{"id":"https://openalex.org/W2004570876","doi":"https://doi.org/10.1158/0008-5472.sabcs11-pd05-04","title":"PD05-04: Quantitative Measurement of Antigen Degradation in NCCTG N9831 Tissue Microarrays.","display_name":"PD05-04: Quantitative Measurement of Antigen Degradation in NCCTG N9831 Tissue Microarrays.","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W2004570876","doi":"https://doi.org/10.1158/0008-5472.sabcs11-pd05-04","mag":"2004570876"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.sabcs11-pd05-04","doi":"https://doi.org/10.1158/0008-5472.sabcs11-pd05-04","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.sabcs11-pd05-04","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"H Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Cheng","raw_affiliation_strings":["1Yale University School of Medicine, New Haven, CT; Mayo Clinic, Rochester, MN; Mayo Clinic, Scottsdale, AZ; Mayo Clinic, Jacksonville, FL","Mayo Clinic, Jacksonville, FL","Mayo Clinic, Rochester, MN","Mayo Clinic, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale University School of Medicine, New Haven, CT; Mayo Clinic, Rochester, MN; Mayo Clinic, Scottsdale, AZ; Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I32971472","https://openalex.org/I4210125099","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, Scottsdale, AZ","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103396879","display_name":"DL Rimm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DL Rimm","raw_affiliation_strings":["1Yale University School of Medicine, New Haven, CT; Mayo Clinic, Rochester, MN; Mayo Clinic, Scottsdale, AZ; Mayo Clinic, Jacksonville, FL","Mayo Clinic, Jacksonville, FL","Mayo Clinic, Rochester, MN","Mayo Clinic, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale University School of Medicine, New Haven, CT; Mayo Clinic, Rochester, MN; Mayo Clinic, Scottsdale, AZ; Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I32971472","https://openalex.org/I4210125099","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, Scottsdale, AZ","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090066966","display_name":"Monica Madden Reinholz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MM Reinholz","raw_affiliation_strings":["1Yale University School of Medicine, New Haven, CT; Mayo Clinic, Rochester, MN; Mayo Clinic, Scottsdale, AZ; Mayo Clinic, Jacksonville, FL","Mayo Clinic, Jacksonville, FL","Mayo Clinic, Rochester, MN","Mayo Clinic, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale University School of Medicine, New Haven, CT; Mayo Clinic, Rochester, MN; Mayo Clinic, Scottsdale, AZ; Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I32971472","https://openalex.org/I4210125099","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, Scottsdale, AZ","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029305787","display_name":"Wilma L. Lingle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"WL Lingle","raw_affiliation_strings":["1Yale University School of Medicine, New Haven, CT; Mayo Clinic, Rochester, MN; Mayo Clinic, Scottsdale, AZ; Mayo Clinic, Jacksonville, FL","Mayo Clinic, Jacksonville, FL","Mayo Clinic, Rochester, MN","Mayo Clinic, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale University School of Medicine, New Haven, CT; Mayo Clinic, Rochester, MN; Mayo Clinic, Scottsdale, AZ; Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I32971472","https://openalex.org/I4210125099","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, Scottsdale, AZ","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062152027","display_name":"KV Ballman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"KV Ballman","raw_affiliation_strings":["1Yale University School of Medicine, New Haven, CT; Mayo Clinic, Rochester, MN; Mayo Clinic, Scottsdale, AZ; Mayo Clinic, Jacksonville, FL","Mayo Clinic, Jacksonville, FL","Mayo Clinic, Rochester, MN","Mayo Clinic, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale University School of Medicine, New Haven, CT; Mayo Clinic, Rochester, MN; Mayo Clinic, Scottsdale, AZ; Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I32971472","https://openalex.org/I4210125099","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, Scottsdale, AZ","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090009905","display_name":"Amylou Constance Dueck","orcid":"https://orcid.org/0000-0002-9912-1085","observed_orcids":["https://orcid.org/0000-0002-9912-1085"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"AC Dueck","raw_affiliation_strings":["1Yale University School of Medicine, New Haven, CT; Mayo Clinic, Rochester, MN; Mayo Clinic, Scottsdale, AZ; Mayo Clinic, Jacksonville, FL","Mayo Clinic, Jacksonville, FL","Mayo Clinic, Rochester, MN","Mayo Clinic, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale University School of Medicine, New Haven, CT; Mayo