{"id":"https://openalex.org/W2004458745","doi":"https://doi.org/10.1034/j.1399-6576.2003.00033.x","title":"A new short\u2010acting non\u2010depolarizing muscle relaxant (SZ1677) without cardiovascular side\u2010effects","display_name":"A new short\u2010acting non\u2010depolarizing muscle relaxant (SZ1677) without cardiovascular side\u2010effects","publication_year":2003,"publication_date":"2003-03-01","ids":{"openalex":"https://openalex.org/W2004458745","doi":"https://doi.org/10.1034/j.1399-6576.2003.00033.x","mag":"2004458745","pmid":"https://pubmed.ncbi.nlm.nih.gov/12648195"},"language":"en","primary_location":{"id":"doi:10.1034/j.1399-6576.2003.00033.x","doi":"https://doi.org/10.1034/j.1399-6576.2003.00033.x","is_oa":false,"landing_page_url":"https://doi.org/10.1034/j.1399-6576.2003.00033.x","pdf_url":null,"source":{"id":"https://openalex.org/S177321322","display_name":"Acta Anaesthesiologica Scandinavica","issn_l":"0001-5172","issn":["0001-5172","1399-6576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Anaesthesiologica Scandinavica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070442560","display_name":"E. Sylvester Vizi","orcid":"https://orcid.org/0000-0002-9557-4597","observed_orcids":["https://orcid.org/0000-0002-9557-4597"]},"institutions":[{"id":"https://openalex.org/I4210106880","display_name":"HUN-REN Institute of Experimental Medicine","ror":"https://ror.org/01jsgmp44","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210106880","https://openalex.org/I4387152226"]},{"id":"https://openalex.org/I7597260","display_name":"Hungarian Academy of Sciences","ror":"https://ror.org/02ks8qq67","country_code":"HU","type":"government","lineage":["https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"E. S. Vizi","raw_affiliation_strings":["Department of Pharmacology, Institute of Experimental Medicine, Budapest, Hungary. esvizi@koki.hu","Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Institute of Experimental Medicine, Budapest, Hungary. esvizi@koki.hu","institution_ids":["https://openalex.org/I4210106880"]},{"raw_affiliation_string":"Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences and","institution_ids":["https://openalex.org/I4210106880","https://openalex.org/I7597260"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Z. Tuba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2808169635","display_name":"Gedeon Richter (Hungary)","ror":"https://ror.org/0033rtn64","country_code":"HU","type":"company","lineage":["https://openalex.org/I2808169635"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Z. Tuba","raw_affiliation_strings":["Gedeon Richter Co., Budapest, Hungary; and","Gedeon Richter Co., Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gedeon Richter Co., Budapest, Hungary; and","institution_ids":["https://openalex.org/I2808169635"]},{"raw_affiliation_string":"Gedeon Richter Co., Budapest, Hungary","institution_ids":["https://openalex.org/I2808169635"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028068809","display_name":"S\u00e1ndor Mah\u00f3","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2808169635","display_name":"Gedeon Richter (Hungary)","ror":"https://ror.org/0033rtn64","country_code":"HU","type":"company","lineage":["https://openalex.org/I2808169635"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"S. Mah\u00f3","raw_affiliation_strings":["Gedeon Richter Co., Budapest, Hungary; and","Gedeon Richter Co., Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gedeon Richter Co., Budapest, Hungary; and","institution_ids":["https://openalex.org/I2808169635"]},{"raw_affiliation_string":"Gedeon Richter Co., Budapest, Hungary","institution_ids":["https://openalex.org/I2808169635"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113601173","display_name":"F. F. F\u00f6ldes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I4210106880","display_name":"HUN-REN Institute of Experimental Medicine","ror":"https://ror.org/01jsgmp44","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210106880","https://openalex.org/I4387152226"]},{"id":"https://openalex.org/I7597260","display_name":"Hungarian Academy of Sciences","ror":"https://ror.org/02ks8qq67","country_code":"HU","type":"government","lineage":["https://openalex.org/I7597260"]}],"countries":["HU","US"],"is_corresponding":false,"raw_author_name":"F. F. Foldes","raw_affiliation_strings":["Department of