{"id":"https://openalex.org/W2004351167","doi":"https://doi.org/10.1002/art.10445","title":"Diminished peripheral blood memory B cells and accumulation of memory B cells in the salivary glands of patients with Sj\u00f6gren's syndrome","display_name":"Diminished peripheral blood memory B cells and accumulation of memory B cells in the salivary glands of patients with Sj\u00f6gren's syndrome","publication_year":2002,"publication_date":"2002-08-01","ids":{"openalex":"https://openalex.org/W2004351167","doi":"https://doi.org/10.1002/art.10445","mag":"2004351167","pmid":"https://pubmed.ncbi.nlm.nih.gov/12209521"},"language":"en","primary_location":{"id":"doi:10.1002/art.10445","doi":"https://doi.org/10.1002/art.10445","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.10445","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis & Rheumatism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Arne Hansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Arne Hansen","raw_affiliation_strings":["University Hospital Charit\u00e9, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Charit\u00e9, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083419667","display_name":"Marcus Odendahl","orcid":"https://orcid.org/0000-0002-5821-6328","observed_orcids":["https://orcid.org/0000-0002-5821-6328"]},"institutions":[{"id":"https://openalex.org/I4210095248","display_name":"German Rheumatism Research Centre","ror":"https://ror.org/00shv0x82","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210095248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marcus Odendahl","raw_affiliation_strings":["Deutsches Rheumaforschungszentrum Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deutsches Rheumaforschungszentrum Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I4210095248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040910192","display_name":"Karin Reiter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karin Reiter","raw_affiliation_strings":["University Hospital Charit\u00e9, Berlin Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Charit\u00e9, Berlin Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110172931","display_name":"Annett M. Jacobi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Annett M. Jacobi","raw_affiliation_strings":["University Hospital Charit\u00e9, Berlin Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Charit\u00e9, Berlin Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043776691","display_name":"Eugen Feist","orcid":"https://orcid.org/0000-0002-9872-5282","observed_orcids":["https://orcid.org/0000-0002-9872-5282"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eugen Feist","raw_affiliation_strings":["University Hospital Charit\u00e9, Berlin Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Charit\u00e9, Berlin Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012010207","display_name":"J\u00fcrgen Scholze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Scholze","raw_affiliation_strings":["University Hospital Charit\u00e9, Berlin Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Charit\u00e9, Berlin Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076851275","display_name":"Gerd R\u00fcdiger Burmester","orcid":"https://orcid.org/0000-0001-7518-1131","observed_orcids":["https://orcid.org/0000-0001-7518-1131"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerd R. Burmester","raw_affiliation_strings":["University Hospital Charit\u00e9, Berlin Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Charit\u00e9, Berlin Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043874873","display_name":"Peter E. Lipsky","orcid":"https://orcid.org/0000-0002-9287-1676","observed_orcids":["https://orcid.org/0000-0002-9287-1676"]},"institutions":[{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter E. Lipsky","raw_affiliation_strings":["National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH Bethesda  Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH Bethesda  Maryland","institution_ids":["https://openalex.org/I4210087962"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086942556","display_name":"Thomas D\u00f6rner","orcid":"https://orcid.org/0000-0002-6478-7725","observed_orcids":["https://orcid.org/0000-0002-6478-7725"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas D\u00f6rner","raw_affiliation_strings":["University Hospital Charit\u00e9, Berlin Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Charit\u00e9, Berlin Germany","institution_ids":["https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.5736,"has_fulltext":false,"cited_by_count":270,"citation_normalized_percentile":{"value":0.98463249,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"46","issue":"8","first_page":"2160","last_page":"2171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-sjogren-syndrome","display_name":"primary