{"id":"https://openalex.org/W2004455838","doi":"https://doi.org/10.3171/jns.1996.85.5.0846","title":"Inhibition of vascular contraction by intracisternal administration of preproendothelin-1 mRNA antisense oligoDNA in a rat experimental vasospasm model","display_name":"Inhibition of vascular contraction by intracisternal administration of preproendothelin-1 mRNA antisense oligoDNA in a rat experimental vasospasm model","publication_year":1996,"publication_date":"1996-11-01","ids":{"openalex":"https://openalex.org/W2004455838","doi":"https://doi.org/10.3171/jns.1996.85.5.0846","mag":"2004455838","pmid":"https://pubmed.ncbi.nlm.nih.gov/8893723"},"language":"en","primary_location":{"id":"doi:10.3171/jns.1996.85.5.0846","doi":"https://doi.org/10.3171/jns.1996.85.5.0846","is_oa":false,"landing_page_url":"https://doi.org/10.3171/jns.1996.85.5.0846","pdf_url":null,"source":{"id":"https://openalex.org/S1995308","display_name":"Journal of neurosurgery","issn_l":"0022-3085","issn":["0022-3085","1933-0693"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316861","host_organization_name":"American Association of Neurological Surgeons","host_organization_lineage":["https://openalex.org/P4310316861"],"host_organization_lineage_names":["American Association of Neurological Surgeons"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009935852","display_name":"Keisuke Onoda","orcid":"https://orcid.org/0000-0002-3640-8345","observed_orcids":["https://orcid.org/0000-0002-3640-8345"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keisuke Onoda","raw_affiliation_strings":["Department of Neurological Surgery, Okayama University Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Okayama University Medical School, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shigeki Ono","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shigeki Ono","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108466035","display_name":"Kotaro Ogihara","orcid":"https://orcid.org/0009-0000-0146-4198","observed_orcids":["https://orcid.org/0009-0000-0146-4198"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kotaro Ogihara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079423410","display_name":"Tomomi Shiota","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomomi Shiota","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110070375","display_name":"Shoji Asari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shoji Asari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110129563","display_name":"Takashi Ohmoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takashi Ohmoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5105989278","display_name":"Yoshifumi Ninomiya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshifumi Ninomiya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.7374,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.95157882,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"85","issue":"5","first_page":"846","last_page":"852"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.6890000104904175,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.6890000104904175,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.2542000114917755,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/preproendothelin-1-mrna","display_name":"preproendothelin-1 mRNA","score":0.9129999876022339},{"id":"https://openalex.org/keywords/antisense-oligodeoxynucleotides","display_name":"antisense oligodeoxynucleotides","score":0.9110000133514404},{"id":"https://openalex.org/keywords/phosphorothioate-antisense","display_name":"phosphorothioate antisense","score":0.8009999990463257},{"id":"https://openalex.org/keywords/intracisternal-administration","display_name":"intracisternal administration","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cerebral-vasospasm","display_name":"cerebral vasospasm","score":0.9330000281333923},{"id":"https://openalex.org/keywords/basilar-artery","display_name":"basilar artery","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.7850000262260437},{"id":"https://openalex.org/keywords/gene-expression-inhibition","display_name":"gene expression inhibition","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.7621100544929504},{"id":"https://openalex.org/C2778506911","wikidata":"https://www.wikidata.org/wiki/Q2849606","display_name":"Vasospasm","level":3,"score":0.7534415125846863},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6387637257575989},{"id":"https://openalex.org/C2778200158","wikidata":"https://www.wikidata.org/wiki/Q5122306","display_name":"Cisterna magna","level":3,"score":0.6333889961242676},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.6312103271484375},{"id":"https://openalex.org/C2776820941","wikidata":"https://www.wikidata.org/wiki/Q5064103","display_name":"Cerebral vasospasm","level":4,"score":0.6184179186820984},{"id":"https://openalex.org/C2781012200","wikidata":"https://www.wikidata.org/wiki/Q500339","display_name":"Basilar artery","level":2,"score":0.4858052730560303},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.4707542061805725},{"id":"https://openalex.org/C149601957","wikidata":"https://www.wikidata.org/wiki/Q390566","display_name":"Endothelin 