Anesthesiology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA","Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences and","F. F. Foldes and H. Nagashima are now deceased"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]},{"raw_affiliation_string":"Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences and","institution_ids":["https://openalex.org/I4210106880","https://openalex.org/I7597260"]},{"raw_affiliation_string":"F. F. Foldes and H. Nagashima are now deceased","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070955736","display_name":"Osamu Nagano","orcid":"https://orcid.org/0000-0002-7630-142X","observed_orcids":["https://orcid.org/0000-0002-7630-142X"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O. Nagano","raw_affiliation_strings":["Department of Anesthesiology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108220801","display_name":"M D\u00f3da","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106880","display_name":"HUN-REN Institute of Experimental Medicine","ror":"https://ror.org/01jsgmp44","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210106880","https://openalex.org/I4387152226"]},{"id":"https://openalex.org/I7597260","display_name":"Hungarian Academy of Sciences","ror":"https://ror.org/02ks8qq67","country_code":"HU","type":"government","lineage":["https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"M. D\u00f3da","raw_affiliation_strings":["Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences and","institution_ids":["https://openalex.org/I4210106880","https://openalex.org/I7597260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108571309","display_name":"Shunichi Takagi","orcid":"https://orcid.org/0000-0002-9982-3140","observed_orcids":["https://orcid.org/0000-0002-9982-3140"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Takagi","raw_affiliation_strings":["Department of Anesthesiology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074919787","display_name":"Imran Ali Chaudhry","orcid":"https://orcid.org/0000-0001-6726-0753","observed_orcids":["https://orcid.org/0000-0001-6726-0753"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I. A. Chaudhry","raw_affiliation_strings":["Department of Anesthesiology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045464305","display_name":"Albert J. Saubermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. J. Saubermann","raw_affiliation_strings":["Department of Anesthesiology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004628028","display_name":"Hideo Nagashima","orcid":"https://orcid.org/0000-0001-9495-9666","observed_orcids":["https://orcid.org/0000-0001-9495-9666"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Nagashima","raw_affiliation_strings":["Department of Anesthesiology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA","F. F. Foldes and H. Nagashima are now deceased"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]},{"raw_affiliation_string":"F. F. Foldes and H. Nagashima are now deceased","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":1.9123,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.84381808,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"47","issue":"3","first_page":"291","last_page":"300"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nondepolarizing-muscle-relaxants","display_name":"nondepolarizing muscle relaxants","score":0.9509999752044678},{"id":"https://openalex.org/keywords/neuromuscular-blocking-agents","display_name":"neuromuscular blocking agents","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cardiovascular-side-effects","display_name":"cardiovascular side effects","score":0.8270000219345093},{"id":"https://openalex.org/keywords/muscarinic-m3-receptor","display_name":"M3 muscarinic receptor","score":0.7440000176429749},{"id":"https://openalex.org/keywords/antimuscarinic-activity","display_name":"antimuscarinic activity","score":0.7120000123977661},{"id":"https://openalex.org/keywords/vagal-blockade","display_name":"vagal blockade","score":0.4620000123977661},{"id":"https://openalex.org/keywords/endotracheal-intubation","display_name":"endotracheal intubation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/neuromuscular-transmission","display_name":"neuromuscular transmission","score":0.8450000286102295},{"id":"https://openalex.org/keywords/phrenic-nerve-hemidiaphragm-preparation","display_name":"phrenic nerve-hemidiaphragm