{"id":"https://openalex.org/W2004288362","doi":"https://doi.org/10.1165/ajrcmb.23.5.4164","title":"Enhanced Epithelial Gene Transfer by Modulation of Tight Junctions with Sodium Caprate","display_name":"Enhanced Epithelial Gene Transfer by Modulation of Tight Junctions with Sodium Caprate","publication_year":2000,"publication_date":"2000-11-01","ids":{"openalex":"https://openalex.org/W2004288362","doi":"https://doi.org/10.1165/ajrcmb.23.5.4164","mag":"2004288362","pmid":"https://pubmed.ncbi.nlm.nih.gov/11062138"},"language":"en","primary_location":{"id":"doi:10.1165/ajrcmb.23.5.4164","doi":"https://doi.org/10.1165/ajrcmb.23.5.4164","is_oa":false,"landing_page_url":"https://doi.org/10.1165/ajrcmb.23.5.4164","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.17615/7hsz-r551","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026779976","display_name":"Carolyn B. Coyne","orcid":"https://orcid.org/0000-0002-1884-6309","observed_orcids":["https://orcid.org/0000-0002-1884-6309"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolyn B. Coyne","raw_affiliation_strings":["Departments of Pharmacology and Medicine, and Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Medicine, and Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001274851","display_name":"Miriam M. Kelly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miriam M. Kelly","raw_affiliation_strings":["Departments of Pharmacology and Medicine, and Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Medicine, and Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001166056","display_name":"Richard C. Boucher","orcid":"https://orcid.org/0000-0002-5745-3989","observed_orcids":["https://orcid.org/0000-0002-5745-3989"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard C. Boucher","raw_affiliation_strings":["Departments of Pharmacology and Medicine, and Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Medicine, and Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085752252","display_name":"Larry G. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Larry G. Johnson","raw_affiliation_strings":["Departments of Pharmacology and Medicine, and Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Medicine, and Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085752252"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":4.137,"has_fulltext":false,"cited_by_count":106,"citation_normalized_percentile":{"value":0.94273981,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"23","issue":"5","first_page":"602","last_page":"609"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.5863999724388123,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.5863999724388123,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.19089999794960022,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.10840000212192535,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-caprate","display_name":"sodium caprate","score":0.906000018119812},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.7369999885559082},{"id":"https://openalex.org/keywords/paracellular-permeability","display_name":"paracellular permeability","score":0.9129999876022339},{"id":"https://openalex.org/keywords/airway-epithelium","display_name":"airway epithelium","score":0.9559999704360962},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.9079999923706055},{"id":"https://openalex.org/keywords/egta","display_name":"EGTA","score":0.824999988079071},{"id":"https://openalex.org/keywords/claudin-1","display_name":"claudin-1","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cftr","display_name":"CFTR","score":0.7490000128746033},{"id":"https://openalex.org/keywords/chloride-transport","display_name":"chloride transport","score":0.8569999933242798},{"id":"https://openalex.org/keywords/mannitol-permeability","display_name":"mannitol permeability","score":0.7279999852180481},{"id":"https://openalex.org/keywords/dextran-permeability","display_name":"dextran permeability","score":0.9440000057220459},{"id":"https://openalex.org/keywords/transepithelial-electrical-resistance","display_name":"transepithelial electrical resistance","score":0.890999972820282},{"id":"https://openalex.org/keywords/medium-chain-fatty-acids","display_name":"medium-chain fatty acids","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C60903277","wikidata":"https://www.wikidata.org/wiki/Q2051926","display_name":"Paracellular transport","level":4,"score":0.9398595094680786},{"id":"https://openalex.org/C2777658833","wikidata":"https://www.wikidata.org/wiki/Q408437","display_name":"EGTA","level":3,"score":0.8434857130050659},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5810709595680237},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4889203608036041},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.46030759811401367},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.4204924702644348},{"id":"https://openalex.org/C2778445172","wikidata":"https://www.wikidata.org/wiki/Q407646","display_name":"Mannitol","level":2,"score":0.4203651249408722},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41785645484924316},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3614616096019745},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.274161159992218},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24488568305969238},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.22180795669555664},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003652","descriptor_name":"Decanoic Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1165/ajrcmb.23.5.4164","doi":"https://doi.org/10.1165/ajrcmb.23.5.4164","is_oa":false,"landing_page_url":"https://doi.org/10.1165/ajrcmb.23.5.4164","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},{"id":"pmid:11062138","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11062138","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory cell and molecular biology","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:kk91fw14s","doi":null,"is_oa":false,"landing_page_url":"https://cdr.lib.unc.edu/downloads/w6634c88f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology, 23(5)","raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.320.5105","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.320.5105","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ajrcmb.atsjournals.org/content/23/5/602.full.pdf","raw_type":"text"},{"id":"doi:10.17615/7hsz-r551","doi":"https://doi.org/10.17615/7hsz-r551","is_oa":true,"landing_page_url":"https://doi.org/10.17615/7hsz-r551","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.17615/7hsz-r551","doi":"https://doi.org/10.17615/7hsz-r551","is_oa":true,"landing_page_url":"https://doi.org/10.17615/7hsz-r551","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2689150868","display_name":"Gene Therapy for Cystic Fibrosis","funder_award_id":"P01HL051818","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3645565544","display_name":"Enhanced Gene Transfer to Lung Epithelia","funder_award_id":"R01HL058342","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W63651712","https://openalex.org/W888493226","https://openalex.org/W1491436713","https://openalex.org/W1504811282","https://openalex.org/W1921798839","https://openalex.org/W1967670116","https://openalex.org/W1986769432","https://openalex.org/W1996955331","https://openalex.org/W2008840871","https://openalex.org/W2017558860","https://openalex.org/W2019604979","https://openalex.org/W2025678616","https://openalex.org/W2028719355","https://openalex.org/W2071008278","https://openalex.org/W2077541686","https://openalex.org/W2084429010","https://openalex.org/W2086274688","https://openalex.org/W2086412362","https://openalex.org/W2092482647","https://openalex.org/W2130936034","https://openalex.org/W2151534641","https://openalex.org/W2165573391","https://openalex.org/W2313932305","https://openalex.org/W2341041769","https://openalex.org/W2401773150"],"related_works":["https://openalex.org/W2010459343","https://openalex.org/W2047753215","https://openalex.org/W1989493456","https://openalex.org/W2126588819","https://openalex.org/W2078051637","https://openalex.org/W2529720690","https://openalex.org/W2042089608","https://openalex.org/W4401107821","https://openalex.org/W7099911676","https://openalex.org/W2078988079"],"abstract_inverted_index":{"The":[0],"airway":[1,21,64,152],"epithelium":[2],"is":[3,25,198],"resistant":[4],"to":[5,26,36,55,62,93],"infection":[6],"by":[7,81,104,113,125,131,181],"gene":[8,23,121,195],"transfer":[9,24,122,196],"vectors":[10,35],"when":[11],"infected":[12],"from":[13,156],"the":[14,32,37,47],"luminal":[15],"surface.":[16],"One":[17],"strategy":[18],"for":[19,193],"enhancing":[20,194],"epithelial":[22,153],"modify":[27],"paracellular":[28,65],"permeability,":[29],"thereby":[30],"permitting":[31],"diffusion":[33],"of":[34,49,76,118,142,146,166,178,207],"basolateral":[38],"surface,":[39],"where":[40],"uptake":[41],"receptors":[42],"are":[43],"expressed.":[44],"We":[45],"investigated":[46],"ability":[48],"a":[50,95,109,139,164,175,190],"medium-chain":[51],"fatty":[52],"acid":[53,72],"known":[54],"enhance":[56],"drug":[57],"absorption,":[58],"sodium":[59],"caprate":[60],"(C10),":[61],"increase":[63,111],"permeability":[66,103],"in":[67,149],"comparison":[68],"with":[69,108,138],"ethyleneglycol-bis-(beta-aminoethyl":[70],"ether)-N,N'-tetraacetic":[71],"(EGTA).":[73],"Apical":[74],"application":[75],"C10":[77,98,126,169,187],"decreased":[78],"transepithelial":[79],"resistance":[80],">":[82],"90%":[83],"within":[84],"minutes,":[85],"whereas":[86],"EGTA":[87,132,172],"required":[88],"an":[89],"hour":[90],"or":[91],"more":[92],"produce":[94],"similar":[96],"effect.":[97],"increased":[99],"mannitol":[100],"and":[101,200],"dextran":[102],"sevenfold,":[105],"as":[106,174],"compared":[107],"twofold":[110],"produced":[112],"EGTA.":[114],"A":[115],"greater":[116],"enhancement":[117,141,180],"adenoviral":[119,143],"lacZ":[120],"was":[123],"mediated":[124],"(50-fold":[127],"over":[128,134],"controls)":[129],"than":[130,197],"(10-fold":[133],"controls).":[135],"This":[136],"correlated":[137],"significant":[140],"CFTR-mediated":[144],"correction":[145],"Cl(-)":[147],"transport":[148],"polarized":[150],"human":[151],"(HAE)":[154],"cells":[155],"cystic":[157],"fibrosis":[158],"(CF)":[159],"patients.":[160],"Confocal":[161],"microscopy":[162],"revealed":[163],"redistribution":[165],"claudin-1":[167],"following":[168],"but":[170],"not":[171],"treatment":[173],"possible":[176],"mechanism":[177],"gene-transfer":[179],"C10.":[182],"These":[183],"data":[184],"suggest":[185],"that":[186,201],"may":[188],"be":[189],"better":[191],"agent":[192],"EGTA,":[199],"this":[202],"effect":[203],"occurs":[204],"through":[205],"disruption":[206],"claudin-1.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
