{"id":"https://openalex.org/W2004201104","doi":"https://doi.org/10.1590/s1415-475738138120140132","title":"Enhanced tethered-flight duration and locomotor activity by overexpression of the human gene SOD1 in Drosophila motorneurons","display_name":"Enhanced tethered-flight duration and locomotor activity by overexpression of the human gene SOD1 in Drosophila motorneurons","publication_year":2015,"publication_date":"2015-03-01","ids":{"openalex":"https://openalex.org/W2004201104","doi":"https://doi.org/10.1590/s1415-475738138120140132","mag":"2004201104","pmid":"https://pubmed.ncbi.nlm.nih.gov/25983632","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4415569"},"language":"en","primary_location":{"id":"doi:10.1590/s1415-475738138120140132","doi":"https://doi.org/10.1590/s1415-475738138120140132","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s1415-475738138120140132","pdf_url":"https://www.scielo.br/j/gmb/a/PmV6BQJdWCrD8vfs98zsbXN/?lang=en&format=pdf","source":{"id":"https://openalex.org/S151355818","display_name":"Genetics and Molecular Biology","issn_l":"1415-4757","issn":["1415-4757","1678-4685"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310312091","host_organization_name":"Brazilian Society of Genetics","host_organization_lineage":["https://openalex.org/P4310312091"],"host_organization_lineage_names":["Brazilian Society of Genetics"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics and Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.scielo.br/j/gmb/a/PmV6BQJdWCrD8vfs98zsbXN/?lang=en&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016323107","display_name":"Agavni Petrosyan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Agavni Petrosyan","raw_affiliation_strings":["University of California, USA","Department of Cognitive Sciences, University of California, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Cognitive Sciences, University of California, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022604430","display_name":"I-Hui Hsieh","orcid":"https://orcid.org/0000-0003-4001-4274","observed_orcids":["https://orcid.org/0000-0003-4001-4274"]},"institutions":[{"id":"https://openalex.org/I22265921","display_name":"National Central University","ror":"https://ror.org/00944ve71","country_code":"TW","type":"education","lineage":["https://openalex.org/I22265921"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"I-Hui Hsieh","raw_affiliation_strings":["National Central University, Taiwan","Institute of Cognitive Neuroscience, National Central University, Jhongli City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Central University, Taiwan","institution_ids":["https://openalex.org/I22265921"]},{"raw_affiliation_string":"Institute of Cognitive Neuroscience, National Central University, Jhongli City, Taiwan","institution_ids":["https://openalex.org/I22265921"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John P. Phillips","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John P. Phillips","raw_affiliation_strings":["University of Guelph, Canada","Department of Molecular Biology & Genetics, University of Guelph, Guelph, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Guelph, Canada","institution_ids":["https://openalex.org/I79817857"]},{"raw_affiliation_string":"Department of Molecular Biology & Genetics, University of Guelph, Guelph, Ontario, Canada","institution_ids":["https://openalex.org/I79817857"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090825561","display_name":"Kourosh Saberi","orcid":"https://orcid.org/0000-0001-8500-7356","observed_orcids":["https://orcid.org/0000-0001-8500-7356"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kourosh Saberi","raw_affiliation_strings":["University of California, USA","University of California Irvine (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, USA","institution_ids":[]},{"raw_affiliation_string":"University of California Irvine (USA)","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5090825561"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":700,"currency":"USD","value_usd":700},"apc_paid":{"value":700,"currency":"USD","value_usd":700},"fwci":0.0,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.06457243,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"38","issue":"1","first_page":"107","last_page":"114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/superoxide-dismutase-1","display_name":"superoxide