{"id":"https://openalex.org/W2004265166","doi":"https://doi.org/10.1002/(sici)1522-7278(199902)14:1<151::aid-tox19>3.0.co;2-d","title":"Use of HPLC-MS/MS to monitor cylindrospermopsin, a blue-green algal toxin, for public health purposes","display_name":"Use of HPLC-MS/MS to monitor cylindrospermopsin, a blue-green algal toxin, for public health purposes","publication_year":1999,"publication_date":"1999-02-01","ids":{"openalex":"https://openalex.org/W2004265166","doi":"https://doi.org/10.1002/(sici)1522-7278(199902)14:1<151::aid-tox19>3.0.co;2-d","mag":"2004265166"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1522-7278(199902)14:1<151::aid-tox19>3.0.co;2-d","doi":"https://doi.org/10.1002/(sici)1522-7278(199902)14:1<151::aid-tox19>3.0.co;2-d","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1522-7278(199902)14:1<151::aid-tox19>3.0.co;2-d","pdf_url":null,"source":{"id":"https://openalex.org/S172436580","display_name":"Environmental Toxicology","issn_l":"1520-4081","issn":["1520-4081","1522-7278"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000556005","display_name":"Geoffrey K. Eaglesham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302211766","display_name":"Queensland Health","ror":"https://ror.org/00c1dt378","country_code":"AU","type":"government","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2801244131"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Geoffrey K. Eaglesham","raw_affiliation_strings":["Queensland Health Scientific Services, 39 Kessels Road, Coopers Plains, Qld. 4108, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queensland Health Scientific Services, 39 Kessels Road, Coopers Plains, Qld. 4108, Australia","institution_ids":["https://openalex.org/I1302211766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069042090","display_name":"Ross L. G. Norris","orcid":"https://orcid.org/0000-0002-4806-0657","observed_orcids":["https://orcid.org/0000-0002-4806-0657"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ross L. Norris","raw_affiliation_strings":["National Research Centre for Environmental Toxicology, 39 Kessels Road, Coopers Plains, Qld. 4108, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Centre for Environmental Toxicology, 39 Kessels Road, Coopers Plains, Qld. 4108, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008468826","display_name":"Glen R Shaw","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Glen R. Shaw","raw_affiliation_strings":["National Research Centre for Environmental Toxicology, 39 Kessels Road, Coopers Plains, Qld. 4108, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Centre for Environmental Toxicology, 39 Kessels Road, Coopers Plains, Qld. 4108, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085691012","display_name":"Maree J. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302211766","display_name":"Queensland Health","ror":"https://ror.org/00c1dt378","country_code":"AU","type":"government","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2801244131"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Maree J. Smith","raw_affiliation_strings":["National Research Centre for Environmental Toxicology, 39 Kessels Road, Coopers Plains, Qld. 4108, Australia","Queensland Health Scientific Services, 39 Kessels Road, Coopers Plains, Qld. 4108, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Centre for Environmental Toxicology, 39 Kessels Road, Coopers Plains, Qld. 4108, Australia","institution_ids":[]},{"raw_affiliation_string":"Queensland Health Scientific Services, 39 Kessels Road, Coopers Plains, Qld. 4108, Australia","institution_ids":["https://openalex.org/I1302211766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002481226","display_name":"Robyn K. Chiswell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robyn K. Chiswell","raw_affiliation_strings":["National Research Centre for Environmental Toxicology, 39 Kessels Road, Coopers Plains, Qld. 4108, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Centre for Environmental Toxicology, 39 Kessels Road, Coopers Plains, Qld. 4108, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bradley C. Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302211766","display_name":"Queensland Health","ror":"https://ror.org/00c1dt378","country_code":"AU","type":"government","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2801244131"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Bradley C. Davis","raw_affiliation_strings":["Queensland Health Scientific Services, 39 Kessels Road, Coopers Plains, Qld. 4108, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queensland Health Scientific Services, 39 Kessels Road, Coopers Plains, Qld. 4108, Australia","institution_ids":["https://openalex.org/I1302211766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112026317","display_name":"Gerard R. Neville","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302211766","display_name":"Queensland Health","ror":"https://ror.org/00c1dt378","country_code":"AU","type":"government","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2801244131"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Gerard R. Neville","raw_affiliation_strings":["Environmental Health Unit, Queensland Health, 147-163 Charlotte Street, Brisbane, Qld. 4000, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Health Unit, Queensland Health, 147-163 Charlotte Street, Brisbane, Qld. 4000, Australia","institution_ids":["https://openalex.org/I1302211766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113515998","display_name":"Alan A. Seawright","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan A. Seawright","raw_affiliation_strings":["National Research Centre for Environmental Toxicology, 39 Kessels Road, Coopers Plains, Qld. 4108, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Centre for Environmental Toxicology, 39 Kessels Road, Coopers Plains, Qld. 4108, Australia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101882464","display_name":"Michael R. Moore","orcid":"https://orcid.org/0000-0003-2381-1853","observed_orcids":["https://orcid.org/0000-0003-2381-1853","https://orcid.org/0000-0001-7769-4694"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael R. Moore","raw_affiliation_strings":["National Research Centre for Environmental Toxicology, 39 Kessels Road, Coopers Plains, Qld. 4108, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Centre for Environmental Toxicology, 39 Kessels Road, Coopers Plains, Qld. 4108, Australia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5069042090"],"corresponding_institution_ids":[],"apc_list":{"value":4120,"currency":"USD","value_usd":4120},"apc_paid":null,"fwci":10.0459,"has_fulltext":false,"cited_by_count":156,"citation_normalized_percentile":{"value":0.99271782,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"151","last_page":"154"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10236","display_name":"Aquatic Ecosystems and Phytoplankton Dynamics","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10236","display_name":"Aquatic Ecosystems and Phytoplankton Dynamics","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11985","display_name":"Marine Toxins and Detection Methods","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12756","display_name":"Plant Toxicity and Pharmacological Properties","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cylindrospermopsin","display_name":"cylindrospermopsin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cylindrospermopsis-raciborskii","display_name":"Cylindrospermopsis raciborskii","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cyanobacteria","display_name":"cyanobacteria","score":0.7360000014305115},{"id":"https://openalex.org/keywords/cyanotoxins","display_name":"cyanotoxins","score":0.9229999780654907},{"id":"https://openalex.org/keywords/water-quality-monitoring","display_name":"water quality monitoring","score":0.7099999785423279},{"id":"https://openalex.org/keywords/algal-blooms","display_name":"algal blooms","score":0.7570000290870667},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.7429999709129333},{"id":"https://openalex.org/keywords/mouse-bioassay","display_name":"mouse bioassay","score":0.9539999961853027}],"concepts":[{"id":"https://openalex.org/C2779149278","wikidata":"https://www.wikidata.org/wiki/Q3008693","display_name":"Cylindrospermopsin","level":4,"score":0.974734902381897},{"id":"https://openalex.org/C2777559882","wikidata":"https://www.wikidata.org/wiki/Q5199329","display_name":"Cylindrospermopsis raciborskii","level":4,"score":0.8999147415161133},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7562971115112305},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.6207996606826782},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5854284763336182},{"id":"https://openalex.org/C2779669040","wikidata":"https://www.wikidata.org/wiki/Q93315","display_name":"Cyanobacteria","level":3,"score":0.5149710774421692},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.45837026834487915},{"id":"https://openalex.org/C2777646408","wikidata":"https://www.wikidata.org/wiki/Q412694","display_name":"Saxitoxin","level":3,"score":0.453504353761673},{"id":"https://openalex.org/C2775986502","wikidata":"https://www.wikidata.org/wiki/Q420466","display_name":"Ammonium