{"id":"https://openalex.org/W2004239258","doi":"https://doi.org/10.1046/j.1529-8817.2004.00090.x","title":"The Sib TDT Adjusted For Age Of Disease Onset","display_name":"The Sib TDT Adjusted For Age Of Disease Onset","publication_year":2004,"publication_date":"2004-05-01","ids":{"openalex":"https://openalex.org/W2004239258","doi":"https://doi.org/10.1046/j.1529-8817.2004.00090.x","mag":"2004239258","pmid":"https://pubmed.ncbi.nlm.nih.gov/15180705"},"language":"en","primary_location":{"id":"doi:10.1046/j.1529-8817.2004.00090.x","doi":"https://doi.org/10.1046/j.1529-8817.2004.00090.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1529-8817.2004.00090.x","pdf_url":null,"source":{"id":"https://openalex.org/S131700781","display_name":"Annals of Human Genetics","issn_l":"0003-4800","issn":["0003-4800","1469-1809"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Human Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032008509","display_name":"Saurabh Ghosh","orcid":"https://orcid.org/0000-0003-1061-0390","observed_orcids":["https://orcid.org/0000-0003-1061-0390"]},"institutions":[{"id":"https://openalex.org/I6498739","display_name":"Indian Statistical Institute","ror":"https://ror.org/00q2w1j53","country_code":"IN","type":"education","lineage":["https://openalex.org/I6498739"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Saurabh Ghosh","raw_affiliation_strings":["Applied Statistics Unit, Indian Statistical Institute, Kolkata, India. saurabh@isical.ac.in","Applied Statistics Unit, Indian Statistical Institute, Kolkata"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Statistics Unit, Indian Statistical Institute, Kolkata, India. saurabh@isical.ac.in","institution_ids":["https://openalex.org/I6498739"]},{"raw_affiliation_string":"Applied Statistics Unit, Indian Statistical Institute, Kolkata","institution_ids":["https://openalex.org/I6498739"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042438318","display_name":"Theodore Reich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodore Reich","raw_affiliation_strings":["Department of Psychiatry, Washington University School of Medicine, St. Louis, MO","Department of Psychiatry, Washington University School of Medicine, St Louis, Mo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Psychiatry, Washington University School of Medicine, St Louis, Mo","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032008509"],"corresponding_institution_ids":["https://openalex.org/I6498739"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":null,"fwci":0.1786,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.54561463,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"68","issue":"3","first_page":"249","last_page":"256"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-of-disease-onset","display_name":"age of disease onset","score":0.8659999966621399},{"id":"https://openalex.org/keywords/age-standardization","display_name":"age adjustment","score":0.7910000085830688},{"id":"https://openalex.org/keywords/linkage-analysis","display_name":"linkage analysis","score":0.800000011920929},{"id":"https://openalex.org/keywords/cox-proportional-hazards-model","display_name":"Cox proportional hazards model","score":0.7369999885559082},{"id":"https://openalex.org/keywords/statistical-power","display_name":"statistical power","score":0.9399999976158142},{"id":"https://openalex.org/keywords/multiallelic-markers","display_name":"multiallelic markers","score":0.9890000224113464},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8500000238418579},{"id":"https://openalex.org/keywords/genetic-association-testing","display_name":"genetic association testing","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C119043178","wikidata":"https://www.wikidata.org/wiki/Q320723","display_name":"Covariate","level":2,"score":0.7356926202774048},{"id":"https://openalex.org/C89128539","wikidata":"https://www.wikidata.org/wiki/Q1949963","display_name":"Statistic","level":2,"score":0.6340172290802002},{"id":"https://openalex.org/C31266012","wikidata":"https://www.wikidata.org/wiki/Q6554340","display_name":"Linkage (software)","level":3,"score":0.6152487993240356},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5726854205131531},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5362132787704468},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4959488809108734},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4723323881626129},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.42763713002204895},{"id":"https://openalex.org/C2777767895","wikidata":"https://www.wikidata.org/wiki/Q4691924","display_name":"Age