{"id":"https://openalex.org/W2004402883","doi":"https://doi.org/10.1002/jbmr.5650081312","title":"Journal of Bone and Mineral Research","display_name":"Journal of Bone and Mineral Research","publication_year":1993,"publication_date":"1993-12-01","ids":{"openalex":"https://openalex.org/W2004402883","doi":"https://doi.org/10.1002/jbmr.5650081312","mag":"2004402883","pmid":"https://pubmed.ncbi.nlm.nih.gov/8122518"},"language":"en","primary_location":{"id":"doi:10.1002/jbmr.5650081312","doi":"https://doi.org/10.1002/jbmr.5650081312","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbmr.5650081312","pdf_url":null,"source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2004402883"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111981403","display_name":"Arthur Veis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arthur Veis","raw_affiliation_strings":["Department of Basic Sciences, Division of Oral Biology, Northwestern University Dental School, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, Division of Oral Biology, Northwestern University Dental School, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111981403"],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":0.5534,"has_fulltext":false,"cited_by_count":166,"citation_normalized_percentile":{"value":0.49122807,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"8","issue":"S2","first_page":"S493","last_page":"S497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dentin-matrix","display_name":"dentin matrix","score":0.6169999837875366},{"id":"https://openalex.org/keywords/cementum","display_name":"cementum","score":0.7519999742507935},{"id":"https://openalex.org/keywords/bone-mineralization","display_name":"bone mineralization","score":0.7440000176429749},{"id":"https://openalex.org/keywords/collagen-fibrils","display_name":"collagen fibrils","score":0.8140000104904175},{"id":"https://openalex.org/keywords/apatite-nucleation","display_name":"apatite nucleation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.906000018119812},{"id":"https://openalex.org/keywords/odontoblasts","display_name":"odontoblasts","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cementoblasts","display_name":"cementoblasts","score":0.9990000128746033},{"id":"https://openalex.org/keywords/secretory-vesicles","display_name":"secretory vesicles","score":0.7139999866485596},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8560000061988831},{"id":"https://openalex.org/keywords/tissue-stability","display_name":"tissue stability","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C2777894202","wikidata":"https://www.wikidata.org/wiki/Q848382","display_name":"Cementum","level":3,"score":0.714158296585083},{"id":"https://openalex.org/C2779263046","wikidata":"https://www.wikidata.org/wiki/Q189637","display_name":"Dentin","level":2,"score":0.6806862354278564},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6562767028808594},{"id":"https://openalex.org/C106434640","wikidata":"https://www.wikidata.org/wiki/Q2844797","display_name":"Amelogenin","level":3,"score":0.6013882756233215},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5864673256874084},{"id":"https://openalex.org/C2520015","wikidata":"https://www.wikidata.org/wiki/Q853338","display_name":"Odontoblast","level":3,"score":0.5849610567092896},{"id":"https://openalex.org/C2777131851","wikidata":"https://www.wikidata.org/wiki/Q6864399","display_name":"Mineralized tissues","level":3,"score":0.5632742643356323},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.5146535634994507},{"id":"https://openalex.org/C183586093","wikidata":"https://www.wikidata.org/wiki/Q610457","display_name":"Biomineralization","level":2,"score":0.4939776062965393},{"id":"https://openalex.org/C111696902","wikidata":"https://www.wikidata.org/wiki/Q6864413","display_name":"Mineralization (soil science)","level":3,"score":0.49024635553359985},{"id":"https://openalex.org/C56302369","wikidata":"https://www.wikidata.org/wiki/Q189341","display_name":"Cementoblast","level":4,"score":0.4783836603164673},{"id":"https://openalex.org/C2777746296","wikidata":"https://www.wikidata.org/wiki/Q178397","display_name":"Apatite","level":2,"score":0.4523162245750427},{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.45075342059135437},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4222198724746704},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32502514123916626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19252851605415344},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1621454954147339},{"id":"https://openalex.org/C199289684","wikidata":"https://www.wikidata.org/wiki/Q83353","display_name":"Mineralogy","level":1,"score":0.09505048394203186},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0662451684474945},{"id":"https://openalex.org/C537208039","wikidata":"https://www.wikidata.org/wiki/Q627","display_name":"Nitrogen","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001857","descriptor_name":"Bone Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002113","descriptor_name":"Calcification, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003739","descriptor_name":"Dental