{"id":"https://openalex.org/W2004197577","doi":"https://doi.org/10.1111/j.1872-034x.2008.00317.x","title":"Sustained response to interferon\u2010\u03b1 plus ribavirin therapy for chronic hepatitis C is closely associated with increased dynamism of intrahepatic natural killer and natural killer T cells","display_name":"Sustained response to interferon\u2010\u03b1 plus ribavirin therapy for chronic hepatitis C is closely associated with increased dynamism of intrahepatic natural killer and natural killer T cells","publication_year":2008,"publication_date":"2008-03-05","ids":{"openalex":"https://openalex.org/W2004197577","doi":"https://doi.org/10.1111/j.1872-034x.2008.00317.x","mag":"2004197577","pmid":"https://pubmed.ncbi.nlm.nih.gov/18328072"},"language":"en","primary_location":{"id":"doi:10.1111/j.1872-034x.2008.00317.x","doi":"https://doi.org/10.1111/j.1872-034x.2008.00317.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1872-034x.2008.00317.x","pdf_url":null,"source":{"id":"https://openalex.org/S110399111","display_name":"Hepatology Research","issn_l":"1386-6346","issn":["1386-6346","1872-034X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031398294","display_name":"Satoshi Yamagiwa","orcid":"https://orcid.org/0000-0003-4791-6107","observed_orcids":["https://orcid.org/0000-0003-4791-6107"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Satoshi Yamagiwa","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054249950","display_name":"Yasunobu Matsuda","orcid":"https://orcid.org/0000-0003-4363-1884","observed_orcids":["https://orcid.org/0000-0003-4363-1884"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasunobu Matsuda","raw_affiliation_strings":["Division of Gastroenterology and Hepatology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112655466","display_name":"Takafumi Ichida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]},{"id":"https://openalex.org/I4210130703","display_name":"Juntendo University Shizuoka Hospital","ror":"https://ror.org/035svbv36","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210130703"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takafumi Ichida","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Juntendo University School of Medicine, Shizuoka Hospital, Izunokuni, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Juntendo University School of Medicine, Shizuoka Hospital, Izunokuni, Japan","institution_ids":["https://openalex.org/I34077901","https://openalex.org/I4210130703"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yutaka Honda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yutaka Honda","raw_affiliation_strings":["Division of Gastroenterology and Hepatology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010895501","display_name":"Masaaki Takamura","orcid":"https://orcid.org/0000-0001-6773-4613","observed_orcids":["https://orcid.org/0000-0001-6773-4613"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masaaki Takamura","raw_affiliation_strings":["Division of Gastroenterology and Hepatology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112156689","display_name":"Satoshi Sugahara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satoshi Sugahara","raw_affiliation_strings":["Division of Gastroenterology and Hepatology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073095975","display_name":"Toru Ishikawa","orcid":"https://orcid.org/0000-0002-5470-9694","observed_orcids":["https://orcid.org/0000-0002-5470-9694"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toru Ishikawa","raw_affiliation_strings":["Division of Gastroenterology and Hepatology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009080092","display_name":"Shogo Ohkoshi","orcid":"https://orcid.org/0000-0003-2706-0209","observed_orcids":["https://orcid.org/0000-0003-2706-0209"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shogo Ohkoshi","raw_affiliation_strings":["Division of Gastroenterology and Hepatology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083824689","display_name":"Yoshinobu Sato","orcid":"https://orcid.org/0000-0001-6199-3681","observed_orcids":["https://orcid.org/0000-0001-6199-3681"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinobu Sato","raw_affiliation_strings":["Division of Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, and","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101014248","display_name":"Yutaka Aoyagi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yutaka Aoyagi","raw_affiliation_strings":["Division of Gastroenterology and Hepatology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5031398294"],"corresponding_institution_ids":["https://openalex.org/I71395657"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":4.1266,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.93445657,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"38","issue":"7","first_page":"664","last_page":"672"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":1.0},{"id":"https://openalex.org/keywords/sustained-virologic-response","display_name":"sustained virological response","score":0.8949999809265137},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.972000002861023},{"id":"https://openalex.org/keywords/nkt-cells","display_name":"NKT cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cd161","display_name":"CD161","score":0.718999981880188},{"id":"https://openalex.org/keywords/cd56","display_name":"CD56","score":0.9409999847412109},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.8629999756813049},{"id":"https://openalex.org/keywords/hcv-clearance","display_name":"HCV clearance","score":0.7200000286102295},{"id":"https://openalex.org/keywords/liver-biopsy","display_name":"liver biopsy","score":0.722000002861023},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.8863388299942017},{"id":"https://openalex.org/C2775836275","wikidata":"https://www.wikidata.org/wiki/Q3502310","display_name":"Dynamism","level":2,"score":0.6349602937698364},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.6068880558013916},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5664977431297302},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.5229343175888062},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.49843764305114746},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4880884885787964},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.33801034092903137},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.09798315167427063},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1872-034x.2008.00317.x","doi":"https://doi.org/10.1111/j.1872-034x.2008.00317.