{"id":"https://openalex.org/W2004469740","doi":"https://doi.org/10.1046/j.1471-4159.1995.65031374.x","title":"Spinal Cord Dynorphin Precursor Intermediates Decline During Late Gestation","display_name":"Spinal Cord Dynorphin Precursor Intermediates Decline During Late Gestation","publication_year":1995,"publication_date":"1995-09-01","ids":{"openalex":"https://openalex.org/W2004469740","doi":"https://doi.org/10.1046/j.1471-4159.1995.65031374.x","mag":"2004469740","pmid":"https://pubmed.ncbi.nlm.nih.gov/7643115"},"language":"en","primary_location":{"id":"doi:10.1046/j.1471-4159.1995.65031374.x","doi":"https://doi.org/10.1046/j.1471-4159.1995.65031374.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1471-4159.1995.65031374.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055925092","display_name":"V. Medina","orcid":"https://orcid.org/0000-0001-5325-8337","observed_orcids":["https://orcid.org/0000-0001-5325-8337"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor M. Medina","raw_affiliation_strings":["Department of Biochemistry, State University of New York, Health Science Center at Brooklyn, 11203, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, State University of New York, Health Science Center at Brooklyn, 11203, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041894038","display_name":"Daya Shankar Gupta","orcid":"https://orcid.org/0000-0003-1084-9932","observed_orcids":["https://orcid.org/0000-0003-1084-9932"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daya Gupta","raw_affiliation_strings":["Department of Biochemistry, State University of New York Health Science Center at Brooklyn, Brooklyn, New York, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, State University of New York Health Science Center at Brooklyn, Brooklyn, New York, U.S.A","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082607533","display_name":"Alan R. Gintzler","orcid":"https://orcid.org/0000-0003-1307-0588","observed_orcids":["https://orcid.org/0000-0003-1307-0588"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alan R. Gintzler","raw_affiliation_strings":["Department of Biochemistry, State University of New York Health Science Center at Brooklyn, Brooklyn, New York, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, State University of New York Health Science Center at Brooklyn, Brooklyn, New York, U.S.A","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5082607533"],"corresponding_institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":0.1193,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.30626384,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"65","issue":"3","first_page":"1374","last_page":"1380"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12715","display_name":"Pregnancy-related medical research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dynorphin-a-1-17","display_name":"dynorphin A(1-17)","score":0.8629999756813049},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.6940000057220459},{"id":"https://openalex.org/keywords/late-pregnancy","display_name":"late pregnancy","score":0.8799999952316284},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.6660000085830688},{"id":"https://openalex.org/keywords/childbirth","display_name":"childbirth","score":0.7960000038146973},{"id":"https://openalex.org/keywords/enkephalin","display_name":"enkephalin","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C151077648","wikidata":"https://www.wikidata.org/wiki/Q324076","display_name":"Dynorphin","level":5,"score":0.786232590675354},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.6698172092437744},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.6329282522201538},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39065608382225037},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36813104152679443},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36693859100341797},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33915531635284424},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3304378390312195},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.2575046122074127},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.243017315864563},{"id":"https://openalex.org/C88016717","wikidata":"https://www.wikidata.org/wiki/Q417189","display_name":"Opioid peptide","level":4,"score":0.1288529634475708},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.08747240900993347},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05830380320549011},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000698","descriptor_name":"Analgesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004399","descriptor_name":"Dynorphins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004743","descriptor_name":"Enkephalin, Leucine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004743","descriptor_name":"Enkephalin, Leucine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004743","descriptor_name":"Enkephalin, Leucine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011270","descriptor_name":"Pregnancy, Animal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1471-4159.1995.65031374.x","doi":"https://doi.org/10.1046/j.1471-4159.1995.65031374.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1471-4159.1995.65031374.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:7643115","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7643115","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2075724227","https://openalex.org/W2062866484","https://openalex.org/W1564842764","https://openalex.org/W2077514162","https://openalex.org/W2065703483","https://openalex.org/W2127921089","https://openalex.org/W2023000793","https://openalex.org/W2014200234","https://openalex.org/W2022108298","https://openalex.org/W4232231985"],"abstract_inverted_index":{"This":[0,29,143],"laboratory":[1],"has":[2],"previously":[3],"reported":[4],"that":[5,167],"the":[6,43,60,69,77,88,102,115,122,130,135,155,175],"maternal":[7,23],"opioid":[8,27],"analgesia":[9,30],"associated":[10],"with":[11],"pregnancy":[12],"and":[13,40,56,141],"parturition":[14],"is":[15,31,107,165],"mediated,":[16],"at":[17,82],"least":[18],"in":[19,36,42,76,114,121,134,154],"part,":[20],"by":[21,33,149],"a":[22,83,151],"spinal":[24,45,67,123,160,182],"cord":[25,124,161],"dynorphin/kappa":[26],"system.":[28],"accompanied":[32],"an":[34],"increase":[35,133,153],"dynorphin":[37,63,72,92,96,105,118,138,162,171,183],"peptides":[38,139],"(1-17":[39,140],"1-8)":[41],"lumbar":[44],"cord.":[46],"Levels":[47],"of":[48,62,71,79,90,104,117,125,132,137,157,159,170,179,181,188],"trypsin-generated":[49],"arginine6-leucine-enkephalin":[50],"(Leu-Enk-Arg)-immunoreactive":[51],"determinants":[52],"were":[53],"also":[54],"determined":[55],"used":[57],"to":[58,185],"reflect":[59],"content":[61,89,103,136],"precursor":[64,80,106,119,172],"intermediates.":[65],"In":[66],"tissue,":[68],"amount":[70],"A":[73,93],"(1-17)":[74,94],"contained":[75],"form":[78],"is,":[81],"minimum,":[84],"10-fold":[85],"higher":[86],"than":[87],"mature":[91],"or":[95],"(1-8).":[97],"During":[98],"gestational":[99],"day":[100],"22,":[101],"reduced":[108],"significantly":[109],"(approximately":[110],"50%).":[111],"The":[112],"decline":[113],"magnitude":[116,131],"intermediates":[120,173],"pregnant":[126],"rats":[127],"vastly":[128],"exceeds":[129],"1-8).":[142],"difference":[144],"can":[145],"best":[146],"be":[147],"explained":[148],"postulating":[150],"corresponding":[152],"rate":[156],"release":[158],"(1-17).":[163],"It":[164],"suggested":[166],"enhanced":[168],"processing":[169],"represents":[174],"initial":[176],"biochemical":[177],"level":[178],"adaptation":[180],"neurons":[184],"increased":[186],"demands":[187],"pregnancy.":[189]},"counts_by_year":[{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
