{"id":"https://openalex.org/W2004384813","doi":"https://doi.org/10.1021/jm701425k","title":"Synthesis and Pharmacological Evaluation of Novel \u03b3-Aminobutyric Acid Type B (GABAB) Receptor Agonists as Gastroesophageal Reflux Inhibitors","display_name":"Synthesis and Pharmacological Evaluation of Novel \u03b3-Aminobutyric Acid Type B (GABAB) Receptor Agonists as Gastroesophageal Reflux Inhibitors","publication_year":2008,"publication_date":"2008-06-25","ids":{"openalex":"https://openalex.org/W2004384813","doi":"https://doi.org/10.1021/jm701425k","mag":"2004384813","pmid":"https://pubmed.ncbi.nlm.nih.gov/18578471"},"language":"en","primary_location":{"id":"doi:10.1021/jm701425k","doi":"https://doi.org/10.1021/jm701425k","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm701425k","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082795672","display_name":"Christer Alstermark","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36344538","display_name":"Albany Molecular Research (United States)","ror":"https://ror.org/03y76pe29","country_code":"US","type":"company","lineage":["https://openalex.org/I36344538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christer Alstermark","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098","institution_ids":["https://openalex.org/I36344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062812764","display_name":"Kosrat Amin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36344538","display_name":"Albany Molecular Research (United States)","ror":"https://ror.org/03y76pe29","country_code":"US","type":"company","lineage":["https://openalex.org/I36344538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kosrat Amin","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098","institution_ids":["https://openalex.org/I36344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013063930","display_name":"Sean R. Dinn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36344538","display_name":"Albany Molecular Research (United States)","ror":"https://ror.org/03y76pe29","country_code":"US","type":"company","lineage":["https://openalex.org/I36344538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean R. Dinn","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098","institution_ids":["https://openalex.org/I36344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079684925","display_name":"Thomas Elebring","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36344538","display_name":"Albany Molecular Research (United States)","ror":"https://ror.org/03y76pe29","country_code":"US","type":"company","lineage":["https://openalex.org/I36344538"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas Elebring","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098","institution_ids":["https://openalex.org/I36344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045245311","display_name":"Ola Fjellstr\u00f6m","orcid":"https://orcid.org/0000-0002-2301-2130","observed_orcids":["https://orcid.org/0000-0002-2301-2130"]},"institutions":[{"id":"https://openalex.org/I36344538","display_name":"Albany Molecular Research (United States)","ror":"https://ror.org/03y76pe29","country_code":"US","type":"company","lineage":["https://openalex.org/I36344538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ola Fjellstr\u00f6m","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098","institution_ids":["https://openalex.org/I36344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110001205","display_name":"Kevin Fitzpatrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36344538","display_name":"Albany Molecular Research (United States)","ror":"https://ror.org/03y76pe29","country_code":"US","type":"company","lineage":["https://openalex.org/I36344538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Fitzpatrick","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098","institution_ids":["https://openalex.org/I36344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018278543","display_name":"William B. Geiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36344538","display_name":"Albany Molecular Research (United States)","ror":"https://ror.org/03y76pe29","country_code":"US","type":"company","lineage":["https://openalex.org/I36344538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William B. Geiss","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098","institution_ids":["https://openalex.org/I36344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049616606","display_name":"Johan Gottfries","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36344538","display_name":"Albany Molecular Research (United States)","ror":"https://ror.org/03y76pe29","country_code":"US","type":"company","lineage":["https://openalex.org/I36344538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Johan Gottfries","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098","institution_ids":["https://openalex.org/I36344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047963260","display_name":"Peter R. Guzzo","orcid":"https://orcid.org/0009-0007-4773-8052","observed_orcids":["https://orcid.org/0009-0007-4773-8052"]},"institutions":[{"id":"https://openalex.org/I36344538","display_name":"Albany Molecular Research (United States)","ror":"https://ror.org/03y76pe29","country_code":"US","type":"company","lineage":["https://openalex.org/I36344538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter R. Guzzo","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098","institution_ids":["https://openalex.org/I36344538"]}]},{"author_position":"middle","author":{"id":null,"display_name":"James P. Harding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36344538","display_name":"Albany Molecular Research (United States)","ror":"https://ror.org/03y76pe29","country_code":"US","type":"company","lineage":["https://openalex.org/I36344538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James