{"id":"https://openalex.org/W2004330197","doi":"https://doi.org/10.1158/1538-7445.am2011-5525","title":"Abstract 5525: Profiling counter-regulatory and cytotoxic immune pathways with cellular biomarkers in thyroid cancer patients","display_name":"Abstract 5525: Profiling counter-regulatory and cytotoxic immune pathways with cellular biomarkers in thyroid cancer patients","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2004330197","doi":"https://doi.org/10.1158/1538-7445.am2011-5525","mag":"2004330197"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2011-5525","doi":"https://doi.org/10.1158/1538-7445.am2011-5525","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-5525","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Mohammad S. Hossain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad S. Hossain","raw_affiliation_strings":["1Emory Univ. Winship Cancer Inst., Atlanta, GA","1Emory University Winship Cancer Institute, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Emory Univ. Winship Cancer Inst., Atlanta, GA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]},{"raw_affiliation_string":"1Emory University Winship Cancer Institute, Atlanta, GA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005291686","display_name":"Chandar Bhimani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chandar Bhimani","raw_affiliation_strings":["1Emory Univ. Winship Cancer Inst., Atlanta, GA","1Emory University Winship Cancer Institute, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Emory Univ. Winship Cancer Inst., Atlanta, GA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]},{"raw_affiliation_string":"1Emory University Winship Cancer Institute, Atlanta, GA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103553939","display_name":"Chen Zhengjia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chen Zhengjia","raw_affiliation_strings":["1Emory Univ. Winship Cancer Inst., Atlanta, GA","1Emory University Winship Cancer Institute, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Emory Univ. Winship Cancer Inst., Atlanta, GA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]},{"raw_affiliation_string":"1Emory University Winship Cancer Institute, Atlanta, GA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dong Shin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong Shin","raw_affiliation_strings":["1Emory Univ. Winship Cancer Inst., Atlanta, GA","1Emory University Winship Cancer Institute, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Emory Univ. Winship Cancer Inst., Atlanta, GA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]},{"raw_affiliation_string":"1Emory University Winship Cancer Institute, Atlanta, GA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088178599","display_name":"Suresh S. Ramalingam","orcid":"https://orcid.org/0000-0002-0757-3106","observed_orcids":["https://orcid.org/0000-0002-0757-3106"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suresh S. Ramalingam","raw_affiliation_strings":["1Emory Univ. Winship Cancer Inst., Atlanta, GA","1Emory University Winship Cancer Institute, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Emory Univ. Winship Cancer Inst., Atlanta, GA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]},{"raw_affiliation_string":"1Emory University Winship Cancer Institute, Atlanta, GA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059710197","display_name":"Fadlo Raja Khuri","orcid":"https://orcid.org/0000-0002-8638-7618","observed_orcids":["https://orcid.org/0000-0002-8638-7618"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fadlo R. Khuri","raw_affiliation_strings":["1Emory Univ. Winship Cancer Inst., Atlanta, GA","1Emory University Winship Cancer Institute, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Emory Univ. Winship Cancer Inst., Atlanta, GA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]},{"raw_affiliation_string":"1Emory University Winship Cancer Institute, Atlanta, GA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011386306","display_name":"Edmund K. Waller","orcid":"https://orcid.org/0000-0003-0816-6729","observed_orcids":["https://orcid.org/0000-0003-0816-6729"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Waller K. Edmund","raw_affiliation_strings":["1Emory Univ. Winship Cancer Inst., Atlanta, GA","1Emory University Winship Cancer Institute, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Emory Univ. Winship Cancer Inst., Atlanta, GA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]},{"raw_affiliation_string":"1Emory