{"id":"https://openalex.org/W2004351969","doi":"https://doi.org/10.1016/j.neurobiolaging.2006.06.024","title":"Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis","display_name":"Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis","publication_year":2006,"publication_date":"2006-08-07","ids":{"openalex":"https://openalex.org/W2004351969","doi":"https://doi.org/10.1016/j.neurobiolaging.2006.06.024","mag":"2004351969","pmid":"https://pubmed.ncbi.nlm.nih.gov/16890326"},"language":"en","primary_location":{"id":"doi:10.1016/j.neurobiolaging.2006.06.024","doi":"https://doi.org/10.1016/j.neurobiolaging.2006.06.024","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neurobiolaging.2006.06.024","pdf_url":null,"source":{"id":"https://openalex.org/S284573","display_name":"Neurobiology of Aging","issn_l":"0197-4580","issn":["0197-4580","1558-1497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Aging","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087419105","display_name":"Shinichi Someya","orcid":"https://orcid.org/0000-0001-9895-6227","observed_orcids":["https://orcid.org/0000-0001-9895-6227"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Shinichi Someya","raw_affiliation_strings":["Department of Genetics, University of Wisconsin, Madison, WI 53706, USA","Department of Applied Biological Chemistry, University of Tokyo, Tokyo 113-8657, Japan","Departments of Genetics & Medical Genetics, University of Wisconsin, Madison, WI 53706, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Wisconsin, Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Applied Biological Chemistry, University of Tokyo, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Departments of Genetics & Medical Genetics, University of Wisconsin, Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000861547","display_name":"Tatsuya Yamasoba","orcid":"https://orcid.org/0000-0003-3608-0973","observed_orcids":["https://orcid.org/0000-0003-3608-0973"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuya Yamasoba","raw_affiliation_strings":["Department of Otolaryngology, University of Tokyo, Tokyo 113-8655, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, University of Tokyo, Tokyo 113-8655, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075151701","display_name":"Richard H. Weindruch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Weindruch","raw_affiliation_strings":["Department of Medicine and Veterans Administration Hospital, University of Wisconsin, Madison, WI 53705, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Veterans Administration Hospital, University of Wisconsin, Madison, WI 53705, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052480428","display_name":"Tomas A. Prolla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomas A. Prolla","raw_affiliation_strings":["Departments of Genetics & Medical Genetics, University of Wisconsin, Madison, WI 53706, USA","Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, WI 53706, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Genetics & Medical Genetics, University of Wisconsin, Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039444335","display_name":"Masaru Tanokura","orcid":"https://orcid.org/0000-0001-5072-2480","observed_orcids":["https://orcid.org/0000-0001-5072-2480"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masaru Tanokura","raw_affiliation_strings":["Department of Applied Biological Chemistry, University of Tokyo, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biological Chemistry, University of Tokyo, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039444335"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":null,"fwci":2.3088,"has_fulltext":false,"cited_by_count":135,"citation_normalized_percentile":{"value":0.87813808,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"28","issue":"10","first_page":"1613","last_page":"1622"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caloric-restriction","display_name":"caloric restriction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/age-related-hearing-loss","display_name":"age-related hearing loss","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hair-cell-degeneration","display_name":"hair cell degeneration","score":0.800000011920929},{"id":"https://openalex.org/keywords/spiral-ganglion-neurons","display_name":"spiral ganglion neurons","score":0.843999981880188},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8709999918937683},{"id":"https://openalex.org/keywords/bak","display_name":"Bak","score":0.9259999990463257},{"id":"https://openalex.org/keywords/building-information-modeling","display_name":"building information modeling","score":1.0},{"id":"https://openalex.org/keywords/inner-ear","display_name":"inner ear","score":0.38600000739097595},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C2779912225","wikidata":"https://www.wikidata.org/wiki/Q1756133","display_name":"Presbycusis","level":3,"score":0.9712342023849487},{"id":"https://openalex.org/C2779152698","wikidata":"https://www.wikidata.org/wiki/Q3095145","display_name":"Spiral