{"id":"https://openalex.org/W2004358965","doi":"https://doi.org/10.1507/endocrj.47.supplmarch_s85","title":"Functional Significance of Prop-1 Gene Expression in Pituitary Adenomas","display_name":"Functional Significance of Prop-1 Gene Expression in Pituitary Adenomas","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2004358965","doi":"https://doi.org/10.1507/endocrj.47.supplmarch_s85","mag":"2004358965","pmid":"https://pubmed.ncbi.nlm.nih.gov/10890192"},"language":"en","primary_location":{"id":"doi:10.1507/endocrj.47.supplmarch_s85","doi":"https://doi.org/10.1507/endocrj.47.supplmarch_s85","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj.47.supplmarch_s85","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj1993/47/SupplMarch/47_SupplMarch_S85/_pdf","source":{"id":"https://openalex.org/S191387813","display_name":"Endocrine Journal","issn_l":"0918-8959","issn":["0918-8959","1348-4540"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/endocrj1993/47/SupplMarch/47_SupplMarch_S85/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032612272","display_name":"Takeshi Usui","orcid":"https://orcid.org/0000-0002-8301-6766","observed_orcids":["https://orcid.org/0000-0002-8301-6766"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I3017590076","display_name":"Kyoto Medical Center","ror":"https://ror.org/045kb1d14","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I3017590076","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TAKESHI USUI","raw_affiliation_strings":["Clinical Research Institute, Kyoto National Hospital","Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Institute, Kyoto National Hospital","institution_ids":["https://openalex.org/I3017590076"]},{"raw_affiliation_string":"Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103069815","display_name":"Yoshio Nakamura","orcid":"https://orcid.org/0000-0003-2860-8600","observed_orcids":["https://orcid.org/0000-0003-2860-8600"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"YOSHIO NAKAMURA","raw_affiliation_strings":["Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043537605","display_name":"Haruo Mizuta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HARUO MIZUTA","raw_affiliation_strings":["Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048207427","display_name":"Hiroyuki Murabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIROYUKI MURABE","raw_affiliation_strings":["Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109155608","display_name":"Seiji Muro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SEIJI MURO","raw_affiliation_strings":["Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":null,"display_name":"MICHIO SUDA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"MICHIO SUDA","raw_affiliation_strings":["Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103373815","display_name":"Kiyoshi Tanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KIYOSHI TANAKA","raw_affiliation_strings":["Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053657669","display_name":"Issei Tanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"ISSEI TANAKA","raw_affiliation_strings":["Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049772836","display_name":"Akira Shimatsu","orcid":"https://orcid.org/0000-0002-9688-006X","observed_orcids":["https://orcid.org/0000-0002-9688-006X"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"AKIRA SHIMATSU","raw_affiliation_strings":["Department of Laboratory Medicine, Kyoto University Graduate School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Kyoto University Graduate School of Medicine","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105832217","display_name":"Kazuwa Nakao","orcid":"https://orcid.org/0000-0003-3483-4196","observed_orcids":["https://orcid.org/0000-0003-3483-4196"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KAZUWA NAKAO","raw_affiliation_strings":["Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7258,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.71756785,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"47","issue":"SupplMarch","first_page":"S85","last_page":"S89"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pit-1","display_name":"Pit-1","score":0.8899999856948853},{"id":"https://openalex.org/keywords/pituitary-adenoma","display_name":"pituitary adenoma","score":0.8759999871253967},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.44999998807907104},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cdna-sequencing","display_name":"cDNA sequencing","score":0.5419999957084656},{"id":"https://openalex.org/keywords/pituitary-tumorigenesis","display_name":"pituitary tumorigenesis","score":0.8980000019073486}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6909089088439941},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5872997045516968},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.551295816898346},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.5313996076583862},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5001049041748047},{"id":"https://openalex.org/C196287685","wikidata":"https://www.wikidata.org/wiki/Q83138290","display_name":"POU