{"id":"https://openalex.org/W2004309874","doi":"https://doi.org/10.1038/sj.jcbfm.9600040","title":"Minocycline Protects against Permanent Cerebral Ischemia in Wild Type but Not in Matrix Metalloprotease-9-Deficient Mice","display_name":"Minocycline Protects against Permanent Cerebral Ischemia in Wild Type but Not in Matrix Metalloprotease-9-Deficient Mice","publication_year":2005,"publication_date":"2005-01-26","ids":{"openalex":"https://openalex.org/W2004309874","doi":"https://doi.org/10.1038/sj.jcbfm.9600040","mag":"2004309874","pmid":"https://pubmed.ncbi.nlm.nih.gov/15674236"},"language":"en","primary_location":{"id":"doi:10.1038/sj.jcbfm.9600040","doi":"https://doi.org/10.1038/sj.jcbfm.9600040","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.jcbfm.9600040","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1038/sj.jcbfm.9600040","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1038/sj.jcbfm.9600040","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077906923","display_name":"Milla Koistinaho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Milla Koistinaho","raw_affiliation_strings":["Department of Neurobiology, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000776705","display_name":"Tarja Malm","orcid":"https://orcid.org/0000-0002-9530-7472","observed_orcids":["https://orcid.org/0000-0002-9530-7472"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Tarja M Malm","raw_affiliation_strings":["Department of Neurobiology, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067646436","display_name":"Mikko I. Kettunen","orcid":"https://orcid.org/0000-0002-2004-660X","observed_orcids":["https://orcid.org/0000-0002-2004-660X"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mikko I Kettunen","raw_affiliation_strings":["Department of Biomedical NMR, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland","Department of Neurobiology, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical NMR, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Department of Neurobiology, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003020479","display_name":"Gundars Goldsteins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Gundars Goldsteins","raw_affiliation_strings":["Department of Neurobiology, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031567125","display_name":"Sofie Starckx","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Sofie Starckx","raw_affiliation_strings":["Rega Institute for Medical Research, University of Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045742506","display_name":"Risto A. Kauppinen","orcid":"https://orcid.org/0000-0003-3383-6608","observed_orcids":["https://orcid.org/0000-0003-3383-6608"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Risto A Kauppinen","raw_affiliation_strings":["Department of Biomedical NMR, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland","Department of Neurobiology, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical NMR, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Department of Neurobiology, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100906398","display_name":"Ghislain Opdenakker","orcid":"https://orcid.org/0000-0003-1714-2294","observed_orcids":["https://orcid.org/0000-0003-1714-2294"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Ghislain Opdenakker","raw_affiliation_strings":["Rega Institute for Medical Research, University of Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070430837","display_name":"Jari Ko\u0131st\u0131naho","orcid":"https://orcid.org/0000-0001-6559-1153","observed_orcids":["https://orcid.org/0000-0001-6559-1153"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jari Koistinaho","raw_affiliation_strings":["Department of Neurobiology, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland","Department of Oncology, Kuopio University Hospital Kuopio, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Department of Oncology, Kuopio University Hospital Kuopio, Kuopio, Finland","institution_ids":["https://openalex.org/I4210092991"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5077906923"],"corresponding_institution_ids":["https://openalex.org/I175532246"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":5.7743,"has_fulltext":false,"cited_by_count":123,"citation_normalized_percentile":{"value":0.96353336,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"25","issue":"4","first_page":"460","last_page":"467"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.7465999722480774,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.7465999722480774,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.10760000348091125,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.07429999858140945,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/minocycline","display_name":"minocycline","score":1.0},{"id":"https://openalex.org/keywords/doxycycline","display_name":"doxycycline","score":0.9750000238418579},{"id":"https://openalex.org/keywords/tetracycline","display_name":"tetracycline","score":0.9200000166893005},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.8830000162124634},{"id":"https://openalex.org/keywords/mmp-9-knockout-mice","display_name":"MMP-9 knockout mice","score":0.8579999804496765},{"id":"https://openalex.org/keywords/permanent-cerebral-ischemia","display_name":"permanent cerebral ischemia","score":0.8410000205039978},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8339999914169312},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9070000052452087},{"id":"https://openalex.org/keywords/timing-of-drug-administration","display_name":"timing of drug