{"id":"https://openalex.org/W2004351198","doi":"https://doi.org/10.3109/00016489109134991","title":"Influenza a Virus-induced Otitis Media and Mucociliary Dysfunction in the Guinea Pig","display_name":"Influenza a Virus-induced Otitis Media and Mucociliary Dysfunction in the Guinea Pig","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2004351198","doi":"https://doi.org/10.3109/00016489109134991","mag":"2004351198","pmid":"https://pubmed.ncbi.nlm.nih.gov/1842862"},"language":"en","primary_location":{"id":"doi:10.3109/00016489109134991","doi":"https://doi.org/10.3109/00016489109134991","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00016489109134991","pdf_url":null,"source":{"id":"https://openalex.org/S198335345","display_name":"Acta Oto-Laryngologica","issn_l":"0001-6489","issn":["0001-6489","1651-2251","1651-2553"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Oto-Laryngologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111648943","display_name":"Yoshihiro Ohashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Ohashi","raw_affiliation_strings":["Department of Otolaryngology, Osaka City University Medical School, Japan","Department of Otolaryngology, Osaka City University Medical School, Osaka, 545, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Osaka City University Medical School, Japan","institution_ids":["https://openalex.org/I317356780"]},{"raw_affiliation_string":"Department of Otolaryngology, Osaka City University Medical School, Osaka, 545, Japan","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110343680","display_name":"Yoshiaki Nakai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiaki Nakai","raw_affiliation_strings":["Department of Otolaryngology, Osaka City, University Medical School, Osaka, 545, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Osaka City, University Medical School, Osaka, 545, Japan","institution_ids":["https://openalex.org/I317356780","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013484241","display_name":"Yusuke Esaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Esaki","raw_affiliation_strings":["Department of Otolaryngology, Osaka City, University Medical School, Osaka, 545, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Osaka City, University Medical School, Osaka, 545, Japan","institution_ids":["https://openalex.org/I317356780","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056652401","display_name":"Yoshiharu Ohno","orcid":"https://orcid.org/0000-0002-4431-1084","observed_orcids":["https://orcid.org/0000-0002-4431-1084"]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiharu Ohno","raw_affiliation_strings":["Department of Otolaryngology, Osaka City, University Medical School, Osaka, 545, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Osaka City, University Medical School, Osaka, 545, Japan","institution_ids":["https://openalex.org/I317356780","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086536243","display_name":"Yoshikazu Sugiura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshikazu Sugiura","raw_affiliation_strings":["Department of Otolaryngology, Osaka City, University Medical School, Osaka, 545, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Osaka City, University Medical School, Osaka, 545, Japan","institution_ids":["https://openalex.org/I317356780","https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":null,"display_name":"Hideki Okamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Okamoto","raw_affiliation_strings":["Department of Otolaryngology, Osaka City, University Medical School, Osaka, 545, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Osaka City, University Medical School, Osaka, 545, Japan","institution_ids":["https://openalex.org/I317356780","https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6683,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.67048711,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"111","issue":"sup486","first_page":"135","last_page":"148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10861","display_name":"Ear Surgery and Otitis Media","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10861","display_name":"Ear Surgery and Otitis Media","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14326","display_name":"Ear and Head Tumors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/influenza-a-virus","display_name":"influenza A virus","score":0.9660000205039978},{"id":"https://openalex.org/keywords/otitis-media-with-effusion","display_name":"otitis media with effusion","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mucociliary-dysfunction","display_name":"mucociliary dysfunction","score":0.8740000128746033},{"id":"https://openalex.org/keywords/middle-ear-effusion","display_name":"middle ear effusion","score":0.7770000100135803},{"id":"https://openalex.org/keywords/ciliary-activity","display_name":"ciliary activity","score":0.7429999709129333},{"id":"https://openalex.org/keywords/mucociliary-clearance","display_name":"mucociliary clearance","score":0.7820000052452087},{"id":"https://openalex.org/keywords/eustachian-tube","display_name":"Eustachian tube","score":0.765999972820282},{"id":"https://openalex.org/keywords/virus-bacteria-interactions","display_name":"viral-bacterial interactions","score":0.6389999985694885},{"id":"https://openalex.org/keywords/guinea-pig-model","display_name":"guinea pig model","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C2776439223","wikidata":"https://www.wikidata.org/wiki/Q480700","display_name":"Otitis","level":2,"score":0.7484370470046997},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.6630726456642151},{"id":"https://openalex.org/C3017739461","wikidata":"https://www.wikidata.org/wiki/Q40285","display_name":"New