{"id":"https://openalex.org/W2004365998","doi":"https://doi.org/10.1016/j.ydbio.2007.07.021","title":"Disruption of sphingolipid metabolism elicits apoptosis-associated reproductive defects in Drosophila","display_name":"Disruption of sphingolipid metabolism elicits apoptosis-associated reproductive defects in Drosophila","publication_year":2007,"publication_date":"2007-07-27","ids":{"openalex":"https://openalex.org/W2004365998","doi":"https://doi.org/10.1016/j.ydbio.2007.07.021","mag":"2004365998","pmid":"https://pubmed.ncbi.nlm.nih.gov/17706961","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2094363"},"language":"en","primary_location":{"id":"doi:10.1016/j.ydbio.2007.07.021","doi":"https://doi.org/10.1016/j.ydbio.2007.07.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ydbio.2007.07.021","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0012160607012158/pdf","source":{"id":"https://openalex.org/S136634221","display_name":"Developmental Biology","issn_l":"0012-1606","issn":["0012-1606","1095-564X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/S0012160607012158/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100869179","display_name":"Van Hieu Phan","orcid":"https://orcid.org/0009-0001-6587-1742","observed_orcids":["https://orcid.org/0009-0001-6587-1742"]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Van H. Phan","raw_affiliation_strings":["Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, and Children's Hospital Oakland Research Institute, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, and Children's Hospital Oakland Research Institute, CA, USA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073539249","display_name":"Deron Raymond Herr","orcid":"https://orcid.org/0000-0001-5755-0896","observed_orcids":["https://orcid.org/0000-0001-5755-0896"]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deron R. Herr","raw_affiliation_strings":["Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, CA, USA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048631391","display_name":"Dionne Panton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dionne Panton","raw_affiliation_strings":["Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, CA, USA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008026499","display_name":"Henrik Fyrst","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henrik Fyrst","raw_affiliation_strings":["Children\u2019s Hospital Oakland Research Institute, Oakland, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital Oakland Research Institute, Oakland, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039889162","display_name":"Julie Deane Saba","orcid":"https://orcid.org/0000-0002-4894-919X","observed_orcids":["https://orcid.org/0000-0002-4894-919X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie D. Saba","raw_affiliation_strings":["Children\u2019s Hospital Oakland Research Institute, Oakland, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital Oakland Research Institute, Oakland, CA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103803116","display_name":"Greg L. Harris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Greg L. Harris","raw_affiliation_strings":["Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, CA, USA","institution_ids":["https://openalex.org/I26538001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103803116"],"corresponding_institution_ids":["https://openalex.org/I26538001"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":1.5233,"has_fulltext":true,"cited_by_count":62,"citation_normalized_percentile":{"value":0.80427181,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"309","issue":"2","first_page":"329","last_page":"341"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sphingolipid-metabolism","display_name":"sphingolipid metabolism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/reproductive-disorders","display_name":"reproductive disorders","score":0.921999990940094},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.8080000281333923},{"id":"https://openalex.org/keywords/sphingosine-1-phosphate-lyase","display_name":"sphingosine-1-phosphate lyase","score":0.9419999718666077},{"id":"https://openalex.org/keywords/spermatheca","display_name":"spermatheca","score":0.746999979019165},{"id":"https://openalex.org/keywords/ovarian-degeneration","display_name":"ovarian degeneration","score":0.9070000052452087},{"id":"https://openalex.org/keywords/reaper","display_name":"reaper","score":0.9729999899864197},{"id":"https://openalex.org/keywords/hid","display_name":"hid","score":0.9860000014305115},{"id":"https://openalex.org/keywords/grim","display_name":"Grim","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pro-apoptotic-genes","display_name":"pro-apoptotic genes","score":0.7829999923706055},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9226210117340088},{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.9164443016052246},{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.7554832100868225},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.682439386844635},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6772449612617493},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5626989603042603},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5053334832191467},{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.4910271167755127},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4122436046600342},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33357298374176025},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2865317463874817},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11673307418823242}],"mesh":[{"descriptor_ui":"D000446","descriptor_name":"Aldehyde-Lyases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000446","descriptor_name":"Aldehyde-Lyases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005835","descriptor_name":"Genitalia","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D005835","descriptor_name":"Genitalia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013107","descriptor_name":"Sphingolipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ydbio.2007.07.021","doi":"https://doi.org/10.1016/j.ydbio.2007.07.