{"id":"https://openalex.org/W2004363572","doi":"https://doi.org/10.1179/135100000101535717","title":"The reactivity of myeloperoxidase compound I formed with hypochlorous acid","display_name":"The reactivity of myeloperoxidase compound I formed with hypochlorous acid","publication_year":2000,"publication_date":"2000-08-01","ids":{"openalex":"https://openalex.org/W2004363572","doi":"https://doi.org/10.1179/135100000101535717","mag":"2004363572","pmid":"https://pubmed.ncbi.nlm.nih.gov/10994870"},"language":"en","primary_location":{"id":"doi:10.1179/135100000101535717","doi":"https://doi.org/10.1179/135100000101535717","is_oa":true,"landing_page_url":"https://doi.org/10.1179/135100000101535717","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1179/135100000101535717?needAccess=true&role=button","source":{"id":"https://openalex.org/S183535129","display_name":"Redox Report","issn_l":"1351-0002","issn":["1351-0002","1743-2928"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Report","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.1179/135100000101535717?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016449058","display_name":"Paul Georg Furtm\u00fcller","orcid":"https://orcid.org/0000-0002-1199-2469","observed_orcids":["https://orcid.org/0000-0002-1199-2469"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P.G. Furtm\u00fcller","raw_affiliation_strings":["Institute of Chemistry, University of Agricultural Sciences, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemistry, University of Agricultural Sciences, Vienna, Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039929219","display_name":"Ursula Burner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U. Burner","raw_affiliation_strings":["Institute of Chemistry University of Agricultural Sciences, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemistry University of Agricultural Sciences, Vienna, Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072143175","display_name":"Walter Jantschko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Jantschko","raw_affiliation_strings":["Institute of Chemistry University of Agricultural Sciences, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemistry University of Agricultural Sciences, Vienna, Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019031580","display_name":"G\u00fcnther Regelsberger","orcid":"https://orcid.org/0000-0002-3233-1491","observed_orcids":["https://orcid.org/0000-0002-3233-1491"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Regelsberger","raw_affiliation_strings":["Institute of Chemistry University of Agricultural Sciences, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemistry University of Agricultural Sciences, Vienna, Austria","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016279871","display_name":"Christian Obinger","orcid":"https://orcid.org/0000-0002-7133-3430","observed_orcids":["https://orcid.org/0000-0002-7133-3430"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Obinger","raw_affiliation_strings":["Institute of Chemistry University of Agricultural Sciences, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemistry University of Agricultural Sciences, Vienna, Austria","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1625,"currency":"GBP","value_usd":1993},"apc_paid":null,"fwci":0.9429,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.73233026,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"5","issue":"4","first_page":"173","last_page":"178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.7515000104904175,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.7515000104904175,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.15410000085830688,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12136","display_name":"Vanadium and Halogenation Chemistry","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.996999979019165},{"id":"https://openalex.org/keywords/compound-i","display_name":"compound I","score":0.9110000133514404},{"id":"https://openalex.org/keywords/hypochlorous-acid","display_name":"hypochlorous acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.6740000247955322},{"id":"https://openalex.org/keywords/redox-intermediates","display_name":"redox intermediates","score":0.7260000109672546},{"id":"https://openalex.org/keywords/ph-dependence","display_name":"pH dependence","score":0.6669999957084656},{"id":"https://openalex.org/keywords/reaction-kinetics","display_name":"reaction kinetics","score":0.7039999961853027},{"id":"https://openalex.org/keywords/thiocyanate","display_name":"thiocyanate","score":0.9869999885559082},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.8410000205039978},{"id":"https://openalex.org/keywords/nitrite","display_name":"nitrite","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tyrosine","display_name":"tyrosine","score":0.9829999804496765},{"id":"https://openalex.org/keywords/methionine","display_name":"methionine","score":0.7120000123977661},{"id":"https://openalex.org/keywords/enzyme-reactivity","display_name":"enzyme reactivity","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C2780908991","wikidata":"https://www.wikidata.org/wiki/Q407318","display_name":"Hypochlorous acid","level":2,"score":0.982498288154602},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9366774559020996},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.7710238695144653},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.6902989745140076},{"id":"https://openalex.org/C2776294642","wikidata":"https://www.wikidata.org/wiki/Q77747995","display_name":"Thiocyanate","level":2,"score":0.5927292108535767},{"id":"https://openalex.org/C93391505","wikidata":"https://www.wikidata.org/wiki/Q658700","display_name":"Reaction rate