guinea","level":2,"score":0.5652286410331726},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5350049734115601},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4946143329143524},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.456623911857605},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.44478166103363037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3103509545326233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14139053225517273},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.07877293229103088},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.05127343535423279},{"id":"https://openalex.org/C2549261","wikidata":"https://www.wikidata.org/wiki/Q43455","display_name":"Ethnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002923","descriptor_name":"Cilia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002923","descriptor_name":"Cilia","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004432","descriptor_name":"Ear, Middle","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004432","descriptor_name":"Ear, Middle","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005064","descriptor_name":"Eustachian Tube","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005064","descriptor_name":"Eustachian Tube","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D010034","descriptor_name":"Otitis Media with Effusion","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D010034","descriptor_name":"Otitis Media with Effusion","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010034","descriptor_name":"Otitis Media with Effusion","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/00016489109134991","doi":"https://doi.org/10.3109/00016489109134991","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00016489109134991","pdf_url":null,"source":{"id":"https://openalex.org/S198335345","display_name":"Acta Oto-Laryngologica","issn_l":"0001-6489","issn":["0001-6489","1651-2251","1651-2553"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Oto-Laryngologica","raw_type":"journal-article"},{"id":"pmid:1842862","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1842862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta oto-laryngologica. Supplementum","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W59671262","https://openalex.org/W1803983316","https://openalex.org/W1972788846","https://openalex.org/W1974616409","https://openalex.org/W1981801190","https://openalex.org/W2012586057","https://openalex.org/W2023275441","https://openalex.org/W2027815873","https://openalex.org/W2029032776","https://openalex.org/W2073171529","https://openalex.org/W2144161140","https://openalex.org/W2148940403","https://openalex.org/W2162145038","https://openalex.org/W2323250280","https://openalex.org/W2328303626","https://openalex.org/W2396179536","https://openalex.org/W2412576454","https://openalex.org/W2416975444"],"related_works":["https://openalex.org/W2312269568","https://openalex.org/W2314839222","https://openalex.org/W2044026297","https://openalex.org/W2060073926","https://openalex.org/W2079614238","https://openalex.org/W1986038852","https://openalex.org/W2130198156","https://openalex.org/W2023275441","https://openalex.org/W3088873244","https://openalex.org/W7095532905"],"abstract_inverted_index":{"There":[0],"is":[1,11],"much":[2],"epidemiologic,":[3],"clinical":[4],"and":[5,50,121,175,184,236,239,271,277,280,301,330],"laboratory":[6],"evidence":[7],"that":[8,194,214,229,320],"viral":[9,307,321,337],"infection":[10,308,322,338],"involved":[12],"in":[13,145,155,171,255,344],"otitis":[14],"media":[15],"with":[16,69,75,106,149,259,314],"effusion":[17],"(OME).":[18],"However,":[19,198,305],"few":[20],"studies":[21],"have":[22],"demonstrated":[23],"any":[24,161],"direct":[25],"influence":[26],"of":[27,34,42,64,79,101,109,130,195,201,215,222,230,250,274,285,298,327,352],"viruses":[28],"on":[29],"the":[30,40,48,53,62,87,91,98,114,131,146,150,156,165,168,172,176,188,196,199,216,223,231,242,256,260,291,306,311,328,345,350],"tubotympanum.":[31],"The":[32,152,218],"purpose":[33],"this":[35,58],"study":[36,318],"was":[37,158,179,190,210,225],"to":[38,61,241,334,349],"establish":[39],"effect":[41],"influenza":[43,80],"A":[44,81,248],"virus":[45,59],"having":[46],"invaded":[47],"tubotympanum":[49,224,257,329],"so":[51],"elucidate":[52],"possible":[54],"mechanism":[55],"by":[56],"which":[57,293],"contributes":[60],"pathogenesis":[63],"OME.":[65,353],"Eighty":[66],"guinea":[67,102],"pigs":[68,103],"normal":[70],"otoscopic":[71],"findings":[72],"were":[73,104,126,142,253],"inoculated":[74,148],"0.2":[76,107],"ml":[77,108],"suspension":[78],"(3.3":[82],"x":[83],"10(8)":[84],"PFU/ml)":[85],"into":[86,113],"tympanic":[88,92,115,177],"cavity":[89],"through":[90],"membrane.":[93],"To":[94],"serve":[95],"as":[96,137,139],"controls,":[97],"same":[99],"number":[100,200,297],"injected":[105],"physiologic":[110],"saline":[111],"solution":[112],"cavity.":[116],"At":[117],"3,":[118,234],"7,":[119,235],"14,":[120],"28":[122,246],"days":[123],"postinoculation,":[124],"they":[125],"used":[127],"for":[128],"examination":[129],"mucociliary":[132,140,219,325],"function.":[133],"Middle":[134],"ear":[135],"effusions":[136],"well":[138],"dysfunction":[141,326],"observed":[143,254,264],"only":[144],"animals":[147],"virus.":[151,261],"ciliary":[153,169],"activity":[154,170],"bulla":[157],"declined":[159],"at":[160,233,245],"time":[162,221],"examined.":[163],"On":[164],"other":[166,272],"hand,":[167],"Eustachian":[173],"tube":[174],"orifice":[178],"slightly":[180],"lowered":[181],"between":[182],"7":[183],"14":[185,237],"days,":[186,238],"but":[187],"level":[189,244],"not":[191],"different":[192],"from":[193],"controls.":[197,217],"active":[202],"ciliated":[203,275,288],"cells":[204,289,300,313],"(showing":[205],"more":[206,226],"than":[207,213,228],"500":[208],"beats/min)":[209],"significantly":[211],"smaller":[212],"clearance":[220],"prolonged":[227],"controls":[232],"returned":[240],"control":[243],"days.":[247],"variety":[249],"morphological":[251],"changes":[252],"treated":[258],"Major":[262],"pathologies":[263],"included":[265,294],"general":[266],"inflammatory":[267],"cell":[268],"infiltration,":[269],"vacuolation":[270],"degeneration":[273],"cells,":[276],"vascular":[278,282],"damage":[279],"increased":[281,296,332],"permeability.":[283],"Regeneration":[284],"cilia":[286],"or":[287],"followed":[290],"degeneration,":[292],"an":[295],"basal":[299],"newly":[302],"formed":[303],"centrioles.":[304,316],"also":[309],"affected":[310],"epithelial":[312],"new":[315],"Our":[317],"demonstrates":[319],"can":[323],"evoke":[324],"create":[331],"susceptibility":[333],"bacteria.":[335],"Therefore,":[336],"may":[339],"enhance":[340],"bacterial":[341],"infectious":[342],"processes":[343],"tubotympanu":[346],"thereby":[347],"contributing":[348],"occurrence":[351]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
