{"id":"https://openalex.org/W2004208175","doi":"https://doi.org/10.1210/endo-116-6-2369","title":"Somatomedin-C Enhances Induction of Luteinizing Hormone Receptors by Follicle-Stimulating Hormone in Cultured Rat Granulosa Cells*","display_name":"Somatomedin-C Enhances Induction of Luteinizing Hormone Receptors by Follicle-Stimulating Hormone in Cultured Rat Granulosa Cells*","publication_year":1985,"publication_date":"1985-06-01","ids":{"openalex":"https://openalex.org/W2004208175","doi":"https://doi.org/10.1210/endo-116-6-2369","mag":"2004208175","pmid":"https://pubmed.ncbi.nlm.nih.gov/2986948"},"language":"en","primary_location":{"id":"doi:10.1210/endo-116-6-2369","doi":"https://doi.org/10.1210/endo-116-6-2369","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-116-6-2369","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086044543","display_name":"Eli Y. Adashi","orcid":"https://orcid.org/0000-0001-7730-1192","observed_orcids":["https://orcid.org/0000-0001-7730-1192"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ELI Y. ADASHI","raw_affiliation_strings":["Division of Reproductive Endocrinology, Departments of Obstetrics/Gynecology and Physiology, University Maryland School of Medicine Baltimore, Maryland 21201; The Division of Endocrinology, Department of Pediatrics, University of North Carolina at Chapel Hill Chapel Hill, North Carolina 27514","Division of Reproductive Endocrinology, Departments of Obstetrics/Gynecology and Physiology, University Maryland School of Medicine Baltimore, Maryland 21201","The Division of Endocrinology, Department of Pediatrics, University of North Carolina at Chapel Hill Chapel Hill, North Carolina 27514"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive Endocrinology, Departments of Obstetrics/Gynecology and Physiology, University Maryland School of Medicine Baltimore, Maryland 21201; The Division of Endocrinology, Department of Pediatrics, University of North Carolina at Chapel Hill Chapel Hill, North Carolina 27514","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I126744593"]},{"raw_affiliation_string":"Division of Reproductive Endocrinology, Departments of Obstetrics/Gynecology and Physiology, University Maryland School of Medicine Baltimore, Maryland 21201","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"The Division of Endocrinology, Department of Pediatrics, University of North Carolina at Chapel Hill Chapel Hill, North Carolina 27514","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098587903","display_name":"CAROL E. ESNICK","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CAROL E. ESNICK","raw_affiliation_strings":["Division of Reproductive Endocrinology, Departments of Obstetrics/Gynecology and Physiology, University Maryland School of Medicine Baltimore, Maryland 21201; The Division of Endocrinology, Department of Pediatrics, University of North Carolina at Chapel Hill Chapel Hill, North Carolina 27514","Division of Reproductive Endocrinology, Departments of Obstetrics/Gynecology and Physiology, University Maryland School of Medicine Baltimore, Maryland 21201","The Division of Endocrinology, Department of Pediatrics, University of North Carolina at Chapel Hill Chapel Hill, North Carolina 27514"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive Endocrinology, Departments of Obstetrics/Gynecology and Physiology, University Maryland School of Medicine Baltimore, Maryland 21201; The Division of Endocrinology, Department of Pediatrics, University of North Carolina at Chapel Hill Chapel Hill, North Carolina 27514","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I126744593"]},{"raw_affiliation_string":"Division of Reproductive Endocrinology, Departments of Obstetrics/Gynecology and Physiology, University Maryland School of Medicine Baltimore, Maryland 21201","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"The Division of Endocrinology, Department of Pediatrics, University of North Carolina at Chapel Hill Chapel Hill, North Carolina 27514","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040709592","display_name":"MARJORIE E. SVOBODA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MARJORIE E. SVOBODA","raw_affiliation_strings":["Division of Reproductive Endocrinology, Departments of