{"id":"https://openalex.org/W2004281843","doi":"https://doi.org/10.1385/ijgc:35:1:033","title":"Clinical Significance of K-ras and c-erbB-2 Mutations in Pancreatic Adenocarcinoma and Chronic Pancreatitis","display_name":"Clinical Significance of K-ras and c-erbB-2 Mutations in Pancreatic Adenocarcinoma and Chronic Pancreatitis","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2004281843","doi":"https://doi.org/10.1385/ijgc:35:1:033","mag":"2004281843","pmid":"https://pubmed.ncbi.nlm.nih.gov/15722572"},"language":"en","primary_location":{"id":"doi:10.1385/ijgc:35:1:033","doi":"https://doi.org/10.1385/ijgc:35:1:033","is_oa":false,"landing_page_url":"https://doi.org/10.1385/ijgc:35:1:033","pdf_url":null,"source":{"id":"https://openalex.org/S44780361","display_name":"International Journal of Gastrointestinal Cancer","issn_l":"1537-3649","issn":["1537-3649","1559-0739"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Gastrointestinal Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017329070","display_name":"Renata Talar\u2010Wojnarowska","orcid":"https://orcid.org/0000-0003-3887-2712","observed_orcids":["https://orcid.org/0000-0003-3887-2712"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Renata Talar-Wojnarowska","raw_affiliation_strings":["Department of Digestive Tract Diseases, Medical University, Lodz, Poland. r-wojnarowska@wp.pl","Department of Digestive Tract Diseases, Medical University, Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Digestive Tract Diseases, Medical University, Lodz, Poland. r-wojnarowska@wp.pl","institution_ids":["https://openalex.org/I4210122071"]},{"raw_affiliation_string":"Department of Digestive Tract Diseases, Medical University, Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046939518","display_name":"Anita G\u0105siorowska","orcid":"https://orcid.org/0000-0001-8288-3721","observed_orcids":["https://orcid.org/0000-0001-8288-3721"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Anita Gasiorowska","raw_affiliation_strings":["Department of Digestive Tract Diseases, Medical University, Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Digestive Tract Diseases, Medical University, Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055313584","display_name":"Beata Smolarz","orcid":"https://orcid.org/0000-0003-3168-062X","observed_orcids":["https://orcid.org/0000-0003-3168-062X"]},"institutions":[{"id":"https://openalex.org/I4210091339","display_name":"Laboratory of Molecular Genetics","ror":"https://ror.org/00fwhek95","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210091339"]},{"id":"https://openalex.org/I4210143919","display_name":"Polish Mother\u2019s Memorial Hospital Research Institute","ror":"https://ror.org/059ex7y15","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210143919"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Beata Smolarz","raw_affiliation_strings":["Department of Pathology, Institute of Polish Mother\u2019s Memorial Hospital, Laboratory of Molecular Genetics, Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Institute of Polish Mother\u2019s Memorial Hospital, Laboratory of Molecular Genetics, Lodz, Poland","institution_ids":["https://openalex.org/I4210091339","https://openalex.org/I4210143919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087208481","display_name":"Hanna Romanowicz\u2010Makowska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091339","display_name":"Laboratory of Molecular Genetics","ror":"https://ror.org/00fwhek95","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210091339"]},{"id":"https://openalex.org/I4210143919","display_name":"Polish Mother\u2019s Memorial Hospital Research Institute","ror":"https://ror.org/059ex7y15","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210143919"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Hanna Romanowicz-Makowska","raw_affiliation_strings":["Department of Pathology, Institute of Polish Mother\u2019s Memorial Hospital, Laboratory of Molecular Genetics, Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Institute of Polish Mother\u2019s Memorial Hospital, Laboratory of Molecular Genetics, Lodz, Poland","institution_ids":["https://openalex.org/I4210091339","https://openalex.org/I4210143919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039986027","display_name":"Janusz Strzelczyk","orcid":"https://orcid.org/0000-0003-3438-9512","observed_orcids":["https://orcid.org/0000-0003-3438-9512"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Janusz Strzelczyk","raw_affiliation_strings":["Department of General Surgery and Transplantology, Medical University, Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery and Transplantology, Medical University, Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Adam Janiak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Adam Janiak","raw_affiliation_strings":["Department of General Surgery and Transplantology, Medical University, Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery and Transplantology, Medical University, Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020175840","display_name":"Andrzej Kulig","orcid":"https://orcid.org/0000-0001-6122-3169","observed_orcids":["https://orcid.org/0000-0001-6122-3169"]},"institutions":[{"id":"https://openalex.org/I4210091339","display_name":"Laboratory of Molecular Genetics","ror":"https://ror.org/00fwhek95","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210091339"]},{"id":"https://openalex.org/I4210143919","display_name":"Polish Mother\u2019s Memorial Hospital Research Institute","ror":"https://ror.org/059ex7y15","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210143919"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Andrzej Kulig","raw_affiliation_strings":["Department of Pathology, Institute of Polish Mother\u2019s Memorial Hospital, Laboratory of Molecular Genetics, Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Institute of Polish Mother\u2019s Memorial Hospital, Laboratory of Molecular