1","level":3,"score":0.4464944899082184},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.4460323452949524},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3666544258594513},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3071576952934265},{"id":"https://openalex.org/C2777736543","wikidata":"https://www.wikidata.org/wiki/Q693442","display_name":"Subarachnoid hemorrhage","level":2,"score":0.287283718585968},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2850187122821808},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2807328701019287},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.19943863153457642},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.06730291247367859},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016232","descriptor_name":"Endothelins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3171/jns.1996.85.5.0846","doi":"https://doi.org/10.3171/jns.1996.85.5.0846","is_oa":false,"landing_page_url":"https://doi.org/10.3171/jns.1996.85.5.0846","pdf_url":null,"source":{"id":"https://openalex.org/S1995308","display_name":"Journal of neurosurgery","issn_l":"0022-3085","issn":["0022-3085","1933-0693"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316861","host_organization_name":"American Association of Neurological Surgeons","host_organization_lineage":["https://openalex.org/P4310316861"],"host_organization_lineage_names":["American Association of Neurological Surgeons"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosurgery","raw_type":"journal-article"},{"id":"pmid:8893723","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8893723","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurosurgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1513717105","https://openalex.org/W1963882365","https://openalex.org/W1965319333","https://openalex.org/W1967067462","https://openalex.org/W1970148323","https://openalex.org/W1977135493","https://openalex.org/W1988460287","https://openalex.org/W1989231795","https://openalex.org/W1996179195","https://openalex.org/W2000409508","https://openalex.org/W2002532000","https://openalex.org/W2005431808","https://openalex.org/W2006239014","https://openalex.org/W2020234907","https://openalex.org/W2031056911","https://openalex.org/W2034487226","https://openalex.org/W2045874302","https://openalex.org/W2063467571","https://openalex.org/W2066797341","https://openalex.org/W2068611486","https://openalex.org/W2073890849","https://openalex.org/W2081931352","https://openalex.org/W2084928266","https://openalex.org/W2090343238","https://openalex.org/W2111787291","https://openalex.org/W2114918609","https://openalex.org/W2127406901","https://openalex.org/W2144000290","https://openalex.org/W2146046550","https://openalex.org/W2147643233","https://openalex.org/W2153467120","https://openalex.org/W2162804111","https://openalex.org/W2427588808","https://openalex.org/W2434867231"],"related_works":["https://openalex.org/W55840843","https://openalex.org/W2001612453","https://openalex.org/W2016487221","https://openalex.org/W2025119936","https://openalex.org/W2076872618","https://openalex.org/W2315062626","https://openalex.org/W1878379619","https://openalex.org/W2129845236","https://openalex.org/W1996036619","https://openalex.org/W2145727880"],"abstract_inverted_index":{"To":[0],"clarify":[1],"the":[2,8,15,39,56,68,74,108,112,120,140,144],"role":[3,132],"of":[4,10,13,29,62,89,105],"endothelin-1":[5],"(ET-1)":[6],"in":[7,25,67,72,107,110,133,136,143],"etiology":[9],"hemolysate-induced":[11,134],"contraction":[12,80],"vessels,":[14],"authors":[16],"introduced":[17],"antisense":[18,32,45,141],"oligoDNA":[19],"for":[20,34,152],"preproendothelin-1":[21],"(ppET-1)":[22],"messenger":[23],"RNA":[24],"a":[26,149],"rat":[27],"model":[28],"vasospasm.":[30,155],"Phosphorothioate":[31],"oligoDNAs":[33,46,75,85],"ppET-1":[35,106],"were":[36,47,65,76],"injected":[37],"into":[38,55],"cisterna":[40],"magna.":[41],"Fluorescein":[42],"isothiocyanate-labeled":[43],"phosphorothioate":[44],"proven":[48],"by":[49,84],"fluorescence":[50],"chasing":[51],"to":[52],"be":[53,148],"incorporated":[54],"vascular":[57,79],"wall.":[58],"Striking":[59],"inhibitory":[60],"effects":[61],"experimental":[63],"vasospasm":[64],"observed":[66],"basilar":[69],"artery":[70],"(BA)":[71],"which":[73,92,111],"injected.":[77],"The":[78,123],"was":[81,114,116],"significantly":[82],"inhibited":[83,115],"after":[86,101],"20":[87,99],"minutes":[88,100],"hemolysate":[90,102],"exposure,":[91],"suggested":[93],"that":[94,126],"ET":[95],"synthesis":[96],"started":[97],"approximately":[98],"stimulation.":[103],"Expression":[104],"BA":[109],"spasm":[113],"markedly":[117],"suppressed":[118],"at":[119],"transcription":[121],"level.":[122],"results":[124],"indicate":[125],"ET-1":[127],"may":[128],"play":[129],"an":[130],"important":[131],"vasoconstriction":[135],"rats.":[137],"In":[138],"addition,":[139],"approach":[142],"cerebrospinal":[145],"fluid":[146],"might":[147],"useful":[150],"tool":[151],"preventing":[153],"cerebral":[154]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}