{"id":"https://openalex.org/W2004201542","doi":"https://doi.org/10.1134/s1061934813040023","title":"Simultaneous determination of thirteen main components and identification of eight major metabolites in Xuebijing Injection by UPLC/Q-TOF","display_name":"Simultaneous determination of thirteen main components and identification of eight major metabolites in Xuebijing Injection by UPLC/Q-TOF","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W2004201542","doi":"https://doi.org/10.1134/s1061934813040023","mag":"2004201542"},"language":"en","primary_location":{"id":"doi:10.1134/s1061934813040023","doi":"https://doi.org/10.1134/s1061934813040023","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s1061934813040023","pdf_url":null,"source":{"id":"https://openalex.org/S3394804","display_name":"Journal of Analytical Chemistry","issn_l":"0021-8766","issn":["0021-8766","0044-4502","1061-9348","1608-3199","3034-512X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","norway-1","poland-40","russia-white-list-1","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057639636","display_name":"Hao Huang","orcid":"https://orcid.org/0000-0002-7788-5519","observed_orcids":["https://orcid.org/0000-0002-7788-5519"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]},{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"H. Huang","raw_affiliation_strings":["College of Pharmacy, Nankai University Tianjin, 300071, Tianjin, P.R. China","School of Pharmacy, Gannan Medical University Ganzhou, 341000, Ganzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Nankai University Tianjin, 300071, Tianjin, P.R. China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"School of Pharmacy, Gannan Medical University Ganzhou, 341000, Ganzhou, P.R. China","institution_ids":["https://openalex.org/I4210113195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100711180","display_name":"Jinhuan Wang","orcid":"https://orcid.org/0000-0003-3816-1291","observed_orcids":["https://orcid.org/0000-0003-3816-1291"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J. Wang","raw_affiliation_strings":["College of Pharmacy, Nankai University Tianjin, 300071, Tianjin, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Nankai University Tianjin, 300071, Tianjin, P.R. China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101927964","display_name":"Junzeng Fu","orcid":"https://orcid.org/0009-0002-4047-3737","observed_orcids":["https://orcid.org/0009-0002-4047-3737"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J. Z. Fu","raw_affiliation_strings":["College of Pharmacy, Nankai University Tianjin, 300071, Tianjin, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Nankai University Tianjin, 300071, Tianjin, P.R. China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037903010","display_name":"L. Q. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"L. Q. Wang","raw_affiliation_strings":["College of Pharmacy, Nankai University Tianjin, 300071, Tianjin, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Nankai University Tianjin, 300071, Tianjin, P.R. China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039625672","display_name":"Hongzhi Zhao","orcid":"https://orcid.org/0000-0002-9355-164X","observed_orcids":["https://orcid.org/0000-0002-9355-164X"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"H. Z. Zhao","raw_affiliation_strings":["College of Pharmacy, Nankai University Tianjin, 300071, Tianjin, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Nankai University Tianjin, 300071, Tianjin, P.R. China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054981974","display_name":"Shengyou Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"S. Y. Song","raw_affiliation_strings":["College of Pharmacy, Nankai University Tianjin, 300071, Tianjin, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Nankai University Tianjin, 300071, Tianjin, P.R. China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044105175","display_name":"Ligong Ji","orcid":"https://orcid.org/0009-0000-6383-3008","observed_orcids":["https://orcid.org/0009-0000-6383-3008"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"L. X. Ji","raw_affiliation_strings":["College of Pharmacy, Nankai University Tianjin, 