{"id":"https://openalex.org/W2004336126","doi":"https://doi.org/10.1182/blood-2007-08-106229","title":"Determination of surface tissue factor thresholds that trigger coagulation at venous and arterial shear rates: amplification of 100 fM circulating tissue factor requires flow","display_name":"Determination of surface tissue factor thresholds that trigger coagulation at venous and arterial shear rates: amplification of 100 fM circulating tissue factor requires flow","publication_year":2008,"publication_date":"2008-01-19","ids":{"openalex":"https://openalex.org/W2004336126","doi":"https://doi.org/10.1182/blood-2007-08-106229","mag":"2004336126","pmid":"https://pubmed.ncbi.nlm.nih.gov/18203955","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3321613"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2007-08-106229","doi":"https://doi.org/10.1182/blood-2007-08-106229","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2007-08-106229","pdf_url":"https://ashpublications.org/blood/article-pdf/111/7/3507/1480917/zh800708003507.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/111/7/3507/1480917/zh800708003507.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024769228","display_name":"Uzoma M. Okorie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uzoma M. Okorie","raw_affiliation_strings":["Institute for Medicine and Engineering, Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medicine and Engineering, Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041025811","display_name":"William S. Denney","orcid":"https://orcid.org/0000-0002-5759-428X","observed_orcids":["https://orcid.org/0000-0002-5759-428X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William S. Denney","raw_affiliation_strings":["Institute for Medicine and Engineering, Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medicine and Engineering, Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078865106","display_name":"Manash Shankar Chatterjee","orcid":"https://orcid.org/0009-0005-2706-1342","observed_orcids":["https://orcid.org/0009-0005-2706-1342"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manash S. Chatterjee","raw_affiliation_strings":["Institute for Medicine and Engineering, Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medicine and Engineering, Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070205215","display_name":"Keith B. Neeves","orcid":"https://orcid.org/0000-0001-7546-4588","observed_orcids":["https://orcid.org/0000-0001-7546-4588"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith B. Neeves","raw_affiliation_strings":["Institute for Medicine and Engineering, Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medicine and Engineering, Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065179734","display_name":"Scott L. Diamond","orcid":"https://orcid.org/0000-0002-9791-2238","observed_orcids":["https://orcid.org/0000-0002-9791-2238"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott L. Diamond","raw_affiliation_strings":["Institute for Medicine and Engineering, Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medicine and Engineering, Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":6.0594,"has_fulltext":true,"cited_by_count":135,"citation_normalized_percentile":{"value":0.96642357,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"111","issue":"7","first_page":"3507","last_page":"3513"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-factor","display_name":"tissue factor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/coagulation-initiation","display_name":"coagulation initiation","score":0.7509999871253967},{"id":"https://openalex.org/keywords/wall-shear-rate","display_name":"wall shear rate","score":0.7670000195503235},{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.36399999260902405},{"id":"https://openalex.org/keywords/fibrin-formation","display_name":"fibrin formation","score":0.7639999985694885},{"id":"https://openalex.org/keywords/corn-trypsin-inhibitor","display_name":"corn trypsin inhibitor","score":0.6859999895095825},{"id":"https://openalex.org/keywords/whole-blood-perfusion","display_name":"whole blood perfusion","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C186738567","wikidata":"https://www.wikidata.org/wiki/Q412841","display_name":"Tissue factor","level":3,"score":0.8958603143692017},{"id":"https://openalex.org/C1621761","wikidata":"https://www.wikidata.org/wiki/Q7997549","display_name":"Whole blood","level":2,"score":0.5998597145080566},{"id":"https://openalex.org/C2777151630","wikidata":"https://www.wikidata.org/wiki/Q14878075","display_name":"Tissue factor pathway inhibitor","level":4,"score":0.599192202091217},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.5844814777374268},{"id":"https://openalex.org/C2781362458","wikidata":"https://www.wikidata.org/wiki/Q1588755","display_name":"Thrombus","level":2,"score":0.5487629771232605},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5141756534576416},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.5088565349578857},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.42397522926330566},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.41703522205352783},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38392549753189087},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3398445248603821},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23237377405166626},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21480593085289001},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19387966394424438},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15401962399482727},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1534857153892517}],"mesh":[{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013925","descriptor_name":"Thromboplastin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013925","descriptor_name":"Thromboplastin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015956","descriptor_name":"Factor XIIa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015956","descriptor_name":"Factor XIIa","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019038","descriptor_name":"Platelet Glycoprotein GPIb-IX Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019038","descriptor_name":"Platelet Glycoprotein GPIb-IX Complex","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D033081","descriptor_name":"Shear Strength","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood-2007-08-106229","doi":"https://doi.org/10.1182/blood-2007-08-106229","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2007-08-106229","pdf_url":"https://ashpublications.org/blood/article-pdf/111/7/3507/1480917/zh800708003507.