{"id":"https://openalex.org/W2004451237","doi":"https://doi.org/10.1111/joim.12352","title":"White matter changes in familial Alzheimer's disease","display_name":"White matter changes in familial Alzheimer's disease","publication_year":2015,"publication_date":"2015-01-31","ids":{"openalex":"https://openalex.org/W2004451237","doi":"https://doi.org/10.1111/joim.12352","mag":"2004451237","pmid":"https://pubmed.ncbi.nlm.nih.gov/25639959"},"language":"en","primary_location":{"id":"doi:10.1111/joim.12352","doi":"https://doi.org/10.1111/joim.12352","is_oa":false,"landing_page_url":"https://doi.org/10.1111/joim.12352","pdf_url":null,"source":{"id":"https://openalex.org/S29157290","display_name":"Journal of Internal Medicine","issn_l":"0954-6820","issn":["0954-6820","1365-2796"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100445615","display_name":"Xia Li","orcid":"https://orcid.org/0000-0003-1922-7152","observed_orcids":["https://orcid.org/0000-0003-1922-7152"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"X. Li","raw_affiliation_strings":["Karolinska Institutet Department of Neurobiology, Care Science and Society (NVS) Division of Clinical Geriatrics Stockholm Sweden","Karolinska Institutet, Department of Neurobiology, Care Science and Society (NVS), Division of Clinical Geriatrics, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institutet Department of Neurobiology, Care Science and Society (NVS) Division of Clinical Geriatrics Stockholm Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Karolinska Institutet, Department of Neurobiology, Care Science and Society (NVS), Division of Clinical Geriatrics, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081777822","display_name":"Eric Westman","orcid":"https://orcid.org/0000-0002-3115-2977","observed_orcids":["https://orcid.org/0000-0002-3115-2977"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"E. Westman","raw_affiliation_strings":["Karolinska Institutet Department of Neurobiology, Care Science and Society (NVS) Division of Clinical Geriatrics Stockholm Sweden","Karolinska Institutet, Department of Neurobiology, Care Science and Society (NVS), Division of Clinical Geriatrics, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institutet Department of Neurobiology, Care Science and Society (NVS) Division of Clinical Geriatrics Stockholm Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Karolinska Institutet, Department of Neurobiology, Care Science and Society (NVS), Division of Clinical Geriatrics, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113972184","display_name":"Anne Kinhult St\u00e5hlbom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"A. K. St\u00e5hlbom","raw_affiliation_strings":["Department of Geriatric Medicine Karolinska University Hospital Huddinge Stockholm Sweden","Karolinska Institutet Department of NVS, Division of Neurogeriatrics Center for Alzheimer Disease Research Huddinge Stockholm Sweden","Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden","Karolinska Institutet, Department of NVS, Division of Neurogeriatrics, Center for Alzheimer Disease Research, Huddinge, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Medicine Karolinska University Hospital Huddinge Stockholm Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Karolinska Institutet Department of NVS, Division of Neurogeriatrics Center for Alzheimer Disease Research Huddinge Stockholm Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Karolinska Institutet, Department of NVS, Division of Neurogeriatrics, Center for Alzheimer Disease Research, Huddinge, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Thordardottir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"S. Thordardottir","raw_affiliation_strings":["Department of Geriatric Medicine Karolinska University Hospital Huddinge Stockholm Sweden","Karolinska Institutet Department of NVS, Division of Neurogeriatrics Center for Alzheimer Disease Research Huddinge Stockholm Sweden","Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden","Karolinska Institutet, Department of NVS, Division of Neurogeriatrics, Center for Alzheimer Disease Research, Huddinge, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Medicine Karolinska University Hospital Huddinge Stockholm Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Karolinska Institutet Department of NVS, Division of Neurogeriatrics Center for Alzheimer Disease Research Huddinge Stockholm Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Karolinska Institutet, Department of NVS, Division of Neurogeriatrics, Center for Alzheimer Disease Research, Huddinge, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087294774","display_name":"Ove Almkvist","orcid":"https://orcid.org/0000-0003-0556-625X","observed_orcids":["https://orcid.org/0000-0003-0556-625X"]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"O. Almkvist","raw_affiliation_strings":["Karolinska Institutet Department of Neurobiology, Care Science and Society (NVS) Division of Clinical Geriatrics Stockholm Sweden","Stockholm University Department of Psychology Stockholm Sweden","Karolinska Institutet, Department of Neurobiology, Care Science and Society (NVS), Division of Clinical Geriatrics, Stockholm, Sweden","Stockholm University; Department of Psychology; Stockholm Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institutet Department of Neurobiology, Care Science and Society (NVS) Division of Clinical Geriatrics Stockholm Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Stockholm