{"id":"https://openalex.org/W2004396803","doi":"https://doi.org/10.1117/12.349207","title":"Scatter imaging of injured brain slices: detection of mitochondrial injury","display_name":"Scatter imaging of injured brain slices: detection of mitochondrial injury","publication_year":1999,"publication_date":"1999-06-01","ids":{"openalex":"https://openalex.org/W2004396803","doi":"https://doi.org/10.1117/12.349207","mag":"2004396803"},"language":"en","primary_location":{"id":"doi:10.1117/12.349207","doi":"https://doi.org/10.1117/12.349207","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.349207","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Lee J. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee J. Johnson","raw_affiliation_strings":["Johns Hopkins Univ. School of Medicine (United States)","Johns Hopkins University School of Medicine, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. School of Medicine (United States)","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University School of Medicine, United States","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040619239","display_name":"Daniel F. Hanley","orcid":"https://orcid.org/0000-0002-9536-4258","observed_orcids":["https://orcid.org/0000-0002-9536-4258"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel F. Hanley","raw_affiliation_strings":["Johns Hopkins Univ. School of Medicine (United States)","Johns Hopkins University School of Medicine, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. School of Medicine (United States)","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University School of Medicine, United States","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088964967","display_name":"Nitish V. Thakor","orcid":"https://orcid.org/0000-0002-9981-9395","observed_orcids":["https://orcid.org/0000-0002-9981-9395"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nitish V. Thakor","raw_affiliation_strings":["Johns Hopkins Univ. School of Medicine (United States)","Johns Hopkins University School of Medicine, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. School of Medicine (United States)","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University School of Medicine, United States","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15217391,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3604","issue":null,"first_page":"18","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12050","display_name":"Optical Polarization and Ellipsometry","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-swelling","display_name":"mitochondrial swelling","score":0.8130000233650208},{"id":"https://openalex.org/keywords/cell-swelling","display_name":"cell swelling","score":0.8349999785423279},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.9319999814033508},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.5720000267028809},{"id":"https://openalex.org/keywords/hypotonicity","display_name":"hypotonicity","score":0.75},{"id":"https://openalex.org/keywords/hippocampal-slices","display_name":"hippocampal slices","score":0.8880000114440918},{"id":"https://openalex.org/keywords/light-scattering","display_name":"light scattering","score":0.6570000052452087},{"id":"https://openalex.org/keywords/particle-size","display_name":"particle size","score":0.6309999823570251},{"id":"https://openalex.org/keywords/mitochondrial-injury","display_name":"mitochondrial injury","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.8591797351837158},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.618395209312439},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5525177717208862},{"id":"https://openalex.org/C117277713","wikidata":"https://www.wikidata.org/wiki/Q925744","display_name":"Tonicity","level":2,"score":0.5507312417030334},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4920367896556854},{"id":"https://openalex.org/C3020214508","wikidata":"https://www.wikidata.org/wiki/Q979168","display_name":"Brain swelling","level":2,"score":0.44863787293434143},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4115089774131775},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40592172741889954},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.27589040994644165},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23955395817756653},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2293243110179901},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20346692204475403},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.1950562596321106},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06218007206916809},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.349207","doi":"https://doi.org/10.1117/12.349207","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.349207","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3033837391","https://openalex.org/W2103682703","https://openalex.org/W2147323612","https://openalex.org/W6982342229","https://openalex.org/W2329180447","https://openalex.org/W2328885489","https://openalex.org/W3042810748","https://openalex.org/W2110895006","https://openalex.org/W1996216532","https://openalex.org/W2049234711"],"abstract_inverted_index":{"Stroke":[0],"has":[1,62],"been":[2,63],"shown":[3],"to":[4,23,56,70],"cause":[5],"exitotoxic":[6],"injury,":[7,45],"two":[8],"of":[9,20,27,43],"its":[10],"manifestations":[11],"being":[12],"cellular":[13,72,79],"and":[14,77,80],"mitochondrial":[15,81],"swelling.":[16],"In":[17],"vitro":[18],"models":[19],"stroke":[21,28,44],"attempt":[22],"reproduce":[24],"the":[25,41],"effects":[26],"by":[29,75,84],"treating":[30],"brain":[31],"tissue":[32],"with":[33,65],"excitotoxins":[34],"or":[35],"hypotonic":[36,90],"solutions.":[37],"To":[38],"further":[39],"resolve":[40],"mechanism":[42],"we":[46],"have":[47],"designed":[48],"a":[49,66,104],"dual-angle":[50],"scatter":[51],"imaging":[52],"(DASI)":[53],"system":[54,61],"sensitive":[55],"particle":[57],"size.":[58],"The":[59],"DASI":[60],"used":[64],"hippocampal":[67],"slice":[68],"preparation":[69],"contrast":[71],"swelling,":[73],"induced":[74],"hypotonicity,":[76],"combined":[78],"swelling":[82],"caused":[83,94,103],"excitotoxicity.":[85],"We":[86],"found":[87],"that":[88],"both":[89],"end":[91],"excitotoxic":[92,101],"treatments":[93],"changes":[95],"in":[96,107],"light":[97],"scatter.":[98],"However,":[99],"only":[100],"treatment":[102],"significant":[105],"change":[106],"DASI.":[108]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
