{"id":"https://openalex.org/W2004281179","doi":"https://doi.org/10.1001/jama.1949.02900520003002","title":"ARTANE\u00ae THERAPY FOR PARKINSONISM","display_name":"ARTANE\u00ae THERAPY FOR PARKINSONISM","publication_year":1949,"publication_date":"1949-08-27","ids":{"openalex":"https://openalex.org/W2004281179","doi":"https://doi.org/10.1001/jama.1949.02900520003002","mag":"2004281179","pmid":"https://pubmed.ncbi.nlm.nih.gov/18137284"},"language":"en","primary_location":{"id":"doi:10.1001/jama.1949.02900520003002","doi":"https://doi.org/10.1001/jama.1949.02900520003002","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.1949.02900520003002","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Association","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043443297","display_name":"Lewis J. Doshay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"LEWIS J. DOSHAY","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5043443297"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":13.4535,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.99048443,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"140","issue":"17","first_page":"1317","last_page":"1317"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trihexyphenidyl","display_name":"trihexyphenidyl","score":0.9950000047683716},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9739999771118164},{"id":"https://openalex.org/keywords/antispasmodic-agents","display_name":"antispasmodic agents","score":0.8320000171661377},{"id":"https://openalex.org/keywords/antiparkinsonian-treatment","display_name":"antiparkinsonian therapy","score":0.7850000262260437},{"id":"https://openalex.org/keywords/drug-administration","display_name":"medication administration","score":0.8460000157356262},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7630000114440918},{"id":"https://openalex.org/keywords/clinical-efficacy","display_name":"clinical efficacy","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C2779406339","wikidata":"https://www.wikidata.org/wiki/Q2991856","display_name":"Trihexyphenidyl","level":2,"score":0.9008608460426331},{"id":"https://openalex.org/C2776525014","wikidata":"https://www.wikidata.org/wiki/Q1531991","display_name":"Parkinsonism","level":3,"score":0.783785343170166},{"id":"https://openalex.org/C2776798904","wikidata":"https://www.wikidata.org/wiki/Q93978","display_name":"Antispasmodic","level":2,"score":0.6260895729064941},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49051016569137573},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.422692209482193},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37562572956085205},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.30356645584106445},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15360769629478455}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014282","descriptor_name":"Trihexyphenidyl","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020734","descriptor_name":"Parkinsonian Disorders","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1001/jama.1949.02900520003002","doi":"https://doi.org/10.1001/jama.1949.02900520003002","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.1949.02900520003002","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Association","raw_type":"journal-article"},{"id":"pmid:18137284","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18137284","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Association","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1976732484","https://openalex.org/W2049561461","https://openalex.org/W2141727002","https://openalex.org/W2314378742","https://openalex.org/W2410370493"],"related_works":["https://openalex.org/W2333237237","https://openalex.org/W2060960163","https://openalex.org/W2009148000","https://openalex.org/W2039468397","https://openalex.org/W2087216438","https://openalex.org/W1990757266","https://openalex.org/W2473536399","https://openalex.org/W2999839299","https://openalex.org/W2413288218","https://openalex.org/W1966227548"],"abstract_inverted_index":{"Trihexyphenidyl":[0],"(artane,\u00ae":[1],"3-[1-piperidyl]-1-phenyl1-cyclohexyl-1-propanol":[2],"hydrochloride)":[3],"is":[4],"a":[5,8,43,125],"member":[6],"of":[7,11,20,45,48,54,94,98,104,110,128],"new":[9],"series":[10,44],"antispasmodic":[12],"compounds.1After":[13],"intensive":[14],"pharmacologic":[15],"investigation2of":[16],"its":[17],"effects":[18,38],"and":[19,96,107],"reactions":[21,109],"to":[22,32,80,142],"the":[23,27,52,55,57,73,84,92,102,105,108,111,143],"drug":[24,58,114],"in":[25,42,64,78,88],"animals,":[26],"product":[28],"was":[29],"turned":[30],"over":[31],"us":[33,63],"for":[34],"clinical":[35],"evaluation.":[36],"Its":[37],"were":[39,75],"carefully":[40],"studied":[41],"117":[46],"cases":[47,68],"Parkinson's":[49],"disease.":[50],"(Since":[51],"preparation":[53],"paper,":[56],"has":[59,115,134],"been":[60,116,137],"employed":[61],"by":[62],"some":[65],"150":[66],"additional":[67],"with":[69,83,101,131],"favorable":[70],"results,":[71],"but":[72],"observations":[74],"not":[76,135],"available":[77],"time":[79],"be":[81],"incorporated":[82],"earlier":[85],"cases.)":[86],"Embodied":[87],"this":[89],"report":[90],"are":[91,141],"method":[93],"administration":[95],"use":[97],"trihexyphenidyl,":[99],"correlated":[100],"results":[103],"therapy":[106],"patients.":[112],"The":[113],"under":[117],"study":[118],"at":[119],"several":[120],"other":[121],"clinics,":[122],"and,":[123],"although":[124],"detailed":[126],"comparison":[127],"such":[129],"data":[130],"our":[132],"own":[133],"yet":[136],"made,":[138],"verbal":[139],"reports":[140],"effect":[144],"that":[145]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
