{"id":"https://openalex.org/W2004206751","doi":"https://doi.org/10.1016/j.intimp.2010.07.010","title":"Ginsenoside Rb1 and paeoniflorin inhibit transient receptor potential vanilloid-1-activated IL-8 and PGE2 production in a human keratinocyte cell line HaCaT","display_name":"Ginsenoside Rb1 and paeoniflorin inhibit transient receptor potential vanilloid-1-activated IL-8 and PGE2 production in a human keratinocyte cell line HaCaT","publication_year":2010,"publication_date":"2010-08-03","ids":{"openalex":"https://openalex.org/W2004206751","doi":"https://doi.org/10.1016/j.intimp.2010.07.010","mag":"2004206751","pmid":"https://pubmed.ncbi.nlm.nih.gov/20678598"},"language":"en","primary_location":{"id":"doi:10.1016/j.intimp.2010.07.010","doi":"https://doi.org/10.1016/j.intimp.2010.07.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.intimp.2010.07.010","pdf_url":null,"source":{"id":"https://openalex.org/S158377717","display_name":"International Immunopharmacology","issn_l":"1567-5769","issn":["1567-5769","1878-1705"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100620996","display_name":"Jin Huang","orcid":"https://orcid.org/0000-0001-5758-7197","observed_orcids":["https://orcid.org/0000-0001-5758-7197"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin Huang","raw_affiliation_strings":["Department of Pharmacy, Changhai Hospital, Second Military Medical University, 168, Changhai Road, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Changhai Hospital, Second Military Medical University, 168, Changhai Road, Shanghai 200433, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021851719","display_name":"Lei Qiu","orcid":"https://orcid.org/0000-0002-9614-7757","observed_orcids":["https://orcid.org/0000-0002-9614-7757"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Qiu","raw_affiliation_strings":["Department of Biochemical Pharmacy, College of Pharmacy, Second Military Medical University, Shanghai, 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Pharmacy, College of Pharmacy, Second Military Medical University, Shanghai, 200433, China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Li Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Ding","raw_affiliation_strings":["Department of Biochemical Pharmacy, College of Pharmacy, Second Military Medical University, Shanghai, 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Pharmacy, College of Pharmacy, Second Military Medical University, Shanghai, 200433, China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060516607","display_name":"Shaozhan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaozhan Wang","raw_affiliation_strings":["Department of Biochemical Pharmacy, College of Pharmacy, Second Military Medical University, Shanghai, 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Pharmacy, College of Pharmacy, Second Military Medical University, Shanghai, 200433, China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jing Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["Department of Biochemical Pharmacy, College of Pharmacy, Second Military Medical University, Shanghai, 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Pharmacy, College of Pharmacy, Second Military Medical University, Shanghai, 200433, China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034976685","display_name":"Quangang Zhu","orcid":"https://orcid.org/0000-0002-0574-4020","observed_orcids":["https://orcid.org/0000-0002-0574-4020"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Quangang Zhu","raw_affiliation_strings":["Department of Pharmacy, Changhai Hospital, Second Military Medical University, 168, Changhai Road, Shanghai, 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Changhai Hospital, Second Military Medical University, 168, Changhai Road, Shanghai, 200433, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100994269","display_name":"Fengyu Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fengyu Song","raw_affiliation_strings":["Department of Oral Biology, Indiana University School of Dentistry, Indianapolis, Indiana, 46022, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology, Indiana University School of Dentistry, Indianapolis, Indiana, 46022, USA","institution_ids":["https://openalex.org/I4388446366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048715243","display_name":"Jinhong Hu","orcid":"https://orcid.org/0000-0003-3626-9602","observed_orcids":["https://orcid.org/0000-0003-3626-9602"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jinhong Hu","raw_affiliation_strings":["Department of Pharmacy, Changhai Hospital, Second Military Medical University, 168, Changhai Road, Shanghai, 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Changhai Hospital, Second Military Medical University, 168, Changhai Road, Shanghai, 200433, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5048715243"],"corresponding_institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"],"apc_list":{"value":3220,"currency":"USD","value_usd":3220},"apc_paid":null,"fwci":1.4692,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.76540591,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"10","first_page":"1279","last_page":"1283"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11889","display_name":"Ginseng