{"id":"https://openalex.org/W2004201056","doi":"https://doi.org/10.1074/jbc.271.37.22663","title":"The Highly Stereoselective Oxidation of Polyunsaturated Fatty Acids by Cytochrome P450BM-3","display_name":"The Highly Stereoselective Oxidation of Polyunsaturated Fatty Acids by Cytochrome P450BM-3","publication_year":1996,"publication_date":"1996-09-01","ids":{"openalex":"https://openalex.org/W2004201056","doi":"https://doi.org/10.1074/jbc.271.37.22663","mag":"2004201056","pmid":"https://pubmed.ncbi.nlm.nih.gov/8798438"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.271.37.22663","doi":"https://doi.org/10.1074/jbc.271.37.22663","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.271.37.22663","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2004201056"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.271.37.22663","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112817943","display_name":"Jorge H. Capdevila","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge H. Capdevila","raw_affiliation_strings":["Department of Biochemistry, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA","Departments of Biochemistry, Vanderbilt University Medical School, Nashville, Tennessee 37232","Departments of Medicine and Vanderbilt University Medical School, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Departments of Biochemistry, Vanderbilt University Medical School, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Departments of Medicine and Vanderbilt University Medical School, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110181759","display_name":"Shozou Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shozou Wei","raw_affiliation_strings":["Departments of Medicine and Vanderbilt University Medical School, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Vanderbilt University Medical School, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007874923","display_name":"Christian F. Helvig","orcid":"https://orcid.org/0009-0004-0745-8812","observed_orcids":["https://orcid.org/0009-0004-0745-8812"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian Helvig","raw_affiliation_strings":["Departments of Medicine and Vanderbilt University Medical School, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Vanderbilt University Medical School, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077198825","display_name":"John Russell Falck","orcid":"https://orcid.org/0000-0002-9219-7845","observed_orcids":["https://orcid.org/0000-0002-9219-7845"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Falck","raw_affiliation_strings":["Molecular Genetics, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75325-9038"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75325-9038","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060154155","display_name":"Yuri Y. Belosludtsev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuri Belosludtsev","raw_affiliation_strings":["Molecular Genetics, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75325-9038"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75325-9038","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044887967","display_name":"Gilles Truan","orcid":"https://orcid.org/0000-0002-3560-8302","observed_orcids":["https://orcid.org/0000-0002-3560-8302"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gilles Truan","raw_affiliation_strings":["Departments of Biochemistry and The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75325-9038"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75325-9038","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033734831","display_name":"Sandra E. Graham-Lorence","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra E. Graham-Lorence","raw_affiliation_strings":["Departments of Biochemistry and The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75325-9038"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75325-9038","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110175219","display_name":"Julian A. Peterson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Julian A. Peterson","raw_affiliation_strings":["Departments of Biochemistry and The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75325-9038"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75325-9038","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110175219"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":6.5451,"has_fulltext":false,"cited_by_count":178,"citation_normalized_percentile":{"value":0.97953753,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"271","issue":"37","first_page":"22663","last_page":"22671"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.6460000276565552,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.6460000276565552,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.2712000012397766,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.028300000354647636,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arachidonic-acid-oxidation","display_name":"arachidonic acid oxidation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/polyunsaturated-fatty-acids","display_name":"polyunsaturated fatty acids","score":0.8820000290870667},{"id":"https://openalex.org/keywords/stereoselective-oxidation","display_name":"stereoselective oxidation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/epoxidation","display_name":"epoxidation","score":0.6579999923706055},{"id":"https://openalex.org/keywords/hydroxylation","display_name":"hydroxylation","score":0.878000020980835},{"id":"https://openalex.org/keywords/eicosapentaenoic-acid","display_name":"eicosapentaenoic acid","score":0.8899999856948853},{"id":"https://openalex.org/keywords/eicosatrienoic-acid","display_name":"eicosatrienoic acid","score":0.9909999966621399},{"id":"https://openalex.org/keywords/active-site-conformation","display_name":"active site conformation","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8595117330551147},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.8244193196296692},{"id":"https://openalex.org/C2776091944","wikidata":"https://www.wikidata.org/wiki/Q409990","display_name":"Eicosapentaenoic