{"id":"https://openalex.org/W2004414770","doi":"https://doi.org/10.1111/j.1471-4159.2009.06429.x","title":"Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid","display_name":"Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid","publication_year":2009,"publication_date":"2009-10-10","ids":{"openalex":"https://openalex.org/W2004414770","doi":"https://doi.org/10.1111/j.1471-4159.2009.06429.x","mag":"2004414770","pmid":"https://pubmed.ncbi.nlm.nih.gov/19818102"},"language":"en","primary_location":{"id":"doi:10.1111/j.1471-4159.2009.06429.x","doi":"https://doi.org/10.1111/j.1471-4159.2009.06429.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.2009.06429.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073328066","display_name":"Ana Rita Vaz","orcid":"https://orcid.org/0000-0002-3418-3269","observed_orcids":["https://orcid.org/0000-0002-3418-3269"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ana Rita Vaz","raw_affiliation_strings":["Centro de Patog\u00e9nese Molecular - UBMBE/iMed.UL, Faculdade de Farm\u00e1cia, University of Lisbon, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Patog\u00e9nese Molecular - UBMBE/iMed.UL, Faculdade de Farm\u00e1cia, University of Lisbon, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051150443","display_name":"Mar\u00eda Delgado\u2010Esteban","orcid":"https://orcid.org/0000-0002-6205-6611","observed_orcids":["https://orcid.org/0000-0002-6205-6611"]},"institutions":[{"id":"https://openalex.org/I4210094790","display_name":"Instituto de Estudios de Ciencias de la Salud de Castilla y Le\u00f3n","ror":"https://ror.org/00vn23s59","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210094790"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Delgado\u2010Esteban","raw_affiliation_strings":["Unidad de Investigacio\u0301n, Hospital Universitario de Salamanca, Instituto de Estudios de Ciencias de la Salud de Castilla y Leo\u0301n, Salamanca, Spain","Unidad de Investigaci\u00f3n, Hospital Universitario de Salamanca, Instituto de Estudios de Ciencias de la Salud de Castilla y Le\u00f3n, Salamanca, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de Investigacio\u0301n, Hospital Universitario de Salamanca, Instituto de Estudios de Ciencias de la Salud de Castilla y Leo\u0301n, Salamanca, Spain","institution_ids":["https://openalex.org/I4210094790"]},{"raw_affiliation_string":"Unidad de Investigaci\u00f3n, Hospital Universitario de Salamanca, Instituto de Estudios de Ciencias de la Salud de Castilla y Le\u00f3n, Salamanca, Spain","institution_ids":["https://openalex.org/I4210094790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102753944","display_name":"Mar\u00eda Alexandra Brito","orcid":"https://orcid.org/0000-0002-8493-4649","observed_orcids":["https://orcid.org/0000-0002-8493-4649"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Maria Alexandra Brito","raw_affiliation_strings":["Centro de Patoge\u0301nese Molecular \u2013 UBMBE/iMed.UL, Faculdade de Farma\u0301cia, University of Lisbon, Lisbon, Portugal","Centro de Patog\u00e9nese Molecular \u2013 UBMBE/iMed.UL, Faculdade de Farm\u00e1cia, University of Lisbon, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Patoge\u0301nese Molecular \u2013 UBMBE/iMed.UL, Faculdade de Farma\u0301cia, University of Lisbon, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]},{"raw_affiliation_string":"Centro de Patog\u00e9nese Molecular \u2013 UBMBE/iMed.UL, Faculdade de Farm\u00e1cia, University of Lisbon, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058571857","display_name":"Juan Pedro Bola\u00f1os","orcid":"https://orcid.org/0000-0002-3949-6862","observed_orcids":["https://orcid.org/0000-0002-3949-6862"]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]},{"id":"https://openalex.org/I4387156156","display_name":"Instituto de Neurociencias de Castilla y Le\u00f3n","ror":"https://ror.org/03fwfk305","country_code":"ES","type":"facility","lineage":["https://openalex.org/I108103353","https://openalex.org/I184999862","https://openalex.org/I4387156156"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Juan P. Bola\u00f1os","raw_affiliation_strings":["Departamento de Bioqui\u0301mica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leo\u0301n, University of Salamanca, Salamanca, Spain","Departamento de Bioqu\u00edmica y Biologia Molecular, Instituto de Neurociencias de Castilla y Le\u00f3n, University of