University Department of Psychology Stockholm Sweden","institution_ids":["https://openalex.org/I161593684"]},{"raw_affiliation_string":"Karolinska Institutet, Department of Neurobiology, Care Science and Society (NVS), Division of Clinical Geriatrics, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Stockholm University; Department of Psychology; Stockholm Sweden","institution_ids":["https://openalex.org/I161593684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025313057","display_name":"Kaj Blennow","orcid":"https://orcid.org/0000-0002-1890-4193","observed_orcids":["https://orcid.org/0000-0002-1890-4193"]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"K. Blennow","raw_affiliation_strings":["Institute of Clinical Neuroscience Sahlgrenska University Hospital M\u00f6lndal Sweden","Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Molndal, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Neuroscience Sahlgrenska University Hospital M\u00f6lndal Sweden","institution_ids":["https://openalex.org/I2801112325"]},{"raw_affiliation_string":"Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Molndal, Sweden","institution_ids":["https://openalex.org/I2801112325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035250882","display_name":"Lars\u2010Olof Wahlund","orcid":"https://orcid.org/0000-0002-9905-8426","observed_orcids":["https://orcid.org/0000-0002-9905-8426"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"L.\u2010O. Wahlund","raw_affiliation_strings":["Karolinska Institutet Department of Neurobiology, Care Science and Society (NVS) Division of Clinical Geriatrics Stockholm Sweden","Karolinska Institutet, Department of Neurobiology, Care Science and Society (NVS), Division of Clinical Geriatrics, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institutet Department of Neurobiology, Care Science and Society (NVS) Division of Clinical Geriatrics Stockholm Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Karolinska Institutet, Department of Neurobiology, Care Science and Society (NVS), Division of Clinical Geriatrics, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012540754","display_name":"Caroline Graff","orcid":"https://orcid.org/0000-0002-9949-2951","observed_orcids":["https://orcid.org/0000-0002-9949-2951"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"C. Graff","raw_affiliation_strings":["Department of Geriatric Medicine Karolinska University Hospital Huddinge Stockholm Sweden","Karolinska Institutet Department of NVS, Division of Neurogeriatrics Center for Alzheimer Disease Research Huddinge Stockholm Sweden","Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden","Karolinska Institutet, Department of NVS, Division of Neurogeriatrics, Center for Alzheimer Disease Research, Huddinge, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Medicine Karolinska University Hospital Huddinge Stockholm Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Karolinska Institutet Department of NVS, Division of Neurogeriatrics Center for Alzheimer Disease Research Huddinge Stockholm Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Karolinska Institutet, Department of NVS, Division of Neurogeriatrics, Center for Alzheimer Disease Research, Huddinge, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5035250882"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":2.5757,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.88722113,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"278","issue":"2","first_page":"211","last_page":"218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7505000233650208,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7505000233650208,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.23360000550746918,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/familial-alzheimer-s-disease","display_name":"familial Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/white-matter-changes","display_name":"white matter changes","score":0.8180000185966492},{"id":"https://openalex.org/keywords/psen1-mutations","display_name":"PSEN1 mutations","score":0.7239999771118164},{"id":"https://openalex.org/keywords/app-mutations","display_name":"APP mutations","score":0.9750000238418579},{"id":"https://openalex.org/keywords/presymptomatic-mutation-carriers","display_name":"presymptomatic mutation carriers","score":0.9340000152587891},{"id":"https://openalex.org/keywords/mean-diffusivity","display_name":"mean diffusivity","score":0.9390000104904175},{"id":"https://openalex.org/keywords/fractional-anisotropy","display_name":"fractional anisotropy","score":0.984000027179718},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-biomarkers","display_name":"cerebrospinal fluid biomarkers","score":0.8970000147819519},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.8679999709129333},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.5839999914169312},{"id":"https://openalex.org/keywords/inferior-longitudinal-fasciculus","display_name":"inferior longitudinal fasciculus","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cingulum","display_name":"cingulum","score":0.9110000133514404},{"id":"https://openalex.org/keywords/superior-longitudinal-fasciculus","display_name":"superior longitudinal fasciculus","score":0.9800000190734863},{"id":"https://openalex.org/keywords/grey-matter-volume","display_name":"gray matter