{"id":"https://openalex.org/W2004336249","doi":"https://doi.org/10.1254/jphs.14017fp","title":"Ursolic Acid Induces Apoptosis Through Mitochondrial Intrinsic Pathway and Suppression of ERK1/2 MAPK in HeLa Cells","display_name":"Ursolic Acid Induces Apoptosis Through Mitochondrial Intrinsic Pathway and Suppression of ERK1/2 MAPK in HeLa Cells","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2004336249","doi":"https://doi.org/10.1254/jphs.14017fp","mag":"2004336249","pmid":"https://pubmed.ncbi.nlm.nih.gov/24881958"},"language":"en","primary_location":{"id":"doi:10.1254/jphs.14017fp","doi":"https://doi.org/10.1254/jphs.14017fp","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jphs.14017fp","pdf_url":"https://www.jstage.jst.go.jp/article/jphs/125/2/125_14017FP/_pdf","source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/jphs/125/2/125_14017FP/_pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yanhong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102208913","display_name":"Shihezi University","ror":"https://ror.org/04x0kvm78","country_code":"CN","type":"education","lineage":["https://openalex.org/I102208913"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanhong Li","raw_affiliation_strings":["Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, China","College of Animal Science and Technology, Shihezi University, China","Department of Physical Education, Xinjian Education Institute, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]},{"raw_affiliation_string":"College of Animal Science and Technology, Shihezi University, China","institution_ids":["https://openalex.org/I102208913"]},{"raw_affiliation_string":"Department of Physical Education, Xinjian Education Institute, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101430690","display_name":"Xueying Lu","orcid":"https://orcid.org/0000-0001-6850-4676","observed_orcids":["https://orcid.org/0000-0001-6850-4676"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueying Lu","raw_affiliation_strings":["Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037031711","display_name":"Hongxue Qi","orcid":"https://orcid.org/0000-0002-0728-4312","observed_orcids":["https://orcid.org/0000-0002-0728-4312","https://orcid.org/0000-0002-9028-2624"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongxue Qi","raw_affiliation_strings":["Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaobo Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaobo Li","raw_affiliation_strings":["Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087647138","display_name":"Xiangwen Xiao","orcid":"https://orcid.org/0000-0002-5621-816X","observed_orcids":["https://orcid.org/0000-0002-5621-816X"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangwen Xiao","raw_affiliation_strings":["Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}]},{"author_position":"last","author":{"id":null,"display_name":"Jianfeng Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102208913","display_name":"Shihezi University","ror":"https://ror.org/04x0kvm78","country_code":"CN","type":"education","lineage":["https://openalex.org/I102208913"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianfeng Gao","raw_affiliation_strings":["College of Animal Science and Technology, Shihezi University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology, Shihezi University, China","institution_ids":["https://openalex.org/I102208913"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2070,"currency":"USD","value_usd":2070},"apc_paid":null,"fwci":2.9403,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.9080198,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"125","issue":"2","first_page":"202","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.093299999833107,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ursolic-acid","display_name":"ursolic acid","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/mitochondrial-pathway","display_name":"mitochondrial pathway","score":0.9480000138282776},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8939999938011169},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9509999752044678},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cytochrome-c-release","display_name":"cytochrome c release","score":0.9200000166893005},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.871999979019165},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9869999885559082},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.8870000243186951},{"id":"https://openalex.org/keywords/pentacyclic-triterpenoids","display_name":"pentacyclic triterpenes","score":0.8899999856948853}],"concepts":[{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.8198196887969971},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7812776565551758},{"id":"https://openalex.org/C2779513101","wikidata":"https://www.wikidata.org/wiki/Q416260","display_name":"Ursolic acid","level":2,"score":0.7584947347640991},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.7447419166564941},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.7078574895858765},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6361101269721985},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6286523342132568},{"id":"https://openalex.org/C181912034","wikidata":"https://www.wikidata.org/wiki/Q1101143","display_name":"Dephosphorylation","level":4,"score":0.621569812297821},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.539023756980896},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.5254729986190796},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5167376399040222},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.50654137134552},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.4960883557796478},{"id":"https://openalex.org/C163421366","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Intrinsic