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ydbio.2007.07.021","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0012160607012158/pdf","source":{"id":"https://openalex.org/S136634221","display_name":"Developmental Biology","issn_l":"0012-1606","issn":["0012-1606","1095-564X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Biology","raw_type":"journal-article"},{"id":"pmid:17706961","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17706961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2094363","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2094363/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Dev Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.ydbio.2007.07.021","doi":"https://doi.org/10.1016/j.ydbio.2007.07.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ydbio.2007.07.021","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0012160607012158/pdf","source":{"id":"https://openalex.org/S136634221","display_name":"Developmental Biology","issn_l":"0012-1606","issn":["0012-1606","1095-564X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1909019451","display_name":"Genetic analysis of sphingolipid metabolism and obesity","funder_award_id":"R21HL080811","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3294295741","display_name":"Oligopyrrole-based Anion Binding Agents","funder_award_id":"R01GM058907","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4767239518","display_name":null,"funder_award_id":"5R25GM58907","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5075705393","display_name":"SDSU Initiative for Maximizing Student Development (SDSU IMSD)","funder_award_id":"R25GM058906","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7271907731","display_name":"Sphingolipid Metabolism in Drosophila Development","funder_award_id":"R01GM066954","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004365998.pdf","grobid_xml":"https://content.openalex.org/works/W2004365998.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W207672058","https://openalex.org/W1529853299","https://openalex.org/W1570743730","https://openalex.org/W1832760132","https://openalex.org/W1852053365","https://openalex.org/W1889455744","https://openalex.org/W1922143649","https://openalex.org/W1964822872","https://openalex.org/W1966566812","https://openalex.org/W1970911936","https://openalex.org/W1971062375","https://openalex.org/W1971788554","https://openalex.org/W1971799685","https://openalex.org/W1973019129","https://openalex.org/W1978492782","https://openalex.org/W1979139420","https://openalex.org/W1980331623","https://openalex.org/W1981531462","https://openalex.org/W1984167528","https://openalex.org/W1984689602","https://openalex.org/W1984925149","https://openalex.org/W1987121211","https://openalex.org/W1987125060","https://openalex.org/W2000973050","https://openalex.org/W2008597649","https://openalex.org/W2018583173","https://openalex.org/W2019256890","https://openalex.org/W2021432120","https://openalex.org/W2021974175","https://openalex.org/W2022770236","https://openalex.org/W2031596218","https://openalex.org/W2036039480","https://openalex.org/W2038436316","https://openalex.org/W2040004663","https://openalex.org/W2041294469","https://openalex.org/W2044138450","https://openalex.org/W2045780506","https://openalex.org/W2057697250","https://openalex.org/W2059589149","https://openalex.org/W2068170987","https://openalex.org/W2070378123","https://openalex.org/W2070532728","https://openalex.org/W2085420149","https://openalex.org/W2087942104","https://openalex.org/W2089208780","https://openalex.org/W2095291794","https://openalex.org/W2096012158","https://openalex.org/W2097904707","https://openalex.org/W2101910352","https://openalex.org/W2102109561","https://openalex.org/W2103812115","https://openalex.org/W2104245351","https://openalex.org/W2104872660","https://openalex.org/W2106969664","https://openalex.org/W2110975163","https://openalex.org/W2120155501","https://openalex.org/W2125040660","https://openalex.org/W2135936986","https://openalex.org/W2137411441","https://openalex.org/W2139865462","https://openalex.org/W2148030604","https://openalex.org/W2149912558","https://openalex.org/W2151885059","https://openalex.org/W2155309157","https://openalex.org/W2160917745","https://openalex.org/W2162838509"],"related_works":["https://openalex.org/W2038436316","https://openalex.org/W148113462","https://openalex.org/W1979139420","https://openalex.org/W2111382472","https://openalex.org/W2108238627","https://openalex.org/W3131735646","https://openalex.org/W2072325518","https://openalex.org/W1973019129","https://openalex.org/W1503653826","https://openalex.org/W3176430651"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