Salamanca, Salamanca, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqui\u0301mica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leo\u0301n, University of Salamanca, Salamanca, Spain","institution_ids":["https://openalex.org/I184999862","https://openalex.org/I4387156156"]},{"raw_affiliation_string":"Departamento de Bioqu\u00edmica y Biologia Molecular, Instituto de Neurociencias de Castilla y Le\u00f3n, University of Salamanca, Salamanca, Spain","institution_ids":["https://openalex.org/I184999862","https://openalex.org/I4387156156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088219344","display_name":"Dora Maria Tuna Oliveira Brites","orcid":"https://orcid.org/0000-0002-3024-9777","observed_orcids":["https://orcid.org/0000-0002-3024-9777"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Dora Brites","raw_affiliation_strings":["Centro de Patoge\u0301nese Molecular \u2013 UBMBE/iMed.UL, Faculdade de Farma\u0301cia, University of Lisbon, Lisbon, Portugal","Centro de Patog\u00e9nese Molecular \u2013 UBMBE/iMed.UL, Faculdade de Farm\u00e1cia, University of Lisbon, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Patoge\u0301nese Molecular \u2013 UBMBE/iMed.UL, Faculdade de Farma\u0301cia, University of Lisbon, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]},{"raw_affiliation_string":"Centro de Patog\u00e9nese Molecular \u2013 UBMBE/iMed.UL, Faculdade de Farm\u00e1cia, University of Lisbon, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050991733","display_name":"\u00c1ngeles Almeida","orcid":"https://orcid.org/0000-0003-0485-8904","observed_orcids":["https://orcid.org/0000-0003-0485-8904"]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]},{"id":"https://openalex.org/I4210094790","display_name":"Instituto de Estudios de Ciencias de la Salud de Castilla y Le\u00f3n","ror":"https://ror.org/00vn23s59","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210094790"]},{"id":"https://openalex.org/I4387156156","display_name":"Instituto de Neurociencias de Castilla y Le\u00f3n","ror":"https://ror.org/03fwfk305","country_code":"ES","type":"facility","lineage":["https://openalex.org/I108103353","https://openalex.org/I184999862","https://openalex.org/I4387156156"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Angeles Almeida","raw_affiliation_strings":["Departamento de Bioqui\u0301mica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leo\u0301n, University of Salamanca, Salamanca, Spain","Unidad de Investigacio\u0301n, Hospital Universitario de Salamanca, Instituto de Estudios de Ciencias de la Salud de Castilla y Leo\u0301n, Salamanca, Spain","Departamento de Bioqu\u00edmica y Biologia Molecular, Instituto de Neurociencias de Castilla y Le\u00f3n, University of Salamanca, Salamanca, Spain","Unidad de Investigaci\u00f3n, Hospital Universitario de Salamanca, Instituto de Estudios de Ciencias de la Salud de Castilla y Le\u00f3n, Salamanca, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqui\u0301mica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leo\u0301n, University of Salamanca, Salamanca, Spain","institution_ids":["https://openalex.org/I184999862","https://openalex.org/I4387156156"]},{"raw_affiliation_string":"Unidad de Investigacio\u0301n, Hospital Universitario de Salamanca, Instituto de Estudios de Ciencias de la Salud de Castilla y Leo\u0301n, Salamanca, Spain","institution_ids":["https://openalex.org/I4210094790"]},{"raw_affiliation_string":"Departamento de Bioqu\u00edmica y Biologia Molecular, Instituto de Neurociencias de Castilla y Le\u00f3n, University of Salamanca, Salamanca, Spain","institution_ids":["https://openalex.org/I184999862","https://openalex.org/I4387156156"]},{"raw_affiliation_string":"Unidad de Investigaci\u00f3n, Hospital Universitario de Salamanca, Instituto de Estudios de Ciencias de la Salud de Castilla y Le\u00f3n, Salamanca, Spain","institution_ids":["https://openalex.org/I4210094790"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5058571857","https://openalex.org/A5088219344"],"corresponding_institution_ids":["https://openalex.org/I141596103","https://openalex.org/I184999862","https://openalex.org/I4387156156"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":6.5153,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.96632256,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"112","issue":"1","first_page":"56","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/unconjugated-bilirubin","display_name":"unconjugated