apoptosis","level":5,"score":0.4579031467437744},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4448796510696411},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.423922598361969},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3403248190879822},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2771914601325989},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.19440874457359314},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.1519114077091217},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.08399757742881775},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0741640031337738},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000097245","descriptor_name":"Ursolic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D045304","descriptor_name":"Cytochromes c","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050998","descriptor_name":"bcl-2 Homologous Antagonist-Killer Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053453","descriptor_name":"Caspase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054637","descriptor_name":"Dual-Specificity Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1254/jphs.14017fp","doi":"https://doi.org/10.1254/jphs.14017fp","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jphs.14017fp","pdf_url":"https://www.jstage.jst.go.jp/article/jphs/125/2/125_14017FP/_pdf","source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},{"id":"pmid:24881958","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24881958","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmacological sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:216fb13369304664b5fd415814e3cec7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/216fb13369304664b5fd415814e3cec7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Pharmacological Sciences, Vol 125, Iss 2, Pp 202-210 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1254/jphs.14017fp","doi":"https://doi.org/10.1254/jphs.14017fp","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jphs.14017fp","pdf_url":"https://www.jstage.jst.go.jp/article/jphs/125/2/125_14017FP/_pdf","source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320328898","display_name":"Natural Science Foundation of Xinjiang","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004336249.pdf","grobid_xml":"https://content.openalex.org/works/W2004336249.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1966329249","https://openalex.org/W1969150166","https://openalex.org/W1971287536","https://openalex.org/W1971925780","https://openalex.org/W1990065094","https://openalex.org/W1992361007","https://openalex.org/W1996323392","https://openalex.org/W1996405087","https://openalex.org/W2006676149","https://openalex.org/W2007555056","https://openalex.org/W2008574867","https://openalex.org/W2008701700","https://openalex.org/W2013552453","https://openalex.org/W2019093886","https://openalex.org/W2031495829","https://openalex.org/W2037826267","https://openalex.org/W2038433050","https://openalex.org/W2056031476","https://openalex.org/W2056126636","https://openalex.org/W2060630008","https://openalex.org/W2068405904","https://openalex.org/W2069920032","https://openalex.org/W2074967040","https://openalex.org/W2085419794","https://openalex.org/W2089506765","https://openalex.org/W2095162782","https://openalex.org/W2095821804","https://openalex.org/W2101326169","https://openalex.org/W2106787323","https://openalex.org/W2107495112","https://openalex.org/W2111305451","https://openalex.org/W2127535407","https://openalex.org/W2127868048","https://openalex.org/W2137655819","https://openalex.org/W2140416475","https://openalex.org/W2144169031","https://openalex.org/W2145340234","https://openalex.org/W2148712853","https://openalex.org/W2165721689","https://openalex.org/W2324138891","https://openalex.org/W2396509159"],"related_works":["https://openalex.org/W2885664423","https://openalex.org/W2359386156","https://openalex.org/W2336071846","https://openalex.org/W2025237652","https://openalex.org/W2069920032","https://openalex.org/W2045795884","https://openalex.org/W2155494329","https://openalex.org/W2091085622","https://openalex.org/W1992185123","https://openalex.org/W2348128262"],"abstract_inverted_index":{"Ursolic":[0],"acid":[1],"(UA),":[2],"a":[3,161],"natural":[4],"pentacyclic":[5],"triterpenoid":[6],"compound,":[7],"has":[8],"been":[9],"demonstrated":[10],"to":[11,24],"induce":[12],"apoptosis":[13,31,41],"in":[14,32,47,182],"various":[15],"tumors.":[16],"The":[17,88],"aim":[18],"of":[19,29,54,59,64,70,78,84,90,115,122,166,168,179,197],"the":[20,26,43,76,98,110,113,120,131,135,164,176,187,195,198],"present":[21],"study":[22],"was":[23,86,185],"elucidate":[25],"molecular":[27],"mechanisms":[28],"UA-induced":[30,109],"HeLa":[33,48,183],"cells.":[34],"Here,":[35],"we":[36],"reported":[37],"that":[38,175],"UA":[39,74,144,180],"induced":[40],"through":[42,186],"mitochondrial":[44,188],"intrinsic":[45,189],"pathway":[46,138,190],"cells,":[49],"as":[50],"shown":[51],"by":[52],"release":[53],"cytosol":[55,116],"cytochrome":[56,117],"c,":[57,118],"activation":[58],"caspase-9":[60],"and":[61,66,68,72,80,92,102,119,154,170,191],"-3,":[62],"reduction":[63],"Bcl-2":[65],"Bcl-xL,":[67],"increase":[69,114],"Bax":[71],"Bak.":[73],"down-regulated":[75],"phosphorylation":[77,83],"ERK1/2":[79,91,99,136,169,199],"p38,":[81],"whereas":[82],"JNK":[85],"unchanged.":[87],"roles":[89],"p38":[93,103],"were":[94],"further":[95],"confirmed":[96],"using":[97],"inhibitor":[100,104],"(U0126)":[101],"(SB203580).":[105],"U0126":[106],"markedly":[107],"increased":[108],"Bax/Bcl-2":[111],"ratio,":[112],"levels":[121],"cleaved":[123],"caspase-3,":[124],"but":[125],"SB203580":[126],"had":[127],"little":[128],"effects":[129],"on":[130],"above":[132],"characters,":[133],"suggesting":[134],"signaling":[137,200],"is":[139],"required":[140],"for":[141,163],"apoptosis.":[142],"Furthermore,":[143],"up-regulated":[145],"DUSP":[146],"1,":[147],"2,":[148],"4,":[149],"5,":[150],"6,":[151],"7,":[152],"9,":[153],"10":[155],"mRNA":[156],"expressions,":[157],"which":[158],"may":[159],"be":[160],"clue":[162],"role":[165],"dephosphorylation":[167],"p38.":[171],"These":[172],"data":[173],"suggested":[174],"apoptotic":[177],"mechanism":[178],"treatment":[181],"cells":[184],"closely":[192],"associated":[193],"with":[194],"suppression":[196],"pathway.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
