{"id":"https://openalex.org/W2004522080","doi":"https://doi.org/10.1111/j.1365-2559.1989.tb01588.x","title":"Histopathology of bone marrow reconstitution after allogeneic bone marrow transplantation","display_name":"Histopathology of bone marrow reconstitution after allogeneic bone marrow transplantation","publication_year":1989,"publication_date":"1989-10-01","ids":{"openalex":"https://openalex.org/W2004522080","doi":"https://doi.org/10.1111/j.1365-2559.1989.tb01588.x","mag":"2004522080","pmid":"https://pubmed.ncbi.nlm.nih.gov/2807194"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2559.1989.tb01588.x","doi":"https://doi.org/10.1111/j.1365-2559.1989.tb01588.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2559.1989.tb01588.x","pdf_url":null,"source":{"id":"https://openalex.org/S14376486","display_name":"Histopathology","issn_l":"0309-0167","issn":["0309-0167","1365-2559"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histopathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010615884","display_name":"Henk van den Berg","orcid":"https://orcid.org/0009-0002-1437-2895","observed_orcids":["https://orcid.org/0009-0002-1437-2895"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"H. VAN DEN BERG","raw_affiliation_strings":["Department of Pediatrics, State University Leiden, The Netherlands","Departments of Pediatrics, State University Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, State University Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"Departments of Pediatrics, State University Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108486909","display_name":"Ph. M. Kluin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ph. M. KLUIN","raw_affiliation_strings":["Departments of Pathology, State University Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology, State University Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110047564","display_name":"FERRY E. ZWAAN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"F. E. ZWAAN","raw_affiliation_strings":["Hematology and Bone Marrow Transplantation, State University Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Bone Marrow Transplantation, State University Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111956885","display_name":"Jaak M J J Vossen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J. M. VOSSEN","raw_affiliation_strings":["Departments of Pediatrics, State University Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics, State University Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010615884"],"corresponding_institution_ids":["https://openalex.org/I121797337"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":0.7565,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.70369744,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"15","issue":"4","first_page":"363","last_page":"373"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allogeneic-bone-marrow-transplantation","display_name":"allogeneic bone marrow transplantation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/bone-marrow-histology","display_name":"bone marrow histology","score":0.8619999885559082},{"id":"https://openalex.org/keywords/haematopoietic-reconstitution","display_name":"haematopoietic reconstitution","score":0.996999979019165},{"id":"https://openalex.org/keywords/bone-marrow-stroma","display_name":"bone marrow stroma","score":0.6240000128746033},{"id":"https://openalex.org/keywords/edema","display_name":"edema","score":0.7979999780654907},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/granuloma","display_name":"granuloma","score":0.9829999804496765},{"id":"https://openalex.org/keywords/bone-marrow-cellularity","display_name":"bone marrow cellularity","score":0.8149999976158142},{"id":"https://openalex.org/keywords/dyserythropoiesis","display_name":"dyserythropoiesis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/myeloid-to-erythroid-ratio","display_name":"myeloid:erythroid ratio","score":0.9470000267028809},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.9020000100135803},{"id":"https://openalex.org/keywords/aplastic-anemia","display_name":"aplastic anemia","score":0.8529999852180481}],"concepts":[{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.7898108959197998},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7023956775665283},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6807843446731567},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6284474730491638},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6236497759819031},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5983231663703918},{"id":"https://openalex.org/C2781440808","wikidata":"https://www.wikidata.org/wiki/Q846316","display_name":"Aplastic