volume","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8701488971710205},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.5625637769699097},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5201849937438965},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5021417140960693},{"id":"https://openalex.org/C56273599","wikidata":"https://www.wikidata.org/wiki/Q3122841","display_name":"White (mutation)","level":3,"score":0.4851161241531372},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24990373849868774},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1790427565574646},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.13273504376411438},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/joim.12352","doi":"https://doi.org/10.1111/joim.12352","is_oa":false,"landing_page_url":"https://doi.org/10.1111/joim.12352","pdf_url":null,"source":{"id":"https://openalex.org/S29157290","display_name":"Journal of Internal Medicine","issn_l":"0954-6820","issn":["0954-6820","1365-2796"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:25639959","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25639959","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of internal medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.44999998807907104,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322315","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691"},{"id":"https://openalex.org/F4320322570","display_name":"Stockholms L\u00e4ns Landsting","ror":"https://ror.org/02zrae794"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320324405","display_name":"Swedish Brain Power","ror":"https://ror.org/046w6p285"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W16095117","https://openalex.org/W1606825164","https://openalex.org/W1798803748","https://openalex.org/W1847168837","https://openalex.org/W1964933013","https://openalex.org/W1978177698","https://openalex.org/W1979876709","https://openalex.org/W1981027686","https://openalex.org/W1994206031","https://openalex.org/W2000397440","https://openalex.org/W2001791518","https://openalex.org/W2011402798","https://openalex.org/W2015629132","https://openalex.org/W2029486567","https://openalex.org/W2029695041","https://openalex.org/W2030641075","https://openalex.org/W2036906743","https://openalex.org/W2039911756","https://openalex.org/W2055649795","https://openalex.org/W2058621419","https://openalex.org/W2062073930","https://openalex.org/W2063715964","https://openalex.org/W2085851888","https://openalex.org/W2093508373","https://openalex.org/W2096410114","https://openalex.org/W2099166256","https://openalex.org/W2111425471","https://openalex.org/W2117635180","https://openalex.org/W2128197886","https://openalex.org/W2136936410","https://openalex.org/W2154749730","https://openalex.org/W2155346147","https://openalex.org/W2158592797","https://openalex.org/W2163958074","https://openalex.org/W2165441361","https://openalex.org/W2171250577","https://openalex.org/W4299344199"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W2586801360","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"BACKGROUND:":[0],"Familial":[1],"Alzheimer's":[2,229],"disease":[3],"(FAD)":[4],"resulting":[5],"from":[6,111],"gene":[7,198],"mutations":[8,53,199],"in":[9,18,31,43,54,64,119,123,135,147,181,205,219,227],"PSEN1,":[10],"PSEN2":[11],"and":[12,38,56,58,71,86,93,103,106,130,170,175,184],"APP":[13,57],"is":[14],"associated":[15],"with":[16,50,138,164,173,222],"changes":[17,30,204,213,218],"the":[19,39,65,124,143,148,150,165,187,220],"brain.":[20],"OBJECTIVE:":[21],"The":[22,154,190,211],"aim":[23],"of":[24,142,157,168,192],"this":[25,193],"study":[26,194],"was":[27,121],"to":[28,217],"investigate":[29],"grey":[32],"matter":[33,36],"(GM),":[34],"white":[35],"(WM)":[37],"cerebrospinal":[40],"fluid":[41],"(CSF)":[42],"FAD.":[44],"SUBJECTS:":[45],"Ten":[46],"mutation":[47],"carriers":[48],"(MCs)":[49],"three":[51,144],"different":[52],"PSEN1":[55],"20":[59],"noncarriers":[60],"(NCs)":[61],"were":[62,69,73,99,109,179,215],"included":[63],"study.":[66],"Three":[67],"MCs":[68,102,146],"symptomatic":[70,145],"seven":[72],"presymptomatic":[74],"(pre-MCs).":[75],"METHODS:":[76],"Whole-brain":[77],"GM":[78,182,206],"volume":[79,183,207],"as":[80,82],"well":[81],"fractional":[83],"anisotropy":[84],"(FA)":[85],"mean":[87,155],"diffusivity":[88,202],"(MD)":[89],"using":[90],"voxel-based":[91],"morphometry":[92],"tract-based":[94],"spatial":[95],"statistics":[96],"analyses,":[97],"respectively,":[98],"compared":[100,137],"between":[101,186],"NCs.":[104,139],"FA":[105,185],"MD":[107,120,156],"maps":[108],"obtained":[110],"diffusion":[112],"tensor":[113],"imaging.":[114],"RESULTS:":[115],"A":[116],"significant":[117,161],"increase":[118],"found":[122],"left":[125],"inferior":[126],"longitudinal":[127,133],"fasciculus,":[128],"cingulum":[129],"bilateral":[131],"superior":[132],"fasciculus":[134],"pre-MCs":[136],"After":[140],"inclusion":[141],"analysis,":[149],"regions":[151,159],"became":[152],"wider.":[153],"these":[158],"showed":[160],"negative":[162],"correlation":[163],"CSF":[166],"level":[167],"A\u03b242,":[169],"positive":[171],"correlations":[172],"P-tau181p":[174],"T-tau.":[176],"No":[177],"differences":[178],"observed":[180,214,226],"groups.":[188],"CONCLUSIONS:":[189],"results":[191],"suggest":[195],"that":[196],"FAD":[197],"affect":[200],"WM":[201,212],"before":[203],"can":[208],"be":[209],"detected.":[210],"related":[216],"CSF,":[221],"similar":[223],"patterns":[224],"previously":[225],"sporadic":[228],"disease.":[230]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}