{"id":"https://openalex.org/W2004248345","doi":"https://doi.org/10.1016/j.jalz.2012.05.872","title":"P2\u2010166: Cognitive status, APOE\u2010\u03b54 status and risk of death: A report from the Einstein Aging Study (EAS)","display_name":"P2\u2010166: Cognitive status, APOE\u2010\u03b54 status and risk of death: A report from the Einstein Aging Study (EAS)","publication_year":2012,"publication_date":"2012-07-01","ids":{"openalex":"https://openalex.org/W2004248345","doi":"https://doi.org/10.1016/j.jalz.2012.05.872","mag":"2004248345"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2012.05.872","doi":"https://doi.org/10.1016/j.jalz.2012.05.872","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2012.05.872","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040281324","display_name":"Carol A. Derby","orcid":"https://orcid.org/0000-0002-5657-4519","observed_orcids":["https://orcid.org/0000-0002-5657-4519"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol Derby","raw_affiliation_strings":["Albert Einstein College of Medicine Bronx New York United States","Albert Einstein Coll of Medicine, Bronx, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine Bronx New York United States","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Albert Einstein Coll of Medicine, Bronx, New York, United States","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108463869","display_name":"Mindy Joy Katz","orcid":"https://orcid.org/0009-0004-7524-0292","observed_orcids":["https://orcid.org/0009-0004-7524-0292"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mindy Katz","raw_affiliation_strings":["Albert Einstein College of Medicine Bronx New York United States","Albert Einstein Coll of Medicine, Bronx, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine Bronx New York United States","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Albert Einstein Coll of Medicine, Bronx, New York, United States","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006028447","display_name":"Cuiling Wang","orcid":"https://orcid.org/0000-0002-7557-6982","observed_orcids":["https://orcid.org/0000-0002-7557-6982"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cuiling Wang","raw_affiliation_strings":["Albert Einstein College of Medicine Bronx New York United States","Albert Einstein Coll of Medicine, Bronx, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine Bronx New York United States","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Albert Einstein Coll of Medicine, Bronx, New York, United States","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040538097","display_name":"Charles B. Hall","orcid":"https://orcid.org/0000-0001-9982-8120","observed_orcids":["https://orcid.org/0000-0001-9982-8120"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Hall","raw_affiliation_strings":["Albert Einstein College of Medicine Bronx New York United States","Albert Einstein Coll of Medicine, Bronx, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine Bronx New York United States","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Albert Einstein Coll of Medicine, Bronx, New York, United States","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058565083","display_name":"Molly E. Zimmerman","orcid":"https://orcid.org/0000-0002-8071-5369","observed_orcids":["https://orcid.org/0000-0002-8071-5369"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Molly Zimmerman","raw_affiliation_strings":["Albert Einstein College of Medicine Bronx New York United States","Albert Einstein Coll of Medicine, Bronx, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine Bronx New York United States","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Albert Einstein Coll of Medicine, Bronx, New York, United States","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060242044","display_name":"Joe Verghese","orcid":"https://orcid.org/0000-0003-4252-2547","observed_orcids":["https://orcid.org/0000-0003-4252-2547"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joe Verghese","raw_affiliation_strings":["Albert Einstein College of Medicine Bronx New York United States","Albert Einstein Coll of Medicine, Bronx, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine Bronx New York United States","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Albert Einstein Coll of Medicine, Bronx, New York, United States","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101988389","display_name":"Amy E. Sanders","orcid":"https://orcid.org/0000-0002-0164-0208","observed_orcids":["https://orcid.org/0000-0002-0164-0208"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Sanders","raw_affiliation_strings":["Albert Einstein College of Medicine Bronx New York United States","Albert Einstein Coll of Medicine, Bronx, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine Bronx New York United States","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Albert Einstein Coll of Medicine, Bronx, New York, United States","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000448269","display_name":"Richard B. Lipton","orcid":"https://orcid.org/0000-0003-2652-2897","observed_orcids":["https://orcid.org/0000-0003-2652-2897"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Lipton","raw_affiliation_strings":["Albert Einstein College of Medicine Bronx New York United States","Albert Einstein Coll of Medicine, Bronx, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine Bronx New York United States","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Albert Einstein Coll of Medicine, Bronx, New York, United