P. Harding","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098","institution_ids":["https://openalex.org/I36344538"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anders Holm\u00e9n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36344538","display_name":"Albany Molecular Research (United States)","ror":"https://ror.org/03y76pe29","country_code":"US","type":"company","lineage":["https://openalex.org/I36344538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anders Holm\u00e9n","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098","institution_ids":["https://openalex.org/I36344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034212187","display_name":"M Kothare","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36344538","display_name":"Albany Molecular Research (United States)","ror":"https://ror.org/03y76pe29","country_code":"US","type":"company","lineage":["https://openalex.org/I36344538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohit Kothare","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098","institution_ids":["https://openalex.org/I36344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113689490","display_name":"Anders Lehmann","orcid":"https://orcid.org/0000-0002-6800-0205","observed_orcids":["https://orcid.org/0000-0002-6800-0205"]},"institutions":[{"id":"https://openalex.org/I36344538","display_name":"Albany Molecular Research (United States)","ror":"https://ror.org/03y76pe29","country_code":"US","type":"company","lineage":["https://openalex.org/I36344538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anders Lehmann","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098","institution_ids":["https://openalex.org/I36344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087598046","display_name":"Jan P. Mattsson","orcid":"https://orcid.org/0009-0004-0674-0197","observed_orcids":["https://orcid.org/0009-0004-0674-0197"]},"institutions":[{"id":"https://openalex.org/I36344538","display_name":"Albany Molecular Research (United States)","ror":"https://ror.org/03y76pe29","country_code":"US","type":"company","lineage":["https://openalex.org/I36344538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan P. Mattsson","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098","institution_ids":["https://openalex.org/I36344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103419107","display_name":"Karolina A. Nilsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36344538","display_name":"Albany Molecular Research (United States)","ror":"https://ror.org/03y76pe29","country_code":"US","type":"company","lineage":["https://openalex.org/I36344538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karolina Nilsson","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098","institution_ids":["https://openalex.org/I36344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067960329","display_name":"Gunnel Sund\u00e9n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36344538","display_name":"Albany Molecular Research (United States)","ror":"https://ror.org/03y76pe29","country_code":"US","type":"company","lineage":["https://openalex.org/I36344538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gunnel Sund\u00e9n","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098","institution_ids":["https://openalex.org/I36344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022512718","display_name":"Marianne Swanson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36344538","display_name":"Albany Molecular Research (United States)","ror":"https://ror.org/03y76pe29","country_code":"US","type":"company","lineage":["https://openalex.org/I36344538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marianne Swanson","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098","institution_ids":["https://openalex.org/I36344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069732853","display_name":"Sverker von Unge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36344538","display_name":"Albany Molecular Research (United States)","ror":"https://ror.org/03y76pe29","country_code":"US","type":"company","lineage":["https://openalex.org/I36344538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sverker von Unge","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098","institution_ids":["https://openalex.org/I36344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021923590","display_name":"Alex M. Woo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36344538","display_name":"Albany Molecular Research (United States)","ror":"https://ror.org/03y76pe29","country_code":"US","type":"company","lineage":["https://openalex.org/I36344538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex M. Woo","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098","institution_ids":["https://openalex.org/I36344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009205049","display_name":"Michael J. Wyle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36344538","display_name":"Albany Molecular Research (United States)","ror":"https://ror.org/03y76pe29","country_code":"US","type":"company","lineage":["https://openalex.org/I36344538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Wyle","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098","institution_ids":["https://openalex.org/I36344538"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112448965","display_name":"Xiaozhang Zheng","orcid":"https://orcid.org/0000-0002-8403-7374","observed_orcids":["https://orcid.org/0000-0002-8403-7374"]},"institutions":[{"id":"https://openalex.org/I36344538","display_name":"Albany Molecular Research (United States)","ror":"https://ror.org/03y76pe29","country_code":"US","type":"company","lineage":["https://openalex.org/I36344538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaozhang Zheng","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, S-431 83 M\u00f6lndal, Sweden, and Albany Molecular Research, Inc., 21 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098","institution_ids":["https://openalex.org/I36344538"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079684925"],"corresponding_institution_ids":["https://openalex.org/I36344538"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":4.6124,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.94193676,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"51","issue":"14","first_page":"4315","last_page":"4320"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.03229999914765358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gaba-b-receptor-agonist","display_name":"GABA-B receptor agonist","score":0.9010000228881836},{"id":"https://openalex.org/keywords/gastroesophageal-reflux-disease","display_name":"gastroesophageal reflux disease","score":0.9309999942779541},{"id":"https://openalex.org/keywords/transient-lower-esophageal-sphincter-relaxations","display_name":"transient lower esophageal sphincter relaxations","score":0.9509999752044678},{"id":"https://openalex.org/keywords/baclofen","display_name":"baclofen","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cns-side-effects","display_name":"CNS side effects","score":0.8339999914169312},{"id":"https://openalex.org/keywords/medication-optimization","display_name":"medication optimization","score":0.4790000021457672},{"id":"https://openalex.org/keywords/esophageal-motility","display_name":"esophageal motility","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8839585185050964},{"id":"https://openalex.org/C2779414652","wikidata":"https://www.wikidata.org/wiki/Q3604505","display_name":"Aminobutyric acid","level":3,"score":0.7616233825683594},{"id":"https://openalex.org/C43270747","wikidata":"https://www.wikidata.org/wiki/Q898610","display_name":"Reflux","level":3,"score":0.7341543436050415},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5036606192588806},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.48628246784210205},{"id":"https://openalex.org/C2777771985","wikidata":"https://www.wikidata.org/wiki/Q210021","display_name":"gamma-Aminobutyric acid","level":3,"score":0.46884310245513916},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4648311138153076},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.4280463755130768},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30077987909317017},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26798492670059204},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.07870239019393921},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005764","descriptor_name":"Gastroesophageal Reflux","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016339","descriptor_name":"Spectrometry, Mass, Fast Atom Bombardment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018755","descriptor_name":"GABA Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018755","descriptor_name":"GABA Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018755","descriptor_name":"GABA Agonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D058786","descriptor_name":"GABA-B Receptor Agonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm701425k","doi":"https://doi.org/10.1021/jm701425k","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm701425k","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:18578471","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18578471","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1975610405","https://openalex.org/W1982745349","https://openalex.org/W1989294119","https://openalex.org/W1989685422","https://openalex.org/W2008553169","https://openalex.org/W2016154261","https://openalex.org/W2016897045","https://openalex.org/W2025224527","https://openalex.org/W2070993187","https://openalex.org/W2111176930","https://openalex.org/W2127443130","https://openalex.org/W2156522371","https://openalex.org/W2950718210","https://openalex.org/W2951346997"],"related_works":["https://openalex.org/W1517064514","https://openalex.org/W2018487285","https://openalex.org/W2156002969","https://openalex.org/W2149550261","https://openalex.org/W2111176930","https://openalex.org/W2051606897","https://openalex.org/W2127443130","https://openalex.org/W2057355625","https://openalex.org/W2151560027","https://openalex.org/W31480333"],"abstract_inverted_index":{"We":[0,71],"have":[1],"previously":[2,51],"demonstrated":[3],"that":[4,117],"the":[5,19,34,74,95],"prototypical":[6],"GABA":[7,27,53,78,84],"B":[8,28,54,79,85],"receptor":[9],"agonist":[10,86],"baclofen":[11],"inhibits":[12],"transient":[13],"lower":[14],"esophageal":[15],"sphincter":[16],"relaxations":[17],"(TLESRs),":[18],"most":[20],"important":[21],"mechanism":[22],"for":[23,33,102],"gastroesophageal":[24,37],"reflux.":[25],"Thus,":[26],"agonists":[29,55,80],"could":[30],"be":[31],"exploited":[32],"treatment":[35],"of":[36,76,82,97,100,104],"reflux":[38],"disease.":[39],"However,":[40],"baclofen,":[41],"which":[42,106],"is":[43,118],"used":[44],"as":[45,62],"an":[46],"antispastic":[47],"agent,":[48],"and":[49,66,94],"other":[50],"known":[52],"can":[56],"produce":[57],"CNS":[58,88],"side":[59,89],"effects":[60,90],"such":[61],"sedation,":[63],"dizziness,":[64],"nausea,":[65],"vomiting":[67],"at":[68,91],"higher":[69],"doses.":[70],"now":[72],"report":[73],"discovery":[75],"atypical":[77],"devoid":[81],"classical":[83],"related":[87],"therapeutic":[92],"doses":[93],"optimization":[96],"this":[98],"type":[99],"compound":[101],"inhibition":[103],"TLESRs,":[105],"has":[107],"resulted":[108],"in":[109,122],"a":[110],"candidate":[111],"drug":[112],"(":[113],"R)-":[114],"7":[115],"(AZD3355)":[116],"presently":[119],"being":[120],"evaluated":[121],"man.":[123]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