anemia","level":3,"score":0.5522511005401611},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.4254271388053894},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4230024516582489},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.4123949706554413},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3106192350387573},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25531554222106934},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23059606552124023},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15677592158317566},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000741","descriptor_name":"Anemia, Aplastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001707","descriptor_name":"Biopsy, Needle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016026","descriptor_name":"Bone Marrow Transplantation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2559.1989.tb01588.x","doi":"https://doi.org/10.1111/j.1365-2559.1989.tb01588.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2559.1989.tb01588.x","pdf_url":null,"source":{"id":"https://openalex.org/S14376486","display_name":"Histopathology","issn_l":"0309-0167","issn":["0309-0167","1365-2559"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histopathology","raw_type":"journal-article"},{"id":"pmid:2807194","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2807194","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histopathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W23129651","https://openalex.org/W53286061","https://openalex.org/W115641494","https://openalex.org/W129073512","https://openalex.org/W235982319","https://openalex.org/W284351244","https://openalex.org/W1044182079","https://openalex.org/W1585526875","https://openalex.org/W1974264531","https://openalex.org/W1978341830","https://openalex.org/W1983293449","https://openalex.org/W1986621535","https://openalex.org/W1987444612","https://openalex.org/W1996907886","https://openalex.org/W2008319625","https://openalex.org/W2016179579","https://openalex.org/W2022992625","https://openalex.org/W2027449499","https://openalex.org/W2041310166","https://openalex.org/W2048813396","https://openalex.org/W2093287415","https://openalex.org/W2095239239","https://openalex.org/W2146204405","https://openalex.org/W2148891141","https://openalex.org/W2243781553","https://openalex.org/W2271710655","https://openalex.org/W2417737654","https://openalex.org/W2418396433","https://openalex.org/W2426877673","https://openalex.org/W3006425656"],"related_works":["https://openalex.org/W2068673144","https://openalex.org/W2426828061","https://openalex.org/W1996584108","https://openalex.org/W2015646468","https://openalex.org/W2035146124","https://openalex.org/W1969411059","https://openalex.org/W2417737654","https://openalex.org/W1974264531","https://openalex.org/W1975901002","https://openalex.org/W23129651"],"abstract_inverted_index":{"In":[0],"order":[1],"to":[2,103],"study":[3],"haematopoietic":[4,116,130],"reconstitution":[5],"in":[6,16,50,69,82,127,132],"allogeneic":[7],"bone":[8,13,25,90,134],"marrow":[9,14,26,91,135],"transplantation":[10,42,92],"we":[11],"investigated":[12],"histology":[15],"61":[17],"biopsies":[18,35,70,84],"of":[19,41,62,100,115,121,129,138],"37":[20],"patients,":[21],"treated":[22],"with":[23,77],"HLA-compatible":[24],"grafts":[27],"for":[28],"leukaemia":[29,72],"or":[30],"severe":[31],"aplastic":[32,78],"anaemia.":[33,79],"The":[34,80],"were":[36,56,66,108,143],"taken":[37],"from":[38,71,75],"the":[39,59,83,112,133,139],"day":[40],"until":[43,86],"100":[44],"d":[45,88],"after":[46,89],"transplantation.":[47],"Stromal":[48],"changes,":[49],"particular":[51],"oedema,":[52],"fibrosis":[53],"and":[54,93,137],"granulomas,":[55],"found":[57],"during":[58],"whole":[60],"period":[61],"observation.":[63],"These":[64],"changes":[65],"more":[67],"prominent":[68],"patients":[73,76],"than":[74],"cellularity":[81],"increased":[85],"28":[87],"was":[94,146],"stable":[95],"thereafter.":[96],"Initially,":[97],"only":[98],"clusters":[99],"cells":[101,117,131],"belonging":[102],"a":[104],"single":[105],"cell":[106],"lineage":[107],"seen,":[109],"suggesting":[110],"that":[111],"first":[113],"outgrowth":[114],"is":[118],"by":[119],"proliferation":[120],"committed":[122],"precursor":[123],"cells.":[124],"Long-lasting":[125],"abnormalities":[126],"localization":[128],"space":[136],"myeloid:":[140],"erythroid":[141],"ratio":[142],"seen;":[144],"dyserythropoiesis":[145],"common.":[147]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