preparation","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7840065956115723},{"id":"https://openalex.org/C3020341438","wikidata":"https://www.wikidata.org/wiki/Q776995","display_name":"Neuromuscular transmission","level":2,"score":0.7592304944992065},{"id":"https://openalex.org/C2776184885","wikidata":"https://www.wikidata.org/wiki/Q27108523","display_name":"Vecuronium bromide","level":2,"score":0.5462512373924255},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.507190465927124},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.48737794160842896},{"id":"https://openalex.org/C2777240379","wikidata":"https://www.wikidata.org/wiki/Q776995","display_name":"Neuromuscular junction","level":2,"score":0.4372245669364929},{"id":"https://openalex.org/C2776860028","wikidata":"https://www.wikidata.org/wiki/Q1225289","display_name":"Muscle relaxant","level":2,"score":0.4322531819343567},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38132959604263306},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.343355268239975},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.09759330749511719},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07992386817932129}],"mesh":[{"descriptor_ui":"D000731","descriptor_name":"Androstanes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000731","descriptor_name":"Androstanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003473","descriptor_name":"Neuromuscular Nondepolarizing Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003473","descriptor_name":"Neuromuscular Nondepolarizing Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003964","descriptor_name":"Diaphragm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003964","descriptor_name":"Diaphragm","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009469","descriptor_name":"Neuromuscular Junction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010791","descriptor_name":"Phrenic Nerve","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018727","descriptor_name":"Muscarinic Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043585","descriptor_name":"Receptor, Muscarinic M2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043587","descriptor_name":"Receptor, Muscarinic M3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1034/j.1399-6576.2003.00033.x","doi":"https://doi.org/10.1034/j.1399-6576.2003.00033.x","is_oa":false,"landing_page_url":"https://doi.org/10.1034/j.1399-6576.2003.00033.x","pdf_url":null,"source":{"id":"https://openalex.org/S177321322","display_name":"Acta Anaesthesiologica Scandinavica","issn_l":"0001-5172","issn":["0001-5172","1399-6576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Anaesthesiologica Scandinavica","raw_type":"journal-article"},{"id":"pmid:12648195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12648195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta anaesthesiologica Scandinavica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W22742566","https://openalex.org/W623330879","https://openalex.org/W1965022313","https://openalex.org/W1968224530","https://openalex.org/W1974018894","https://openalex.org/W1978306706","https://openalex.org/W1991373132","https://openalex.org/W1995921885","https://openalex.org/W2012032544","https://openalex.org/W2014522372","https://openalex.org/W2015154473","https://openalex.org/W2027480337","https://openalex.org/W2035980303","https://openalex.org/W2036291564","https://openalex.org/W2045707927","https://openalex.org/W2063202080","https://openalex.org/W2065186421","https://openalex.org/W2073078141","https://openalex.org/W2073490199","https://openalex.org/W2074863006","https://openalex.org/W2075070814","https://openalex.org/W2077748275","https://openalex.org/W2078408911","https://openalex.org/W2079390564","https://openalex.org/W2086887229","https://openalex.org/W2088692152","https://openalex.org/W2089593978","https://openalex.org/W2090932488","https://openalex.org/W2094134062","https://openalex.org/W2101426091","https://openalex.org/W2103893486","https://openalex.org/W2114560884","https://openalex.org/W2116410301","https://openalex.org/W2118661969","https://openalex.org/W2125719967","https://openalex.org/W2138211402","https://openalex.org/W2156018461","https://openalex.org/W2261643195","https://openalex.org/W2410870229","https://openalex.org/W2438896472","https://openalex.org/W4243090935","https://openalex.org/W4318444686"],"related_works":["https://openalex.org/W2403625002","https://openalex.org/W7128488927","https://openalex.org/W