University Winship Cancer Institute, Atlanta, GA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015060656","display_name":"Taofeek Kunle Owonikoko","orcid":"https://orcid.org/0000-0002-7724-7728","observed_orcids":["https://orcid.org/0000-0002-7724-7728"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taofeek K. Owonikoko","raw_affiliation_strings":["2Emory University, Winship Cancer Institute, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Emory University, Winship Cancer Institute, Atlanta, GA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"8_Supplement","first_page":"5525","last_page":"5525"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5708000063896179,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5708000063896179,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.37700000405311584,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-cancer","display_name":"thyroid cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.8740000128746033},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.8330000042915344},{"id":"https://openalex.org/keywords/immune-exhaustion","display_name":"immune exhaustion","score":0.7409999966621399},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.7699999809265137},{"id":"https://openalex.org/keywords/granzyme-b","display_name":"granzyme B","score":0.8379999995231628},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9070000052452087},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.8180000185966492},{"id":"https://openalex.org/keywords/remission","display_name":"remission","score":0.656000018119812},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.5389999747276306},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.46000000834465027},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2780380082","wikidata":"https://www.wikidata.org/wiki/Q12646460","display_name":"Granzyme B","level":4,"score":0.7025249004364014},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6475553512573242},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5717626214027405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5656514167785645},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5434631705284119},{"id":"https://openalex.org/C2776989580","wikidata":"https://www.wikidata.org/wiki/Q421320","display_name":"Ionomycin","level":3,"score":0.5409901738166809},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5367118120193481},{"id":"https://openalex.org/C183193105","wikidata":"https://www.wikidata.org/wiki/Q425068","display_name":"Granzyme","level":5,"score":0.464230477809906},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4558575749397278},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43932825326919556},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.4319068491458893},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.417360782623291},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35172608494758606},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33274731040000916},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2956432104110718},{"id":"https://openalex.org/C2776062744","wikidata":"https://www.wikidata.org/wiki/Q21103279","display_name":"Perforin","level":4,"score":0.1801050901412964},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.15871146321296692},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.14408954977989197},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2011-5525","doi":"https://doi.org/10.1158/1538-7445.am2011-5525","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-5525","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6899999976158142,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2590105923","https://openalex.org/W2752206543","https://openalex.org/W4401637570","https://openalex.org/W2920959287","https://openalex.org/W2395888168","https://openalex.org/W2991464428","https://openalex.org/W2867125995","https://openalex.org/W4280653878","https://openalex.org/W2132855268","https://openalex.org/W2009476155"],"abstract_inverted_index":{"Abstract":[0],"Clinical":[1],"studies":[2],"suggested":[3],"an":[4],"association":[5],"between":[6,137,158,244],"thyroid":[7,71,205,212,298,328,343],"cancer":[8,72,159,206,213,299,329,344],"outcome":[9],"and":[10,19,54,60,118,139,147,161,171,181,193,227,233,249,274,313,388,402,417],"patient":[11,214,245,383],"immunologic":[12,103],"function.":[13],"Cytotoxic":[14],"T-Lymphocyte":[15],"Antigen":[16],"4":[17],"(CTLA4)":[18],"Programmed":[20],"Death":[21],"1":[22],"(PD-1)":[23