{"id":"https://openalex.org/W2004387016","doi":"https://doi.org/10.1128/aac.33.5.742","title":"Pharmacokinetics of intermittently administered intravenous foscarnet in the treatment of acquired immunodeficiency syndrome patients with serious cytomegalovirus retinitis","display_name":"Pharmacokinetics of intermittently administered intravenous foscarnet in the treatment of acquired immunodeficiency syndrome patients with serious cytomegalovirus retinitis","publication_year":1989,"publication_date":"1989-05-01","ids":{"openalex":"https://openalex.org/W2004387016","doi":"https://doi.org/10.1128/aac.33.5.742","mag":"2004387016","pmid":"https://pubmed.ncbi.nlm.nih.gov/2546491","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/172525"},"language":"en","primary_location":{"id":"doi:10.1128/aac.33.5.742","doi":"https://doi.org/10.1128/aac.33.5.742","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.33.5.742","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/172525","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063298724","display_name":"Francesca  T. Aweeka","orcid":"https://orcid.org/0000-0002-6005-6124","observed_orcids":["https://orcid.org/0000-0002-6005-6124"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F Aweeka","raw_affiliation_strings":["Division of Clinical Pharmacy, University of California, San Francisco 94143-0622"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacy, University of California, San Francisco 94143-0622","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008158010","display_name":"John G. Gambertoglio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Gambertoglio","raw_affiliation_strings":["Division of Clinical Pharmacy, University of California, San Francisco 94143-0622"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacy, University of California, San Francisco 94143-0622","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050922635","display_name":"JOHN S. MILLS","orcid":"https://orcid.org/0000-0002-4603-9117","observed_orcids":["https://orcid.org/0000-0002-4603-9117"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Mills","raw_affiliation_strings":["Division of Clinical Pharmacy, University of California, San Francisco 94143-0622"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacy, University of California, San Francisco 94143-0622","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":null,"display_name":"M A Jacobson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M A Jacobson","raw_affiliation_strings":["Division of Clinical Pharmacy, University of California, San Francisco 94143-0622"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacy, University of California, San Francisco 94143-0622","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":null,"apc_paid":null,"fwci":7.4144,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.97157904,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"33","issue":"5","first_page":"742","last_page":"745"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.8256999850273132,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.8256999850273132,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.054099999368190765,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.02410000003874302,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foscarnet","display_name":"foscarnet","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cytomegalovirus-retinitis","display_name":"cytomegalovirus retinitis","score":0.984000027179718},{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.703000009059906},{"id":"https://openalex.org/keywords/intermittent-dosing","display_name":"intermittent dosing","score":0.7850000262260437},{"id":"https://openalex.org/keywords/plasma-concentration","display_name":"plasma concentration","score":0.5820000171661377},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.5799999833106995},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.6600000262260437},{"id":"https://openalex.org/keywords/drug-clearance","display_name":"drug clearance","score":0.5389999747276306},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.7889999747276306},{"id":"https://openalex.org/keywords/half-life","display_name":"half-life","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C2776724271","wikidata":"https://www.wikidata.org/wiki/Q420387","display_name":"Foscarnet","level":5,"score":0.9745275378227234},{"id":"https://openalex.org/C2777016524","wikidata":"https://www.wikidata.org/wiki/Q630552","display_name":"Retinitis","level":4,"score":0.8443909883499146},{"id":"https://openalex.org/C2777324356","wikidata":"https://www.wikidata.org/wiki/Q4271835","display_name":"Cytomegalovirus retinitis","level":5,"score":0.7443044185638428},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7439550161361694},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6532590985298157},{"id":"https://openalex.org/C139254425","wikidata":"https://www.wikidata.org/wiki/Q1332167","display_name":"Volume of distribution","level":3,"score":0.6102899312973022},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.5705822706222534},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4635685086250305},{"id":"https://openalex.org/C2777965375","wikidata":"https://www.wikidata.org/wiki/Q417640","display_name":"Ganciclovir","level":4,"score":0.398882657289505},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37142670154571533},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3369278311729431},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21116074919700623},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.11692619323730469}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D010746","descriptor_name":"Phosphonoacetic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010746","descriptor_name":"Phosphonoacetic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010746","descriptor_name":"Phosphonoacetic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010746","descriptor_name":"Phosphonoacetic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010746","descriptor_name":"Phosphonoacetic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010746","descriptor_name":"Phosphonoacetic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010746","descriptor_name":"Phosphonoacetic