administration","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C2778275353","wikidata":"https://www.wikidata.org/wiki/Q415336","display_name":"Minocycline","level":3,"score":0.9851412773132324},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.6538164615631104},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6157047152519226},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6151264309883118},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.612395703792572},{"id":"https://openalex.org/C2777179404","wikidata":"https://www.wikidata.org/wiki/Q422442","display_name":"Doxycycline","level":3,"score":0.5917766690254211},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.4538021683692932},{"id":"https://openalex.org/C177430391","wikidata":"https://www.wikidata.org/wiki/Q1173648","display_name":"Zymography","level":3,"score":0.45301514863967896},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.44693997502326965},{"id":"https://openalex.org/C2780923616","wikidata":"https://www.wikidata.org/wiki/Q193045","display_name":"Tetracycline","level":3,"score":0.4398857355117798},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3290417194366455},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26993298530578613},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26843249797821045},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.23338386416435242},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17059418559074402},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11759498715400696},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.10106834769248962}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004318","descriptor_name":"Doxycycline","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008911","descriptor_name":"Minocycline","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020244","descriptor_name":"Infarction, Middle Cerebral Artery","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061965","descriptor_name":"Matrix Metalloproteinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/sj.jcbfm.9600040","doi":"https://doi.org/10.1038/sj.jcbfm.9600040","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.jcbfm.9600040","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1038/sj.jcbfm.9600040","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:15674236","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15674236","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/56bde868-8955-459f-8a26-24b98c12f1be","doi":null,"is_oa":false,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/56bde868-8955-459f-8a26-24b98c12f1be","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Koistinaho, M, Lappetelainen, T, Kettunen, MI, Goldsteins, G, Starckx, S, Kauppinen, R, Opdenakker, G & Koistinaho, J 2005, 'The protective effect of minocycline in permanent cerebral ischaemia in MM9-dependent', Journal of Cerebral Blood Flow Metabolism, vol. 25, pp. 460-467. https://doi.org/10.1038/sj.jcbfm.9600040","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/sj.jcbfm.9600040","doi":"https://doi.org/10.1038/sj.jcbfm.9600040","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.jcbfm.9600040","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1038/sj.jcbfm.9600040","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2004309874.pdf"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1485896673","https://openalex.org/W1514824226","https://openalex.org/W1540146056","https://openalex.org/W1546619202","https://openalex.org/W1987197699","https://openalex.org/W1990711278","https://openalex.org/W1992981081","https://openalex.org/W1996413321","https://openalex.org/W2005993855","https://openalex.org/W2015600477","https://openalex.org/W2019492870","https://openalex.org/W2022943823","https://openalex.org/W2035569448","https://openalex.org/W2036717742","https://openalex.org/W2040088974","https://openalex.org/W2048047884","https://openalex.org/W2067811787","https://openalex.org/W2068210940","https://openalex.org/W2072001685","https://openalex.org/W2072109619","https://openalex.org/W2073259535","https://openalex.org/W2073649666","https://openalex.org/W2085431369","https://openalex.org/W2086414747","https://openalex.org/W2086812549","https://openalex.org/W2097281218","https://openalex.org/W2103738800","https://openalex.org/W2106361045","https://openalex.org/W2113617025","https://openalex.org/W2113892795","https://openalex.org/W2124894661","https://openalex.org/W2126634468","https://openalex.org/W2136348600","https://openalex.org/W2158230836","https://openalex.org/W2166138570","https://openalex.org/W2166615294","https://openalex.org/W2286903127","https://openalex.org/W2408836120"],"related_works":["https://openalex.org/W1545606956","https://openalex.org/W4402606825","https://openalex.org/W2154553672","https://openalex.org/W2002886729","https://openalex.org/W3166006370","https://openalex.org/W1514824226","https://openalex.org/W2010206045","https://openalex.org/W2040088974","https://openalex.org/W1993525670","https://openalex.org/W1972518913"],"abstract_inverted_index":{"Minocycline":[0,130,196],"is":[1,191],"protective":[2,36,141,184],"in":[3,23,38,135,142,151,164,169,178,185],"models":[4],"of":[5,53,84,103],"transient":[6],"middle":[7],"cerebral":[8],"artery":[9],"occlusion":[10],"(MCAO).":[11],"We":[12],"studied":[13],"whether":[14],"minocycline":[15,27,162],"and":[16,42,50,56,153],"doxycycline,":[17],"another":[18],"tetracycline":[19,108],"derivative,":[20],"provide":[21,198],"protection":[22,199],"permanent":[24,68,186],"MCAO.":[25,69,85],"Because":[26],"inhibits":[28],"matrix":[29],"metalloprotease-9":[30],"(MMP-9),":[31],"we":[32],"also":[33],"compared":[34],"minocycline's":[35],"effect":[37],"wild":[39],"type":[40],"(wt)":[41],"MMP-9":[43,54,143,154,170],"knock-out":[44],"(ko)":[45],"mice.":[46,145,156,181],"Wt":[47],"FVB/N,":[48],"Balb/C,":[49],"two":[51],"lines":[52],"ko":[55,144,155,171],"their":[57],"wt":[58,106,136,152,165,180],"C57Bl/6":[59],"control":[60],"mice":[61,166,172],"were":[62],"subjected":[63],"to":[64,99,119],"24-":[65],"or":[66,78,93],"72-hour":[67],"Drug":[70],"administration":[71],"was":[72,88,97,127,139,147,159],"started":[73,110,124,192],"either":[74],"12":[75],"hours":[76,80],"before":[77,111,193],"2":[79],"after":[81,125],"the":[82,101,114,122,174,189,194],"onset":[83],"Infarct":[86],"size":[87,116],"determined":[89],"by":[90,117,149,161,200],"triphenyltetrazolium":[91],"staining":[92],"T2-weighted":[94],"MRI.":[95],"Zymography":[96],"used":[98],"study":[100],"expression":[102],"MMPs.":[104,203],"In":[105],"strains,":[107],"treatments":[109],"MCAO":[112,126,150,187],"reduced":[113],"infarct":[115],"25%":[118],"50%,":[120],"whereas":[121],"treatment":[123,163,190],"not":[128,140],"protective.":[129],"inhibited":[131],"ischemia-provoked":[132],"pro-MMP-9":[133],"induction":[134],"mice,":[137],"but":[138,167],"Pro-MMP-2":[146],"induced":[148],"MCAO-induced":[157],"pro-MMP-2":[158],"downregulated":[160],"remained":[168],"at":[173],"same":[175],"level":[176],"as":[177],"saline-treated":[179],"Tetracyclines":[182],"are":[183],"when":[188],"insult.":[195],"may":[197],"interfering":[201],"with":[202]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
