{"id":"https://openalex.org/W2004274172","doi":"https://doi.org/10.1055/s-2000-13471","title":"Molecular Evaluation of the Gonadotropin-Releasing Hormone Receptor","display_name":"Molecular Evaluation of the Gonadotropin-Releasing Hormone Receptor","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2004274172","doi":"https://doi.org/10.1055/s-2000-13471","mag":"2004274172","pmid":"https://pubmed.ncbi.nlm.nih.gov/11299515"},"language":"en","primary_location":{"id":"doi:10.1055/s-2000-13471","doi":"https://doi.org/10.1055/s-2000-13471","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2000-13471","pdf_url":null,"source":{"id":"https://openalex.org/S19775678","display_name":"Seminars in Reproductive Medicine","issn_l":"1526-4564","issn":["1526-4564","1526-8004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Reproductive Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091794519","display_name":"David Cohen","orcid":"https://orcid.org/0000-0003-4321-4554","observed_orcids":["https://orcid.org/0000-0003-4321-4554"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David P. Cohen","raw_affiliation_strings":["Department of Obstetrics & Gynecology, University of Chicago, Chicago, Illinois, USA","Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics & Gynecology, University of Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois USA","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5091794519"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":0.461,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.58674599,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"18","issue":"01","first_page":"011","last_page":"016"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gnrh-receptor","display_name":"GnRH receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hypogonadotropic-hypogonadism","display_name":"hypogonadotropic hypogonadism","score":0.968999981880188},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.8339999914169312},{"id":"https://openalex.org/keywords/gonadotropin-secretion","display_name":"gonadotropin secretion","score":0.7720000147819519},{"id":"https://openalex.org/keywords/follicular-development","display_name":"folliculogenesis","score":0.7139999866485596},{"id":"https://openalex.org/keywords/ovulation","display_name":"ovulation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/constitutively-active-receptor","display_name":"constitutively active receptor","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C2776817873","wikidata":"https://www.wikidata.org/wiki/Q15316535","display_name":"GNRHR","level":5,"score":0.988362729549408},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.684459924697876},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6095007658004761},{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.5757853388786316},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.5342580080032349},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4784022271633148},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4476168751716614},{"id":"https://openalex.org/C2781255401","wikidata":"https://www.wikidata.org/wiki/Q1641332","display_name":"Hypogonadotropic hypogonadism","level":3,"score":0.4330172538757324},{"id":"https://openalex.org/C2778894405","wikidata":"https://www.wikidata.org/wiki/Q318896","display_name":"Gonadotropin-releasing hormone","level":4,"score":0.43284448981285095},{"id":"https://openalex.org/C29390026","wikidata":"https://www.wikidata.org/wiki/Q14904760","display_name":"Follicle-stimulating hormone receptor","level":5,"score":0.41722187399864197},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4126882553100586},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3804664611816406},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3368138074874878},{"id":"https://openalex.org/C2779279165","wikidata":"https://www.wikidata.org/wiki/Q200774","display_name":"Follicle-stimulating hormone","level":4,"score":0.1611017882823944},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.14417579770088196},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08376708626747131},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007006","descriptor_name":"Hypogonadism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007246","descriptor_name":"Infertility","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011628","descriptor_name":"Puberty, Delayed","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-2000-13471","doi":"https://doi.org/10.1055/s-2000-13471","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2000-13471","pdf_url":null,"source":{"id":"https://openalex.org/S19775678","display_name":"Seminars in Reproductive Medicine","issn_l":"1526-4564","issn":["1526-4564","1526-8004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Reproductive Medicine","raw_type":"journal-article"},{"id":"pmid:11299515","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11299515","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in reproductive medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1966197692","https://openalex.org/W2311466716","https://openalex.org/W1595484966","https://openalex.org/W2145311261","https://openalex.org/W3040850366","https://openalex.org/W2167056551","https://openalex.org/W2008771207","https://openalex.org/W83549992","https://openalex.org/W2048782297","https://openalex.org/W1972654216"],"abstract_inverted_index":{"The":[0,98],"gonadotropin-releasing":[1,27],"hormone":[2,35],"receptor":[3,10],"(GnRHR)":[4],"is":[5],"a":[6,12,110],"guanine":[7],"nucleotide-binding":[8],"protein-coupled":[9],"with":[11,92],"characteristic":[13],"seven":[14],"transmembrane":[15],"domain":[16],"motif.":[17],"It":[18],"transduces":[19],"the":[20,25,30,34,38,58,62,82,85,89,105,115,139,142,158],"hypothalamic":[21,116],"message":[22,117],"carried":[23],"by":[24],"decapeptide":[26],"hormone.":[28],"At":[29],"gonadotrope":[31],"cell":[32,106],"surface":[33,107],"binds":[36],"to":[37,41,64,67,113,128,145,155],"receptor,":[39],"leading":[40],"pituitary":[42],"synthesis":[43],"and":[44,55,87,108,132,147],"secretion":[45],"of":[46,61,95,160],"gonadotropins.":[47],"These":[48,76],"glycoprotein":[49],"hormones,":[50],"in":[51,57,74,81,141],"turn,":[52],"modulate":[53],"folliculogenesis":[54],"ovulation":[56],"ovary.":[59],"Failure":[60],"GnRHR":[63,86,143],"respond":[65],"appropriately":[66],"its":[68],"cognate":[69],"ligand":[70],"has":[71],"been":[72,124],"demonstrated":[73],"humans.":[75],"patients":[77],"have":[78,109,123],"genomic":[79],"mutations":[80,122,140],"gene":[83],"for":[84],"represent":[88],"first":[90],"individuals":[91],"hypogonadotropic":[93],"hypogonadism":[94],"autosomal":[96],"inheritance.":[97],"mutant":[99],"receptors":[100,131,152],"are":[101],"poorly":[102],"expressed":[103],"at":[104],"diminished":[111],"capacity":[112],"transduce":[114],"efficiently.":[118],"To":[119],"date,":[120],"no":[121],"identified":[125],"that":[126],"lead":[127],"constitutively":[129],"active":[130],"autonomous":[133],"gonadotropin":[134],"function.":[135],"This":[136],"article":[137],"identifies":[138],"reported":[144],"date":[146],"reviews":[148],"how":[149],"these":[150],"abnormal":[151],"help":[153],"us":[154],"better":[156],"understand":[157],"biology":[159],"this":[161],"interesting":[162],"molecule.":[163]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