Acid","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D010746","descriptor_name":"Phosphonoacetic Acid","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D010746","descriptor_name":"Phosphonoacetic Acid","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D010746","descriptor_name":"Phosphonoacetic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010746","descriptor_name":"Phosphonoacetic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010746","descriptor_name":"Phosphonoacetic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012173","descriptor_name":"Retinitis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D012173","descriptor_name":"Retinitis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D012173","descriptor_name":"Retinitis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D012173","descriptor_name":"Retinitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012173","descriptor_name":"Retinitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012173","descriptor_name":"Retinitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012173","descriptor_name":"Retinitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012173","descriptor_name":"Retinitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012173","descriptor_name":"Retinitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017245","descriptor_name":"Foscarnet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017245","descriptor_name":"Foscarnet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017245","descriptor_name":"Foscarnet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/aac.33.5.742","doi":"https://doi.org/10.1128/aac.33.5.742","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.33.5.742","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:172525","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/172525","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:2546491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2546491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:172525","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/172525","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1273453458","display_name":"ESTABLISHMENT OF AIDS TREATMENT EVALUATION UNITS","funder_award_id":"n01ai062541-004","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1467690219","display_name":null,"funder_award_id":"N01-AI-62541","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W39413060","https://openalex.org/W175722645","https://openalex.org/W1550111394","https://openalex.org/W1963969155","https://openalex.org/W1976466959","https://openalex.org/W1999436929","https://openalex.org/W2001394429","https://openalex.org/W2010363116","https://openalex.org/W2048466021","https://openalex.org/W2052794617","https://openalex.org/W2057597535","https://openalex.org/W2115460688","https://openalex.org/W2403611052"],"related_works":["https://openalex.org/W1980143223","https://openalex.org/W2085890145","https://openalex.org/W2085115990","https://openalex.org/W1984791309","https://openalex.org/W2085179561","https://openalex.org/W2090992410","https://openalex.org/W2048466021","https://openalex.org/W2045026708","https://openalex.org/W2156030303","https://openalex.org/W2920947006"],"abstract_inverted_index":{"Foscarnet":[0],"has":[1],"been":[2],"shown":[3],"to":[4,34],"be":[5,197],"active":[6],"in":[7,117,142,186,191],"vitro":[8],"against":[9],"the":[10,36,46,108,162,170,179,182],"human":[11,16],"immunodeficiency":[12,55],"virus":[13],"and":[14,38,57,90,94,114,122,135,147,152,169,181],"all":[15],"herpesviruses":[17],"including":[18],"cytomegalovirus":[19],"(CMV).":[20],"A":[21],"pharmacokinetic":[22],"study":[23],"was":[24,165,174],"carried":[25],"out":[26],"as":[27],"part":[28],"of":[29,40,48,65,70,73,92,106,172,184],"a":[30,68],"clinical":[31],"trial":[32],"designed":[33],"evaluate":[35],"safety":[37],"efficacy":[39],"intermittently":[41],"administered":[42],"intravenous":[43,63],"foscarnet":[44,66,95,185],"for":[45,79,199],"treatment":[47],"CMV":[49,59],"retinitis.":[50],"Eight":[51],"patients":[52,200],"with":[53,189,201],"acquired":[54],"syndrome":[56],"serious":[58],"retinitis":[60],"received":[61],"2-h":[62],"infusions":[64],"at":[67],"dosage":[69,194],"60":[71],"mg/kg":[72],"body":[74],"weight":[75],"every":[76],"8":[77],"h":[78,168],"14":[80,91,130,148],"days.":[81],"Serial":[82],"plasma":[83,118,143,187],"samples":[84],"were":[85,97,119,132,149],"collected":[86],"on":[87,128,144],"days":[88,145],"3":[89,105,146],"therapy,":[93,107],"concentrations":[96],"determined":[98],"by":[99],"high-pressure":[100],"liquid":[101],"chromatography.":[102],"On":[103,159],"day":[104,129,160],"mean":[109,140,163],"(+/-":[110],"standard":[111],"deviation)":[112],"peak":[113],"trough":[115],"levels":[116,131],"509":[120],"(200)":[121],"98":[123],"(29)":[124],"microM,":[125],"respectively,":[126],"while":[127],"495":[133],"(149)":[134],"126":[136],"(59)":[137],"microM.":[138],"The":[139],"clearance":[141,183],"1.9":[150],"(0.6)":[151],"1.7":[153],"(0.9)":[154],"ml/min":[155],"per":[156],"kg,":[157],"respectively.":[158],"14,":[161],"half-life":[164,180],"4.5":[166],"(1.2)":[167],"volume":[171],"distribution":[173],"0.74":[175],"(0.60)":[176],"liter/kg.":[177],"As":[178],"correlated":[188],"changes":[190],"renal":[192,203],"function,":[193],"adjustments":[195],"must":[196],"made":[198],"decreased":[202],"function.":[204]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
