{"id":"https://openalex.org/W2004249948","doi":"https://doi.org/10.1016/0026-0495(93)90076-z","title":"Protein turnover in advanced lung cancer patients","display_name":"Protein turnover in advanced lung cancer patients","publication_year":1993,"publication_date":"1993-03-01","ids":{"openalex":"https://openalex.org/W2004249948","doi":"https://doi.org/10.1016/0026-0495(93)90076-z","mag":"2004249948","pmid":"https://pubmed.ncbi.nlm.nih.gov/8487646"},"language":"en","primary_location":{"id":"doi:10.1016/0026-0495(93)90076-z","doi":"https://doi.org/10.1016/0026-0495(93)90076-z","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0026-0495(93)90076-z","pdf_url":null,"source":{"id":"https://openalex.org/S119661813","display_name":"Metabolism","issn_l":"0026-0495","issn":["0026-0495","1532-8600"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018058624","display_name":"Ernest W. Richards","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ernest W. Richards","raw_affiliation_strings":["Department of Research, Baptist Medical Centers, Birmingham, AL 35211"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, Baptist Medical Centers, Birmingham, AL 35211","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110074278","display_name":"Calvin L. Long","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Calvin L. Long","raw_affiliation_strings":["Department of Research, The Baptist Medical Centers, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, The Baptist Medical Centers, Birmingham, AL, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113798378","display_name":"Karl M. Nelson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karl M. Nelson","raw_affiliation_strings":["Department of Research, The Baptist Medical Centers, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, The Baptist Medical Centers, Birmingham, AL, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029212348","display_name":"Ocilia K. Tohver","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ocilia K. Tohver","raw_affiliation_strings":["Department of Research, The Baptist Medical Centers, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, The Baptist Medical Centers, Birmingham, AL, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037862854","display_name":"John Alexander Pinkston","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John A. Pinkston","raw_affiliation_strings":["Department of Research, The Baptist Medical Centers, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, The Baptist Medical Centers, Birmingham, AL, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076594436","display_name":"Rudolph M. Navari","orcid":"https://orcid.org/0000-0002-8513-896X","observed_orcids":["https://orcid.org/0000-0002-8513-896X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rudolph M. Navari","raw_affiliation_strings":["Department of Research, The Baptist Medical Centers, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, The Baptist Medical Centers, Birmingham, AL, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108594495","display_name":"William S. Blakemore","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William S. Blakemore","raw_affiliation_strings":["Department of Research, The Baptist Medical Centers, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, The Baptist Medical Centers, Birmingham, AL, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110074278"],"corresponding_institution_ids":[],"apc_list":{"value":5340,"currency":"USD","value_usd":5340},"apc_paid":null,"fwci":0.4063,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.57064085,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"42","issue":"3","first_page":"291","last_page":"296"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.8330000042915344,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.8330000042915344,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.13779999315738678,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.021900000050663948,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/whole-body-protein-turnover","display_name":"whole-body protein turnover","score":0.8700000047683716},{"id":"https://openalex.org/keywords/advanced-lung-cancer","display_name":"advanced lung cancer","score":0.7379999756813049},{"id":"https://openalex.org/keywords/cancer-cachexia","display_name":"cancer cachexia","score":0.7770000100135803},{"id":"https://openalex.org/keywords/lean-body-mass","display_name":"lean body mass","score":0.7940000295639038},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/urinary-nitrogen-excretion","display_name":"urinary nitrogen excretion","score":0.8220000267028809},{"id":"https://openalex.org/keywords/resting-metabolic-rate","display_name":"resting metabolic rate","score":0.7820000052452087},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C195580219","wikidata":"https://www.wikidata.org/wiki/Q7251511","display_name":"Protein turnover","level":3,"score":0.736793577671051},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6498757600784302},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5411081314086914},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4481351971626282},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42973899841308594},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3915093243122101},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38104772567749023},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3577888309955597},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2586338520050049},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.1883394420146942},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14925351738929749}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001806","descriptor_name":"Blood Urea Nitrogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002151","descriptor_name":"Calorimetry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0026-0495(93)90076-z","doi":"https://doi.org/10.1016/0026-0495(93)90076-z","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0026-0495(93)90076-z","pdf_url":null,"source":{"id":"https://openalex.org/S119661813","display_name":"Metabolism","issn_l":"0026-0495","issn":["0026-0495","1532-8600"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolism","raw_type":"journal-article"},{"id":"pmid:8487646","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8487646","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolism: clinical and experimental","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G8147307454","display_name":"ENERGY, PROTEIN METABOLISM, AND CANCER CACHEXIA","funder_award_id":"R01CA042972","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W124000308","https://openalex.org/W1520207718","https://openalex.org/W1532267411","https://openalex.org/W1538762462","https://openalex.org/W1991757616","https://openalex.org/W2011311205","https://openalex.org/W2013051460","https://openalex.org/W2014613747","https://openalex.org/W2014867066","https://openalex.org/W2016326720","https://openalex.org/W2025676248","https://openalex.org/W2034703675","https://openalex.org/W2040509429","https://openalex.org/W2046652195","https://openalex.org/W2048731982","https://openalex.org/W2068008235","https://openalex.org/W2069550949","https://openalex.org/W2074707768","https://openalex.org/W2080120165","https://openalex.org/W2081862925","https://openalex.org/W2087224771","https://openalex.org/W2089332254","https://openalex.org/W2092269844","https://openalex.org/W2093084887","https://openalex.org/W2101569857","https://openalex.org/W2166297867","https://openalex.org/W2170775996","https://openalex.org/W2258054138","https://openalex.org/W2321735528","https://openalex.org/W2406231556","https://openalex.org/W2413635027","https://openalex.org/W2417338145","https://openalex.org/W2550248021","https://openalex.org/W3023055056","https://openalex.org/W4234542203","https://openalex.org/W4294570588","https://openalex.org/W4302557728"],"related_works":["https://openalex.org/W1532267411","https://openalex.org/W2166297867","https://openalex.org/W2054363076","https://openalex.org/W2170775996","https://openalex.org/W2279880151","https://openalex.org/W2040509429","https://openalex.org/W2400304431","https://openalex.org/W2276424286","https://openalex.org/W2111690029","https://openalex.org/W2061972055"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}