dismutase 1","score":0.9240000247955322},{"id":"https://openalex.org/keywords/motor-neurons","display_name":"motor neurons","score":0.7170000076293945},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.7940000295639038},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/lifespan-extension","display_name":"lifespan extension","score":0.6990000009536743},{"id":"https://openalex.org/keywords/flight-endurance","display_name":"flight endurance","score":0.5329999923706055},{"id":"https://openalex.org/keywords/wingbeat-frequency","display_name":"wingbeat frequency","score":0.9940000176429749},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.8989999890327454},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5889999866485596},{"id":"https://openalex.org/keywords/sensorimotor-function","display_name":"sensorimotor function","score":0.7929999828338623},{"id":"https://openalex.org/keywords/age-related-decline","display_name":"age-related decline","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8751674890518188},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.7012551426887512},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.6326805353164673},{"id":"https://openalex.org/C2777615887","wikidata":"https://www.wikidata.org/wiki/Q15328137","display_name":"SOD1","level":4,"score":0.5433389544487},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.48205074667930603},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46920838952064514},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4012031555175781},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3647220730781555},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2713853716850281},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.25963714718818665},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19109168648719788},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1590/s1415-475738138120140132","doi":"https://doi.org/10.1590/s1415-475738138120140132","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s1415-475738138120140132","pdf_url":"https://www.scielo.br/j/gmb/a/PmV6BQJdWCrD8vfs98zsbXN/?lang=en&format=pdf","source":{"id":"https://openalex.org/S151355818","display_name":"Genetics and Molecular Biology","issn_l":"1415-4757","issn":["1415-4757","1678-4685"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310312091","host_organization_name":"Brazilian Society of Genetics","host_organization_lineage":["https://openalex.org/P4310312091"],"host_organization_lineage_names":["Brazilian Society of Genetics"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics and Molecular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4415569","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4415569","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genet Mol Biol","raw_type":"Text"},{"id":"pmid:25983632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25983632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics and molecular biology","raw_type":"Journal Article"},{"id":"pmh:oai:scielo:S1415-47572015000100107","doi":null,"is_oa":true,"landing_page_url":"http://old.scielo.br/scielo.php?script=sci_arttext&amp;pid=S1415-47572015000100107","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics and Molecular Biology v.38 n.1 2015","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:americanae.aecid.es:2501221","doi":null,"is_oa":true,"landing_page_url":"http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000100107","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genetics and Molecular Biology v.38 n.1 2015","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:5de83ae7852e4381a2688026841a335f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5de83ae7852e4381a2688026841a335f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genetics and Molecular Biology, Vol 38, Iss 1, Pp 107-114 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1590/s1415-475738138120140132","doi":"https://doi.org/10.1590/s1415-475738138120140132","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s1415-475738138120140132","pdf_url":"https://www.scielo.br/j/gmb/a/PmV6BQJdWCrD8vfs98zsbXN/?lang=en&format=pdf","source":{"id":"https://openalex.org/S151355818","display_name":"Genetics and Molecular Biology","issn_l":"1415-4757","issn":["1415-4757","1678-4685"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310312091","host_organization_name":"Brazilian Society of Genetics","host_organization_lineage":["https://openalex.org/P4310312091"],"host_organization_lineage_names":["Brazilian Society of Genetics"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics and Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004201104.pdf","grobid_xml":"https://content.openalex.org/works/W2004201104.