Biological Effects and Applications","score":0.6532999873161316,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11889","display_name":"Ginseng Biological Effects and Applications","score":0.6532999873161316,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.3034999966621399,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ginsenoside-rb1","display_name":"ginsenoside Rb1","score":1.0},{"id":"https://openalex.org/keywords/paeoniflorin","display_name":"paeoniflorin","score":1.0},{"id":"https://openalex.org/keywords/trpv1","display_name":"TRPV1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9160000085830688},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9459999799728394},{"id":"https://openalex.org/keywords/capsaicin","display_name":"capsaicin","score":0.7900000214576721},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.9200000166893005},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.921999990940094},{"id":"https://openalex.org/keywords/skin-inflammation","display_name":"skin inflammation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/hacat-cells","display_name":"HaCaT keratinocytes","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C118995209","wikidata":"https://www.wikidata.org/wiki/Q5636366","display_name":"HaCaT","level":3,"score":0.9339052438735962},{"id":"https://openalex.org/C160145004","wikidata":"https://www.wikidata.org/wiki/Q413209","display_name":"TRPV1","level":4,"score":0.8347439765930176},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.7673102617263794},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6555811166763306},{"id":"https://openalex.org/C2780071552","wikidata":"https://www.wikidata.org/wiki/Q5036336","display_name":"Capsazepine","level":5,"score":0.5754773616790771},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.553878128528595},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4847121238708496},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4468306005001068},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37618395686149597},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3490268588066101},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32287681102752686},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26220375299453735},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.152726948261261},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1213848888874054},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001565","descriptor_name":"Benzoates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001952","descriptor_name":"Bridged-Ring Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005960","descriptor_name":"Glucosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006027","descriptor_name":"Glycosides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036145","descriptor_name":"Ginsenosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D039821","descriptor_name":"Monoterpenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.intimp.2010.07.010","doi":"https://doi.org/10.1016/j.intimp.2010.07.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.intimp.2010.07.010","pdf_url":null,"source":{"id":"https://openalex.org/S158377717","display_name":"International Immunopharmacology","issn_l":"1567-5769","issn":["1567-5769","1878-1705"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunopharmacology","raw_type":"journal-article"},{"id":"pmid:20678598","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20678598","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International immunopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1511198581","https://openalex.org/W1602071948","https://openalex.org/W1978275908","https://openalex.org/W1979407676","https://openalex.org/W1982472177","https://openalex.org/W1993100083","https://openalex.org/W2006898389","https://openalex.org/W2019999527","https://openalex.org/W2020158187","https://openalex.org/W2022346603","https://openalex.org/W2024420229","https://openalex.org/W2033576768","https://openalex.org/W2037670041","https://openalex.org/W2042172408","https://openalex.org/W2049943073","https://openalex.org/W2056888789","https://openalex.org/W2072227743","https://openalex.org/W2072629836","https://openalex.org/W2078070096","https://openalex.org/W2080794368","https://openalex.org/W2080872013","https://openalex.org/W2090692313","https://openalex.org/W2093896029","https://openalex.org/W2123221350","https://openalex.org/W2133543836","https://openalex.org/W2134448193","https://openalex.org/W2134742719","https://openalex.org/W2170389215","https://openalex.org/W2170432735"],"related_works":["https://openalex.org/W1960500447","https://openalex.org/W2361408043","https://openalex.org/W4403377000","https://openalex.org/W2087444248","https://openalex.org/W2004337674","https://openalex.org/W4398156223","https://openalex.org/W2016593035","https://openalex.org/W2523110839","https://openalex.org/W2372000823","https://openalex.org/W3177336671"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
