649798380","https://openalex.org/W7096420001","https://openalex.org/W2024291208","https://openalex.org/W3211795435","https://openalex.org/W7221815838","https://openalex.org/W1528988694","https://openalex.org/W4367052125"],"abstract_inverted_index":{"The":[0,35,54],"entire":[1],"protein":[2],"sequence":[3,27,46],"database":[4,28],"has":[5],"been":[6],"exhaustively":[7],"matched.":[8],"Definitive":[9],"mutation":[10],"matrices":[11],"and":[12,22,40,83,88],"models":[13],"for":[14,66,77,89],"scoring":[15],"gaps":[16],"were":[17],"obtained":[18],"from":[19],"the":[20,26,59,63,72],"matching":[21,61],"used":[23,43],"to":[24,44],"organize":[25],"as":[29],"sets":[30],"of":[31,71,75,80],"evolutionarily":[32],"connected":[33],"components.":[34],"methods":[36],"developed":[37],"are":[38,62],"general":[39],"can":[41],"be":[42],"manage":[45],"data":[47],"generated":[48],"by":[49,58],"major":[50],"genome":[51],"sequencing":[52],"projects.":[53],"alignments":[55],"made":[56],"possible":[57],"exhaustive":[60],"starting":[64],"point":[65],"successful":[67],"de":[68],"novo":[69],"prediction":[70],"folded":[73],"structures":[74],"proteins,":[76],"reconstructing":[78],"sequences":[79],"ancient":[81,86],"proteins":[82],"metabolisms":[84],"in":[85,93],"organisms,":[87],"obtaining":[90],"new":[91],"perspectives":[92],"structural":[94],"biochemistry.":[95]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":53},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":22}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
