{"id":"https://openalex.org/W2004200321","doi":"https://doi.org/10.1592/phco.28.9.1188","title":"Simvastatin\u2010Ezetimibe\u2010Induced Hepatic Failure Necessitating Liver Transplantation","display_name":"Simvastatin\u2010Ezetimibe\u2010Induced Hepatic Failure Necessitating Liver Transplantation","publication_year":2008,"publication_date":"2008-08-27","ids":{"openalex":"https://openalex.org/W2004200321","doi":"https://doi.org/10.1592/phco.28.9.1188","mag":"2004200321","pmid":"https://pubmed.ncbi.nlm.nih.gov/18752389"},"language":"en","primary_location":{"id":"doi:10.1592/phco.28.9.1188","doi":"https://doi.org/10.1592/phco.28.9.1188","is_oa":false,"landing_page_url":"https://doi.org/10.1592/phco.28.9.1188","pdf_url":null,"source":{"id":"https://openalex.org/S122731057","display_name":"Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy","issn_l":"0277-0008","issn":["0277-0008","1875-9114"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021831441","display_name":"Sony Tuteja","orcid":"https://orcid.org/0000-0001-7007-3289","observed_orcids":["https://orcid.org/0000-0001-7007-3289"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sony Tuteja","raw_affiliation_strings":["Division of Clinical and Administrative Pharmacy, College of Pharmacy, University of Iowa, Iowa City, Iowa 52242, USA. sony-tuteja@uiowa.edu","Division of Clinical and Administrative Pharmacy, College of Pharmacy, University of Iowa, Iowa City, Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical and Administrative Pharmacy, College of Pharmacy, University of Iowa, Iowa City, Iowa 52242, USA. sony-tuteja@uiowa.edu","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Division of Clinical and Administrative Pharmacy, College of Pharmacy, University of Iowa, Iowa City, Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016235995","display_name":"Nikolaos Pyrsopoulos","orcid":"https://orcid.org/0000-0002-6950-8174","observed_orcids":["https://orcid.org/0000-0002-6950-8174"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikolaos T. Pyrsopoulos","raw_affiliation_strings":["Division of Hepatology, University of Miami School of Medicine, Miami, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatology, University of Miami School of Medicine, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069941023","display_name":"William R. Wolowich","orcid":"https://orcid.org/0000-0002-0256-8535","observed_orcids":["https://orcid.org/0000-0002-0256-8535"]},"institutions":[{"id":"https://openalex.org/I203088144","display_name":"Nova Southeastern University","ror":"https://ror.org/042bbge36","country_code":"US","type":"education","lineage":["https://openalex.org/I203088144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William R. Wolowich","raw_affiliation_strings":["Department of Pharmacy Practice, College of Pharmacy, Nova Southeastern University, Ft. Lauderdale, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, College of Pharmacy, Nova Southeastern University, Ft. Lauderdale, Florida","institution_ids":["https://openalex.org/I203088144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067118294","display_name":"Kamran Khanmoradi","orcid":"https://orcid.org/0000-0003-3097-1011","observed_orcids":["https://orcid.org/0000-0003-3097-1011"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kamran Khanmoradi","raw_affiliation_strings":["Department of Surgery, Division of Transplantation, University of Miami School of Medicine, Miami, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Transplantation, University of Miami School of Medicine, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111471956","display_name":"David Levi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Levi","raw_affiliation_strings":["Department of Surgery, Division of Transplantation, University of Miami School of Medicine, Miami, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Transplantation, University of Miami School of Medicine, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072224155","display_name":"Gennaro Selvaggi","orcid":"https://orcid.org/0000-0003-4675-7095","observed_orcids":["https://orcid.org/0000-0003-4675-7095"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gennaro Selvaggi","raw_affiliation_strings":["Department of Surgery, Division of Transplantation, University of Miami School of Medicine, Miami, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Transplantation, University of Miami School of Medicine, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086625318","display_name":"Geoffrey S. Weisbaum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109487","display_name":"Broward Health Medical