{"id":"https://openalex.org/W2004263490","doi":"https://doi.org/10.2220/biomedres.34.231","title":"Neurotrophin-3 influences the number and the laminar fate of cortical progenitors in the developing cerebral cortex of mice through the MEK/ERK1/2 signaling pathway","display_name":"Neurotrophin-3 influences the number and the laminar fate of cortical progenitors in the developing cerebral cortex of mice through the MEK/ERK1/2 signaling pathway","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2004263490","doi":"https://doi.org/10.2220/biomedres.34.231","mag":"2004263490","pmid":"https://pubmed.ncbi.nlm.nih.gov/24190235"},"language":"en","primary_location":{"id":"doi:10.2220/biomedres.34.231","doi":"https://doi.org/10.2220/biomedres.34.231","is_oa":true,"landing_page_url":"https://doi.org/10.2220/biomedres.34.231","pdf_url":"https://www.jstage.jst.go.jp/article/biomedres/34/5/34_231/_pdf","source":{"id":"https://openalex.org/S4210239922","display_name":"Biomedical Research","issn_l":"0388-6107","issn":["0388-6107","1880-313X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315810","host_organization_name":"Allied Academies","host_organization_lineage":["https://openalex.org/P4310315810","https://openalex.org/P4310320466"],"host_organization_lineage_names":["Allied Academies","OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/biomedres/34/5/34_231/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058415503","display_name":"Masanari Ohtsuka","orcid":"https://orcid.org/0000-0002-7083-9325","observed_orcids":["https://orcid.org/0000-0002-7083-9325"]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masanari OHTSUKA","raw_affiliation_strings":["Laboratory of Molecular Biology, Department of Biofunctional Analysis, Gifu Pharmaceutical University, Daigakunishi 1-25-4, Gifu 501-1196, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, Department of Biofunctional Analysis, Gifu Pharmaceutical University, Daigakunishi 1-25-4, Gifu 501-1196, Japan","institution_ids":["https://openalex.org/I173865709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062025693","display_name":"Hitomi Soumiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitomi SOUMIYA","raw_affiliation_strings":["Laboratory of Molecular Biology, Department of Biofunctional Analysis, Gifu Pharmaceutical University, Daigakunishi 1-25-4, Gifu 501-1196, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, Department of Biofunctional Analysis, Gifu Pharmaceutical University, Daigakunishi 1-25-4, Gifu 501-1196, Japan","institution_ids":["https://openalex.org/I173865709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070071984","display_name":"Masami Hanai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masami HANAI","raw_affiliation_strings":["Laboratory of Molecular Biology, Department of Biofunctional Analysis, Gifu Pharmaceutical University, Daigakunishi 1-25-4, Gifu 501-1196, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, Department of Biofunctional Analysis, Gifu Pharmaceutical University, Daigakunishi 1-25-4, Gifu 501-1196, Japan","institution_ids":["https://openalex.org/I173865709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102076023","display_name":"Shoei Furukawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shoei FURUKAWA","raw_affiliation_strings":["Laboratory of Molecular Biology, Department of Biofunctional Analysis, Gifu Pharmaceutical University, Daigakunishi 1-25-4, Gifu 501-1196, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, Department of Biofunctional Analysis, Gifu Pharmaceutical University, Daigakunishi 1-25-4, Gifu 501-1196, Japan","institution_ids":["https://openalex.org/I173865709"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026505592","display_name":"Hidefumi Fukumitsu","orcid":"https://orcid.org/0000-0002-9279-9344","observed_orcids":["https://orcid.org/0000-0002-9279-9344"]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidefumi FUKUMITSU","raw_affiliation_strings":["Laboratory of Molecular Biology, Department of Biofunctional Analysis, Gifu Pharmaceutical University, Daigakunishi 1-25-4, Gifu 501-1196, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, Department of Biofunctional Analysis, Gifu Pharmaceutical University, Daigakunishi 1-25-4, Gifu 501-1196, Japan","institution_ids":["https://openalex.org/I173865709"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I173865709"],"apc_list":null,"apc_paid":null,"fwci":0.3653,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.47846284,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"34","issue":"5","first_page":"231","last_page":"239"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurotrophin-3","display_name":"neurotrophin-3","score":1.0},{"id":"https://openalex.org/keywords/cortical-progenitors","display_name":"cortical progenitors","score":0.6850000023841858},{"id":"https://openalex.org/keywords/cortical-development","display_name":"cortical development","score":0.6769999861717224},{"id":"https://openalex.org/keywords/cortical-lamination","display_name":"cortical lamination","score":0.8610000014305115},{"id":"https://openalex.org/keywords/mek-erk-signaling","display_name":"MEK/ERK signaling","score":0.8360000252723694},{"id":"https://openalex.org/keywords/neuronal-fate-specification","display_name":"neuronal fate specification","score":0.6759999990463257},{"id":"https://openalex.org/keywords/cell-cycle-phase-dependence","display_name":"cell cycle phase