{"id":"https://openalex.org/W2004355273","doi":"https://doi.org/10.1159/000022419","title":"Increase in Thrombin Generation after Coronary Thrombolysis with rt-PA or Streptokinase with Simultaneous Heparin versus Heparin Alone","display_name":"Increase in Thrombin Generation after Coronary Thrombolysis with rt-PA or Streptokinase with Simultaneous Heparin versus Heparin Alone","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2004355273","doi":"https://doi.org/10.1159/000022419","mag":"2004355273","pmid":"https://pubmed.ncbi.nlm.nih.gov/10087435"},"language":"en","primary_location":{"id":"doi:10.1159/000022419","doi":"https://doi.org/10.1159/000022419","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000022419","pdf_url":null,"source":{"id":"https://openalex.org/S155951557","display_name":"Pathophysiology of Haemostasis and Thrombosis","issn_l":"1424-8832","issn":["1424-8832","1424-8840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathophysiology of Haemostasis and Thrombosis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111723126","display_name":"E. Rega\u00f1\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019010403","display_name":"Hospital Universitari i Polit\u00e8cnic La Fe","ror":"https://ror.org/01ar2v535","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I3019010403","https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"E. R\u00e9ganon","raw_affiliation_strings":["Research Center, La Fe University Hospital, Valencia, Spain","Research Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center, La Fe University Hospital, Valencia, Spain","institution_ids":["https://openalex.org/I3019010403"]},{"raw_affiliation_string":"Research Center,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089948152","display_name":"Fernando Ferrando","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Ferrando","raw_affiliation_strings":["Research Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113424605","display_name":"V. Vila","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. Vila","raw_affiliation_strings":["Research Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"P. Villa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019010403","display_name":"Hospital Universitari i Polit\u00e8cnic La Fe","ror":"https://ror.org/01ar2v535","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I3019010403","https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"P. Villa","raw_affiliation_strings":["Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain","institution_ids":["https://openalex.org/I3019010403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110337704","display_name":"Vicenta Mart\u00ednez\u2010Sales","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. Mart\u00ednez-Sales","raw_affiliation_strings":["Research Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072374970","display_name":"Laura Fayos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Fayos","raw_affiliation_strings":["Coronary Care Unit and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coronary Care Unit and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109776202","display_name":"M Ruano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Ruano","raw_affiliation_strings":["Coronary Care Unit and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coronary Care Unit and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111865026","display_name":"J Aznar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019010403","display_name":"Hospital Universitari i Polit\u00e8cnic La Fe","ror":"https://ror.org/01ar2v535","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I3019010403","https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J. Aznar","raw_affiliation_strings":["Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain","institution_ids":["https://openalex.org/I3019010403"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7956,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.70572182,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"2","first_page":"99","last_page":"105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.8335000276565552,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.8335000276565552,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.15690000355243683,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombin-generation","display_name":"thrombin generation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/coronary-thrombolysis","display_name":"coronary thrombolysis","score":0.8320000171661377},{"id":"https://openalex.org/keywords/streptokinase","display_name":"streptokinase","score":0.777999997138977},{"id":"https://openalex.org/keywords/alteplase","display_name":"alteplase","score":0.8360000252723694},{"id":"https://openalex.org/keywords/thrombolysis","display_name":"thrombolysis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.7960000038146973},{"id":"https://openalex.org/keywords/acute-myocardial-infarction","display_name":"acute myocardial infarction","score":0.9589999914169312},{"id":"https://openalex.org/keywords/prothrombin-fragment-1-2","display_name":"prothrombin fragment 1+2","score":0.9470000267028809},{"id":"https://openalex.org/keywords/thrombin-antithrombin-complex","display_name":"thrombin-antithrombin complex","score":0.9240000247955322},{"id":"https://openalex.org/keywords/fibrinopeptide-a","display_name":"fibrinopeptide A","score":0.9990000128746033},{"id":"https://openalex.org/keywords/activated-partial-thromboplastin-time","display_name":"activated partial thromboplastin time","score":0.9160000085830688},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.93482506275177},{"id":"https://openalex.org/C2776336681","wikidata":"https://www.wikidata.org/wiki/Q416485","display_name":"Streptokinase","level":3,"score":0.8036608695983887},{"id":"https://openalex.org/C2778261982","wikidata":"https://www.wikidata.org/wiki/Q1755136","display_name":"Partial