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1872-034x.2008.00317.x","pdf_url":null,"source":{"id":"https://openalex.org/S110399111","display_name":"Hepatology Research","issn_l":"1386-6346","issn":["1386-6346","1872-034X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Research","raw_type":"journal-article"},{"id":"pmid:18328072","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18328072","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology research : the official journal of the Japan Society of Hepatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1890880588","https://openalex.org/W1964482008","https://openalex.org/W1968213123","https://openalex.org/W1969814796","https://openalex.org/W1972264376","https://openalex.org/W1972453204","https://openalex.org/W1979027729","https://openalex.org/W1984007630","https://openalex.org/W1985234901","https://openalex.org/W1994969460","https://openalex.org/W2000115037","https://openalex.org/W2006497369","https://openalex.org/W2007252749","https://openalex.org/W2023828666","https://openalex.org/W2028161109","https://openalex.org/W2039441730","https://openalex.org/W2045631856","https://openalex.org/W2047208492","https://openalex.org/W2048314573","https://openalex.org/W2066720352","https://openalex.org/W2078845721","https://openalex.org/W2085388521","https://openalex.org/W2095178743","https://openalex.org/W2095326716","https://openalex.org/W2104277266","https://openalex.org/W2107749930","https://openalex.org/W2109492054","https://openalex.org/W2111220263","https://openalex.org/W2118888785","https://openalex.org/W2121381066","https://openalex.org/W2128759062","https://openalex.org/W2139250003","https://openalex.org/W2142805401","https://openalex.org/W2145171830","https://openalex.org/W2148067363","https://openalex.org/W2152870540","https://openalex.org/W2171212904"],"related_works":["https://openalex.org/W2081666281","https://openalex.org/W1132160997","https://openalex.org/W1969035614","https://openalex.org/W1976950676","https://openalex.org/W2998065269","https://openalex.org/W2018188612","https://openalex.org/W2100856307","https://openalex.org/W2133659227","https://openalex.org/W2317095461","https://openalex.org/W1593550791"],"abstract_inverted_index":{"AIM:":[0],"Previous":[1],"studies":[2],"have":[3],"revealed":[4],"that":[5,232],"functional":[6],"impairment":[7],"of":[8,28,37,58,67,85,160,191,201,212,223,248],"innate":[9,38,60],"immune":[10,39,61],"cells,":[11,21,40],"including":[12],"natural":[13,17],"killer":[14,18],"(NK)":[15],"and":[16,87,94,105,115,134,157,163,250],"T":[19],"(NKT)":[20],"might":[22],"be":[23],"associated":[24,244],"with":[25,69,75,183,240,245],"the":[26,35,44,56,64,83,155,168,199,204,221,254],"persistence":[27],"hepatitis":[29,71],"C":[30,72],"virus":[31],"(HCV)":[32],"infection.":[33],"However,":[34],"involvement":[36],"which":[41],"predominate":[42],"in":[43,46,63,90,142,146,167,172,177,198,220,253],"liver,":[45,169],"therapeutic":[47],"HCV":[48],"clearance":[49],"is":[50,242],"still":[51],"unclear.":[52],"METHODS:":[53],"To":[54],"clarify":[55],"role":[57],"intrahepatic":[59,132],"cells":[62,89,136,166,194,215,219,252],"clinical":[65],"outcome":[66],"patients":[68,103,144,239],"chronic":[70],"(CHC)":[73],"treated":[74],"interferon-alpha":[76],"plus":[77],"ribavirin":[78],"(IFN/RBV),":[79],"we":[80],"prospectively":[81],"investigated":[82],"status":[84],"NK":[86,133,162,249],"NKT":[88,135,165,193,218,251],"paired":[91],"liver":[92,114,127,200,222],"biopsy":[93],"peripheral":[95],"blood":[96],"(PB)":[97],"samples":[98,117],"obtained":[99,119],"from":[100,120],"21":[101],"CHC":[102,143,241],"before":[104],"immediately":[106],"after":[107,203],"IFN/RBV":[108,153,236],"treatment":[109,237],"by":[110],"flow":[111],"cytometry.":[112],"Normal":[113],"PB":[116],"were":[118,174],"10":[121],"healthy":[122,147],"donors":[123],"for":[124,238],"living":[125],"donor":[126],"transplantation.":[128],"RESULTS:":[129],"Before":[130],"treatment,":[131,154],"constituted":[137],"a":[138,209],"significantly":[139,175],"lower":[140],"proportion":[141,190],"than":[145],"individuals":[148],"(P":[149,186,225],"<":[150,187],"0.05).":[151,188],"After":[152],"proportions":[156],"absolute":[158],"numbers":[159],"CD3(-)CD161(+)":[161],"CD3(+)CD56(+)":[164,217],"but":[170],"not":[171],"PB,":[173],"increased":[176,197,246],"sustained":[178,233],"responders":[179,185],"(SR)":[180],"as":[181],"compared":[182],"poor":[184],"The":[189],"CD3(+)CD161(+)":[192],"was":[195,208],"also":[196],"SR":[202,224],"treatment.":[205],"Moreover,":[206],"there":[207],"striking":[210],"increase":[211],"activated":[213],"CD152(+)":[214],"among":[216],"=":[226],"0.041).":[227],"CONCLUSION:":[228],"These":[229],"findings":[230],"demonstrate":[231],"response":[234],"to":[235],"closely":[243],"dynamism":[247],"liver.":[255]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}