{"id":"https://openalex.org/W2004504258","doi":"https://doi.org/10.1089/jir.2006.26.593","title":"Review: Novel Nonviral Delivery Approaches for Interleukin-12 Protein and Gene Systems: Curbing Toxicity and Enhancing Adjuvant Activity","display_name":"Review: Novel Nonviral Delivery Approaches for Interleukin-12 Protein and Gene Systems: Curbing Toxicity and Enhancing Adjuvant Activity","publication_year":2006,"publication_date":"2006-09-01","ids":{"openalex":"https://openalex.org/W2004504258","doi":"https://doi.org/10.1089/jir.2006.26.593","mag":"2004504258","pmid":"https://pubmed.ncbi.nlm.nih.gov/16978064"},"language":"en","primary_location":{"id":"doi:10.1089/jir.2006.26.593","doi":"https://doi.org/10.1089/jir.2006.26.593","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jir.2006.26.593","pdf_url":null,"source":{"id":"https://openalex.org/S109620152","display_name":"Journal of Interferon & Cytokine Research","issn_l":"1079-9907","issn":["1079-9907","1557-7465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Interferon & Cytokine Research","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018009812","display_name":"Mohamed Labib Salem","orcid":"https://orcid.org/0000-0003-0840-5291","observed_orcids":["https://orcid.org/0000-0003-0840-5291"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed Labib Salem","raw_affiliation_strings":["Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, SC, 29425","Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, SC 29425, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, SC, 29425","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, SC 29425, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061892063","display_name":"William E. Gillanders","orcid":"https://orcid.org/0000-0002-0465-3071","observed_orcids":["https://orcid.org/0000-0002-0465-3071","https://orcid.org/0009-0008-7335-6039"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Gillanders","raw_affiliation_strings":["Section of Endocrine and Oncologic Surgery, Washington University in Saint Louis, Saint Louis, MO 63109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Endocrine and Oncologic Surgery, Washington University in Saint Louis, Saint Louis, MO 63109","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077530267","display_name":"Andre N. Kadima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andre N. Kadima","raw_affiliation_strings":["Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, SC, 29425"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, SC, 29425","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051893487","display_name":"Sabry Ali El-Naggar","orcid":"https://orcid.org/0000-0002-3001-795X","observed_orcids":["https://orcid.org/0000-0002-3001-795X"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sabry El-Naggar","raw_affiliation_strings":["Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, SC, 29425"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, SC, 29425","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046739998","display_name":"Mark P. Rubinstein","orcid":"https://orcid.org/0000-0003-4748-0286","observed_orcids":["https://orcid.org/0000-0003-4748-0286","https://orcid.org/0000-0002-9942-7519"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark P. Rubinstein","raw_affiliation_strings":["Department of Immunology, The Scripps Research Institute, La Jolla, CA 29425"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, The Scripps Research Institute, La Jolla, CA 29425","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045694271","display_name":"Marina V. Demcheva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121427","display_name":"Marine Polymer Technologies (United States)","ror":"https://ror.org/02fx6bp88","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121427"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina Demcheva","raw_affiliation_strings":["Marine Polymer Technologies, Inc., Burlington, MA 01803"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine Polymer Technologies, Inc., Burlington, MA 01803","institution_ids":["https://openalex.org/I4210121427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108800192","display_name":"John N. Vournakis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121427","display_name":"Marine Polymer Technologies (United States)","ror":"https://ror.org/02fx6bp88","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121427"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John N. Vournakis","raw_affiliation_strings":["Marine