bilirubin","score":0.9800000190734863},{"id":"https://openalex.org/keywords/neonatal-hyperbilirubinemia","display_name":"neonatal hyperbilirubinemia","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cytochrome-c-oxidase-inhibition","display_name":"cytochrome c oxidase inhibition","score":0.9620000123977661},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7319999933242798},{"id":"https://openalex.org/keywords/glycoursodeoxycholic-acid","display_name":"glycoursodeoxycholic acid","score":0.9869999885559082},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9800000190734863},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8939999938011169},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.8190000057220459},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.7860000133514404},{"id":"https://openalex.org/keywords/glutathione-redox-status","display_name":"glutathione redox state","score":0.878000020980835},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.7540000081062317},{"id":"https://openalex.org/keywords/atp-release","display_name":"ATP release","score":0.5419999957084656},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6504219770431519},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.6269201636314392},{"id":"https://openalex.org/C123249941","wikidata":"https://www.wikidata.org/wiki/Q306116","display_name":"Cytochrome c oxidase","level":3,"score":0.5634849071502686},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5582823157310486},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5242788195610046},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.4938426613807678},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.48392254114151},{"id":"https://openalex.org/C2777513400","wikidata":"https://www.wikidata.org/wiki/Q104219","display_name":"Bilirubin","level":2,"score":0.47338858246803284},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4705379903316498},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4655360281467438},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4407656788825989},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.4288691282272339},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.39308080077171326},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3920356333255768},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36041736602783203},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3540794253349304},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3484814167022705},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19800493121147156},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.16521266102790833},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15874075889587402}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001663","descriptor_name":"Bilirubin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001663","descriptor_name":"Bilirubin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003576","descriptor_name":"Electron Transport Complex IV","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D003576","descriptor_name":"Electron Transport Complex IV","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014580","descriptor_name":"Ursodeoxycholic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014580","descriptor_name":"Ursodeoxycholic Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1471-4159.2009.06429.x","doi":"https://doi.org/10.1111/j.1471-4159.2009.06429.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.2009.06429.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:19818102","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19818102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/7","score":0.4300000071525574,"display_name":"Affordable and clean