{"id":"https://openalex.org/W2004373421","doi":"https://doi.org/10.1128/jvi.79.10.6449-6458.2005","title":"Acylation-Mediated Membrane Anchoring of Avian Influenza Virus Hemagglutinin Is Essential for Fusion Pore Formation and Virus Infectivity","display_name":"Acylation-Mediated Membrane Anchoring of Avian Influenza Virus Hemagglutinin Is Essential for Fusion Pore Formation and Virus Infectivity","publication_year":2005,"publication_date":"2005-04-27","ids":{"openalex":"https://openalex.org/W2004373421","doi":"https://doi.org/10.1128/jvi.79.10.6449-6458.2005","mag":"2004373421","pmid":"https://pubmed.ncbi.nlm.nih.gov/15858028","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1091681"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.79.10.6449-6458.2005","doi":"https://doi.org/10.1128/jvi.79.10.6449-6458.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.79.10.6449-6458.2005","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC1091681","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101540396","display_name":"Ralf Wagner","orcid":"https://orcid.org/0000-0002-4226-6873","observed_orcids":["https://orcid.org/0000-0002-4226-6873"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralf Wagner","raw_affiliation_strings":["Institut fu\u0308r Virologie, Philipps-Universita\u0308t, 35011 Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu\u0308r Virologie, Philipps-Universita\u0308t, 35011 Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103520615","display_name":"Astrid Herwig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Astrid Herwig","raw_affiliation_strings":["Institut fu\u0308r Virologie, Philipps-Universita\u0308t, 35011 Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu\u0308r Virologie, Philipps-Universita\u0308t, 35011 Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001821347","display_name":"Nahid Azzouz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nahid Azzouz","raw_affiliation_strings":["Institut fu\u0308r Virologie, Philipps-Universita\u0308t, 35011 Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu\u0308r Virologie, Philipps-Universita\u0308t, 35011 Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110410221","display_name":"Hans Dieter Klenk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans Dieter Klenk","raw_affiliation_strings":["Institut fu\u0308r Virologie, Philipps-Universita\u0308t, 35011 Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu\u0308r Virologie, Philipps-Universita\u0308t, 35011 Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161103922"],"apc_list":null,"apc_paid":null,"fwci":3.8229,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.92930273,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"79","issue":"10","first_page":"6449","last_page":"6458"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/influenza-virus-hemagglutinin","display_name":"influenza virus hemagglutinin","score":0.8619999885559082},{"id":"https://openalex.org/keywords/protein-palmitoylation","display_name":"palmitoylation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cysteine-acylation","display_name":"cysteine acylation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/membrane-anchoring","display_name":"membrane anchoring","score":0.847000002861023},{"id":"https://openalex.org/keywords/fowl-plague-virus","display_name":"fowl plague virus","score":0.8849999904632568},{"id":"https://openalex.org/keywords/fusion-pore-formation","display_name":"fusion pore formation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/hemifusion","display_name":"hemifusion","score":0.7760000228881836},{"id":"https://openalex.org/keywords/virus-infectivity","display_name":"viral infectivity","score":0.753000020980835},{"id":"https://openalex.org/keywords/cytoplasmic-tail","display_name":"cytoplasmic tail","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.730631411075592},{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.7091715931892395},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6876766681671143},{"id":"https://openalex.org/C2778692840","wikidata":"https://www.wikidata.org/wiki/Q9136673","display_name":"Hemagglutinin (influenza)","level":3,"score":0.6618056893348694},{"id":"https://openalex.org/C193557335","wikidata":"https://www.wikidata.org/wiki/Q61424","display_name":"Acylation","level":3,"score":0.5948208570480347},{"id":"https://openalex.org/C146727910","wikidata":"https://www.wikidata.org/wiki/Q501620","display_name":"Palmitoylation","level":4,"score":0.5650017857551575},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5603879690170288},{"id":"https://openalex.org/C103038307","wikidata":"https://www.wikidata.org/wiki/Q6556360","display_name":"Lipid bilayer fusion","level":3,"score":0.5450109243392944},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.47108662128448486},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4498155415058136},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.42887380719184875},{"id":"https://openalex.org/C2911126560","wikidata":"https://www.wikidata.org/wiki/Q51916573","display_name":"Influenzavirus B","level":5,"score":0.4264093041419983},{"id":"https://openalex.org/C2781416681","wikidata":"https://www.wikidata.org/wiki/Q287246","display_name":"Orthomyxoviridae","level":4,"score":0.3938862681388855},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.37878847122192383},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3461731970310211},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06820279359817505},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000215","descriptor_name":"Acylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002459","descriptor_name":"Cell Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017830","descriptor_name":"Octoxynol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.79.10.6449-6458.2005","doi":"https://doi.org/10.1128/jvi.79.10.6449-6458.