Genetics, Lodz, Poland","institution_ids":["https://openalex.org/I4210091339","https://openalex.org/I4210143919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084861756","display_name":"Ewa I. Malecka-Panas","orcid":"https://orcid.org/0000-0002-1825-1807","observed_orcids":["https://orcid.org/0000-0002-1825-1807"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Ewa Malecka-Panas","raw_affiliation_strings":["Department of Digestive Tract Diseases, Medical University, Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Digestive Tract Diseases, Medical University, Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017329070"],"corresponding_institution_ids":["https://openalex.org/I4210122071"],"apc_list":null,"apc_paid":null,"fwci":0.8615,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.74038328,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"35","issue":"1","first_page":"033","last_page":"042"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9549999833106995},{"id":"https://openalex.org/keywords/chronic-pancreatitis","display_name":"chronic pancreatitis","score":1.0},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.8960000276565552},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.7269999980926514},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/codon-12-mutation","display_name":"codon 12 mutation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.734000027179718},{"id":"https://openalex.org/keywords/pancreatic-carcinogenesis","display_name":"pancreatic carcinogenesis","score":0.8679999709129333},{"id":"https://openalex.org/keywords/whipple-resection","display_name":"Whipple resection","score":0.746999979019165},{"id":"https://openalex.org/keywords/distal-pancreatectomy","display_name":"distal pancreatectomy","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.7430292963981628},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.6870360374450684},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6673926115036011},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6273338198661804},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5853037238121033},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5079942345619202},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.49628597497940063},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.4627765119075775},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4339859187602997},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3219299018383026},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1934809386730194},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1785857081413269},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1724739372730255},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.061152905225753784}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010180","descriptor_name":"Pancreatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018734","descriptor_name":"Genes, erbB-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1385/ijgc:35:1:033","doi":"https://doi.org/10.1385/ijgc:35:1:033","is_oa":false,"landing_page_url":"https://doi.org/10.1385/ijgc:35:1:033","pdf_url":null,"source":{"id":"https://openalex.org/S44780361","display_name":"International Journal of Gastrointestinal Cancer","issn_l":"1537-3649","issn":["1537-3649","1559-0739"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Gastrointestinal Cancer","raw_type":"journal-article"},{"id":"pmid:15722572","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15722572","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of gastrointestinal cancer","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323344","display_name":"Uniwersytet \u0141\u00f3dzki","ror":"https://ror.org/05cq64r17"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W15240469","https://openalex.org/W16294358","https://openalex.org/W41294521","https://openalex.org/W87874552","https://openalex.org/W313890960","https://openalex.org/W1496636902","https://openalex.org/W1502854409","https://openalex.org/W1507991646","https://openalex.org/W1544910013","https://openalex.org/W1557356779","https://openalex.org/W1669656365","https://openalex.org/W1969347752","https://openalex.org/W1970007393","https://openalex.org/W1972585969","https://openalex.org/W1973682477","https://openalex.org/W1976128207","https://openalex.org/W1983008161","https://openalex.org/W1987288213","https://openalex.org/W1990814447","https://openalex.org/W2001868613","https://openalex.org/W2016065772","https://openalex.org/W2020774311","https://openalex.org/W2026122233","https://openalex.org/W2030229250","https://openalex.org/W2035386351","https://openalex.org/W2036675056","https://openalex.org/W2038980248","https://openalex.org/W2047601328","https://openalex.org/W2050985999","https://openalex.org/W2051111830","https://openalex.org/W2054882742","https://openalex.org/W2058095918","https://openalex.org/W2059787292","https://openalex.org/W2071164914","https://openalex.org/W2073304595","https://openalex.org/W2088568452","https://openalex.org/W2088658104","https://openalex.org/W2090723965","https://openalex.org/W2096010941","https://openalex.org/W2097650237","https://openalex.org/W2107438847","https://openalex.org/W2132762606","https://openalex.org/W2134609020","https://openalex.org/W2139224474","https://openalex.org/W2152113072","https://openalex.org/W2172415884","https://openalex.org/W2227802918","https://openalex.org/W2322032774","https://openalex.org/W2409035899","https://openalex.org/W2417796160","https://openalex.org/W2418645868","https://openalex.org/W2434623374"],"related_works":["https://openalex.org/W786549751","https://openalex.org/W2137237214","https://openalex.org/W2188511422","https://openalex.org/W2045519549","https://openalex.org/W2412373264","https://openalex.org/W2016414096","https://openalex.org/W2020774311","https://openalex.org/W2002873491","https://openalex.org/W2429826418","https://openalex.org/W33847238"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