energy"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W601378158","https://openalex.org/W962061814","https://openalex.org/W1512339474","https://openalex.org/W1528220495","https://openalex.org/W1534977663","https://openalex.org/W1564481759","https://openalex.org/W1566830427","https://openalex.org/W1775749144","https://openalex.org/W1804279373","https://openalex.org/W1842081329","https://openalex.org/W1968249160","https://openalex.org/W1974206578","https://openalex.org/W1982028290","https://openalex.org/W1983074550","https://openalex.org/W1985994475","https://openalex.org/W1992587800","https://openalex.org/W2002842565","https://openalex.org/W2009512214","https://openalex.org/W2011241671","https://openalex.org/W2013127483","https://openalex.org/W2013500629","https://openalex.org/W2014944403","https://openalex.org/W2015669748","https://openalex.org/W2018741552","https://openalex.org/W2018960634","https://openalex.org/W2019118443","https://openalex.org/W2019568399","https://openalex.org/W2026974242","https://openalex.org/W2031458979","https://openalex.org/W2031462364","https://openalex.org/W2036685561","https://openalex.org/W2040601222","https://openalex.org/W2043968522","https://openalex.org/W2044222280","https://openalex.org/W2047545717","https://openalex.org/W2054846013","https://openalex.org/W2058137794","https://openalex.org/W2062788787","https://openalex.org/W2064863416","https://openalex.org/W2065083920","https://openalex.org/W2068973405","https://openalex.org/W2073268517","https://openalex.org/W2076049599","https://openalex.org/W2077274456","https://openalex.org/W2078316289","https://openalex.org/W2079705176","https://openalex.org/W2079762064","https://openalex.org/W2090509794","https://openalex.org/W2090929775","https://openalex.org/W2091346965","https://openalex.org/W2092984629","https://openalex.org/W2094360690","https://openalex.org/W2098685543","https://openalex.org/W2103552101","https://openalex.org/W2130630654","https://openalex.org/W2144194910","https://openalex.org/W2164016655","https://openalex.org/W2169714384","https://openalex.org/W2203773224","https://openalex.org/W2335241871","https://openalex.org/W2410325817","https://openalex.org/W2517175497","https://openalex.org/W2767325844","https://openalex.org/W4210965190"],"related_works":["https://openalex.org/W2064863416","https://openalex.org/W2334861007","https://openalex.org/W2019256386","https://openalex.org/W1973500800","https://openalex.org/W2009351490","https://openalex.org/W2103552101","https://openalex.org/W1970077557","https://openalex.org/W2050540705","https://openalex.org/W2063259135","https://openalex.org/W2786000385"],"abstract_inverted_index":{"High":[0],"levels":[1],"of":[2,19,46,55,100,119,162,177],"unconjugated":[3],"bilirubin":[4],"(UCB)":[5],"may":[6,171],"initiate":[7],"encephalopathy":[8,157],"in":[9,13,52,74,77,174],"neonatal":[10,155],"life,":[11],"mainly":[12],"pre-mature":[14],"infants.":[15],"The":[16],"molecular":[17],"mechanisms":[18],"this":[20],"bilirubin-induced":[21,156],"neurologic":[22],"dysfunction":[23],"(BIND)":[24],"are":[25],"not":[26],"yet":[27],"clarified":[28],"and":[29,70,88,91,112,137,144,165],"no":[30],"neuroprotective":[31],"strategy":[32],"is":[33],"currently":[34],"worldwide":[35],"accepted.":[36],"Here,":[37],"we":[38],"show":[39],"that":[40,150,169],"UCB,":[41],"at":[42],"conditions":[43],"mimicking":[44],"those":[45],"hyperbilirubinemic":[47],"newborns":[48],"(50":[49],"microM":[50],"UCB":[51],"the":[53,98,101,124,151,167,175],"presence":[54],"100":[56],"muM":[57],"human":[58],"serum":[59],"albumin),":[60],"rapidly":[61],"(within":[62],"1":[63],"h)":[64],"inhibited":[65],"cytochrome":[66,133],"c":[67,134],"oxidase":[68,135],"activity":[69],"ascorbate-driven":[71],"oxygen":[72],"consumption":[73],"3":[75],"days":[76],"vitro":[78],"rat":[79],"cortical":[80],"neurons.":[81],"This":[82],"was":[83],"accompanied":[84],"by":[85,97],"a":[86,160],"bioenergetic":[87],"oxidative":[89,140],"crisis,":[90],"apoptotic":[92],"cell":[93,145],"death,":[94],"as":[95,115,117],"judged":[96],"collapse":[99],"inner-mitochondrial":[102],"membrane":[103],"potential,":[104],"increased":[105],"glycolytic":[106],"activity,":[107],"superoxide":[108],"anion":[109],"radical":[110],"production,":[111],"ATP":[113],"release,":[114],"well":[116],"disruption":[118],"glutathione":[120],"redox":[121],"status.":[122],"Furthermore,":[123],"antioxidant":[125],"compound":[126],"glycoursodeoxycholic":[127],"acid":[128],"(GUDCA)":[129],"fully":[130],"abrogated":[131],"UCB-induced":[132],"inhibition":[136],"significantly":[138],"prevented":[139],"stress,":[141],"metabolic":[142],"alterations,":[143],"demise.":[146],"These":[147],"results":[148],"suggest":[149],"neurotoxicity":[152],"associated":[153],"with":[154],"occur":[158],"through":[159],"dysregulation":[161],"energy":[163],"metabolism,":[164],"supports":[166],"notion":[168],"GUDCA":[170],"be":[172],"useful":[173],"treatment":[176],"BIND.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}