],"are":[24],"strong":[25],"negative":[26],"regulators":[27],"of":[28,56,58,93,98,102,105,168,178,219,297,306,327,370,378,428,433],"immune":[29,322,340],"function":[30,33],"whose":[31],"aberrant":[32],"has":[34],"been":[35],"associated":[36],"with":[37,42,70,75,185,192,204,246,269,273,279,346],"poor":[38],"outcomes":[39],"in":[40,62,67,126,133,164,251,262,264,267,276,293,324,342,354,361],"patients":[41,69,138,160,203,263,268,300,345,353],"solid":[43],"malignancies.":[44],"We":[45,80],"carried":[46],"out":[47],"this":[48,325,379],"study":[49],"to":[50,85,207,310,352,363,399,410],"compare":[51],"the":[52,87,96,165,176,211,217,367,403,429,434],"degree":[53],"patterns":[55],"expression":[57,191],"CTLA4":[59],"PD-1":[61],"peripheral":[63],"circulating":[64],"mononuclear":[65],"cells":[66,97,235],"adult":[68,76],"(N=21)":[73],"compared":[74,351],"healthy":[77,140,162,208,364],"controls":[78,163],"(N=5).":[79],"used":[81],"multiparameter":[82],"flow":[83],"cytometry":[84],"determine":[86],"absolute":[88],"cell":[89,112,135,173,183],"count":[90,136],"per":[91,284],"ml":[92,285],"blood":[94,286],"for":[95,437],"interest.":[99],"Functional":[100],"assays":[101],"competence":[104],"B-cell,":[106,170],"T-cell":[107,258],"as":[108,110],"well":[109],"NK":[111,172,182],"subpopulations":[113],"was":[114,142,150,154,241,259,359],"assessed":[115,143],"by":[116,144,392],"granzyme-B":[117],"interferon":[119],"(IFN)":[120],"gamma":[121],"production":[122],"following":[123,316],"PMA/ionomycin":[124,195,280,317],"stimulation":[125,196],"vitro":[127,277],"using":[128,381],"standard":[129],"assay":[130],"method.":[131],"Differences":[132],"specific":[134],"control":[141,371],"F-test":[145],"statistics":[146],"p-value":[148],"<0.05":[149],"considered":[151],"significant.":[152],"There":[153],"no":[155],"significant":[156],"difference":[157],"overall":[166],"numbers":[167],"T-cell,":[169],"subsets.":[174],"Similarly,":[175],"proportion":[177],"CD4,":[179],"CD8":[180,307],"subsets":[184],"CTLA4,":[186],"PD-1,":[187],"IFN-gamma":[188,312],"or":[189],"Granzyme-B":[190,254],"without":[194,275],"were":[197],"not":[198],"significantly":[199,242,260],"different":[200,243],"when":[201,350],"comparing":[202],"controls.":[209],"Within":[210],"population,":[215],"however,":[216],"distribution":[218],"CD4":[220,256],"(+)":[221,238,240,255,257,308],"T-cells,":[222],"total":[223],"B-cells,":[224],"plasma":[225],"cells,":[226],"PD":[228],"ligand":[229],"1-expressing":[230],"monocytes,":[231],"macrophages":[232],"dendritic":[234],"i.e.":[236],"CD64":[237],"PD-L1":[239],"active":[247,270,347],"disease":[248,271,348],"those":[250],"remission.":[252,355],"The":[253],"lower":[261],"remission":[265],"than":[266],"both":[272],"activation":[278],"(0.08":[281],"vs.":[282],"0.19":[283],"\u00d7":[287],"10\u20416;":[288],"p=0.03).":[289],"Intriguingly,":[290],"functional":[291],"profiling":[292],"a":[294,302,335],"limited":[295],"number":[296,369],"revealed":[301],"markedly":[303],"impaired":[304,338],"ability":[305],"T-cells":[309],"produce":[311],"Granzyme":[314],"B":[315],"stimulation.":[318],"Thus":[319],"suggesting":[320],"possible":[321],"exhaustion":[323],"subpopulation":[326],"patients.":[330],"Overall,":[331],"our":[332],"results":[333],"show":[334],"trend":[336,358],"toward":[337],"cytotoxic":[339],"pathway":[341],"burden":[349],"A":[356],"similar":[357],"observed":[360],"comparison":[362],"subjects":[365,372],"but":[366],"small":[368],"limits":[373],"statistical":[374],"significance.":[375],"Further":[376],"elucidation":[377],"finding":[380],"larger":[382],"sample":[384],"is":[385],"clearly":[386],"warranted":[387],"currently":[389],"ongoing.":[390],"(Supported":[391],"Career":[393],"Development":[394],"Award":[395,409],"(NCI":[396],"P50":[397],"CA128613)":[398],"TK":[400,418],"Owonikoko":[401],"Georgia":[404],"Cancer":[405,438,448],"Coalition":[406],"Distinguished":[407],"Scholar":[408],"DM":[411],"Shin,":[412],"SS":[413],"Ramalingam,":[414],"FR":[415],"Khuri,":[416],"Owonikoko)":[419],"Citation":[420],"Format:":[421],"{Authors}.":[422],"{Abstract":[423],"title}":[424],"[abstract].":[425],"In:":[426],"Proceedings":[427],"102nd":[430],"Annual":[431],"Meeting":[432],"American":[435],"Association":[436],"Research;":[439],"2011":[440],"Apr":[441],"2-6;":[442],"Orlando,":[443],"FL.":[444],"Philadelphia":[445],"(PA):":[446],"AACR;":[447],"Res":[449],"2011;71(8":[450],"Suppl):Abstract":[451],"nr":[452],"5525.":[453],"doi:10.1158/1538-7445.AM2011-5525":[454]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}