Obstetrics/Gynecology and Physiology, University Maryland School of Medicine Baltimore, Maryland 21201; The Division of Endocrinology, Department of Pediatrics, University of North Carolina at Chapel Hill Chapel Hill, North Carolina 27514","Division of Reproductive Endocrinology, Departments of Obstetrics/Gynecology and Physiology, University Maryland School of Medicine Baltimore, Maryland 21201","The Division of Endocrinology, Department of Pediatrics, University of North Carolina at Chapel Hill Chapel Hill, North Carolina 27514"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive Endocrinology, Departments of Obstetrics/Gynecology and Physiology, University Maryland School of Medicine Baltimore, Maryland 21201; The Division of Endocrinology, Department of Pediatrics, University of North Carolina at Chapel Hill Chapel Hill, North Carolina 27514","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I126744593"]},{"raw_affiliation_string":"Division of Reproductive Endocrinology, Departments of Obstetrics/Gynecology and Physiology, University Maryland School of Medicine Baltimore, Maryland 21201","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"The Division of Endocrinology, Department of Pediatrics, University of North Carolina at Chapel Hill Chapel Hill, North Carolina 27514","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012096607","display_name":"Judson J. Van Wyk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JUDSON J. VAN WYK","raw_affiliation_strings":["Division of Reproductive Endocrinology, Departments of Obstetrics/Gynecology and Physiology, University Maryland School of Medicine Baltimore, Maryland 21201; The Division of Endocrinology, Department of Pediatrics, University of North Carolina at Chapel Hill Chapel Hill, North Carolina 27514","Division of Reproductive Endocrinology, Departments of Obstetrics/Gynecology and Physiology, University Maryland School of Medicine Baltimore, Maryland 21201","The Division of Endocrinology, Department of Pediatrics, University of North Carolina at Chapel Hill Chapel Hill, North Carolina 27514"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive Endocrinology, Departments of Obstetrics/Gynecology and Physiology, University Maryland School of Medicine Baltimore, Maryland 21201; The Division of Endocrinology, Department of Pediatrics, University of North Carolina at Chapel Hill Chapel Hill, North Carolina 27514","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I126744593"]},{"raw_affiliation_string":"Division of Reproductive Endocrinology, Departments of Obstetrics/Gynecology and Physiology, University Maryland School of Medicine Baltimore, Maryland 21201","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"The Division of Endocrinology, Department of Pediatrics, University of North Carolina at Chapel Hill Chapel Hill, North Carolina 27514","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":8.5866,"has_fulltext":false,"cited_by_count":149,"citation_normalized_percentile":{"value":0.98159662,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"116","issue":"6","first_page":"2369","last_page":"2375"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.5698000192642212,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.5698000192642212,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.267300009727478,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.08500000089406967,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9700000286102295},{"id":"https://openalex.org/keywords/luteinizing-hormone-receptor","display_name":"luteinizing hormone receptor","score":0.8259999752044678},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.9869999885559082},{"id":"https://openalex.org/keywords/granulosa-cells","display_name":"granulosa cells","score":0.9890000224113464},{"id":"https://openalex.org/keywords/receptor-induction","display_name":"receptor induction","score":0.7829999923706055},{"id":"https://openalex.org/keywords/synergistic-hormone-action","display_name":"synergistic hormone action","score":0.5820000171661377},{"id":"https://openalex.org/keywords/immunoneutralization","display_name":"immunoneutralization","score":0.8769999742507935},{"id":"https://openalex.org/keywords/gonadotropin-binding","display_name":"gonadotropin