Clinic, Rochester, MN; Mayo Clinic, Scottsdale, AZ; Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I32971472","https://openalex.org/I4210125099","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, Scottsdale, AZ","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044209489","display_name":"B Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Chen","raw_affiliation_strings":["1Yale University School of Medicine, New Haven, CT; Mayo Clinic, Rochester, MN; Mayo Clinic, Scottsdale, AZ; Mayo Clinic, Jacksonville, FL","Mayo Clinic, Jacksonville, FL","Mayo Clinic, Rochester, MN","Mayo Clinic, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale University School of Medicine, New Haven, CT; Mayo Clinic, Rochester, MN; Mayo Clinic, Scottsdale, AZ; Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I32971472","https://openalex.org/I4210125099","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, Scottsdale, AZ","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039303478","display_name":"AE McCullough","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"AE McCullough","raw_affiliation_strings":["1Yale University School of Medicine, New Haven, CT; Mayo Clinic, Rochester, MN; Mayo Clinic, Scottsdale, AZ; Mayo Clinic, Jacksonville, FL","Mayo Clinic, Jacksonville, FL","Mayo Clinic, Rochester, MN","Mayo Clinic, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale University School of Medicine, New Haven, CT; Mayo Clinic, Rochester, MN; Mayo Clinic, Scottsdale, AZ; Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I32971472","https://openalex.org/I4210125099","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, Scottsdale, AZ","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060720802","display_name":"Robert Brian Jenkins","orcid":"https://orcid.org/0000-0002-4049-694X","observed_orcids":["https://orcid.org/0000-0002-4049-694X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RB Jenkins","raw_affiliation_strings":["1Yale University School of Medicine, New Haven, CT; Mayo Clinic, Rochester, MN; Mayo Clinic, Scottsdale, AZ; Mayo Clinic, Jacksonville, FL","Mayo Clinic, Jacksonville, FL","Mayo Clinic, Rochester, MN","Mayo Clinic, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale University School of Medicine, New Haven, CT; Mayo Clinic, Rochester, MN; Mayo Clinic, Scottsdale, AZ; Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I32971472","https://openalex.org/I4210125099","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, Scottsdale, AZ","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065306642","display_name":"Edith A. Perez","orcid":"https://orcid.org/0000-0002-5037-6677","observed_orcids":["https://orcid.org/0000-0002-5037-6677","https://orcid.org/0000-0001-7009-7467"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"EA Perez","raw_affiliation_strings":["1Yale University School of Medicine, New Haven, CT; Mayo Clinic, Rochester, MN; Mayo Clinic, Scottsdale, AZ; Mayo Clinic, Jacksonville, FL","Mayo Clinic, Jacksonville, FL","Mayo Clinic, Rochester, MN","Mayo Clinic, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale University School of Medicine, New Haven, CT; Mayo Clinic, Rochester, MN; Mayo Clinic, Scottsdale, AZ; Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I32971472","https://openalex.org/I4210125099","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, Scottsdale, AZ","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12143748,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"24_Supplement","first_page":"PD05","last_page":"04"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antigen-degradation","display_name":"antigen degradation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tissue-microarray","display_name":"tissue microarray","score":0.796999990940094},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.5849999785423279},{"id":"https://openalex.org/keywords/egf-receptor","display_name":"EGF receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/preanalytical-variables","display_name":"pre-analytical variables","score":0.8539999723434448},{"id":"https://openalex.org/keywords/n9831-trial","display_name":"N9831 trial","score":0.8989999890327454},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.47999998927116394},{"id":"https://openalex.org/keywords/biomarker-expression","display_name":"biomarker expression","score":0.5429999828338623},{"id":"https://openalex.org/keywords/formalin-fixed-paraffin-embedded-tissue","display_name":"formalin-fixed paraffin-embedded tissue","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C193270364","wikidata":"https://www.wikidata.org/wiki/Q17141925","display_name":"Tissue