{"id":"https://openalex.org/W2004370748","doi":"https://doi.org/10.1016/j.addr.2008.09.006","title":"Mathematical modeling of molecular diffusion through mucus","display_name":"Mathematical modeling of molecular diffusion through mucus","publication_year":2008,"publication_date":"2008-12-17","ids":{"openalex":"https://openalex.org/W2004370748","doi":"https://doi.org/10.1016/j.addr.2008.09.006","mag":"2004370748","pmid":"https://pubmed.ncbi.nlm.nih.gov/19135488","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2646819"},"language":"en","primary_location":{"id":"doi:10.1016/j.addr.2008.09.006","doi":"https://doi.org/10.1016/j.addr.2008.09.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.addr.2008.09.006","pdf_url":null,"source":{"id":"https://openalex.org/S114437232","display_name":"Advanced Drug Delivery Reviews","issn_l":"0169-409X","issn":["0169-409X","1872-8294"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Drug Delivery Reviews","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2646819","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075525812","display_name":"Yen Cu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yen Cu","raw_affiliation_strings":["Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA","Department of Biomedical Engineering, Yale University, New Haven, CT 06511, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University, New Haven, CT 06511, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012106344","display_name":"W. Mark Saltzman","orcid":"https://orcid.org/0000-0002-2163-549X","observed_orcids":["https://orcid.org/0000-0002-2163-549X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"W. Mark Saltzman","raw_affiliation_strings":["Department of Biomedical Engineering, Yale University, New Haven, CT 06511, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University, New Haven, CT 06511, United States","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012106344"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":5550,"currency":"USD","value_usd":5550},"apc_paid":null,"fwci":0.3818,"has_fulltext":false,"cited_by_count":127,"citation_normalized_percentile":{"value":0.27826087,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"61","issue":"2","first_page":"101","last_page":"114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13675","display_name":"Diffusion Coefficients in Liquids","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-diffusion","display_name":"molecular diffusion","score":0.8240000009536743},{"id":"https://openalex.org/keywords/mucus-gel","display_name":"mucus gel","score":0.9610000252723694},{"id":"https://openalex.org/keywords/mathematical-modeling","display_name":"mathematical modeling","score":0.8080000281333923},{"id":"https://openalex.org/keywords/oral-drug-delivery","display_name":"oral drug delivery","score":0.7390000224113464},{"id":"https://openalex.org/keywords/intranasal-drug-delivery","display_name":"intranasal drug delivery","score":0.9039999842643738},{"id":"https://openalex.org/keywords/intraocular-drug-delivery","display_name":"intraocular drug delivery","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C2777312293","wikidata":"https://www.wikidata.org/wiki/Q3649349","display_name":"Mucus","level":2,"score":0.9488242268562317},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.554491400718689},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.500262975692749},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.45781010389328003},{"id":"https://openalex.org/C57736034","wikidata":"https://www.wikidata.org/wiki/Q17104113","display_name":"Molecular diffusion","level":3,"score":0.4155806005001068},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20854687690734863},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09260818362236023},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.07045939564704895},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009093","descriptor_name":"Mucus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009093","descriptor_name":"Mucus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009093","descriptor_name":"Mucus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014783","descriptor_name":"Viscosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.addr.2008.09.006","doi":"https://doi.org/10.1016/j.addr.2008.09.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.addr.2008.09.006","pdf_url":null,"source":{"id":"https://openalex.org/S114437232","display_name":"Advanced Drug Delivery Reviews","issn_l":"0169-409X","issn":["0169-409X","1872-8294"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Drug Delivery Reviews","raw_type":"journal-article"},{"id":"pmid:19135488","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19135488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced drug delivery reviews","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2646819","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2646819","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Adv Drug Deliv