ganglion","level":3,"score":0.9526057243347168},{"id":"https://openalex.org/C2780130748","wikidata":"https://www.wikidata.org/wiki/Q317857","display_name":"Cochlea","level":2,"score":0.8598935604095459},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.632020890712738},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6118667721748352},{"id":"https://openalex.org/C2778500370","wikidata":"https://www.wikidata.org/wiki/Q212344","display_name":"Inner ear","level":2,"score":0.5830431580543518},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5267578959465027},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.47695958614349365},{"id":"https://openalex.org/C2778585322","wikidata":"https://www.wikidata.org/wiki/Q1566641","display_name":"Hair cell","level":3,"score":0.4550524652004242},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44999444484710693},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.4294499456882477},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.409895122051239},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37608614563941956},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.32894760370254517},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31303656101226807},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.23398450016975403},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.15695089101791382},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13638338446617126}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005508","descriptor_name":"Food Deprivation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011304","descriptor_name":"Presbycusis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011304","descriptor_name":"Presbycusis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011304","descriptor_name":"Presbycusis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031204","descriptor_name":"Caloric Restriction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.neurobiolaging.2006.06.024","doi":"https://doi.org/10.1016/j.neurobiolaging.2006.06.024","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neurobiolaging.2006.06.024","pdf_url":null,"source":{"id":"https://openalex.org/S284573","display_name":"Neurobiology of Aging","issn_l":"0197-4580","issn":["0197-4580","1558-1497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Aging","raw_type":"journal-article"},{"id":"pmid:16890326","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16890326","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of aging","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6524589859","display_name":null,"funder_award_id":"15110201","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G7073492999","display_name":null,"funder_award_id":"13470357","funder_id":"https://openalex.org/F4320321945","funder_display_name":"Ministry of Health, Labour and Welfare"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320321945","display_name":"Ministry of Health, Labour and Welfare","ror":"https://ror.org/03mwa7s65"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1488124756","https://openalex.org/W1514414732","https://openalex.org/W1535426243","https://openalex.org/W1540436551","https://openalex.org/W1568624108","https://openalex.org/W1572893611","https://openalex.org/W1583148430","https://openalex.org/W1751703055","https://openalex.org/W1887455807","https://openalex.org/W1966318223","https://openalex.org/W1989479480","https://openalex.org/W1990470711","https://openalex.org/W1999053719","https://openalex.org/W2000529918","https://openalex.org/W2005146459","https://openalex.org/W2005766278","https://openalex.org/W2008841204","https://openalex.org/W2012753961","https://openalex.org/W2019524559","https://openalex.org/W2019838809","https://openalex.org/W2027395393","https://openalex.org/W2033996893","https://openalex.org/W2040756940","https://openalex.org/W2044804260","https://openalex.org/W2045663472","https://openalex.org/W2051018963","https://openalex.org/W2067798364","https://openalex.org/W2074740541","https://openalex.org/W2082516237","https://openalex.org/W2082686558","https://openalex.org/W2091127227","https://openalex.org/W2094856549","https://openalex.org/W2103132412","https://openalex.org/W2122683221","https://openalex.org/W2124595934","https://openalex.org/W2127938920","https://openalex.org/W2145211974","https://openalex.org/W2153029275","https://openalex.org/W2156905293","https://openalex.org/W2157999078","https://openalex.org/W2159986891","https://openalex.org/W2168536185"],"related_works":["https://openalex.org/W2156358135","https://openalex.org/W2057663429","https://openalex.org/W3139051363","https://openalex.org/W2049959604","https://openalex.org/W1554664283","https://openalex.org/W2005422662","https://openalex.org/W2370203958","https://openalex.org/W3023827330","https://openalex.org/W1966318223","https://openalex.org/W1751703055"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