Polymer Technologies, Inc., Burlington, MA 01803"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine Polymer Technologies, Inc., Burlington, MA 01803","institution_ids":["https://openalex.org/I4210121427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011910232","display_name":"David J. Cole","orcid":"https://orcid.org/0000-0003-3162-701X","observed_orcids":["https://orcid.org/0000-0003-3162-701X"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Cole","raw_affiliation_strings":["Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, SC, 29425"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, SC, 29425","institution_ids":["https://openalex.org/I153297377"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.427,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.43257576,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"26","issue":"9","first_page":"593","last_page":"608"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.6865000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.6865000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.2703000009059906,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.019600000232458115,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":1.0},{"id":"https://openalex.org/keywords/cytokine-adjuvants","display_name":"cytokine adjuvants","score":0.7360000014305115},{"id":"https://openalex.org/keywords/vaccine-adjuvants","display_name":"vaccine adjuvants","score":0.7720000147819519},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.7689999938011169},{"id":"https://openalex.org/keywords/alum","display_name":"alum","score":0.6510000228881836},{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7390000224113464},{"id":"https://openalex.org/keywords/allergy","display_name":"allergy","score":0.8840000033378601},{"id":"https://openalex.org/keywords/infection","display_name":"infection","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.6117876768112183},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.594182014465332},{"id":"https://openalex.org/C25938499","wikidata":"https://www.wikidata.org/wiki/Q7663812","display_name":"Systemic administration","level":3,"score":0.5680056214332581},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.5167238116264343},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5094755291938782},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49270299077033997},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4610627591609955},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.44918641448020935},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.387848824262619},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36497294902801514},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.3181389570236206},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.2934165596961975},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12042170763015747},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000534","descriptor_name":"Alum Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007154","descriptor_name":"Immune System Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007154","descriptor_name":"Immune System Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1089/jir.2006.26.593","doi":"https://doi.org/10.1089/jir.2006.26.593","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jir.2006.26.593","pdf_url":null,"source":{"id":"https://openalex.org/S109620152","display_name":"Journal of Interferon & Cytokine Research","issn_l":"1079-9907","issn":["1079-9907","1557-7465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Interferon & Cytokine Research","raw_type":"journal-article"},{"id":"pmid:16978064","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16978064","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1511757166","display_name":null,"funder_award_id":"1 R01 