dependence","score":0.621999979019165},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.6678518652915955},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6105026602745056},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.540858268737793},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5314886569976807},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5255414843559265},{"id":"https://openalex.org/C2779456298","wikidata":"https://www.wikidata.org/wiki/Q14904569","display_name":"Neurotrophin-3","level":5,"score":0.506885826587677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48551177978515625},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.4370042383670807},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.42969459295272827},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4101373553276062},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3756789565086365},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34626513719558716},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2715544104576111},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.14626413583755493},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.12726300954818726},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10313865542411804},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.10060402750968933}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020933","descriptor_name":"Neurotrophin 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020933","descriptor_name":"Neurotrophin 3","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056742","descriptor_name":"Cyclin D2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056742","descriptor_name":"Cyclin D2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2220/biomedres.34.231","doi":"https://doi.org/10.2220/biomedres.34.231","is_oa":true,"landing_page_url":"https://doi.org/10.2220/biomedres.34.231","pdf_url":"https://www.jstage.jst.go.jp/article/biomedres/34/5/34_231/_pdf","source":{"id":"https://openalex.org/S4210239922","display_name":"Biomedical Research","issn_l":"0388-6107","issn":["0388-6107","1880-313X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315810","host_organization_name":"Allied Academies","host_organization_lineage":["https://openalex.org/P4310315810","https://openalex.org/P4310320466"],"host_organization_lineage_names":["Allied Academies","OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Research","raw_type":"journal-article"},{"id":"pmid:24190235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24190235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical research (Tokyo, Japan)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2220/biomedres.34.231","doi":"https://doi.org/10.2220/biomedres.34.231","is_oa":true,"landing_page_url":"https://doi.org/10.2220/biomedres.34.231","pdf_url":"https://www.jstage.jst.go.jp/article/biomedres/34/5/34_231/_pdf","source":{"id":"https://openalex.org/S4210239922","display_name":"Biomedical Research","issn_l":"0388-6107","issn":["0388-6107","1880-313X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315810","host_organization_name":"Allied Academies","host_organization_lineage":["https://openalex.org/P4310315810","https://openalex.org/P4310320466"],"host_organization_lineage_names":["Allied Academies","OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004263490.pdf","grobid_xml":"https://content.openalex.org/works/W2004263490.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W590680870","https://openalex.org/W1582081614","https://openalex.org/W1655701149","https://openalex.org/W1965888884","https://openalex.org/W1970323747","https://openalex.org/W1970617579","https://openalex.org/W1979060895","https://openalex.org/W1979952856","https://openalex.org/W1981164058","https://openalex.org/W1983833034","https://openalex.org/W1986166279","https://openalex.org/W2010852678","https://openalex.org/W2022274052","https://openalex.org/W2029245198","https://openalex.org/W2036624970","https://openalex.org/W2053911175","https://openalex.org/W2055532903","https://openalex.org/W2055564874","https://openalex.org/W2055594404","https://openalex.org/W2062657417","https://openalex.org/W2084577485","https://openalex.org/W2093551793","https://openalex.org/W2112055300","https://openalex.org/W2116476971","https://openalex.org/W2128401351","https://openalex.org/W2137801136","https://openalex.org/W2148212562","https://openalex.org/W2154165535","https://openalex.org/W2157862682","https://openalex.org/W2162015825","https://openalex.org/W2164846750","https://openalex.org/W2165890492"],"related_works":["https://openalex.org/W2055594404","https://openalex.org/W2168815409","https://openalex.org/W2027880294","https://openalex.org/W1965888884","https://openalex.org/W2150477061","https://openalex.org/W2055564874","https://openalex.org/W6992952226","https://openalex.org/W2106488802","https://openalex.org/W2322811845","https://openalex.org/W1527229950"],"abstract_inverted_index":{"The":[0,78],"laminar":[1,116,152],"formation":[2,153],"in":[3,22,32,54,92,105,110,123,150],"the":[4,27,33,43,51,55,58,62,84,93,98,106,115,124,132,140,151,155,160],"developing":[5,156],"cerebral":[6,157],"cortex":[7,158],"requires":[8],"precisely":[9],"regulated":[10],"generation":[11],"of":[12,29,45,128,154],"phenotype-specific":[13],"neurons.":[14,77],"To":[15],"determine":[16],"whether":[17],"neurotrophin-3":[18],"(NT3)":[19],"is":[20,148],"involved":[21,149],"this":[23],"formation,":[24],"we":[25],"investigated":[26],"effects":[28,80,100],"NT3":[30,41,91,120,133,147],"administration":[31],"telencephalic":[34],"ventricular":[35],"space":[36],"on":[37],"13.5-day-old":[38],"mouse":[39],"embryos.":[40],"increased":[42],"number":[44],"newly":[46],"generated":[47],"neurons":[48,70],"and":[49,57,131],"altered":[50,72],"neuronal":[52,63],"phenotypes":[53,64],"position":[56],"transcription":[59],"factors-expression":[60],"profiles;":[61],"originally":[65],"committed":[66],"for":[67,74],"layer":[68],"IV":[69],"were":[71,81,88,101,135],"toward":[73],"layers":[75],"II/III":[76],"former":[79],"observed":[82,102,122],"when":[83],"parent":[85],"progenitor":[86],"cells":[87],"exposed":[89],"to":[90,95],"G1-":[94],"S-phase,":[96],"whereas":[97],"latter":[99],"with":[103,139],"exposure":[104],"G1-phase.":[107],"In":[108],"addition,":[109],"vitro":[111],"experiments":[112],"revealed":[113],"that":[114,146],"fate":[117],"alteration":[118],"by":[119,137],"was":[121],"dissociated":[125],"primary":[126],"culture":[127],"cortical":[129],"progenitors":[130],"actions":[134],"suppressed":[136],"cotreatment":[138],"MEK/ERK":[141,162],"inhibitor.":[142],"These":[143],"observations":[144],"suggest":[145],"through":[159],"intercellular":[161],"pathway.":[163]},"counts_by_year":[{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