States","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12928202,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"4S_Part_9","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11265","display_name":"Aging and Gerontology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3206","display_name":"Neuropsychology and Physiological Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.8370000123977661},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.902999997138977}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7681180238723755},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6673731803894043},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6641628742218018},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.632831871509552},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.6036507487297058},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5098413825035095},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.4910604953765869},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.44898727536201477},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.41567254066467285},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.411480575799942},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3440152704715729},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2264707386493683},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.11557662487030029},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.061913639307022095},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2012.05.872","doi":"https://doi.org/10.1016/j.jalz.2012.05.872","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2012.05.872","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1966860490","https://openalex.org/W2059445879","https://openalex.org/W2049481883","https://openalex.org/W4399163797","https://openalex.org/W4210382737","https://openalex.org/W1980929918","https://openalex.org/W1578076680","https://openalex.org/W2563558448","https://openalex.org/W4386692152","https://openalex.org/W2036037082"],"abstract_inverted_index":{"Individuals":[0],"with":[1,16,139,143,150,227,254],"dementia":[2,228,278],"have":[3],"higher":[4,249,294,306,323],"mortality":[5,45,179,211,272],"rates":[6,13],"than":[7],"older":[8],"adults":[9],"without":[10],"dementia.":[11],"Mortality":[12],"in":[14,58,86,93,213],"individuals":[15,56],"Mild":[17],"Cognitive":[18],"Impairment":[19],"(MCI)":[20],"are":[21],"largely":[22],"unknown":[23],"and":[24,73,84,104,108,147,155,173,196,237,279,305],"may":[25],"be":[26],"influenced":[27],"by":[28],"APOE-4":[29,49,76,283],"status.":[30,50,77,199],"The":[31,97,164,210,269],"goal":[32],"of":[33,41,111,166,178,251,271,282,308,325],"this":[34,214],"study":[35],"was":[36,99,180,216,273],"to":[37,160,220,322],"examine":[38],"the":[39,59,94,176,203,208],"relation":[40],"cognition":[42],"on":[43,54,75,175],"all-cause":[44],"taking":[46],"into":[47],"account":[48],"Analyses":[51],"were":[52,81,137,157,223,256,319],"based":[53],"728":[55],"enrolled":[57],"EAS,":[60],"who":[61,222],"had":[62,247],"at":[63,128],"least":[64],"one":[65],"annual":[66],"follow-up":[67],"visit":[68],"(median":[69],"f/u":[70],"=":[71,115,118,122,130,230,235,240,245,261,264,267,286,289,292,297,300,303,311,314,317],"4.9yrs.)":[72],"information":[74],"At":[78,134],"baseline,":[79,135],"participants":[80],"aged":[82],"70+":[83],"resided":[85],"Bronx,":[87],"NY,":[88],"a":[89],"racially/ethnically":[90],"diverse":[91],"county":[92],"United":[95],"States.":[96],"cohort":[98],"systematically":[100],"recruited":[101],"from":[102],"Medicare":[103],"Registered":[105],"Voter":[106],"lists":[107],"is":[109],"representative":[110],"Bronx":[112],"demographics:":[113],"female":[114],"60.4%;":[116],"blacks":[117],"26.6%;":[119],"mean":[120,126],"education":[121],"13.5":[123],"years":[124],"[3.5];":[125],"age":[127],"enrollment":[129,191],"78.8":[131],"[5.3]":[132],"years.":[133],"there":[136],"76(10.4%)":[138],"dementia,":[140],"65":[141],"(8.9%)":[142],"amnestic":[144],"MCI":[145,152],"(aMCI),":[146],"24":[148],"(3.4%)":[149],"nonamnestic":[151],"(naMCI).":[153],"aMCI":[154,238],"naMCI":[156,172,255],"diagnosed":[158],"according":[159],"updated":[161],"Petersen":[162],"criteria.":[163],"effect":[165],"baseline":[167],"cognitive":[168,198],"status":[169],"(dementia,":[170],"aMCI,":[171],"normal)":[174],"risk":[177,270,324],"examined":[181],"using":[182],"Cox":[183],"proportional":[184],"hazards'":[185],"models,":[186],"adjusting":[187],"for":[188],"APOE-4,":[189],"gender,":[190],"age,":[192],"education,":[193],"co-morbidities,":[194],"depression,":[195],"global":[197],"Hazard":[200],"ratios":[201],"used":[202],"cognitively":[204,224],"normal":[205],"group":[206],"as":[207],"reference.":[209],"rate":[212],"sample":[215],"59/1000":[217],"py.":[218],"Compared":[219],"those":[221,253],"normal,":[225],"subjects":[226],"(HR":[229,239,260,285,296,310],"2.51,":[231],"CI":[232,242,263,288,299,313],"1.21-5.18,":[233],"P":[234,244,266,291,302,316],"0.01)":[236],"2.09,":[241],"1.42-3.07,":[243],"0.0002)":[246],"significantly":[248,258,275],"risks":[250],"mortality;":[252],"not":[257,274],"different":[259,276],"0.95,":[262],"0.58-1.66,":[265],"0.98).":[268],"between":[277],"aMCI.":[280],"Presence":[281],"allele":[284],"2.01,":[287],"1.13-3.56,":[290],"0.02),":[293],"co-morbidities":[295],"1.35,":[298],"1.15-1.53,":[301],"0.0001),":[304],"degree":[307],"depression":[309],"1.10,":[312],"1.04-1.16,":[315],"0.001)":[318],"also":[320],"related":[321],"mortality.":[326]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}