microarray","level":3,"score":0.838462233543396},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5441424250602722},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.532272219657898},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4847407042980194},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.45709484815597534},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3610747456550598},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35975131392478943},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3240801692008972},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1996704638004303},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14075720310211182}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.sabcs11-pd05-04","doi":"https://doi.org/10.1158/0008-5472.sabcs11-pd05-04","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.sabcs11-pd05-04","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2540537496","https://openalex.org/W1578411543","https://openalex.org/W2359098452","https://openalex.org/W2361557085","https://openalex.org/W2386812150","https://openalex.org/W2126179258","https://openalex.org/W1969023321","https://openalex.org/W4294043804","https://openalex.org/W2256368028","https://openalex.org/W2381590519"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Unstained":[2],"recuts":[3],"from":[4,53,101,136,211,218,232,327],"formalin-fixed":[5],"paraffin-embedded":[6],"tissues":[7],"are":[8],"commonly":[9],"collected":[10],"for":[11,79,254,311],"cooperative":[12,312],"group":[13,313],"studies.":[14],"There":[15],"is":[16,228,272],"concern":[17],"among":[18],"pathologists":[19],"that":[20,277],"improper":[21],"storage":[22,267],"conditions":[23],"can":[24,278],"lead":[25],"to":[26,32,156,176,198,248],"antigen":[27],"degradation.":[28],"In":[29],"an":[30,177],"effort":[31],"quantify":[33],"this":[34],"effect,":[35],"we":[36],"compared":[37,175,197],"the":[38,54,102,109,142,151,165,172,181,188,207,215,233,261,281],"expression":[39,166],"of":[40,47,94,112,164,167,180,187,206,225,236,269,283,309],"HER1":[41,115,284],"and":[42,71,87,126,145,285,307],"HER2":[43,127,168,209],"on":[44,134,291],"two":[45,81,92,242],"sets":[46,93],"identical":[48],"cohort":[49,104,190],"tissue":[50,270,328],"microarrays":[51],"(TMAs)":[52],"N9831":[55,103],"HER2+":[56],"adjuvant":[57],"phase":[58],"III":[59],"trial":[60],"(NCT00005970;":[61],"www.clinicaltrials.gov);":[62],"one":[63],"freshly":[64],"cut":[65],"set":[66,74],"(cut":[67,83],"April":[68],"18,":[69],"2011)":[70],"a":[72,222,273],"second":[73],"stored":[75,293],"at":[76],"4":[77],"degrees":[78],"over":[80],"years":[82],"between":[84,240],"Nov,":[85],"2007":[86],"Jan,":[88],"2008).":[89],"Methods:":[90],"The":[91,184,266],"TMA":[95],"slides":[96,244,271],"containing":[97],"1580":[98],"tumor":[99],"samples":[100],"were":[105,252],"treated":[106],"identically":[107],"using":[108],"AQUA":[110],"method":[111],"quantitative":[113],"immunofluorescence.":[114],"was":[116,191],"tested":[117],"with":[118,128,303],"D38B1":[119],"(rabbit":[120],"monoclonal,":[121,131],"Cell":[122],"Signaling":[123],"Technology,":[124],"Inc.)":[125,133],"CB11":[129],"(mouse":[130],"Biocare,":[132],"tumors":[135],"695":[137],"patients":[138,147],"(712":[139],"specimens)":[140,149],"in":[141,150,154,171,194],"fresh":[143,173,199,243],"TMAs":[144,153,174,196,213,220],"779":[146],"(800":[148],"old":[152,182,195,219],"up":[155],"three-fold":[157],"redundancy":[158],"per":[159],"specimen.":[160],"Results:":[161],"Frequency":[162],"distributions":[163],"revealed":[169],"bimodality":[170],"attenuated":[178],"distribution":[179],"cases.":[183],"average":[185,208,216],"score":[186,282],"entire":[189,322],"significantly":[192,230],"lower":[193,280],"cuts":[200],"(paired":[201],"t-test,":[202],"p<0.0001).":[203],"Linear":[204],"regression":[205],"scores":[210,217],"new":[212],"versus":[214],"showed":[221,245],"slope":[223],"term":[224],"0.52,":[226],"which":[227],"statistically":[229],"different":[231],"hypothetical":[234],"value":[235],"1":[237],"(p<0.0001).":[238],"Regressions":[239],"any":[241],"slopes":[246],"close":[247],"1.0.":[249],"Similar":[250],"results":[251],"seen":[253],"HER1,":[255],"but":[256,320],"fewer":[257],"positive":[258],"cases":[259],"made":[260],"changes":[262],"less":[263],"dramatic.":[264],"Conclusions:":[265],"condition":[268],"critical":[274],"pre-analytical":[275],"variable":[276],"dramatically":[279],"HER2,":[286],"artificially.":[287],"Thus,":[288],"studies":[289,314],"done":[290],"inadequately":[292],"slides,":[294],"either":[295],"whole":[296],"sections":[297],"or":[298,324],"TMAs,":[299],"must":[300],"be":[301],"interpreted":[302],"caution.":[304],"Tissue":[305],"collection":[306],"analysis":[308],"biomarkers":[310],"should":[315],"not":[316],"include":[317],"unstained":[318],"recuts,":[319],"rather,":[321],"blocks":[323],"large":[325],"cores":[326],"blocks.":[329],"Citation":[330],"Information:":[331],"Cancer":[332],"Res":[333],"2011;71(24":[334],"Suppl):Abstract":[335],"nr":[336],"PD05-04.":[337]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}