Center","ror":"https://ror.org/01jj2sr90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210109487","https://openalex.org/I4210161735"]},{"id":"https://openalex.org/I4210161735","display_name":"Broward Health","ror":"https://ror.org/05acrxx45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210161735"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geoffrey Weisbaum","raw_affiliation_strings":["Department of Pathology, Broward General Medical Center, Ft. Lauderdale, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Broward General Medical Center, Ft. Lauderdale, Florida","institution_ids":["https://openalex.org/I4210109487","https://openalex.org/I4210161735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056568620","display_name":"Andreas G. Tzakis","orcid":"https://orcid.org/0000-0001-8077-2315","observed_orcids":["https://orcid.org/0000-0001-8077-2315"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andreas G. Tzakis","raw_affiliation_strings":["Department of Surgery, Division of Transplantation, University of Miami School of Medicine, Miami, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Transplantation, University of Miami School of Medicine, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043581009","display_name":"Eugene R. Schiff","orcid":"https://orcid.org/0000-0002-0978-2040","observed_orcids":["https://orcid.org/0000-0002-0978-2040"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene R. Schiff","raw_affiliation_strings":["Division of Hepatology, University of Miami School of Medicine, Miami, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatology, University of Miami School of Medicine, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5021831441"],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":{"value":4030,"currency":"USD","value_usd":4030},"apc_paid":null,"fwci":4.2503,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.93196544,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"28","issue":"9","first_page":"1188","last_page":"1193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":0.8970000147819519},{"id":"https://openalex.org/keywords/ezetimibe","display_name":"ezetimibe","score":1.0},{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.7979999780654907},{"id":"https://openalex.org/keywords/acute-liver-failure","display_name":"acute liver failure","score":0.9850000143051147},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/statin-adverse-effects","display_name":"statin adverse effects","score":0.5450000166893005},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.8149999976158142},{"id":"https://openalex.org/keywords/glucuronidation-inhibition","display_name":"glucuronidation inhibition","score":0.75},{"id":"https://openalex.org/keywords/ugt-enzymes","display_name":"UGT enzymes","score":0.8199999928474426},{"id":"https://openalex.org/keywords/aminotransferase-elevation","display_name":"aminotransferase elevation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.7310000061988831},{"id":"https://openalex.org/keywords/escitalopram","display_name":"escitalopram","score":0.6100000143051147},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C2778657065","wikidata":"https://www.wikidata.org/wiki/Q417997","display_name":"Ezetimibe","level":3,"score":0.9598708152770996},{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.9213664531707764},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6959704160690308},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.5958986282348633},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5665357112884521},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5576147437095642},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5272858738899231},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4960099160671234},{"id":"https://openalex.org/C2911118192","wikidata":"https://www.wikidata.org/wiki/Q1192530","display_name":"Fulminant hepatic failure","level":4,"score":0.4498344361782074},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4413304030895233},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36227601766586304},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.31669196486473083}],"mesh":[{"descriptor_ui":"D000069438","descriptor_name":"Ezetimibe","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001384","descriptor_name":"Azetidines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008111","descriptor_name":"Liver Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019821","descriptor_name":"Simvastatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1592/phco.28.9.1188","doi":"https://doi.org/10.1592/phco.28.9.1188","is_oa":false,"landing_page_url":"https://doi.org/10.1592/phco.28.9.1188","pdf_url":null,"source":{"id":"https://openalex.org/S122731057","display_name":"Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy","issn_l":"0277-0008","issn":["0277-0008","1875-9114"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","raw_type":"journal-article"},{"id":"pmid:18752389","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18752389","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacotherapy","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8500000238418579}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W26631921","https://openalex.org/W44455618","https://openalex.org/W1485967434","https://openalex.org/W1498903994","https://openalex.org/W1554387723","https://openalex.org/W1578402817","https://openalex.org/W1970189800","https://openalex.org/W1975847111","https://openalex.org/W1977610644","https://openalex.org/W1981798840","https://openalex.org/W1985410301","https://openalex.org/W1992084132","https://openalex.org/W1994902405","https://openalex.org/W1995116750","https://openalex.org/W1998336053","https://openalex.org/W2001394268","https://openalex.org/W2019552515","https://openalex.org/W2028211844","https://openalex.org/W2062693500","https://openalex.org/W2094384835","https://openalex.org/W2096162459","https://openalex.org/W2111313602","https://openalex.org/W2132211266","https://openalex.org/W2150797190","https://openalex.org/W2568715732","https://openalex.org/W4246650513"],"related_works":["https://openalex.org/W2016617467","https://openalex.org/W26631921","https://openalex.org/W1993783526","https://openalex.org/W3091387850","https://openalex.org/W2065599187","https://openalex.org/W2463816592","https://openalex.org/W4234812477","https://openalex.org/W2058411984","https://openalex.org/W3163875934","https://openalex.org/W1969464487"],"abstract_inverted_index":{"Abstract":[0],"Serum":[1],"aminotransferase":[2,91,119,140,245],"elevations":[3,117],"are":[4],"a":[5,35],"commonly":[6],"known":[7],"adverse":[8,155],"effect":[9],"of":[10,78,108,126,177,198,212,224,231],"3-hydroxy-3-methylglutaryl":[11],"coenzyme":[12],"A":[13,80,112],"reductase":[14],"inhibitor":[15],"(statin)":[16],"therapy.":[17],"However,":[18],"hepatotoxic":[19],"events":[20],"have":[21,173],"not":[22],"been":[23,66],"widely":[24],"published":[25],"with":[26,68,134,234],"ezetimibe":[27,222],"or":[28],"the":[29,74,167,175,194,210,213,217,252],"combination":[30],"agent":[31],"simvastatin-ezetimibe.":[32],"We":[33,207],"describe":[34],"70-year-old":[36],"Hispanic":[37],"woman":[38],"who":[39],"developed":[40],"fulminant":[41],"hepatic":[42],"failure":[43,201],"necessitating":[44],"liver":[45,122,132,170,200,205],"transplantation":[46,133],"10":[47,57,84],"weeks":[48,85],"after":[49,86],"conversion":[50,75,87],"from":[51],"simvastatin":[52,56,69,178,184,219],"40":[53,59],"mg/day":[54],"to":[55,143],"mg-ezetimibe":[58],"mg/day.":[60],"The":[61],"patient's":[62],"lipid":[63],"panel":[64],"had":[65],"maintained":[67],"for":[70,100],"18":[71],"months":[72],"before":[73],"without":[76],"evidence":[77,125],"hepatotoxicity.":[79,188],"routine":[81],"laboratory":[82],"work-up":[83,114],"revealed":[88,115,124],"elevated":[89],"serum":[90,244],"levels.":[92],"Simvastatinezetimibe":[93],"and":[94,104,121,149,169,171,186,240,250],"escitalopram":[95],"(which":[96],"she":[97],"was":[98],"taking":[99],"depression)":[101],"were":[102,110],"discontinued,":[103],"other":[105],"potential":[106,232],"causes":[107],"hepatotoxicity":[109,215,233],"excluded.":[111],"repeat":[113],"further":[116],"in":[118,166,182,204,237],"levels,":[120],"biopsy":[123],"moderate-to-severe":[127],"drug":[128],"toxicity.":[129],"She":[130],"underwent":[131],"an":[135],"uneventful":[136],"postoperative":[137,146],"course.":[138],"Her":[139],"levels":[141,246],"returned":[142],"normal":[144],"by":[145,161,221],"day":[147],"23,":[148],"her":[150],"2-year":[151],"follow-up":[152],"showed":[153],"no":[154],"events.":[156],"Ezetimibe":[157],"undergoes":[158],"extensive":[159],"glucuronidation":[160,176],"uridine":[162],"diphosphate":[163],"glucoronosyltransferases":[164],"(UGT)":[165],"intestine":[168],"may":[172],"inhibited":[174],"hydroxy":[179],"acid,":[180],"resulting":[181],"increased":[183,218],"exposure":[185,220],"subsequent":[187],"To":[189],"our":[190],"knowledge,":[191],"this":[192],"is":[193,216],"first":[195],"case":[196],"report":[197],"simvastatin-ezetimibe-induced":[199],"that":[202,209],"resulted":[203],"transplantation.":[206],"postulate":[208],"mechanism":[211],"simvastatinezetimibe-induced":[214],"inhibition":[223],"UGT":[225],"enzymes.":[226],"Clinicians":[227],"should":[228,241],"be":[229],"aware":[230],"simvastatin-ezetimibe":[235],"especially":[236],"elderly":[238],"patients":[239],"carefully":[242],"monitor":[243],"when":[247],"starting":[248],"therapy":[249],"titrating":[251],"dosage.":[253]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}