CA94856-01","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":167,"referenced_works":["https://openalex.org/W197632038","https://openalex.org/W213967698","https://openalex.org/W1131703683","https://openalex.org/W1485835599","https://openalex.org/W1517571912","https://openalex.org/W1537962162","https://openalex.org/W1547259410","https://openalex.org/W1548525574","https://openalex.org/W1583336492","https://openalex.org/W1584902061","https://openalex.org/W1594950156","https://openalex.org/W1609710757","https://openalex.org/W1705459686","https://openalex.org/W1708782549","https://openalex.org/W1728287466","https://openalex.org/W1754891924","https://openalex.org/W1819195094","https://openalex.org/W1863743259","https://openalex.org/W1899361801","https://openalex.org/W1930568579","https://openalex.org/W1933591612","https://openalex.org/W1965953233","https://openalex.org/W1966400763","https://openalex.org/W1967285591","https://openalex.org/W1968918322","https://openalex.org/W1969061981","https://openalex.org/W1970279697","https://openalex.org/W1970751950","https://openalex.org/W1970874780","https://openalex.org/W1974719895","https://openalex.org/W1977734987","https://openalex.org/W1978426101","https://openalex.org/W1981602007","https://openalex.org/W1983468378","https://openalex.org/W1983594464","https://openalex.org/W1985061834","https://openalex.org/W1986364190","https://openalex.org/W1990531590","https://openalex.org/W1991524518","https://openalex.org/W1991862932","https://openalex.org/W1994318619","https://openalex.org/W1994841440","https://openalex.org/W1995246337","https://openalex.org/W1998358879","https://openalex.org/W1999031183","https://openalex.org/W2005543839","https://openalex.org/W2009219530","https://openalex.org/W2010655750","https://openalex.org/W2011873652","https://openalex.org/W2019386189","https://openalex.org/W2020987313","https://openalex.org/W2023903980","https://openalex.org/W2024161773","https://openalex.org/W2024509030","https://openalex.org/W2025374737","https://openalex.org/W2025757599","https://openalex.org/W2025878105","https://openalex.org/W2026678964","https://openalex.org/W2028144564","https://openalex.org/W2029194129","https://openalex.org/W2031253638","https://openalex.org/W2031464151","https://openalex.org/W2031828604","https://openalex.org/W2032269892","https://openalex.org/W2032555654","https://openalex.org/W2035862592","https://openalex.org/W2038072722","https://openalex.org/W2038707993","https://openalex.org/W2041679777","https://openalex.org/W2046821113","https://openalex.org/W2051041325","https://openalex.org/W2053947451","https://openalex.org/W2055801337","https://openalex.org/W2056229523","https://openalex.org/W2056698790","https://openalex.org/W2058116408","https://openalex.org/W2059433996","https://openalex.org/W2060185077","https://openalex.org/W2061471966","https://openalex.org/W2063885326","https://openalex.org/W2067114252","https://openalex.org/W2068986973","https://openalex.org/W2071015629","https://openalex.org/W2073883965","https://openalex.org/W2073996809","https://openalex.org/W2074174510","https://openalex.org/W2075147772","https://openalex.org/W2078364869","https://openalex.org/W2078961855","https://openalex.org/W2079379520","https://openalex.org/W2079422705","https://openalex.org/W2082742146","https://openalex.org/W2083140739","https://openalex.org/W2083851430","https://openalex.org/W2086656837","https://openalex.org/W2086661398","https://openalex.org/W2090757437","https://openalex.org/W2091835927","https://openalex.org/W2092768308","https://openalex.org/W2094102071","https://openalex.org/W2100041288","https://openalex.org/W2100509244","https://openalex.org/W2100510996","https://openalex.org/W2102755293","https://openalex.org/W2103033656","https://openalex.org/W2105382508","https://openalex.org/W2109435816","https://openalex.org/W2111085423","https://openalex.org/W2111935751","https://openalex.org/W2113269708","https://openalex.org/W2114269429","https://openalex.org/W2114914602","https://openalex.org/W2115832340","https://openalex.org/W2118518879","https://openalex.org/W2119047679","https://openalex.org/W2119969523","https://openalex.org/W2120303897","https://openalex.org/W2121421904","https://openalex.org/W2124103972","https://openalex.org/W2128730859","https://openalex.org/W2128885286","https://openalex.org/W2130549223","https://openalex.org/W2131071261","https://openalex.org/W2131424925","https://openalex.org/W2131746203","https://openalex.org/W2131833906","https://openalex.org/W2133142764","https://openalex.org/W2136674638","https://openalex.org/W2136715799","https://openalex.org/W2139619416","https://openalex.org/W2140148852","https://openalex.org/W2144661894","https://openalex.org/W2146128038","https://openalex.org/W2149694154","https://openalex.org/W2151707711","https://openalex.org/W2154574112","https://openalex.org/W2156467383","https://openalex.org/W2162196408","https://openalex.org/W2162280373","https://openalex.org/W2165625329","https://openalex.org/W2167521488","https://openalex.org/W2167774711","https://openalex.org/W2170103734","https://openalex.org/W2171049578","https://openalex.org/W2171463669","https://openalex.org/W2174658393","https