acid","level":4,"score":0.6638503074645996},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.5944461822509766},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5595476627349854},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.524685800075531},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.4896903336048126},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.4869869649410248},{"id":"https://openalex.org/C181647583","wikidata":"https://www.wikidata.org/wiki/Q903429","display_name":"Stereoselectivity","level":3,"score":0.47899600863456726},{"id":"https://openalex.org/C59759590","wikidata":"https://www.wikidata.org/wiki/Q2275927","display_name":"Regioselectivity","level":3,"score":0.4650149941444397},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.46430686116218567},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.44290050864219666},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.4247053265571594},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.37194228172302246},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2522519826889038},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2099810242652893},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.20332121849060059},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1869058907032013},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005231","descriptor_name":"Fatty Acids, Unsaturated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006893","descriptor_name":"Hydroxyeicosatetraenoic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009251","descriptor_name":"NADPH-Ferrihemoprotein Reductase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013054","descriptor_name":"Spectrophotometry, Atomic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015126","descriptor_name":"8,11,14-Eicosatrienoic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D015126","descriptor_name":"8,11,14-Eicosatrienoic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.271.37.22663","doi":"https://doi.org/10.1074/jbc.271.37.22663","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.271.37.22663","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:8798438","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8798438","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.271.37.22663","doi":"https://doi.org/10.1074/jbc.271.37.22663","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.271.37.22663","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5759635155","display_name":"Novel Eicosanoids: Synthesis and Function","funder_award_id":"R01GM031278","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6042489732","display_name":"P450BM-3--STRUCTURE AND BIOENGINEERING","funder_award_id":"R01GM043479","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7679332629","display_name":"NADPH-Dependent Metabolism of Arachidonic Acid","funder_award_id":"R01GM037922","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W87278874","https://openalex.org/W944320809","https://openalex.org/W994481069","https://openalex.org/W1480079437","https://openalex.org/W1483553420","https://openalex.org/W1497083865","https://openalex.org/W1554781559","https://openalex.org/W1586161739","https://openalex.org/W1595089190","https://openalex.org/W1605985146","https://openalex.org/W1607249944","https://openalex.org/W1657881138","https://openalex.org/W1681118386","https://openalex.org/W1951469402","https://openalex.org/W1993404169","https://openalex.org/W2000051743","https://openalex.org/W2010897322","https://openalex.org/W2027309585","https://openalex.org/W2027481602","https://openalex.org/W2037284298","https://openalex.org/W2045081422","https://openalex.org/W2048946635","https://openalex.org/W2054972846","https://openalex.org/W2055186480","https://openalex.org/W2059913491","https://openalex.org/W2076557221","https://openalex.org/W2077636244","https://openalex.org/W2079003753","https://openalex.org/W2086823401","https://openalex.org/W2092019850","https://openalex.org/W2134408999"],"related_works":["https://openalex.org/W2068925531","https://openalex.org/W1989272963","https://openalex.org/W1605985146","https://openalex.org/W1592030019","https://openalex.org/W2079003753","https://openalex.org/W2006788557","https://openalex.org/W1480079437","https://openalex.org/W2112593855","https://openalex.org/W2029758351","https://openalex.org/W2544518161"],"abstract_inverted_index":{"Cytochrome":[0],"P450BM-3":[1,25,93,133,181],"catalyzes":[2],"NADPH-dependent":[3],"metabolism":[4],"of":[5,21,32,66,84,111,127,140,160,171,182,188],"arachidonic":[6,27,76,172],"acid":[7,13,17,28,77,113,125,143,155],"to":[8,69,123],"nearly":[9,117],"enantiomerically":[10],"pure":[11],"18(R)-hydroxyeicosatetraenoic":[12],"and":[14,19,53,72,97,120,146,153,167,192,196,217,224],"14(S),":[15],"15(R)-epoxyeicosatrienoic":[16],"(80":[18],"20%":[20],"total":[22,128],"products,":[23,129],"respectively).":[24,106],"oxidizes":[26],"with":[29,116,150],"a":[30,158,169,183],"rate":[31],"3.2":[33],"+/-":[34,95,99],"0.4":[35],"micromol/min/nmol":[36,101],"at":[37,102],"30":[38,103],"degrees":[39,104],"C,":[40,105],"the":[41,82,85,108,141,165,178],"fastest":[42],"ever":[43],"reported":[44],"for":[45,214],"an":[46,58],"NADPH-dependent,":[47],"P450-catalyzed":[48],"reaction.":[49],"Fatty":[50],"acid,":[51],"oxygen,":[52],"NADPH":[54],"are":[55,88,205],"utilized":[56],"in":[57,81,157],"approximately":[59],"1:1:1":[60],"molar":[61],"ratio,":[62],"demonstrating":[63],"efficient":[64],"coupling":[65],"electron":[67],"transport":[68],"monooxygenation.":[70],"Eicosapentaenoic":[71],"eicosatrienoic":[73,142],"acids,":[74],"two":[75],"analogs":[78],"that":[79,198],"differ":[80],"properties":[83],"C-15-C-18":[86],"carbons,":[87,149],"also":[89],"actively":[90],"metabolized":[91],"by":[92,180],"(1.4":[94],"0.2":[96],"2.9":[98],"0.1":[100],"While":[107],"17,18-olefinic":[109],"bond":[110,190],"eicosapentaenoic":[112],"is":[114,134],"epoxidized":[115],"absolute":[118],"regio-":[119],"stereochemical":[121],"selectivity":[122],"17(S),18(R)-epoxyeicosatetraenoic":[124],"(>/=99%":[126],"97%":[130],"optical":[131],"purity),":[132],"only":[135],"moderately":[136],"regioselective":[137],"during":[138],"hydroxylation":[139,195],"omega-1,":[144],"omega-2,":[145],"omega-3":[147],"sp3":[148,193],"17-,":[151],"18-,":[152],"19-hydroxyeicosatrienoic":[154],"formed":[156],"ratio":[159],"2.4:2.2:1,":[161],"respectively.":[162],"Based":[163],"on":[164,168,208],"above":[166],"model":[170],"acid-bound":[173],"P450BM-3,":[174],"we":[175],"propose:":[176],"1)":[177],"formation":[179],"single":[184],"oxidant":[185],"species":[186],"capable":[187],"olefinic":[189],"epoxidation":[191],"carbon":[194,226],"2)":[197],"product":[199],"chemistry":[200],"and,":[201],"thus,":[202],"catalytic":[203],"outcome":[204],"critically":[206],"dependent":[207],"active":[209,222],"site":[210],"spatial":[211],"coordinates":[212],"responsible":[213],"substrate":[215],"binding":[216],"productive":[218],"orientation":[219],"between":[220],"heme-bound":[221],"oxygen":[223],"acceptor":[225],"bond(s).":[227]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}