2411002133","https://openalex.org/W2004796089","https://openalex.org/W56836724","https://openalex.org/W2416764944","https://openalex.org/W2535786422","https://openalex.org/W2079925951","https://openalex.org/W2331659236","https://openalex.org/W2089237673"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,299,326],"order":[2],"to":[3,39,61,248,330,346,353,355],"facilitate":[4],"rapid":[5,12,225],"tracheal":[6],"intubation,":[7],"the":[8,28,35,41,121,139,267,289,297,306,310,343],"development":[9],"of":[10,30,34,43,91,106,115,123,128,138,151,159,163,176,199,205,227,232,264,291,309],"a":[11,24,44,214,220,230,332,338],"onset,":[13],"short":[14,197,222],"duration,":[15],"non-depolarizing":[16,46,182,215],"muscle":[17,47,67,76,104,116,152,161,183,274,321],"relaxant":[18,48],"without":[19,238],"cardiovascular":[20,58,356],"side-effects":[21],"would":[22],"be":[23,331],"significant":[25],"accomplishment":[26],"in":[27,85,99,143,169,229,296],"field":[29],"anesthesiology.":[31],"The":[32],"aim":[33],"present":[36],"study":[37,147],"was":[38,72],"test":[40],"action":[42,228],"new":[45],"(SZ1677)":[49],"on":[50,120,126,154,281],"neuromuscular":[51,216,334,348],"transmission,":[52],"muscarinic":[53],"(M2,":[54],"M3)":[55],"receptors":[56],"and":[57,60,94,97,111,131,172,203,224,246,350],"reactions":[59],"compare":[62],"it":[63,285],"with":[64,191,219,316],"clinically":[65],"used":[66],"relaxants.":[68],"METHODS:":[69],"Neuromuscular":[70],"transmission":[71],"studied":[73],"by":[74,79,135],"recording":[75],"contractions":[77,158],"elicited":[78],"indirect":[80],"electrical":[81,136],"stimulation,":[82],"using":[83],"(i).":[84],"vitro":[86],"isolated":[87],"phrenic":[88],"nerve-hemidiaphragm":[89],"preparation":[90,105],"mice,":[92],"rats":[93],"guinea":[95,109,164],"pigs":[96,110],"(ii).":[98],"vivo":[100],"sciatic":[101],"nerve-anterior":[102],"tibial":[103],"anesthetized":[107,144],"rats,":[108],"cats.":[112,145],"Cardiovascular":[113],"effects":[114,125,255,280],"relaxants":[117,153,184],"were":[118,167,256],"evaluated":[119],"grounds":[122],"their":[124,170],"changes":[127],"blood":[129,244],"pressure":[130],"heart":[132],"rate":[133],"induced":[134],"stimulation":[137],"right":[140],"vagal":[141,253],"nerve":[142],"To":[146],"postsynaptic":[148],"antimuscarinic":[149],"affinity":[150],"M3":[155],"receptors,":[156],"oxotremorine-induced":[157],"longitudinal":[160],"strip":[162],"pig":[165],"ileum":[166],"registered":[168],"presence":[171],"absence.":[173],"RESULTS:":[174],"One":[175],"more":[177],"than":[178],"120":[179],"newly":[180],"synthesized":[181],"compounds,":[185],"1-3[alpha-hydroxy-17beta-acetyloxy-2beta-(1,4-dioxa-8-azaspiro[4,5]dec-8-yl)-5alpha-androstane-16beta-il]":[186],"-1-(2-propenyl)pyrrolidinium":[187],"bromide":[188],"(SZ1677),":[189],"excelled":[190],"its":[192],"advantageous":[193],"pharmacological":[194],"properties:":[195],"relatively":[196,221],"duration":[198,223],"action,":[200],"no":[201],"accumulation":[202],"lack":[204],"unwanted":[206],"side-effects.":[207,357],"Pharmacodynamic":[208],"studies":[209],"show":[210],"that":[211],"SZ1677":[212,313,328],"is":[213,237],"blocking":[217,254,335],"agent":[218],"onset":[226],"variety":[231],"laboratory":[233],"animal":[234],"species.":[235],"It":[236],"cumulative":[239],"effect,":[240],"does":[241,276,286],"not":[242,257,277,287],"reduce":[243],"pressure,":[245],"fails":[247],"produce":[249,347],"tachycardia.":[250],"Significant":[251],"cardiac":[252],"observed":[258],"even":[259],"at":[260,303],"concentrations":[261],"or":[262],"dosages":[263],"8":[265],"times":[266],"ED90.":[268],"This":[269],"compound,":[270],"unlike":[271],"many":[272],"other":[273],"relaxants,":[275,322],"have":[278],"atropine-like":[279],"human":[282],"atrial":[283],"tissue;":[284],"increase":[288],"release":[290],"NA":[292],"from":[293,305],"sympathetic":[294],"innervation":[295],"heart.":[298],"all":[300,317],"practical":[301],"ways,":[302],"least":[304],"vantage":[307],"point":[308],"preclinical":[311],"study,":[312],"compares":[314],"favorably":[315],"presently":[318],"available":[319],"short-acting":[320,333],"including":[323],"rapacuronium.":[324],"CONCLUSION:":[325],"experiments,":[327],"proved":[329],"compound":[336],"having":[337],"large":[339],"safety":[340],"margin":[341],"between":[342],"doses":[344],"required":[345],"block":[349],"those":[351],"likely":[352],"lead":[354]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}