thromboplastin time","level":3,"score":0.7961767315864563},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6536931991577148},{"id":"https://openalex.org/C2779581417","wikidata":"https://www.wikidata.org/wiki/Q1931577","display_name":"Thrombolysis","level":3,"score":0.6283280849456787},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.5920851230621338},{"id":"https://openalex.org/C2779026020","wikidata":"https://www.wikidata.org/wiki/Q416336","display_name":"Antithrombin","level":3,"score":0.5350421667098999},{"id":"https://openalex.org/C2780077467","wikidata":"https://www.wikidata.org/wiki/Q2520736","display_name":"Thrombin time","level":4,"score":0.5139686465263367},{"id":"https://openalex.org/C2778205648","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant","level":2,"score":0.5119901299476624},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.42335373163223267},{"id":"https://openalex.org/C57002609","wikidata":"https://www.wikidata.org/wiki/Q5281999","display_name":"Discovery and development of direct thrombin inhibitors","level":4,"score":0.41375288367271423},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40151476860046387},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39186903834342957},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.2931550443172455},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.09385541081428528}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013300","descriptor_name":"Streptokinase","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000022419","doi":"https://doi.org/10.1159/000022419","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000022419","pdf_url":null,"source":{"id":"https://openalex.org/S155951557","display_name":"Pathophysiology of Haemostasis and Thrombosis","issn_l":"1424-8832","issn":["1424-8832","1424-8840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathophysiology of Haemostasis and Thrombosis","raw_type":"journal-article"},{"id":"pmid:10087435","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10087435","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemostasis","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1964523819","https://openalex.org/W1977398058","https://openalex.org/W1983126671","https://openalex.org/W1984143146","https://openalex.org/W1989582579","https://openalex.org/W1992003098","https://openalex.org/W2008293739","https://openalex.org/W2010846107","https://openalex.org/W2019839272","https://openalex.org/W2030145547","https://openalex.org/W2033431715","https://openalex.org/W2036760282","https://openalex.org/W2038391832","https://openalex.org/W2047172923","https://openalex.org/W2058421134","https://openalex.org/W2065206445","https://openalex.org/W2066431065","https://openalex.org/W2068050111","https://openalex.org/W2092416729","https://openalex.org/W2101158087","https://openalex.org/W2124297695","https://openalex.org/W2125646842","https://openalex.org/W2138787652","https://openalex.org/W2150595619","https://openalex.org/W2159162837","https://openalex.org/W2163687471","https://openalex.org/W2333920681","https://openalex.org/W2337057096","https://openalex.org/W2409296984","https://openalex.org/W3025057188"],"related_works":["https://openalex.org/W1984143146","https://openalex.org/W2035262659","https://openalex.org/W1604564424","https://openalex.org/W2262705538","https://openalex.org/W2371471950","https://openalex.org/W2085869089","https://openalex.org/W2409296984","https://openalex.org/W2123001299","https://openalex.org/W2412571124","https://openalex.org/W2068050111"],"abstract_inverted_index":{"This":[0],"study":[1,49],"compares":[2],"the":[3,33,40,94,107,126,134,153,158,181,188,192],"extent":[4],"of":[5,7,109,121,129],"inhibition":[6],"thrombin":[8,174,185],"generation":[9],"and":[10,26,60,75,88,103,111,116,148,167],"activity":[11],"achieved":[12,38],"in":[13,106,119,133,146,173,184],"patients":[14,95],"with":[15,36,39,84,97,164,187],"acute":[16],"myocardial":[17],"infarction":[18],"receiving":[19],"fibrinolytic":[20,46],"treatment":[21,30,136,155],"(streptokinase":[22],"SK,":[23],"or":[24,86],"rt-PA)":[25],"concomitant":[27],"intravenous":[28,178],"heparin":[29,42,61,98,179],"adjusted":[31],"to":[32,55,124,191],"patients'":[34],"weight":[35],"that":[37,120],"same":[41,193],"regimen":[43],"but":[44],"without":[45,62],"therapy.":[47],"The":[48],"involved":[50],"90":[51],"patients,":[52],"grouped":[53],"according":[54],"their":[56],"treatment:":[57],"SK+heparin;":[58],"rt-PA+heparin,":[59],"thrombolytic":[63,162,189],"agents.":[64],"Prothrombin":[65],"fragment":[66],"1+2":[67],"(F1+2),":[68],"thrombin-antithrombin":[69],"complex":[70],"(TAT),":[71],"fibrinopeptide":[72],"A":[73],"(FPA)":[74],"activated":[76],"partial":[77],"thromboplastin":[78],"time":[79],"were":[80,131,142],"measured.":[81],"Patients":[82],"treated":[83,96],"SK+heparin":[85],"rt-PA+heparin":[87],"higher":[89],"F1+2":[90],"plasma":[91,127,150],"levels":[92,128,151],"than":[93],"alone":[99],"at":[100,112,138,157],"12,":[101,113],"48":[102,115],"72":[104,117],"h":[105,118],"case":[108],"SK+heparin,":[110],"24,":[114],"rt-PA+heparin.":[122],"Compared":[123],"baseline,":[125],"FPA":[130,149],"decreased":[132],"three":[135,154],"groups":[137,156],"24-48":[139],"h.":[140],"There":[141],"no":[143],"significant":[144],"changes":[145],"TAT":[147],"among":[152],"different":[159,182],"times.":[160],"After":[161],"therapy":[163],"both":[165],"SK":[166],"rt-PA,":[168],"there":[169],"was":[170],"an":[171],"increase":[172],"generation,":[175],"although":[176],"high-dose":[177],"inhibited":[180],"increases":[183],"associated":[186],"agents":[190],"extent.":[194]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