Cementum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003804","descriptor_name":"Dentin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014074","descriptor_name":"Tooth Calcification","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jbmr.5650081312","doi":"https://doi.org/10.1002/jbmr.5650081312","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbmr.5650081312","pdf_url":null,"source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},{"id":"pmid:8122518","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8122518","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1795727996","display_name":null,"funder_award_id":"AR-13921","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G3116976194","display_name":null,"funder_award_id":"DE-01374","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G5285896723","display_name":null,"funder_award_id":"AR 13921","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W161804251","https://openalex.org/W224546816","https://openalex.org/W1041867893","https://openalex.org/W1493047535","https://openalex.org/W1507596553","https://openalex.org/W1511155152","https://openalex.org/W1524917006","https://openalex.org/W1554427720","https://openalex.org/W1598727792","https://openalex.org/W1825214797","https://openalex.org/W1964597253","https://openalex.org/W1966723290","https://openalex.org/W1971194250","https://openalex.org/W1980463008","https://openalex.org/W1993135337","https://openalex.org/W2003396481","https://openalex.org/W2006325632","https://openalex.org/W2006849160","https://openalex.org/W2015682679","https://openalex.org/W2018098387","https://openalex.org/W2031846886","https://openalex.org/W2032385224","https://openalex.org/W2043352738","https://openalex.org/W2045958305","https://openalex.org/W2045967367","https://openalex.org/W2049651689","https://openalex.org/W2060890641","https://openalex.org/W2065269393","https://openalex.org/W2066403803","https://openalex.org/W2066944614","https://openalex.org/W2077361331","https://openalex.org/W2078969658","https://openalex.org/W2093414614","https://openalex.org/W2120261738","https://openalex.org/W2132658514","https://openalex.org/W2311631122","https://openalex.org/W2325817216","https://openalex.org/W4230292448"],"related_works":["https://openalex.org/W2413903194","https://openalex.org/W2495847487","https://openalex.org/W2500446058","https://openalex.org/W2069987063","https://openalex.org/W2119843976","https://openalex.org/W1500109515","https://openalex.org/W2046751055","https://openalex.org/W2017040446","https://openalex.org/W1984812505","https://openalex.org/W4249526594"],"abstract_inverted_index":{"The":[0,82],"bone,":[1],"dentin,":[2,141],"and":[3,41,56,61,75,96,110,169],"cementum":[4],"of":[5,31,73,77,94,145,161,165,171],"the":[6,19,38,44,54,63,70,78,91,100,116,123,129,137,143,148,159,162,174],"mature":[7],"individual":[8],"are":[9,35,106,126,151,176],"comprised":[10],"from":[11,115],"a":[12,29],"dense":[13],"collagenous":[14,46],"fiber":[15],"network":[16],"into":[17,43],"which":[18],"carbonate-apatite":[20],"mineral":[21,79],"phase":[22,80],"is":[23,26],"deposited.":[24],"It":[25],"hypothesized":[27],"that":[28],"set":[30],"collagen-interactive":[32],"acidic":[33,83],"phosphoproteins":[34,66,85,150],"secreted":[36,111],"by":[37],"osteoblasts,":[39],"odontoblasts,":[40],"cementoblasts":[42],"preformed":[45,130],"matrix.":[47],"These":[48,65],"proteins":[49,105,125],"then":[50],"interact":[51],"specifically":[52],"with":[53],"collagen":[55,117],"nucleate":[57],"apatite":[58],"formation":[59],"on":[60,128],"within":[62,173],"fibrils.":[64,131],"may":[67,86],"also":[68],"regulate":[69],"morphology,":[71],"rate":[72],"growth,":[74],"stability":[76],"crystals.":[81],"matrix":[84,175],"thus":[87,177],"be":[88],"considered":[89],"as":[90,122],"crucial":[92],"regulators":[93],"mineralization":[95],"tissue":[97,146],"stability.":[98],"In":[99,140],"dentin":[101],"system,":[102],"these":[103],"regulatory":[104,124],"synthesized,":[107],"posttranslationally":[108],"modified,":[109],"in":[112,136,142,153],"vesicles":[113],"different":[114],"secretory":[118,167],"vesicles.":[119],"Mineralization":[120],"occurs":[121],"deposited":[127],"This":[132],"model":[133],"requires":[134],"testing":[135],"bone":[138],"system.":[139],"absence":[144],"turnover,":[147],"resident":[149],"degraded":[152],"situ":[154],"over":[155],"time,":[156],"perhaps":[157],"changing":[158],"properties":[160],"tissue.":[163],"Regulation":[164],"synthesis,":[166],"pathways":[168],"retention":[170],"integrity":[172],"important":[178],"areas":[179],"for":[180],"further":[181],"investigation.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}