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1485778651","https://openalex.org/W1982647833","https://openalex.org/W1991109777","https://openalex.org/W2004002095","https://openalex.org/W2006554936","https://openalex.org/W2012328965","https://openalex.org/W2013135033","https://openalex.org/W2028283967","https://openalex.org/W2039295111","https://openalex.org/W2046377871","https://openalex.org/W2062048451","https://openalex.org/W2068785824","https://openalex.org/W2069154171","https://openalex.org/W2069792423","https://openalex.org/W2072954389","https://openalex.org/W2075579767","https://openalex.org/W2077983870","https://openalex.org/W2078377781","https://openalex.org/W2080458091","https://openalex.org/W2086974985","https://openalex.org/W2096386031","https://openalex.org/W2097601880","https://openalex.org/W2110643873","https://openalex.org/W2113162713","https://openalex.org/W2117247000","https://openalex.org/W2125009833","https://openalex.org/W2132082846","https://openalex.org/W2140105828","https://openalex.org/W2149659553","https://openalex.org/W2152012061","https://openalex.org/W2157363882","https://openalex.org/W2160810507","https://openalex.org/W2167228645","https://openalex.org/W2176524705","https://openalex.org/W2177036793","https://openalex.org/W2315512556","https://openalex.org/W2316228352","https://openalex.org/W2728956820"],"related_works":["https://openalex.org/W2316228352","https://openalex.org/W2167228645","https://openalex.org/W1986675971","https://openalex.org/W1518391024","https://openalex.org/W3147035945","https://openalex.org/W4394997903","https://openalex.org/W2156301841","https://openalex.org/W152217336","https://openalex.org/W2800797020","https://openalex.org/W2141566528"],"abstract_inverted_index":{"Mutation":[0],"of":[1,24,33,48,73,104,162],"the":[2,11,60,83,96,101,140,176],"human":[3],"gene":[4,178],"superoxide":[5],"dismutase":[6],"(hSOD1)":[7],"is":[8],"associated":[9],"with":[10,95],"fatal":[12],"neurodegenerative":[13],"disease":[14],"familial":[15],"amyotrophic":[16],"lateral":[17],"sclerosis":[18],"(Lou":[19],"Gehrig's":[20],"disease).":[21],"Selective":[22],"overexpression":[23],"hSOD1":[25,53,81,177],"in":[26,54,100,116,133,191],"Drosophila":[27],"motorneurons":[28],"increases":[29],"lifespan":[30,44],"to":[31,40,43,62,76,88,123,142,157,166,188],"140%":[32],"normal.":[34],"The":[35,106],"current":[36],"study":[37],"was":[38],"designed":[39],"determine":[41],"resistance":[42],"decline":[45,164],"and":[46,66,173],"failure":[47],"sensorimotor":[49,185],"functions":[50],"by":[51],"overexpressing":[52,80],"Drosophila's":[55],"motorneurons.":[56],"First,":[57],"we":[58,127],"measured":[59],"ability":[61,141],"maintain":[63],"continuous":[64],"flight":[65,90],"wingbeat":[67,114],"frequency":[68],"(WBF)":[69],"as":[70],"a":[71],"function":[72],"age":[74],"(5":[75],"50":[77],"days).":[78],"Flies":[79],"under":[82],"D42-GAL4":[84],"activator":[85],"were":[86],"able":[87],"sustain":[89],"significantly":[91,151],"longer":[92],"than":[93],"controls,":[94],"largest":[97],"effect":[98],"observed":[99],"middle":[102],"stages":[103],"life.":[105,193],"hSOD1-expressed":[107,148],"line":[108],"also":[109],"had,":[110],"on":[111],"average,":[112],"slower":[113],"frequencies":[115],"late,":[117],"but":[118,183],"not":[119,179],"early":[120],"life":[121,135],"relative":[122,156],"age-matched":[124],"controls.":[125,158],"Second,":[126],"examined":[128],"locomotor":[129],"(exploratory":[130],"walking)":[131],"behavior":[132],"late":[134,192],"when":[136],"flies":[137,149],"had":[138],"lost":[139],"fly":[143],"(age":[144],"\u2265":[145],"60":[146],"d).":[147],"showed":[150],"more":[152],"robust":[153],"walking":[154],"activity":[155],"Findings":[159],"show":[160],"patterns":[161],"functional":[163],"dissimilar":[165],"those":[167],"reported":[168],"for":[169],"other":[170],"life-extended":[171],"lines,":[172],"suggest":[174],"that":[175],"only":[180],"delays":[181],"death":[182],"enhances":[184],"abilities":[186],"critical":[187],"survival":[189],"even":[190]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