domain","level":5,"score":0.4856640100479126},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.47486376762390137},{"id":"https://openalex.org/C2781449511","wikidata":"https://www.wikidata.org/wiki/Q864296","display_name":"Pituitary tumors","level":2,"score":0.46153247356414795},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.42891162633895874},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3713790774345398},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3103787302970886},{"id":"https://openalex.org/C121587040","wikidata":"https://www.wikidata.org/wiki/Q898769","display_name":"Homeobox","level":4,"score":0.2937961220741272},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21849164366722107},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.1346437633037567}],"mesh":[{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010911","descriptor_name":"Pituitary Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010911","descriptor_name":"Pituitary Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010911","descriptor_name":"Pituitary Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1507/endocrj.47.supplmarch_s85","doi":"https://doi.org/10.1507/endocrj.47.supplmarch_s85","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj.47.supplmarch_s85","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj1993/47/SupplMarch/47_SupplMarch_S85/_pdf","source":{"id":"https://openalex.org/S191387813","display_name":"Endocrine Journal","issn_l":"0918-8959","issn":["0918-8959","1348-4540"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Journal","raw_type":"journal-article"},{"id":"pmid:10890192","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10890192","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1507/endocrj.47.supplmarch_s85","doi":"https://doi.org/10.1507/endocrj.47.supplmarch_s85","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj.47.supplmarch_s85","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj1993/47/SupplMarch/47_SupplMarch_S85/_pdf","source":{"id":"https://openalex.org/S191387813","display_name":"Endocrine Journal","issn_l":"0918-8959","issn":["0918-8959","1348-4540"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G6633757834","display_name":null,"funder_award_id":"96100204","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320309785","display_name":"Naito Foundation","ror":"https://ror.org/02s016q17"},{"id":"https://openalex.org/F4320310760","display_name":"Uehara Memorial Foundation","ror":"https://ror.org/00gc20a07"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004358965.pdf","grobid_xml":"https://content.openalex.org/works/W2004358965.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W103996602","https://openalex.org/W1972501714","https://openalex.org/W1973096120","https://openalex.org/W1990730347","https://openalex.org/W2012315992","https://openalex.org/W2045561759","https://openalex.org/W2064557280","https://openalex.org/W2070224639","https://openalex.org/W2073668865","https://openalex.org/W2079738563","https://openalex.org/W2083727742","https://openalex.org/W2085419335","https://openalex.org/W2111626274","https://openalex.org/W2135676923","https://openalex.org/W2142250972","https://openalex.org/W2327522683","https://openalex.org/W2404453444","https://openalex.org/W6636458883"],"related_works":["https://openalex.org/W1986375785","https://openalex.org/W7097972333","https://openalex.org/W2007375841","https://openalex.org/W1972501714","https://openalex.org/W2098103229","https://openalex.org/W2142250972","https://openalex.org/W1973597366","https://openalex.org/W2079032505","https://openalex.org/W7095646989","https://openalex.org/W4307734745"],"abstract_inverted_index":{"Prophet":[0],"of":[1,13,21,71,85,92,115,124],"Pit-1":[2,23,31],"(Prop-1),":[3],"which":[4],"is":[5,11,32],"a":[6,121],"paired-like":[7],"homeodomain":[8],"transcription":[9],"factor,":[10],"capable":[12],"binding":[14],"to":[15],"sites":[16],"in":[17,35,44,53,61,74,80,83,96],"an":[18],"early":[19],"enhancer":[20],"the":[22,50,86],"gene":[24,42,117],"and":[25],"regulating":[26],"its":[27],"expression.":[28],"As":[29],"human":[30,40,72,93,125],"expressed":[33],"considerably":[34],"pituitary":[36,45,54,63,75,98,126],"adenomas,":[37],"we":[38],"studied":[39],"Prop-1":[41,51,57,73,94,116],"expression":[43,70],"adenomas.":[46,55,88],"We":[47],"also":[48],"sequenced":[49],"cDNAs":[52,95],"Human":[56],"transcript":[58],"was":[59,77],"detected":[60],"all":[62],"adenomas":[64,76,99],"examined":[65],"by":[66,79],"RT-PCR":[67],"analysis.":[68],"The":[69,89],"confirmed":[78],"situ":[81],"hybridization":[82],"one":[84],"GH-producing":[87],"sequence":[90],"analysis":[91],"these":[97],"revealed":[100],"that":[101,113],"there":[102],"were":[103],"no":[104],"mutations":[105,114],"except":[106],"5":[107],"silent":[108],"nucleic":[109],"acid":[110],"substitutions,":[111],"suggesting":[112],"do":[118],"not":[119],"represent":[120],"frequent":[122],"mechanism":[123],"tumorigenesis.":[127]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}