Rev","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2646819","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2646819","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Adv Drug Deliv Rev","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5443484073","display_name":"MOLECULAR AND CELLULAR TRANSPORT IN MUCUS","funder_award_id":"R01GM043873","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6368652804","display_name":"Cellular and molecular transport in mucus","funder_award_id":"R01EB000487","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":120,"referenced_works":["https://openalex.org/W95323076","https://openalex.org/W181415430","https://openalex.org/W278377992","https://openalex.org/W374497283","https://openalex.org/W623904406","https://openalex.org/W1533859251","https://openalex.org/W1551123259","https://openalex.org/W1574989042","https://openalex.org/W1581071628","https://openalex.org/W1586111803","https://openalex.org/W1587638772","https://openalex.org/W1592701309","https://openalex.org/W1597285101","https://openalex.org/W1662742616","https://openalex.org/W1965950722","https://openalex.org/W1973922388","https://openalex.org/W1975273700","https://openalex.org/W1976301609","https://openalex.org/W1976892351","https://openalex.org/W1976954747","https://openalex.org/W1977848926","https://openalex.org/W1978362163","https://openalex.org/W1979343658","https://openalex.org/W1986486038","https://openalex.org/W1988193695","https://openalex.org/W1992292422","https://openalex.org/W1992645896","https://openalex.org/W1993499801","https://openalex.org/W1998991079","https://openalex.org/W2000843748","https://openalex.org/W2003694953","https://openalex.org/W2006744863","https://openalex.org/W2008163518","https://openalex.org/W2009135646","https://openalex.org/W2010753465","https://openalex.org/W2010945250","https://openalex.org/W2011739832","https://openalex.org/W2011998352","https://openalex.org/W2012045438","https://openalex.org/W2012906994","https://openalex.org/W2013930024","https://openalex.org/W2014506080","https://openalex.org/W2014645106","https://openalex.org/W2015383377","https://openalex.org/W2017321219","https://openalex.org/W2022130011","https://openalex.org/W2022132405","https://openalex.org/W2024994244","https://openalex.org/W2025142147","https://openalex.org/W2025653072","https://openalex.org/W2026440602","https://openalex.org/W2026886744","https://openalex.org/W2028872561","https://openalex.org/W2029375419","https://openalex.org/W2032719824","https://openalex.org/W2032848087","https://openalex.org/W2032945955","https://openalex.org/W2037477418","https://openalex.org/W2039124925","https://openalex.org/W2039496381","https://openalex.org/W2040258301","https://openalex.org/W2043061670","https://openalex.org/W2046780084","https://openalex.org/W2047763238","https://openalex.org/W2054780413","https://openalex.org/W2056357374","https://openalex.org/W2058079116","https://openalex.org/W2060569670","https://openalex.org/W2061142100","https://openalex.org/W2063066300","https://openalex.org/W2065072784","https://openalex.org/W2067049282","https://openalex.org/W2070543209","https://openalex.org/W2071326969","https://openalex.org/W2072089288","https://openalex.org/W2072125904","https://openalex.org/W2075028117","https://openalex.org/W2076732912","https://openalex.org/W2077457733","https://openalex.org/W2079551453","https://openalex.org/W2081301060","https://openalex.org/W2082259134","https://openalex.org/W2082871367","https://openalex.org/W2083833327","https://openalex.org/W2083873695","https://openalex.org/W2085723897","https://openalex.org/W2086488604","https://openalex.org/W2089607606","https://openalex.org/W2089678034","https://openalex.org/W2096366360","https://openalex.org/W2097246107","https://openalex.org/W2102002215","https://openalex.org/W2104434002","https://openalex.org/W2122709936","https://openalex.org/W2124154250","https://openalex.org/W2126678049","https://openalex.org/W2128814592","https://openalex.org/W2130420151","https://openalex.org/W2134546261","https://openalex.org/W2141766828","https://openalex.org/W2148285906","https://openalex.org/W2155757349","https://openalex.org/W2158473853","https://openalex.org/W2159949614","https://openalex.org/W2171758860","https://openalex.org/W2180972619","https://openalex.org/W2247971996","https://openalex.org/W2398357178","https://openalex.org/W2402264886","https://openalex.org/W2402464922","https://openalex.org/W2407400602","https://openalex.org/W2410358499","https://openalex.org/W2414766673","https://openalex.org/W2416278293","https://openalex.org/W2429307938","https://openalex.org/W2442465530","https://openalex.org/W2498192137","https://openalex.org/W4249359970","https://openalex.org/W6634959489","https://openalex.org/W6652109627"],"related_works":["https://openalex.org/W2765561039","https://openalex.org/W2039124925","https://openalex.org/W2218584782","https://openalex.org/W3134971165","https://openalex.org/W2068820688","https://openalex.org/W2794998214","https://openalex.org/W1987131235","https://openalex.org/W2765425655","https://openalex.org/W2072125904","https://openalex.org/W2099146958"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}