{"id":"https://openalex.org/W2004402341","doi":"https://doi.org/10.1016/j.coi.2013.04.001","title":"Phosphatase regulation of immunoreceptor signaling in T cells, B cells and mast cells","display_name":"Phosphatase regulation of immunoreceptor signaling in T cells, B cells and mast cells","publication_year":2013,"publication_date":"2013-05-15","ids":{"openalex":"https://openalex.org/W2004402341","doi":"https://doi.org/10.1016/j.coi.2013.04.001","mag":"2004402341","pmid":"https://pubmed.ncbi.nlm.nih.gov/23684445","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3732051"},"language":"en","primary_location":{"id":"doi:10.1016/j.coi.2013.04.001","doi":"https://doi.org/10.1016/j.coi.2013.04.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.coi.2013.04.001","pdf_url":null,"source":{"id":"https://openalex.org/S170047187","display_name":"Current Opinion in Immunology","issn_l":"0952-7915","issn":["0952-7915","1879-0372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3732051","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104682829","display_name":"Yacine Bounab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yacine Bounab","raw_affiliation_strings":["Institut Pasteur, D\u00e9partement d'Immunologie, Centre d'Immunologie Humaine, Paris, France","Inserm, UMS 20, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur, D\u00e9partement d'Immunologie, Centre d'Immunologie Humaine, Paris, France","institution_ids":["https://openalex.org/I157536573"]},{"raw_affiliation_string":"Inserm, UMS 20, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033378036","display_name":"Andrew Getahun","orcid":"https://orcid.org/0000-0002-5663-6812","observed_orcids":["https://orcid.org/0000-0002-5663-6812"]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Getahun","raw_affiliation_strings":["Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health, Denver, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health, Denver, CO, USA","institution_ids":["https://openalex.org/I3019586173","https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063233755","display_name":"John C. Cambier","orcid":"https://orcid.org/0000-0002-7803-242X","observed_orcids":["https://orcid.org/0000-0002-7803-242X"]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John C Cambier","raw_affiliation_strings":["Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health, Denver, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health, Denver, CO, USA","institution_ids":["https://openalex.org/I3019586173","https://openalex.org/I51713134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018921593","display_name":"Marc Da\u00ebron","orcid":"https://orcid.org/0000-0002-5651-9851","observed_orcids":["https://orcid.org/0000-0002-5651-9851"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I4210144005","display_name":"Centre d\u2019Immunologie de Marseille-Luminy","ror":"https://ror.org/03vyjkj45","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144005"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Marc Da\u00ebron","raw_affiliation_strings":["Inserm, Unit\u00e9 1104, Centre d\u2018Immunologie de Marseille-Luminy, Marseille, France","Institut Pasteur, D\u00e9partement d\u2018Immunologie, Centre d\u2018Immunologie Humaine, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, Unit\u00e9 1104, Centre d\u2018Immunologie de Marseille-Luminy, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210144005"]},{"raw_affiliation_string":"Institut Pasteur, D\u00e9partement d\u2018Immunologie, Centre d\u2018Immunologie Humaine, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5018921593","https://openalex.org/A5063233755"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I157536573","https://openalex.org/I3019586173","https://openalex.org/I4210144005","https://openalex.org/I51713134"],"apc_list":{"value":4410,"currency":"USD","value_usd":4410},"apc_paid":null,"fwci":0.2506,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.20002716,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"25","issue":"3","first_page":"313","last_page":"320"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphatase","display_name":"phosphatase","score":0.8330000042915344},{"id":"https://openalex.org/keywords/protein-tyrosine-phosphatase","display_name":"protein tyrosine phosphatase","score":0.8999999761581421},{"id":"https://openalex.org/keywords/phosphoinositide-phosphatase","display_name":"phosphoinositide phosphatase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/immunoreceptor-signaling","display_name":"immunoreceptor signaling","score":0.9940000176429749},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/b-cell-activation","display_name":"B cell activation","score":1.0},{"id":"https://openalex.org/keywords/mast-cell-activation","display_name":"mast cell activation","score":0.9700000286102295},{"id":"https://openalex.org/keywords/receptor-dephosphorylation","display_name":"receptor dephosphorylation","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C29907709","wikidata":"https://www.wikidata.org/wiki/Q6005558","display_name":"Immunoreceptor tyrosine-based activation