{"id":"https://openalex.org/W2004252300","doi":"https://doi.org/10.1371/journal.pone.0000138","title":"NMDA and Dopamine Converge on the NMDA-Receptor to Induce ERK Activation and Synaptic Depression in Mature Hippocampus","display_name":"NMDA and Dopamine Converge on the NMDA-Receptor to Induce ERK Activation and Synaptic Depression in Mature Hippocampus","publication_year":2006,"publication_date":"2006-12-27","ids":{"openalex":"https://openalex.org/W2004252300","doi":"https://doi.org/10.1371/journal.pone.0000138","mag":"2004252300","pmid":"https://pubmed.ncbi.nlm.nih.gov/17205142","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1762427"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0000138","doi":"https://doi.org/10.1371/journal.pone.0000138","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0000138","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000138&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000138&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040458740","display_name":"Hanoch Kaphzan","orcid":"https://orcid.org/0000-0003-4935-358X","observed_orcids":["https://orcid.org/0000-0003-4935-358X"]},"institutions":[{"id":"https://openalex.org/I91203450","display_name":"University of Haifa","ror":"https://ror.org/02f009v59","country_code":"IL","type":"education","lineage":["https://openalex.org/I91203450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Hanoch Kaphzan","raw_affiliation_strings":["Center for Brain and Behavior, Department of Neurobiology and Ethology, Haifa University, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Brain and Behavior, Department of Neurobiology and Ethology, Haifa University, Haifa, Israel","institution_ids":["https://openalex.org/I91203450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049784451","display_name":"Kenneth J. O\u2019Riordan","orcid":"https://orcid.org/0000-0003-0081-6010","observed_orcids":["https://orcid.org/0000-0003-0081-6010"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth J. O'Riordan","raw_affiliation_strings":["Department of Pharmacology and the Waisman Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and the Waisman Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080077524","display_name":"Kile P. Mangan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kile P. Mangan","raw_affiliation_strings":["Department of Pharmacology and the Waisman Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and the Waisman Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091803592","display_name":"Jonathan M. Levenson","orcid":"https://orcid.org/0009-0001-4209-0003","observed_orcids":["https://orcid.org/0009-0001-4209-0003"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan M. Levenson","raw_affiliation_strings":["Department of Pharmacology and the Waisman Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and the Waisman Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002209886","display_name":"Kobi Rosenblum","orcid":"https://orcid.org/0000-0003-4827-0336","observed_orcids":["https://orcid.org/0000-0003-4827-0336"]},"institutions":[{"id":"https://openalex.org/I91203450","display_name":"University of Haifa","ror":"https://ror.org/02f009v59","country_code":"IL","type":"education","lineage":["https://openalex.org/I91203450"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Kobi Rosenblum","raw_affiliation_strings":["Center for Brain and Behavior, Department of Neurobiology and Ethology, Haifa University, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Brain and Behavior, Department of Neurobiology and Ethology, Haifa University, Haifa, Israel","institution_ids":["https://openalex.org/I91203450"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002209886"],"corresponding_institution_ids":["https://openalex.org/I91203450"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.5807,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.57998753,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"1","issue":"1","first_page":"e138","last_page":"e138"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.9850000143051147},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.984000027179718},{"id":"https://openalex.org/keywords/erk2-activation","display_name":"ERK2 activation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/synaptic-depression","display_name":"synaptic depression","score":0.7860000133514404},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.6970000267028809},{"id":"https://openalex.org/keywords/signal-convergence","display_name":"signal convergence","score":0.5600000023841858},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.7239999771118164},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.7889999747276306},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.9810000061988831},{"id":"https://openalex.org/keywords/hippocampal-ca1","display_name":"hippocampal CA1","score":0.902999997138977},{"id":"https://openalex.org/keywords/short-term-synaptic-depression","display_name":"short-term synaptic depression","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.8048812747001648},{"id":"https://openalex.org/C125667969","wikidata":"https://www.wikidata.org/wiki/Q7662036","display_name":"Synaptic fatigue","level":4,"score":0.7995458841323853},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7402255535125732},{"id":"https://openalex.org/C95293801","wikidata":"https://www.wikidata.org/wiki/Q7662035","display_name":"Synaptic augmentation","level":4,"score":0.7025942206382751},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.6939806938171387},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.593002438545227},{"id":"https://openalex.org/C194973443","wikidata":"https://www.wikidata.org/wiki/Q1420291","display_name":"Metaplasticity","level":4,"score":0.5174204111099243},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5151142477989197},{"id":"https://openalex.org/C117718741","wikidata":"https://www.wikidata.org/wiki/Q7662041","display_name":"Synaptic scaling","level":5,"score":0.4521019458770752},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4045320451259613},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36253559589385986},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.21364286541938782},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.19294145703315735},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18347030878067017},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07345464825630188}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013574","descriptor_name":"Synaptosomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013574","descriptor_name":"Synaptosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016202","descriptor_name":"N-Methylaspartate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016202","descriptor_name":"N-Methylaspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018091","descriptor_name":"Receptors, AMPA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D036881","descriptor_name":"Long-Term