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.79.10.6449-6458.2005","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:134992","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1091681","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:15858028","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15858028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:1091681","doi":null,"is_oa":true,"landing_page_url":"http://dx.doi.org/10.1128/JVI.79.10.6449-6458.2005","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:134992","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1091681","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W177909858","https://openalex.org/W1514867182","https://openalex.org/W1553486320","https://openalex.org/W1556716938","https://openalex.org/W1564861448","https://openalex.org/W1609531590","https://openalex.org/W1760105922","https://openalex.org/W1795629378","https://openalex.org/W1902313111","https://openalex.org/W1931522421","https://openalex.org/W1953927339","https://openalex.org/W1963729107","https://openalex.org/W1966998035","https://openalex.org/W1968301751","https://openalex.org/W1968563729","https://openalex.org/W1969401261","https://openalex.org/W1974928798","https://openalex.org/W1978044705","https://openalex.org/W1979066236","https://openalex.org/W1979524548","https://openalex.org/W1998865212","https://openalex.org/W1999678180","https://openalex.org/W2020665587","https://openalex.org/W2021113974","https://openalex.org/W2028564306","https://openalex.org/W2032378111","https://openalex.org/W2035599002","https://openalex.org/W2046182783","https://openalex.org/W2059606249","https://openalex.org/W2063701397","https://openalex.org/W2068738089","https://openalex.org/W2070734260","https://openalex.org/W2075198304","https://openalex.org/W2080494149","https://openalex.org/W2080813177","https://openalex.org/W2081747066","https://openalex.org/W2082045061","https://openalex.org/W2092296126","https://openalex.org/W2102335249","https://openalex.org/W2102537321","https://openalex.org/W2113300998","https://openalex.org/W2117134676","https://openalex.org/W2121936687","https://openalex.org/W2122240125","https://openalex.org/W2123852904","https://openalex.org/W2124159817","https://openalex.org/W2128647460","https://openalex.org/W2129629803","https://openalex.org/W2133106116","https://openalex.org/W2135955581","https://openalex.org/W2140900740","https://openalex.org/W2142061382","https://openalex.org/W2154116964","https://openalex.org/W2158098866","https://openalex.org/W2160937520","https://openalex.org/W2161056514","https://openalex.org/W2161913871","https://openalex.org/W2164142570","https://openalex.org/W2770627470","https://openalex.org/W3135190686","https://openalex.org/W4211239492"],"related_works":["https://openalex.org/W1953927339","https://openalex.org/W1609531590","https://openalex.org/W2113300998","https://openalex.org/W2028564306","https://openalex.org/W2743828285","https://openalex.org/W2585833261","https://openalex.org/W2151255432","https://openalex.org/W2000492055","https://openalex.org/W1990630636","https://openalex.org/W7098073746"],"abstract_inverted_index":{"Attachment":[0],"of":[1,11,39,49,55,89,140,145,167,173,186,204,217,224],"palmitic":[2],"acid":[3],"to":[4,118,156,195],"cysteine":[5,22],"residues":[6,23],"is":[7,220],"a":[8,47],"common":[9],"modification":[10],"viral":[12],"glycoproteins.":[13],"The":[14],"influenza":[15],"virus":[16,58,78,90],"hemagglutinin":[17],"(HA)":[18],"has":[19],"three":[20],"conserved":[21],"at":[24,67],"its":[25],"C":[26],"terminus":[27],"serving":[28],"as":[29],"acylation":[30,65,185],"sites.":[31],"To":[32],"analyze":[33],"the":[34,64,95,98,154,187,199],"structural":[35],"and":[36,53,71,82,97,103,110,122,127,170,175,202,227],"functional":[37],"roles":[38],"acylation,":[40],"we":[41],"have":[42,74],"generated":[43],"by":[44,107,163],"reverse":[45],"genetics":[46],"series":[48],"mutants":[50,96],"(Ac1,":[51],"Ac2,":[52],"Ac3)":[54],"fowl":[56],"plague":[57],"(FPV)":[59],"containing":[60],"HA":[61,206,219],"in":[62,80,207],"which":[63],"sites":[66],"positions":[68],"551,":[69],"559,":[70],"562,":[72],"respectively,":[73],"been":[75],"abolished.":[76],"When":[77,153],"growth":[79],"CV1":[81],"MDCK":[83],"cells":[84,169],"was":[85,150,161,178],"analyzed,":[86],"similar":[87],"amounts":[88],"particles":[91],"were":[92,113,125],"observed":[93],"with":[94],"wild":[99],"type.":[100],"Protein":[101],"patterns":[102],"lipid":[104],"compositions,":[105],"characterized":[106],"high":[108],"cholesterol":[109],"glycolipid":[111,158],"contents,":[112],"also":[114,211],"indistinguishable.":[115],"However,":[116],"compared":[117],"wild-type":[119],"virus,":[120],"Ac2":[121,174],"Ac3":[123,176],"virions":[124],"10":[126],"almost":[128],"1,000":[129],"times":[130],"less":[131],"infectious,":[132],"respectively.":[133],"Fluorescence":[134],"transfer":[135],"experiments":[136],"revealed":[137],"that":[138,184,213],"loss":[139],"acyl":[141],"chains":[142],"impeded":[143],"formation":[144,223],"fusion":[146,225],"pores,":[147],"whereas":[148],"hemifusion":[149],"not":[151,191],"affected.":[152],"affinity":[155],"detergent-insoluble":[157],"(DIG)":[159],"domains":[160],"analyzed":[162],"Triton":[164],"X-100":[165],"treatment":[166],"infected":[168],"virions,":[171],"solubilization":[172],"HAs":[177],"markedly":[179],"facilitated.":[180],"These":[181],"observations":[182],"show":[183],"cytoplasmic":[188],"tail,":[189],"while":[190],"necessary":[192],"for":[193,222,230],"targeting":[194],"DIG":[196,215],"domains,":[197],"promotes":[198],"firm":[200],"anchoring":[201],"retention":[203],"FPV":[205,218],"these":[208],"domains.":[209],"They":[210],"indicate":[212],"tight":[214],"association":[216],"essential":[221],"pores":[226],"thus":[228],"probably":[229],"infectivity.":[231]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}