motif","level":5,"score":0.5947179198265076},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.5909110903739929},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5517232418060303},{"id":"https://openalex.org/C2781140086","wikidata":"https://www.wikidata.org/wiki/Q557945","display_name":"Confusion","level":2,"score":0.5340655446052551},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5141401886940002},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5132551193237305},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.4723580777645111},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42257770895957947},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.3954371511936188},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32230496406555176},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.28776782751083374},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14625397324562073},{"id":"https://openalex.org/C11171543","wikidata":"https://www.wikidata.org/wiki/Q41630","display_name":"Psychoanalysis","level":1,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C197153747","wikidata":"https://www.wikidata.org/wiki/Q24780316","display_name":"SH2 domain","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.coi.2013.04.001","doi":"https://doi.org/10.1016/j.coi.2013.04.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.coi.2013.04.001","pdf_url":null,"source":{"id":"https://openalex.org/S170047187","display_name":"Current Opinion in Immunology","issn_l":"0952-7915","issn":["0952-7915","1879-0372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Immunology","raw_type":"journal-article"},{"id":"pmid:23684445","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23684445","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3015292","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3732051","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3732051","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3732051","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Immunol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3015292","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3732051","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2030838714","display_name":"B Cells and Type 1 Diabetes","funder_award_id":"R01DK096492","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2900422150","display_name":"Antigen Recognition by Lymphocytes","funder_award_id":"P01AI022295","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G401167513","display_name":"Infectious Agents and B Cell Anergy","funder_award_id":"R01AI077597","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8618930486","display_name":null,"funder_award_id":"R01AI097346","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8621180337","display_name":"Mouse modeling of a human STING gene variant for infectious disease","funder_award_id":"R21AI099346","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W1485299124","https://openalex.org/W1499389156","https://openalex.org/W1533374366","https://openalex.org/W1550720214","https://openalex.org/W1587113887","https://openalex.org/W1824062321","https://openalex.org/W1888698281","https://openalex.org/W1906616494","https://openalex.org/W1927916230","https://openalex.org/W1964345708","https://openalex.org/W1969140398","https://openalex.org/W1973173778","https://openalex.org/W1973540902","https://openalex.org/W1974469106","https://openalex.org/W1979769420","https://openalex.org/W1982078333","https://openalex.org/W1985094563","https://openalex.org/W1991988533","https://openalex.org/W1993501111","https://openalex.org/W1995855024","https://openalex.org/W2011444435","https://openalex.org/W2012902336","https://openalex.org/W2022012352","https://openalex.org/W2029182344","https://openalex.org/W2030884423","https://openalex.org/W2031987048","https://openalex.org/W2032588409","https://openalex.org/W2036783666","https://openalex.org/W2048799673","https://openalex.org/W2051118426","https://openalex.org/W2053695562","https://openalex.org/W2069097227","https://openalex.org/W2070829001","https://openalex.org/W2071165514","https://openalex.org/W2079270029","https://openalex.org/W2081064697","https://openalex.org/W2081520685","https://openalex.org/W2085958387","https://openalex.org/W2086397613","https://openalex.org/W2087265576","https://openalex.org/W2087930947","https://openalex.org/W2090574359","https://openalex.org/W2090638735","https://openalex.org/W2095547255","https://openalex.org/W2096898586","https://openalex.org/W2099887519","https://openalex.org/W2101011213","https://openalex.org/W2101073455","https://openalex.org/W2102184867","https://openalex.org/W2106144192","https://openalex.org/W2107556275","https://openalex.org/W2108422069","https://openalex.org/W2110709185","https://openalex.org/W2119077423","https://openalex.org/W2120245870","https://openalex.org/W2120884497","https://openalex.org/W2125479390","https://openalex.org/W2127769439","https://openalex.org/W2129997470","https://openalex.org/W2130313275","https://openalex.org/W2135169909","https://openalex.org/W2137953443","https://openalex.org/W2140430241","https://openalex.org/W2141734680","https://openalex.org/W2144954864","https://openalex.org/W2145170767","https://openalex.org/W2148006813","https://openalex.org/W2149128350","https://openalex.org/W2149505831","https://openalex.org/W2149650496","https://openalex.org/W2151538066","https://openalex.org/W2152529416","https://openalex.org/W2154161087","https://openalex.org/W2163756947","https://openalex.org/W2165018534","https://openalex.org/W2165052240","https://openalex.org/W4313331758"],"related_works":["https://openalex.org/W2419452174","https://openalex.org/W2110594269","https://openalex.org/W2049571223","https://openalex.org/W1985893794","https://openalex.org/W2005674107","https://openalex.org/W1997546191","https://openalex.org/W1995771395","https://openalex.org/W2066278573","https://openalex.org/W69377524","https://openalex.org/W2156501067"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}