formate","level":3,"score":0.42054498195648193},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.30715322494506836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17976626753807068},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09109869599342346},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1522-7278(199902)14:1<151::aid-tox19>3.0.co;2-d","doi":"https://doi.org/10.1002/(sici)1522-7278(199902)14:1<151::aid-tox19>3.0.co;2-d","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1522-7278(199902)14:1<151::aid-tox19>3.0.co;2-d","pdf_url":null,"source":{"id":"https://openalex.org/S172436580","display_name":"Environmental Toxicology","issn_l":"1520-4081","issn":["1520-4081","1522-7278"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Toxicology","raw_type":"journal-article"},{"id":"doi:10.1002/(sici)1522-7278(199902)14:1<151::aid-tox19>3.3.co;2-4","doi":"https://doi.org/10.1002/(sici)1522-7278(199902)14:1<151::aid-tox19>3.3.co;2-4","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1522-7278(199902)14:1<151::aid-tox19>3.3.co;2-4","pdf_url":null,"source":{"id":"https://openalex.org/S172436580","display_name":"Environmental Toxicology","issn_l":"1520-4081","issn":["1520-4081","1522-7278"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Toxicology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/6","score":0.7778000235557556,"display_name":"Clean water and sanitation"},{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1579087017","https://openalex.org/W1937806137","https://openalex.org/W1992870560","https://openalex.org/W2027820305","https://openalex.org/W2406038242","https://openalex.org/W2951339731","https://openalex.org/W2952301376"],"related_works":["https://openalex.org/W2354365572","https://openalex.org/W2082738276","https://openalex.org/W1959983894","https://openalex.org/W2092625576","https://openalex.org/W1967089793","https://openalex.org/W7056554708","https://openalex.org/W4287845847","https://openalex.org/W2059567198","https://openalex.org/W2159607065","https://openalex.org/W2010243979"],"abstract_inverted_index":{"Increasing":[0],"reports":[1],"of":[2,4,29,43,163,182],"blooms":[3],"the":[5,14,41,80,150,156],"blue\u2013green":[6],"alga":[7],"Cylindrospermopsis":[8],"raciborskii":[9],"(C.":[10],"raciborskii),":[11],"which":[12,65],"contains":[13],"hepatotoxic":[15],"alkaloid":[16],"cylindrospermopsin":[17],"(CYN),":[18],"have":[19,39],"led":[20],"to":[21,55,61,118,141,155,210],"public":[22,215],"health":[23,216],"concerns":[24],"in":[25,73,79,201,221],"Australia.":[26],"The":[27,98,136,147,218],"toxicology":[28],"CYN":[30,71],"appears":[31],"complex":[32],"and":[33,45,188,194,207],"is":[34,66,96,139,160,166,199,225],"still":[35],"being":[36],"elucidated.":[37],"We":[38],"utilized":[40,200],"combination":[42],"sensitivity":[44],"specificity":[46],"afforded":[47],"by":[48,85],"coupling":[49],"high":[50],"performance":[51],"liquid":[52],"chromatography":[53],"(HPLC)":[54],"a":[56,86,113,125,175],"tandem":[57],"mass":[58],"spectrometer":[59],"(MS/MS)":[60],"produce":[62],"an":[63,101],"assay":[64,165,198],"suitable":[67],"for":[68,133,214],"monitoring":[69],"low":[70],"concentrations":[72],"water":[74,81,212],"samples.":[75],"Intact":[76],"algal":[77,204],"cells":[78],"sample":[82],"are":[83],"lysed":[84],"freeze\u2013thaw":[87],"cycle.":[88],"After":[89],"filtration":[90],"(0.45":[91],"\u03bcm":[92],"filter),":[93],"110":[94],"\u03bcL":[95],"injected.":[97],"HPLC":[99],"uses":[100],"Altima":[102],"C18":[103],"(250\u00d74.6":[104],"mm,":[105],"5":[106,122,142],"\u03bcm)":[107],"column":[108],"at":[109,130,190],"40\u00b0C.":[110],"Chromatography":[111],"utilizes":[112],"linear":[114],"gradient":[115],"from":[116,149],"1":[117,134],"60%":[119,131],"methanol":[120,132],"over":[121],"min,":[123],"with":[124,144,203],"final":[126],"isocratic":[127],"stage":[128],"holding":[129],"min.":[135],"mobile":[137],"phase":[138],"buffered":[140],"mM":[143],"ammonium":[145],"acetate.":[146],"transition":[148],"M+H":[151],"ion":[152],"(416":[153],"m/z)":[154],"194":[157],"m/z":[158],"fragment":[159],"monitored.":[161],"Linearity":[162],"this":[164],"1\u2013600":[167],"\u03bcg/L":[168],"[peak":[169],"area=304\u00d7CYN":[170],"(\u03bcg/L)\u2212569;":[171],"r2=1.000":[172],"(n=7)].":[173],"Using":[174],"single":[176],"point":[177],"standard":[178],"curve,":[179],"total":[180],"coefficients":[181],"variation":[183],"were":[184],"26.4,":[185],"10.5,":[186],"12.6,":[187],"10.7%":[189],"0.78,":[191],"5.2,":[192],"104,":[193],"1040":[195],"\u03bcg/L.":[196],"This":[197],"conjunction":[202],"cell":[205],"counts":[206],"mouse":[208],"bioassays":[209],"monitor":[211],"bodies":[213],"purposes.":[217],"rationale":[219],"used":[220],"employing":[222],"these":[223],"methods":[224],"discussed.":[226],"\u00a91999":[227],"John":[228],"Wiley":[229],"&":[230],"Sons,":[231],"Inc.":[232],"Environ":[233],"Toxicol":[234],"14:":[235],"151\u2013154,":[236],"1999":[237]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}