300071, Tianjin, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Nankai University Tianjin, 300071, Tianjin, P.R. China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021853076","display_name":"Min Jiang","orcid":"https://orcid.org/0000-0003-4935-315X","observed_orcids":["https://orcid.org/0000-0003-4935-315X"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"M. Jiang","raw_affiliation_strings":["College of Pharmacy, Nankai University Tianjin, 300071, Tianjin, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Nankai University Tianjin, 300071, Tianjin, P.R. China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084393924","display_name":"Gang Bai","orcid":"https://orcid.org/0000-0001-9161-2173","observed_orcids":["https://orcid.org/0000-0001-9161-2173"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"G. Bai","raw_affiliation_strings":["College of Pharmacy, Nankai University Tianjin, 300071, Tianjin, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Nankai University Tianjin, 300071, Tianjin, P.R. China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101862787","display_name":"Gan Luo","orcid":"https://orcid.org/0000-0002-3644-5752","observed_orcids":["https://orcid.org/0000-0002-3644-5752","https://orcid.org/0000-0001-6570-8673","https://orcid.org/0000-0002-9588-7008"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"G. A. Luo","raw_affiliation_strings":["College of Pharmacy, Nankai University Tianjin, 300071, Tianjin, P.R. China","Department of Chemistry, Tsinghua University Beijing, 100084, Tsinghua, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Nankai University Tianjin, 300071, Tianjin, P.R. China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"Department of Chemistry, Tsinghua University Beijing, 100084, Tsinghua, P.R. China","institution_ids":["https://openalex.org/I99065089"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.16747398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"68","issue":"4","first_page":"348","last_page":"356"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13444","display_name":"Medical Research and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xuebijing-injection","display_name":"Xuebijing injection","score":0.9980000257492065},{"id":"https://openalex.org/keywords/simultaneous-determination","display_name":"simultaneous determination","score":0.4350000023841858},{"id":"https://openalex.org/keywords/quality-control","display_name":"quality control","score":0.5630000233650208},{"id":"https://openalex.org/keywords/metabolites","display_name":"metabolites","score":0.5130000114440918},{"id":"https://openalex.org/keywords/uridine","display_name":"uridine","score":0.6570000052452087},{"id":"https://openalex.org/keywords/gallic-acid","display_name":"gallic acid","score":0.9409999847412109},{"id":"https://openalex.org/keywords/guanosine","display_name":"guanosine","score":0.8920000195503235},{"id":"https://openalex.org/keywords/danshensu","display_name":"danshensu","score":0.9670000076293945},{"id":"https://openalex.org/keywords/protocatechualdehyde","display_name":"protocatechuic aldehyde","score":0.9769999980926514},{"id":"https://openalex.org/keywords/oxypaeoniflorin","display_name":"oxypaeoniflorin","score":0.996999979019165},{"id":"https://openalex.org/keywords/hydroxysafflor-yellow-a","display_name":"hydroxysafflor yellow A","score":0.9390000104904175},{"id":"https://openalex.org/keywords/paeoniflorin","display_name":"paeoniflorin","score":1.0},{"id":"https://openalex.org/keywords/ferulic-acid","display_name":"ferulic acid","score":1.0},{"id":"https://openalex.org/keywords/senkyunolide-i","display_name":"senkyunolide I","score":0.9919999837875366},{"id":"https://openalex.org/keywords/salvianolic-acid-b","display_name":"salvianolic acid B","score":0.9980000257492065},{"id":"https://openalex.org/keywords/rat-plasma","display_name":"rat plasma","score":0.8230000138282776},{"id":"https://openalex.org/keywords/rat-urine","display_name":"rat urine","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9233299493789673},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.9131239652633667},{"id":"https://openalex.org/C2776918747","wikidata":"https://www.wikidata.org/wiki/Q7124104","display_name":"Paeoniflorin","level":3,"score":0.7950221300125122},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.6918919086456299},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.49061957001686096},{"id":"https://openalex.org/C3017686574","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"Gradient