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3321613","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3321613","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Text"},{"id":"pmid:18203955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18203955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1182/blood-2007-08-106229","doi":"https://doi.org/10.1182/blood-2007-08-106229","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2007-08-106229","pdf_url":"https://ashpublications.org/blood/article-pdf/111/7/3507/1480917/zh800708003507.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","score":0.5099999904632568,"id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2239581877","display_name":"Blood Systems Biology","funder_award_id":"R33HL087317","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4646378578","display_name":null,"funder_award_id":"R33-HL-87317","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4734696945","display_name":"Reaction and Transport Dynamics in Human Blood","funder_award_id":"R01HL056621","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5520316217","display_name":null,"funder_award_id":"NIH-R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G743103442","display_name":null,"funder_award_id":"R01 HL-56621","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004336126.pdf","grobid_xml":"https://content.openalex.org/works/W2004336126.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W132238790","https://openalex.org/W187459506","https://openalex.org/W340085114","https://openalex.org/W1489988243","https://openalex.org/W1507312029","https://openalex.org/W1567801238","https://openalex.org/W1984730857","https://openalex.org/W1995244172","https://openalex.org/W2009172994","https://openalex.org/W2030665169","https://openalex.org/W2043588253","https://openalex.org/W2058161894","https://openalex.org/W2063546834","https://openalex.org/W2072299517","https://openalex.org/W2082332814","https://openalex.org/W2090085273","https://openalex.org/W2099525487","https://openalex.org/W2105667621","https://openalex.org/W2108446523","https://openalex.org/W2119446923","https://openalex.org/W2122433970","https://openalex.org/W2125487451","https://openalex.org/W2128602721","https://openalex.org/W2129464080","https://openalex.org/W2132540981","https://openalex.org/W2138026018","https://openalex.org/W2142649232","https://openalex.org/W2143201729","https://openalex.org/W2152936026","https://openalex.org/W2167677629","https://openalex.org/W2224814775","https://openalex.org/W2263006099","https://openalex.org/W2338072936","https://openalex.org/W4297820806"],"related_works":["https://openalex.org/W2182135611","https://openalex.org/W135528609","https://openalex.org/W2138328550","https://openalex.org/W2106123643","https://openalex.org/W2048693252","https://openalex.org/W1964747373","https://openalex.org/W2439761214","https://openalex.org/W2980937084","https://openalex.org/W2788265160","https://openalex.org/W2087069387"],"abstract_inverted_index":{"Protein":[0],"microarrays":[1,41],"presenting":[2],"spots":[3,85],"of":[4,14,19,47,59,69,84,89,96,118,130,133,154,183],"collagen":[5,77,119],"and":[6,51,62,72,146],"lipidated":[7],"tissue":[8],"factor":[9,36],"(TF)":[10],"allowed":[11],"a":[12,54,93,110,169],"determination":[13],"the":[15,81,87,102,114,128,152,180],"critical":[16,55],"surface":[17,184],"concentration":[18,57],"TF":[20,56,157,185],"required":[21,100,186],"to":[22,104,107,113,158,187],"trigger":[23,188],"coagulation":[24,189],"under":[25,144,164,175,190],"flow.":[26,176,191],"Whole":[27],"blood":[28,137,160],"supplemented":[29],"with":[30,123],"corn":[31],"trypsin":[32],"inhibitor":[33],"(to":[34],"inhibit":[35],"XIIa)":[37],"was":[38,99,142],"perfused":[39],"over":[40],"for":[42,101],"5":[43,150],"minutes.":[44],"Immunofluorescence":[45],"staining":[46],"platelet":[48],"glycoprotein":[49],"GPIbalpha":[50],"fibrin(ogen)":[52],"revealed":[53],"(EC50)":[58],"3.6,":[60],"8.4,":[61],"10.2":[63],"molecules-TF/microm2":[64],"at":[65],"wall":[66],"shear":[67],"rates":[68],"100,":[70],"500,":[71],"1000":[73],"s(-1),":[74],"respectively.":[75],"For":[76],"arrays":[78],"where":[79],"only":[80],"center":[82],"lane":[83],"(in":[86],"direction":[88],"flow)":[90],"contained":[91],"TF,":[92,135],"downstream":[94],"distance":[95],"14":[97],"mm":[98],"thrombus":[103],"widen":[105],"enough":[106],"reach":[108],"across":[109],"300-micrometer":[111],"gap":[112],"adjacent":[115],"TF-free":[116],"lanes":[117],"spots,":[120],"in":[121,172],"agreement":[122],"numerical":[124],"simulation.":[125],"To":[126],"investigate":[127],"effect":[129,163],"low":[131],"levels":[132],"circulating":[134],"whole":[136,159],"(+/-100":[138],"fM":[139,156],"added":[140],"TF)":[141],"tested":[143],"static":[145,165],"flow":[147],"conditions.":[148],"After":[149],"minutes,":[151],"addition":[153],"100":[155],"had":[161],"negligible":[162],"conditions,":[166],"but":[167],"caused":[168],"2.5-fold":[170],"increase":[171],"fibrin":[173],"formation":[174],"This":[177],"report":[178],"defines":[179],"threshold":[181],"concentrations":[182]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":11}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}