Synaptic Depression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D036881","descriptor_name":"Long-Term Synaptic Depression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pone.0000138","doi":"https://doi.org/10.1371/journal.pone.0000138","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0000138","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000138&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmid:17205142","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17205142","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.279.4014","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.279.4014","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/d6/d1/PLoS_ONE_2006_Dec_27_1(1)_e138.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:7ddcc87e95bb4cc9885c1976ab1cbd4d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7ddcc87e95bb4cc9885c1976ab1cbd4d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 1, p e138 (2006)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0000138","doi":"https://doi.org/10.1371/journal.pone.0000138","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0000138","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000138&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004252300.pdf","grobid_xml":"https://content.openalex.org/works/W2004252300.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1481369757","https://openalex.org/W1499993606","https://openalex.org/W1501143146","https://openalex.org/W1502426712","https://openalex.org/W1557933310","https://openalex.org/W1600539804","https://openalex.org/W1638203569","https://openalex.org/W1639247045","https://openalex.org/W1738144688","https://openalex.org/W1917554980","https://openalex.org/W1937172266","https://openalex.org/W1965901533","https://openalex.org/W1966994444","https://openalex.org/W1972107254","https://openalex.org/W1982771150","https://openalex.org/W1992995828","https://openalex.org/W1998763917","https://openalex.org/W2000965799","https://openalex.org/W2002457970","https://openalex.org/W2008639041","https://openalex.org/W2011007863","https://openalex.org/W2014408809","https://openalex.org/W2014474720","https://openalex.org/W2015592781","https://openalex.org/W2018780716","https://openalex.org/W2020440721","https://openalex.org/W2020969390","https://openalex.org/W2021485981","https://openalex.org/W2025643269","https://openalex.org/W2027436298","https://openalex.org/W2032596004","https://openalex.org/W2040163150","https://openalex.org/W2048356861","https://openalex.org/W2051716212","https://openalex.org/W2061570824","https://openalex.org/W2066113723","https://openalex.org/W2067098350","https://openalex.org/W2069705491","https://openalex.org/W2074650516","https://openalex.org/W2079439105","https://openalex.org/W2084838390","https://openalex.org/W2089664068","https://openalex.org/W2091597912","https://openalex.org/W2094019443","https://openalex.org/W2097872145","https://openalex.org/W2099621465","https://openalex.org/W2100193366","https://openalex.org/W2102787234","https://openalex.org/W2105350975","https://openalex.org/W2114842668","https://openalex.org/W2116949619","https://openalex.org/W2118469169","https://openalex.org/W2118977349","https://openalex.org/W2121220832","https://openalex.org/W2125858639","https://openalex.org/W2132189283","https://openalex.org/W2136497405","https://openalex.org/W2151331628","https://openalex.org/W2155701751","https://openalex.org/W2158929612","https://openalex.org/W2159891593","https://openalex.org/W2160398371","https://openalex.org/W2167707401","https://openalex.org/W2169294911","https://openalex.org/W2172060122","https://openalex.org/W2289014892","https://openalex.org/W2411926328","https://openalex.org/W2425949837","https://openalex.org/W2436697492"],"related_works":["https://openalex.org/W2088347830","https://openalex.org/W1554441317","https://openalex.org/W7100807515","https://openalex.org/W1665668081","https://openalex.org/W2120235333","https://openalex.org/W184331644","https://openalex.org/W2143199515","https://openalex.org/W1548268562","https://openalex.org/W1965901533","https://openalex.org/W1991437921"],"abstract_inverted_index":{"The":[0,22,32],"formation":[1],"of":[2,6,18,37,75,89,104,143,159],"enduring":[3],"internal":[4],"representation":[5],"sensory":[7,26],"information":[8],"demands,":[9],"in":[10,14,72,96,106,164],"many":[11],"cases,":[12],"convergence":[13,145],"time":[15],"and":[16,52,57,78,92,101,113,129,157,161,174],"space":[17],"two":[19],"different":[20],"stimuli.":[21],"first":[23],"conveys":[24,34],"the":[25,35,38,49,64,97,147,165],"input,":[27,39],"mediated":[28,43],"via":[29,44],"fast":[30,55,112,160],"neurotransmission.":[31,46],"second":[33],"meaning":[36],"hypothesized":[40],"to":[41,61],"be":[42],"slow":[45,58,114,162],"We":[47,85],"tested":[48],"biochemical":[50],"conditions":[51],"feasibility":[53],"for":[54,99],"(NMDA)":[56],"(dopamine)":[59],"neurotransmission":[60,163],"converge":[62,120],"on":[63,121,125],"Mitogen":[65],"Activated":[66],"Protein":[67],"Kinase":[68],"signaling":[69],"pathways,":[70],"crucial":[71],"several":[73],"forms":[74],"synaptic":[76,83,93,133,175],"plasticity,":[77],"recorded":[79],"its":[80],"effects":[81],"upon":[82],"transmission.":[84],"detected":[86],"differing":[87],"kinetics":[88],"ERK2":[90,172],"activation":[91,173],"strength":[94],"changes":[95],"CA1":[98],"low":[100],"high":[102],"doses":[103],"neurotransmitters":[105],"hippocampal":[107],"slices.":[108],"Moreover,":[109],"when":[110],"weak":[111],"inputs":[115],"are":[116],"given":[117],"together,":[118],"they":[119],"ERK2,":[122],"but":[123],"not":[124],"p38":[126],"or":[127],"JNK,":[128],"induce":[130],"strong":[131],"short-term":[132],"depression.":[134],"Surprisingly,":[135],"pharmacological":[136],"analysis":[137],"revealed":[138,170],"that":[139],"a":[140,155],"probable":[141],"site":[142],"such":[144],"is":[146],"NMDA":[148],"receptor":[149],"itself,":[150],"suggesting":[151],"it":[152],"serves":[153],"as":[154,169],"detector":[156],"integrator":[158],"mature":[166],"mammalian":[167],"brain,":[168],"by":[171],"function.":[176]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}