elution","level":3,"score":0.4867591857910156},{"id":"https://openalex.org/C73826308","wikidata":"https://www.wikidata.org/wiki/Q684907","display_name":"Elution","level":2,"score":0.48348885774612427},{"id":"https://openalex.org/C2776673659","wikidata":"https://www.wikidata.org/wiki/Q47512","display_name":"Acetic acid","level":2,"score":0.46818816661834717},{"id":"https://openalex.org/C2781259782","wikidata":"https://www.wikidata.org/wiki/Q422573","display_name":"Uridine","level":4,"score":0.4379749000072479},{"id":"https://openalex.org/C2780213334","wikidata":"https://www.wikidata.org/wiki/Q417362","display_name":"Ferulic acid","level":2,"score":0.41431811451911926},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05106097459793091},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1134/s1061934813040023","doi":"https://doi.org/10.1134/s1061934813040023","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s1061934813040023","pdf_url":null,"source":{"id":"https://openalex.org/S3394804","display_name":"Journal of Analytical Chemistry","issn_l":"0021-8766","issn":["0021-8766","0044-4502","1061-9348","1608-3199","3034-512X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","norway-1","poland-40","russia-white-list-1","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Analytical Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5400000214576721,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1645427546","https://openalex.org/W1983522934","https://openalex.org/W2003649314","https://openalex.org/W2013275789","https://openalex.org/W2064724317","https://openalex.org/W2128578351","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2043863063","https://openalex.org/W2371499293","https://openalex.org/W2043512602","https://openalex.org/W2385827005","https://openalex.org/W2349566960","https://openalex.org/W2388971081","https://openalex.org/W2052058093","https://openalex.org/W2015362886","https://openalex.org/W2022807649","https://openalex.org/W1981648665"],"abstract_inverted_index":{"An":[0],"ultra":[1],"performance":[2],"liquid":[3],"chromatographic":[4,47],"method":[5,82,138],"was":[6,49,83],"used":[7],"for":[8,85],"the":[9],"simultaneous":[10],"identification":[11],"and":[12,42,70,92,107,124,144,152],"quantification":[13,110],"of":[14,68,78,103,109,129,133],"thirteen":[15],"main":[16],"components":[17],"in":[18,117,121,154],"Xuebijing":[19,134,146],"Injection,":[20],"including":[21],"uridine,":[22],"gallic":[23],"acid,":[24,34],"guanosine,":[25],"danshensu,":[26],"protocatechualdehyde,":[27],"oxypaeoniflorin,":[28],"hydroxysafflor":[29],"yellow":[30,36],"A,":[31,37],"paeoniflorin,":[32],"ferulic":[33],"safflor":[35],"senkyunolide":[38,40],"I,":[39],"H":[41],"salvianolic":[43],"acid":[44,73],"B.":[45],"The":[46,81,136],"separation":[48],"performed":[50],"on":[51],"an":[52],"Acquity":[53],"UPLC":[54],"BEH":[55],"C18":[56],"column":[57],"(1.7-\u03bcm,":[58],"2.1":[59],"\u00d7":[60],"100":[61],"mm,":[62],"i.d.)":[63],"with":[64],"a":[65,75],"gradient":[66],"elution":[67],"acetonitrile":[69],"0.2%":[71],"acetic":[72],"at":[74],"flow":[76],"rate":[77],"0.4":[79],"mL/min.":[80],"validated":[84],"linearity":[86],"(r":[87],"2":[88],">":[89],"0.9990),":[90],"intra-":[91],"inter-day":[93],"precision":[94],"(RSD":[95],"<":[96],"1.94%),":[97],"accuracy":[98],"(91.8\u201399.7%),":[99],"recovery":[100],"(96.8\u2013103.8%),":[101],"limits":[102,108],"detection":[104],"(0.16\u20138.0":[105],"ng),":[106],"(0.54\u201326.8":[111],"ng).":[112],"At":[113],"least":[114],"eight":[115],"metabolites":[116],"prototype":[118],"were":[119],"found":[120],"rat":[122],"plasma":[123],"urine":[125],"after":[126],"intravenous":[127],"injection":[128],"4":[130],"mL/kg":[131],"doses":[132],"Injection.":[135],"proposed":[137],"could":[139],"be":[140],"utilized":[141],"to":[142,148],"qualify":[143],"control":[145],"Injection":[147],"ensure":[149],"its":[150],"safety":[151],"efficacy":[153],"application.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