binding","score":0.48399999737739563},{"id":"https://openalex.org/keywords/cytodifferentiation","display_name":"cytodifferentiation","score":0.5979999899864197},{"id":"https://openalex.org/keywords/rat-ovary","display_name":"rat ovary","score":0.44699999690055847},{"id":"https://openalex.org/keywords/hypophysectomized-rats","display_name":"hypophysectomized rats","score":0.7020000219345093},{"id":"https://openalex.org/keywords/diethylstilbestrol","display_name":"diethylstilbestrol","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8414337635040283},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.820946991443634},{"id":"https://openalex.org/C2777203538","wikidata":"https://www.wikidata.org/wiki/Q1543282","display_name":"Granulosa cell","level":3,"score":0.6956009864807129},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6741034984588623},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.6526381969451904},{"id":"https://openalex.org/C80862487","wikidata":"https://www.wikidata.org/wiki/Q415679","display_name":"Somatomedin","level":4,"score":0.5909760594367981},{"id":"https://openalex.org/C2779279165","wikidata":"https://www.wikidata.org/wiki/Q200774","display_name":"Follicle-stimulating hormone","level":4,"score":0.5570276975631714},{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.5328389406204224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4395739436149597},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41004323959350586},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4063810706138611},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.23345130681991577},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17960768938064575}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006063","descriptor_name":"Chorionic Gonadotropin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006107","descriptor_name":"Granulosa Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011974","descriptor_name":"Receptors, LH","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013002","descriptor_name":"Somatomedins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013002","descriptor_name":"Somatomedins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013002","descriptor_name":"Somatomedins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/endo-116-6-2369","doi":"https://doi.org/10.1210/endo-116-6-2369","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-116-6-2369","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:2986948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2986948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3511122662","display_name":"TRAINING PROGRAM IN ENDOCRINOLOGY &METABOLISM","funder_award_id":"2t32am007129-12","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8225423539","display_name":"ENDOCRINOLOGIC AND METABOLIC PROBLEMS IN CHILDREN","funder_award_id":"5k06am014115-24","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000080257","display_name":null,"funder_award_id":"5 ROI AM-01022-27","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W8677598","https://openalex.org/W14648726","https://openalex.org/W24355398","https://openalex.org/W54157561","https://openalex.org/W1490958709","https://openalex.org/W1840375545","https://openalex.org/W1966916621","https://openalex.org/W1969854194","https://openalex.org/W1972319572","https://openalex.org/W1975797622","https://openalex.org/W1983394026","https://openalex.org/W1983649348","https://openalex.org/W1991204035","https://openalex.org/W2014493428","https://openalex.org/W2014935390","https://openalex.org/W2029380858","https://openalex.org/W2031180248","https://openalex.org/W2032670749","https://openalex.org/W2032737002","https://openalex.org/W2033458917","https://openalex.org/W2040287894","https://openalex.org/W2056082665","https://openalex.org/W2061782885","https://openalex.org/W2062486679","https://openalex.org/W2064982147","https://openalex.org/W2068304855","https://openalex.org/W2083406280","https://openalex.org/W2087435223","https://openalex.org/W2102123572","https://openalex.org/W2102562394","https://openalex.org/W2112433328","https://openalex.org/W2119808628","https://openalex.org/W2121497355","https://openalex.org/W2124974256","https://openalex.org/W2131391777","https://openalex.org/W2132374234","https://openalex.org/W2137467924","https://openalex.org/W2151261265","https://openalex.org/W2408477582","https://openalex.org/W2411302077"],"related_works":["https://openalex.org/W2104120415","https://openalex.org/W2137467924","https://openalex.org/W2065460036","https://openalex.org/W1994455762","https://openalex.org/W2014301540","https://openalex.org/W1606567685","https://openalex.org/W2043178059","https://openalex.org/W1998487390","https://openalex.org/W2074455091","https://openalex.org/W2015354988"],"abstract_inverted_index":{"Recent":[0],"studies":[1],"have":[2],"documented":[3],"the":[4,14,41,51,56,147,159,194,198,203,243,272,309,319],"ability":[5,151,255],"of":[6,16,26,43,53,58,146,152,161,176,187,193,197,227,242,252,256,287,291,313,321],"somatomedin-C":[7],"(Sm-C)":[8],"to":[9,81,126,154,211,258,318,334],"synergize":[10,155],"with":[11,102,111,137,156,169,265],"FSH":[12,112,115,148,157],"in":[13,40,55,63,123,142,158,206,278,299],"induction":[15,160,262,320],"rat":[17],"granulosa":[18,44,85,327],"cell":[19,45,86,328],"progesterone":[20,49,268,322],"biosynthesis.":[21],"This":[22],"direct":[23,310],"cytodifferentiative":[24,311],"action":[25],"Sm-C":[27,38,54,105,138,153,233,247,257,288,314],"proved":[28],"distinct":[29],"from":[30,69],"its":[31],"established":[32],"mitogenic":[33],"property.":[34],"To":[35],"determine":[36],"whether":[37],"partakes":[39],"differentiation":[42],"functions":[46,329],"other":[47,325],"than":[48],"biosynthesis,":[50,269,323],"role":[52],"acquisition":[57],"LH":[59,162,260],"receptors":[60,163,275],"was":[61,92,96,164,209,263],"investigated":[62],"vitro.":[64],"Granulosa":[65],"cells":[66],"were":[67],"obtained":[68],"immature,":[70],"hypophysectomized":[71],"diethylstilbestrol-treated":[72],"rats":[73],"and":[74,95,166,182,238,248,302],"cultured":[75],"under":[76,89],"serum-free":[77],"conditions":[78,91],"for":[79],"up":[80],"72":[82],"h.":[83],"Specific":[84],"LH/hCG":[87,124,199,207],"binding":[88,125,195,208,213],"basal":[90],"relatively":[93],"low":[94],"not":[97,216,297,316],"significantly":[98],"affected":[99],"by":[100,336],"treatment":[101,110,136],"highly":[103],"purified":[104],"(50":[106,139],"ng/ml).":[107],"In":[108],"contrast,":[109],"(oFSH;":[113],"NIH":[114],"S14;":[116],"20":[117],"ng/ml)":[118,140],"produced":[119,236],"a":[120,143,183,228,300],"3.8-fold":[121],"increase":[122,205],"3167":[127],"+/-":[128,178],"660":[129],"(+/-":[130],"SE)":[131],"cpm/10(6)":[132],"cells.":[133],"However,":[134],"concurrent":[135],"resulted":[141],"6.1-fold":[144],"enhancement":[145],"effect.":[149],"The":[150,254],"dose":[165,174],"time":[167,185],"dependent,":[168],"an":[170],"apparent":[171],"median":[172],"effective":[173],"(ED50)":[175],"6.2":[177],"0.6":[179],"(+/-SE)":[180],"ng/ml,":[181],"minimal":[184],"requirement":[186],"24":[188],"h":[189],"or":[190],"less.":[191],"Examination":[192],"parameters":[196],"receptor":[200,261],"revealed":[201],"that":[202,271,284,308],"Sm-C-mediated":[204],"due":[210],"enhanced":[212],"capacity,":[214,295],"but":[215,296,324],"affinity":[217],"(Kd":[218],"=":[219],"4.4":[220],"X":[221],"10(-11)":[222],"M).":[223],"Decreasing":[224],"dilutions":[225],"(1:128,000-1:8,000)":[226],"monoclonal":[229],"antibody":[230],"raised":[231],"against":[232],"(sm":[234],"1.2),":[235],"progressive":[237],"virtually":[239],"complete":[240],"immunoneutralization":[241],"synergistic":[244],"interaction":[245],"between":[246],"FSH,":[249],"suggesting":[250,270],"specificity":[251],"action.":[253],"enhance":[259],"associated":[264],"increased":[266],"hCG-stimulated":[267],"newly":[273],"acquired":[274],"are":[276,289],"functional":[277],"nature.":[279],"Our":[280],"present":[281],"findings":[282],"indicate":[283],"nanomolar":[285],"concentrations":[286],"capable":[290],"enhancing":[292],"FSH-stimulated":[293],"LH/hCG-binding":[294],"affinity,":[298],"time-":[301],"dose-dependent":[303],"fashion.":[304],"These":[305],"observations":[306],"suggest":[307],"effect":[312],"is":[315],"limited":[317],"key":[326],"may":[330],"also":[331],"be":[332],"subject":[333],"modulation":[335],"this":[337],"regulatory":[338],"peptide.":[339]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}