of onset","level":3,"score":0.4216541647911072},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4108476936817169},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3002881407737732},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2667658030986786},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.21019071340560913},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07883715629577637}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009679","descriptor_name":"Nuclear Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009679","descriptor_name":"Nuclear Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009679","descriptor_name":"Nuclear Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019655","descriptor_name":"Quantitative Trait, Heritable","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019655","descriptor_name":"Quantitative Trait, Heritable","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019655","descriptor_name":"Quantitative Trait, Heritable","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1529-8817.2004.00090.x","doi":"https://doi.org/10.1046/j.1529-8817.2004.00090.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1529-8817.2004.00090.x","pdf_url":null,"source":{"id":"https://openalex.org/S131700781","display_name":"Annals of Human Genetics","issn_l":"0003-4800","issn":["0003-4800","1469-1809"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Human Genetics","raw_type":"journal-article"},{"id":"pmid:15180705","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15180705","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of human genetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.46000000834465027,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1607870077","display_name":null,"funder_award_id":"U10 AA08403","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G4231623812","display_name":"COLLABORATIVE STUDY ON THE GENETICS OF ALCOHOLISM","funder_award_id":"U10AA008403","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G75880103","display_name":null,"funder_award_id":"U10 AA 08401","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000914127","display_name":"Collaborative Study on the Genetics of Alcoholism (COGA).","funder_award_id":"U10AA008401","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1499379539","https://openalex.org/W1517660103","https://openalex.org/W1543868019","https://openalex.org/W1972093120","https://openalex.org/W1996364619","https://openalex.org/W2017915458","https://openalex.org/W2041050891","https://openalex.org/W2046137853","https://openalex.org/W2122992446","https://openalex.org/W2128348740","https://openalex.org/W2130428276","https://openalex.org/W2169556112","https://openalex.org/W2171720857","https://openalex.org/W2794027193","https://openalex.org/W2796700885","https://openalex.org/W2995133996","https://openalex.org/W3147894994","https://openalex.org/W4251285595","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1499406536","https://openalex.org/W2111622989","https://openalex.org/W1996364619","https://openalex.org/W2046137853","https://openalex.org/W1979518390","https://openalex.org/W2074166724","https://openalex.org/W2124336747","https://openalex.org/W2169556112","https://openalex.org/W1969209255","https://openalex.org/W2003984366"],"abstract_inverted_index":{"Since":[0],"the":[1,33,41,55,68,73,78],"Sib-TDT":[2,75],"(Spielman":[3],"&":[4],"Ewens,":[5],"1998)":[6],"ignores":[7],"age":[8,29],"of":[9,16,30,72],"disease":[10,64],"onset,":[11],"there":[12],"could":[13],"be":[14],"loss":[15],"power":[17,71],"in":[18,70],"detecting":[19],"linkage.":[20],"In":[21],"this":[22],"article,":[23],"we":[24],"propose":[25],"an":[26],"adjustment":[27],"for":[28,50],"onset":[31],"using":[32,90],"Cox":[34],"Proportional":[35],"Hazard":[36],"Model":[37],"(Cox,":[38],"1972)":[39],"with":[40],"marker":[42],"allele":[43],"as":[44],"a":[45],"covariate.":[46],"The":[47],"test":[48],"statistic":[49],"linkage":[51],"is":[52,95],"identical":[53],"to":[54,66,77,85],"traditional":[56,79],"Sib-TDT.":[57,80],"Monte-Carlo":[58],"simulations":[59],"are":[60],"performed":[61],"under":[62],"different":[63],"models":[65],"assess":[67],"increase":[69],"age-adjusted":[74],"compared":[76],"We":[81],"extend":[82],"our":[83],"method":[84],"multiallelic":[86],"markers.":[87],"An":[88],"application":[89],"data":[91],"on":[92],"Alzheimer's":[93],"Disease":[94],"also":[96],"presented.":[97]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}