{"id":"https://openalex.org/W2004351126","doi":"https://doi.org/10.1115/imece2004-62111","title":"Design of a Microfabricated Device for the Ligase Detection Reaction (LDR)","display_name":"Design of a Microfabricated Device for the Ligase Detection Reaction (LDR)","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2004351126","doi":"https://doi.org/10.1115/imece2004-62111","mag":"2004351126"},"language":"en","primary_location":{"id":"doi:10.1115/imece2004-62111","doi":"https://doi.org/10.1115/imece2004-62111","is_oa":false,"landing_page_url":"https://doi.org/10.1115/imece2004-62111","pdf_url":null,"source":{"id":"https://openalex.org/S4363606942","display_name":"ASME International Mechanical Engineering Congress and Exposition (IMECE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microelectromechanical Systems","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037647770","display_name":"Dwhyte O. Barrett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dwhyte O. Barrett","raw_affiliation_strings":["Louisiana State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009104089","display_name":"Amit Maha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amit Maha","raw_affiliation_strings":["Louisiana State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100377604","display_name":"Yun Wang","orcid":"https://orcid.org/0000-0001-8619-0455","observed_orcids":["https://orcid.org/0000-0001-8619-0455"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yun Wang","raw_affiliation_strings":["Louisiana State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038208939","display_name":"Steven A. Soper","orcid":"https://orcid.org/0000-0002-8292-7058","observed_orcids":["https://orcid.org/0000-0002-8292-7058"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven A. Soper","raw_affiliation_strings":["Louisiana State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114009501","display_name":"Dimitris E. Nikitopoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dimitris E. Nikitopoulos","raw_affiliation_strings":["Louisiana State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087283200","display_name":"Michael C. Murphy","orcid":"https://orcid.org/0000-0003-1108-3238","observed_orcids":["https://orcid.org/0000-0003-1108-3238"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael C. Murphy","raw_affiliation_strings":["Louisiana State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University","institution_ids":["https://openalex.org/I121820613"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I121820613"],"apc_list":null,"apc_paid":null,"fwci":1.1875,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.77552184,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"311","last_page":"319"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ligase-detection-reaction","display_name":"ligase detection reaction","score":0.9169999957084656},{"id":"https://openalex.org/keywords/point-mutation-detection","display_name":"point mutation detection","score":0.8180000185966492},{"id":"https://openalex.org/keywords/dna-mutation-detection","display_name":"DNA mutation detection","score":0.5929999947547913},{"id":"https://openalex.org/keywords/microfluidic-device-design","display_name":"microfluidic device design","score":0.6579999923706055},{"id":"https://openalex.org/keywords/liga","display_name":"LIGA","score":0.8029999732971191},{"id":"https://openalex.org/keywords/laser-ablation","display_name":"laser ablation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/micro-milling","display_name":"micro-milling","score":0.9919999837875366},{"id":"https://openalex.org/keywords/thermal-cycling","display_name":"thermal cycling","score":0.734000027179718},{"id":"https://openalex.org/keywords/finite-element-thermal-modeling","display_name":"finite element thermal analysis","score":0.5740000009536743},{"id":"https://openalex.org/keywords/thin-film-heaters","display_name":"thin film heaters","score":0.6010000109672546},{"id":"https://openalex.org/keywords/thermoelectric-modules","display_name":"thermoelectric modules","score":0.8949999809265137},{"id":"https://openalex.org/keywords/pid-temperature-control","display_name":"PID temperature control","score":0.8149999976158142},{"id":"https://openalex.org/keywords/residence-time","display_name":"residence time","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C145695476","wikidata":"https://www.wikidata.org/wiki/Q1638483","display_name":"LIGA","level":4,"score":0.8309327960014343},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6605749130249023},{"id":"https://openalex.org/C536315585","wikidata":"https://www.wikidata.org/wiki/Q7698332","display_name":"Temperature control","level":2,"score":0.5757864713668823},{"id":"https://openalex.org/C136525101","wikidata":"https://www.wikidata.org/wiki/Q5428139","display_name":"Fabrication","level":3,"score":0.5574745535850525},{"id":"https://openalex.org/C63662833","wikidata":"https://www.wikidata.org/wiki/Q6839341","display_name":"Microchannel","level":2,"score":0.5126087069511414},{"id":"https://openalex.org/C2780982322","wikidata":"https://www.wikidata.org/wiki/Q3312230","display_name":"Micromixer","level":3,"score":0.5035962462425232},{"id":"https://openalex.org/C128458982","wikidata":"https://www.wikidata.org/wiki/Q18891486","display_name":"Thermoelectric cooling","level":3,"score":0.46784529089927673},{"id":"https://openalex.org/C138777275","wikidata":"https://www.wikidata.org/wiki/Q6884054","display_name":"Mixing (physics)","level":2,"score":0.4586619734764099},{"id":"https://openalex.org/C179428855","wikidata":"https://www.wikidata.org/wiki/Q1069216","display_name":"Microscale chemistry","level":2,"score":0.4182603657245636},{"id":"https://openalex.org/C177564732","wikidata":"https://www.wikidata.org/wiki/Q7698333","display_name":"Temperature cycling","level":3,"score":0.41144153475761414},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.38047972321510315},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.354521244764328},{"id":"https://openalex.org/C204530211","wikidata":"https://www.wikidata.org/wiki/Q752823","display_name":"Thermal","level":2,"score":0.31437957286834717},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2326819896697998},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.229977548122406},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.18271657824516296},{"id":"https://openalex.org/C63024428","wikidata":"https://www.wikidata.org/wiki/Q552456","display_name":"Thermoelectric effect","level":2,"score":0.1815829873085022},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1481304168701172},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.12840992212295532},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C145420912","wikidata":"https://www.wikidata.org/wiki/Q853077","display_name":"Mathematics education","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1115/imece2004-62111","doi":"https://doi.org/10.1115/imece2004-62111","is_oa":false,"landing_page_url":"https://doi.org/10.1115/imece2004-62111","pdf_url":null,"source":{"id":"https://openalex.org/S4363606942","display_name":"ASME International Mechanical Engineering Congress and Exposition (IMECE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microelectromechanical Systems","raw_type":"proceedings-article"},{"id":"pmh:oai:repository.lsu.edu:mechanical_engineering_pubs-2833","doi":null,"is_oa":false,"landing_page_url":"https://repository.lsu.edu/mechanical_engineering_pubs/1833","pdf_url":null,"source":{"id":"https://openalex.org/S4210169993","display_name":"Civil War Book Review","issn_l":"1528-6592","issn":["1528-6592"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315936","host_organization_name":"Louisiana State University","host_organization_lineage":["https://openalex.org/P4310315936"],"host_organization_lineage_names":["Louisiana State University"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4283025951","https://openalex.org/W2079062592","https://openalex.org/W2801264676","https://openalex.org/W2110517222","https://openalex.org/W2155931474","https://openalex.org/W1964943245","https://openalex.org/W2763138759","https://openalex.org/W2057835337","https://openalex.org/W2007592621","https://openalex.org/W4253606363"],"abstract_inverted_index":{"The":[0,74,107,232],"Ligase":[1,21],"Detection":[2,22],"Reaction":[3,23],"(LDR)":[4,24],"is":[5,147],"a":[6,119,199,205],"mutation":[7],"detection":[8],"technique":[9],"used":[10,135,203],"to":[11,72,86,208,217,226,241],"identify":[12],"point":[13],"mutations":[14],"in":[15,30,40,49,139,155,243],"deoxyribonucleic":[16],"acid":[17],"(DNA).":[18],"A":[19,130,181,193],"microscale":[20],"device":[25,183],"was":[26,92,96,103,134,184],"designed":[27],"and":[28,54,84,111,126,161,177,187,198,248],"manufactured":[29],"polycarbonate.":[31],"There":[32],"are":[33,112,251],"at":[34,235],"least":[35],"two":[36],"mixing":[37,179],"stages":[38],"involved":[39],"the":[41,100,104,141,145,156,168,173,178,190,210,236,244],"LDR":[42,245],"identification":[43],"process.":[44,106],"Various":[45],"micromixers":[46,64,108],"were":[47,58,65,76,109,128,202],"simulated":[48],"Fluent":[50],"(v5.4,":[51],"Lebanon,":[52],"NH)":[53],"several":[55],"test":[56,182],"geometries":[57],"selected":[59],"for":[60,98],"fabrication.":[61],"Passive":[62],"diffusional":[63],"made":[66,77],"with":[67,136,189,204],"aspect":[68],"ratios":[69],"from":[70,172,215,224],"7":[71],"20.":[73],"mixers":[75],"by":[78],"SU-8":[79],"lithography,":[80],"LIGA,":[81],"laser":[82],"ablation":[83],"micromilling":[85],"characterize":[87],"each":[88],"fabrication":[89],"method.":[90],"It":[91],"found":[93],"that":[94,162],"LIGA":[95],"best":[97],"making":[99],"micromixers,":[101],"but":[102],"longest":[105],"fabricated":[110],"being":[113],"tested":[114],"using":[115],"fluorescent":[116],"dyes.":[117],"For":[118],"successful":[120],"reaction":[121],"temperatures":[122,154,238],"of":[123],"0\u00b0C,":[124],"95\u00b0C":[125,218,225],"65\u00b0C":[127,216,227],"needed.":[129],"stationary":[131],"chamber":[132],"method":[133],"thermal":[137,169],"cycling":[138],"which":[140],"sample":[142],"held":[143],"while":[144,222],"temperature":[146,191],"cycled.":[148],"Finite":[149],"element":[150],"analysis":[151],"showed":[152],"uniform":[153],"rectangular":[157],"1.5":[158],"\u03bcl":[159],"chambers":[160],"air":[163],"slits":[164],"can":[165,239],"effectively":[166],"separate":[167],"cycle":[170],"zone":[171,176],"0\u00b0C":[174],"cooling":[175,223],"region.":[180],"laid":[185],"out":[186],"micromilled":[188],"zones.":[192],"commercial":[194],"thin":[195],"film":[196],"heater":[197],"thermoelectric":[200],"module":[201],"PID":[206],"controller":[207],"obtain":[209],"required":[211,237],"process":[212],"temperatures.":[213],"Heating":[214],"took":[219,229],"10":[220,230],"seconds,":[221],"also":[228],"seconds.":[231],"residence":[233],"times":[234],"adapt":[240],"changes":[242],"as":[246],"parameters":[247],"reactant":[249],"concentrations":[250],"varied.":[252]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