constant","level":3,"score":0.4618033766746521},{"id":"https://openalex.org/C98015330","wikidata":"https://www.wikidata.org/wiki/Q907315","display_name":"Absorbance","level":2,"score":0.45383524894714355},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.4389963448047638},{"id":"https://openalex.org/C2776832558","wikidata":"https://www.wikidata.org/wiki/Q409049","display_name":"Hypochlorite","level":2,"score":0.4375770390033722},{"id":"https://openalex.org/C2777379063","wikidata":"https://www.wikidata.org/wiki/Q161233","display_name":"Formic acid","level":2,"score":0.4365995228290558},{"id":"https://openalex.org/C2776910235","wikidata":"https://www.wikidata.org/wiki/Q18574","display_name":"Reactivity (psychology)","level":3,"score":0.43604856729507446},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.41159164905548096},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.4006247818470001},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.3120202422142029},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2200547158718109},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006997","descriptor_name":"Hypochlorous Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1179/135100000101535717","doi":"https://doi.org/10.1179/135100000101535717","is_oa":true,"landing_page_url":"https://doi.org/10.1179/135100000101535717","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1179/135100000101535717?needAccess=true&role=button","source":{"id":"https://openalex.org/S183535129","display_name":"Redox Report","issn_l":"1351-0002","issn":["1351-0002","1743-2928"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Report","raw_type":"journal-article"},{"id":"pmid:10994870","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10994870","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox report : communications in free radical research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1179/135100000101535717","doi":"https://doi.org/10.1179/135100000101535717","is_oa":true,"landing_page_url":"https://doi.org/10.1179/135100000101535717","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1179/135100000101535717?needAccess=true&role=button","source":{"id":"https://openalex.org/S183535129","display_name":"Redox Report","issn_l":"1351-0002","issn":["1351-0002","1743-2928"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Report","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321181","display_name":"Austrian Science Fund","ror":"https://ror.org/013tf3c58"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004363572.pdf","grobid_xml":"https://content.openalex.org/works/W2004363572.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1497764520","https://openalex.org/W1547929361","https://openalex.org/W1567781128","https://openalex.org/W1839923189","https://openalex.org/W1997449896","https://openalex.org/W2016573311","https://openalex.org/W2028633454","https://openalex.org/W2035568334","https://openalex.org/W2041309279","https://openalex.org/W2069309047","https://openalex.org/W2070548987","https://openalex.org/W2072228771","https://openalex.org/W2072651499","https://openalex.org/W2073089909","https://openalex.org/W2109173122","https://openalex.org/W2127470368","https://openalex.org/W2314530439"],"related_works":["https://openalex.org/W2072651499","https://openalex.org/W2072377400","https://openalex.org/W1517408457","https://openalex.org/W1992375300","https://openalex.org/W2079006586","https://openalex.org/W2073089909","https://openalex.org/W1972778961","https://openalex.org/W2076451437","https://openalex.org/W1997449896","https://openalex.org/W2047563894"],"abstract_inverted_index":{"The":[0,118],"reaction":[1,24],"of":[2,25,89,92,97,129,172,186],"human":[3],"myeloperoxidase":[4],"(MPO)":[5],"with":[6,27,45,108],"hypochlorous":[7,134],"acid":[8,135],"(HOCl)":[9],"was":[10],"investigated":[11,113],"by":[12,184],"conventional":[13],"stopped-flow":[14,151],"spectroscopy":[15],"at":[16,80],"pH":[17],"5,":[18],"7,":[19],"and":[20,73,87,94,96,105,144,146,175,200],"9.":[21],"In":[22,150],"the":[23,46,85,90,115,123,140,153,194],"MPO":[26,138,177],"HOCl,":[28],"compound":[29,110,173],"I":[30,111],"is":[31,35],"formed.":[32],"Its":[33],"formation":[34],"strongly":[36],"dependent":[37],"on":[38],"pH.":[39],"HOCl":[40,165,189],"(rather":[41],"than":[42],"OCl-)":[43],"reacts":[44],"unprotonated":[47],"enzyme":[48],"in":[49,161,202],"its":[50],"ferric":[51],"state.":[52],"Apparent":[53],"second-order":[54],"rate":[55],"constants":[56],"were":[57,112],"determined":[58],"to":[59,136,163],"be":[60,180],"8.1":[61],"x":[62,68,75],"10(7)":[63],"M(-1)s(-1)":[64,70,77],"(pH":[65,71,78],"5),":[66],"2.0":[67,74],"10(8)":[69],"7)":[72],"10(6)":[76],"9)":[79],"15":[81],"degrees":[82],"C.":[83],"Furthermore,":[84],"kinetics":[86],"spectra":[88],"reactions":[91],"halides":[93],"thiocyanate":[95],"physiologically":[98],"relevant":[99],"one-electron":[100,170],"donors":[101],"(ascorbate,":[102],"nitrite,":[103],"tyrosine":[104],"hydrogen":[106,131],"peroxide)":[107],"this":[109],"using":[114],"sequential-mixing":[116],"technique.":[117],"results":[119],"show":[120],"conclusively":[121],"that":[122],"redox":[124],"intermediates":[125],"formed":[126],"upon":[127],"addition":[128,185],"either":[130],"peroxide":[132],"or":[133],"native":[137],"exhibit":[139],"same":[141],"spectral":[142],"features":[143],"reactivities":[145],"thus":[147],"are":[148,198,205],"identical.":[149],"investigations,":[152],"MPO/HOCl":[154],"system":[155],"has":[156],"some":[157],"advantage":[158],"since:":[159],"(i)":[160],"contrast":[162],"H2O2,":[164],"cannot":[166],"function":[167],"as":[168,188],"a":[169,192],"donor":[171],"I;":[174],"(ii)":[176],"can":[178],"easily":[179],"prevented":[181],"from":[182],"cycling":[183],"methionine":[187],"scavenger.":[190],"As":[191],"consequence,":[193],"observed":[195],"absorbance":[196],"changes":[197],"bigger":[199],"errors":[201],"data":[203],"analysis":[204],"smaller.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}