://openalex.org/W2175034533","https://openalex.org/W2177606866","https://openalex.org/W2178037542","https://openalex.org/W2178116120","https://openalex.org/W2226022121","https://openalex.org/W2234015367","https://openalex.org/W2314388722","https://openalex.org/W2315570957","https://openalex.org/W2316005366","https://openalex.org/W2317040013","https://openalex.org/W2333509514","https://openalex.org/W2335430894","https://openalex.org/W2394745099","https://openalex.org/W2404960818","https://openalex.org/W2412157395","https://openalex.org/W2419548263","https://openalex.org/W2419661617","https://openalex.org/W2420441154","https://openalex.org/W4241169271","https://openalex.org/W4250647025","https://openalex.org/W4313379468"],"related_works":["https://openalex.org/W4403542270","https://openalex.org/W2899134125","https://openalex.org/W3093225819","https://openalex.org/W906880332","https://openalex.org/W2138905511","https://openalex.org/W2767171253","https://openalex.org/W2079422705","https://openalex.org/W2097177465","https://openalex.org/W7162122832","https://openalex.org/W2113058480"],"abstract_inverted_index":{"It":[0],"has":[1,68,92,144,172],"become":[2],"increasingly":[3],"apparent":[4],"that":[5,34,158,232],"the":[6,20,26,53,78,126,176,198,207,223,273],"ability":[7],"to":[8,58,95,161,166,205],"generate":[9],"an":[10,123],"optimal":[11],"host":[12],"immune":[13,27],"response":[14],"requires":[15],"effective":[16],"cross":[17,80],"talk":[18],"between":[19],"innate":[21],"and":[22,51,138,150,186,209,254,289],"adaptive":[23],"components":[24],"of":[25,49,55,90,120,133,178,200,225,276],"system.":[28],"Pro-inflammatory":[29],"cytokines,":[30],"in":[31,46,66,117,125,140,153,203,222,282],"particular":[32,67],"those":[33],"can":[35,105,233],"induce":[36],"a":[37,72,87,109,118,163,219],"danger":[38],"signal,":[39],"often":[40],"called":[41],"signal":[42],"3,":[43],"are":[44,248],"crucial":[45],"this":[47,83],"role":[48],"initiating":[50],"augmenting":[52],"presentation":[54],"exogenous":[56],"antigen":[57,79],"T":[59,114],"cells":[60],"by":[61],"dendritic":[62],"cells.":[63],"Interleukin-12":[64],"(IL-12)":[65],"been":[69,93,145],"defined":[70],"as":[71,108],"\"signal":[73],"3\"":[74],"cytokine":[75],"required":[76,211],"for":[77,100,112,212,229,241],"priming.":[81],"Given":[82],"unique":[84],"interactive":[85],"function,":[86],"significant":[88,148,220],"amount":[89],"work":[91],"performed":[94],"define":[96],"possible":[97],"therapeutic":[98],"applications":[99],"IL-12.":[101],"Systemic":[102],"IL-12":[103,130,179,230,242,279],"administration":[104,231],"clearly":[106],"act":[107],"potent":[110],"adjuvant":[111,263],"postvaccination":[113],"cell":[115],"responses":[116],"variety":[119],"diseases.":[121],"As":[122],"example,":[124],"cancer":[127],"setting,":[128],"systemic":[129,268],"is":[131,218],"capable":[132],"suppressing":[134],"tumor":[135],"growth,":[136],"metastasis,":[137],"angiogenesis":[139],"vivo.":[141],"IL-12,":[142],"however,":[143],"associated":[146],"with":[147,265],"dose-":[149],"schedule-dependent":[151],"toxicity":[152,177],"early":[154],"clinical":[155,168,214],"trials,":[156],"results":[157],"have":[159,195,260],"proven":[160],"be":[162],"major":[164],"obstacle":[165],"its":[167],"application.":[169,215],"Recent":[170],"research":[171],"focused":[173],"on":[174],"decreasing":[175],"using":[180],"different":[181,283],"delivery":[182,227,239,280],"approaches,":[183],"including":[184,197,251,286],"virus-based":[185],"gene-modified":[187],"cell-based":[188],"delivery.":[189,256],"Although":[190],"effective,":[191],"these":[192,235,277],"approaches":[193,228,240,259],"also":[194],"limitations,":[196],"generation":[199],"neutralizing":[201],"antibodies,":[202],"addition":[204],"lacking":[206],"simplicity":[208],"versatility":[210],"universal":[213],"Thus,":[216],"there":[217],"interest":[221],"development":[224],"alternative":[226],"overcome":[234],"issues.":[236],"Several":[237],"nonviral":[238],"protein":[243],"or":[244],"gene":[245],"expression":[246],"vectors":[247],"being":[249],"defined,":[250],"alum,":[252],"liposomes,":[253],"polymer-based":[255],"These":[257],"developing":[258],"shown":[261],"promising":[262],"effects":[264],"significantly":[266],"lessened":[267],"toxicity.":[269],"This":[270],"article":[271],"discusses":[272],"potential":[274],"capabilities":[275],"nonvirus-based":[278],"systems":[281],"disease":[284],"settings,":[285],"allergy,":[287],"infection,":[288],"cancer.":[290]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}