Sj\u00f6gren's syndrome","score":0.9649999737739563},{"id":"https://openalex.org/keywords/memory-b-cells","display_name":"memory B cells","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cd27","display_name":"CD27","score":0.8339999914169312},{"id":"https://openalex.org/keywords/b-cell-subsets","display_name":"B cell subsets","score":0.718999981880188},{"id":"https://openalex.org/keywords/parotid-gland","display_name":"parotid gland","score":0.8240000009536743},{"id":"https://openalex.org/keywords/salivary-glands","display_name":"salivary glands","score":0.902999997138977},{"id":"https://openalex.org/keywords/immunoglobulin-gene-mutation","display_name":"immunoglobulin gene mutation","score":0.6439999938011169},{"id":"https://openalex.org/keywords/plasmablasts","display_name":"plasmablasts","score":0.8539999723434448},{"id":"https://openalex.org/keywords/secondary-lymphoma","display_name":"secondary lymphoma","score":0.8740000128746033},{"id":"https://openalex.org/keywords/naive-b-cells","display_name":"naive B cells","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C48010095","wikidata":"https://www.wikidata.org/wiki/Q79447","display_name":"Immunoglobulin D","level":4,"score":0.7174099683761597},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.639660656452179},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5594644546508789},{"id":"https://openalex.org/C113067387","wikidata":"https://www.wikidata.org/wiki/Q14912836","display_name":"CD5","level":3,"score":0.5134204626083374},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.48219218850135803},{"id":"https://openalex.org/C200180986","wikidata":"https://www.wikidata.org/wiki/Q3269473","display_name":"Naive B cell","level":5,"score":0.47834512591362},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4557863771915436},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4489268660545349},{"id":"https://openalex.org/C2779359726","wikidata":"https://www.wikidata.org/wiki/Q1195394","display_name":"Memory B cell","level":4,"score":0.4472827613353729},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42756664752960205},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.42752695083618164},{"id":"https://openalex.org/C2778630268","wikidata":"https://www.wikidata.org/wiki/Q17113277","display_name":"Cell sorting","level":3,"score":0.41661956906318665},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.415372371673584},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35834407806396484},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28356802463531494},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.26829391717910767},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.22633963823318481},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2252902388572693},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.11475884914398193}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007072","descriptor_name":"Immunoglobulin D","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010306","descriptor_name":"Parotid Gland","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010306","descriptor_name":"Parotid Gland","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012859","descriptor_name":"Sjogren's Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012859","descriptor_name":"Sjogren's Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D012859","descriptor_name":"Sjogren's Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015326","descriptor_name":"Gene Rearrangement, B-Lymphocyte, Heavy Chain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016175","descriptor_name":"B-Lymphocyte Subsets","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018127","descriptor_name":"Tumor Necrosis Factor Receptor Superfamily, Member 7","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018956","descriptor_name":"CD5 Antigens","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/art.10445","doi":"https://doi.org/10.1002/art.10445","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.10445","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis & Rheumatism","raw_type":"journal-article"},{"id":"pmid:12209521","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12209521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis and rheumatism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W5248081","https://openalex.org/W61866898","https://openalex.org/W303895199","https://openalex.org/W1525531086","https://openalex.org/W1588486949","https://openalex.org/W1598042555","https://openalex.org/W1604843352","https://openalex.org/W1642392901","https://openalex.org/W1673227951","https://openalex.org/W1919334117","https://openalex.org/W1930962503","https://openalex.org/W1965443232","https://openalex.org/W1967131603","https://openalex.org/W1969952390","https://openalex.org/W1979824536","https://openalex.org/W1987024404","https://openalex.org/W1987200092","https://openalex.org/W1994805954","https://openalex.org/W1995882260","https://openalex.org/W2002011103","https://openalex.org/W2002598093","https://openalex.org/W2004911925","https://openalex.org/W2005945803","https://openalex.org/W2026075310","https://openalex.org/W2035975585","https://openalex.org/W2036452905","https://openalex.org/W2036930370","https://openalex.org/W2043629172","https://openalex.org/W2044070430","https://openalex.org/W2047494163","https://openalex.org/W2050587051","https://openalex.org/W2051703818","https://openalex.org/W2054686030","https://openalex.org/W2058262705","https://openalex.org/W2058330988","https://openalex.org/W2062501706","https://openalex.org/W2064531916","https://openalex.org/W2066528142","https://openalex.org/W2077679863","https://openalex.org/W2079653398","https://openalex.org/W2080894267","https://openalex.org/W2081287287","https://openalex.org/W2081579806","https://openalex.org/W2086703018","https://openalex.org/W2099868898","https://openalex.org/W2105331461","https://openalex.org/W2106840540","https://openalex.org/W2110297391","https://openalex.org/W2112084656","https://openalex.org/W2163266260","https://openalex.org/W2169957589","https://openalex.org/W2170620478","https://openalex.org/W2183605822","https://openalex.org/W2315168692","https://openalex.org/W2338264038","https://openalex.org/W2407994371","https://openalex.org/W2411528948","https://openalex.org/W4251633039"],"related_works":["https://openalex.org/W2002521110","https://openalex.org/W2086923213","https://openalex.org/W2033139060","https://openalex.org/W2053838509","https://openalex.org/W2981411550","https://openalex.org/W2084571469","https://openalex.org/W1703840689","https://openalex.org/W4390964901","https://openalex.org/W1480499212","https://openalex.org/W2302883411"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"delineate":[2],"the":[3,6,52,67,129,132,144,154,174,184,200,219,227],"mechanism":[4],"of":[5,23,69,85,134,149,157,195,204,213],"abnormalities":[7],"in":[8,13,28,46,66,77,100,124,163,168,199,218,226],"B":[9,25,48,73,88,103,136,151,165,171,197,216],"cell":[10,26,60],"biology":[11],"found":[12,76],"patients":[14,30,92],"with":[15,31,93],"primary":[16,32],"Sj\u00f6gren's":[17],"syndrome":[18],"(SS).":[19],"METHODS:":[20],"The":[21],"distribution":[22],"peripheral":[24,53,70,102,130,169,228],"subpopulations":[27],"21":[29],"SS":[33,78,91,205],"was":[34,75],"analyzed":[35,45],"by":[36,58],"immunofluorescence":[37],"labeling":[38],"and":[39,55,121,147],"flow":[40],"cytometry.":[41],"Immunoglobulin":[42],"rearrangements":[43,114,159],"were":[44,160],"single":[47],"cells":[49,74,123,137,166,198,217],"isolated":[50],"from":[51,138],"blood":[54,170],"parotid":[56,135,164,221],"glands":[57,203],"fluorescence-activated":[59],"sorting.":[61],"RESULTS:":[62],"A":[63],"significant":[64],"reduction":[65,225],"number":[68,84],"CD27+":[71,214],"memory":[72,87,122,150,196,215],"patients,":[79],"including":[80,105],"a":[81],"significantly":[82,161],"reduced":[83],"CD27+/IgD+/IgM+/CD5+":[86],"cells.":[89,152],"Remarkably,":[90],"secondary":[94],"lymphoma":[95],"uniquely":[96],"exhibited":[97,142],"an":[98,193],"increase":[99],"CD27-expressing":[101],"cells,":[104,172],"CD27(high)":[106],"plasmablasts.":[107],"Molecular":[108],"analysis":[109],"for":[110],"mutated":[111],"Ig":[112],"gene":[113,176],"confirmed":[115],"that":[116,190,210],"CD27":[117],"expression":[118],"distinguished":[119],"naive":[120],"SS.":[125],"In":[126],"contrast":[127],"to":[128,179],"blood,":[131],"majority":[133],"1":[139],"patient":[140],"examined":[141],"both":[143],"mutational":[145,155],"status":[146],"phenotype":[148],"Accordingly,":[153],"frequencies":[156],"V(H)":[158,175],"greater":[162],"than":[167],"whereas":[173],"repertoire":[177],"appeared":[178],"be":[180],"very":[181],"similar":[182],"between":[183],"compartments.":[185],"CONCLUSION:":[186],"These":[187],"data":[188],"indicate":[189],"there":[191],"is":[192,208],"accumulation/retention":[194],"inflamed":[201,220],"salivary":[202],"patients.":[206],"It":[207],"possible":[209],"preferential":[211],"accumulation":[212],"gland":[222],"explains":[223],"their":[224],"blood.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":14}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}