{"id":"https://openalex.org/W2004186414","doi":"https://doi.org/10.1179/joc.1996.8.6.472","title":"Methotrexate Serum Concentration and Histological Response to Multiagent Primary Chemotherapy for Osteosarcoma of the Limbs","display_name":"Methotrexate Serum Concentration and Histological Response to Multiagent Primary Chemotherapy for Osteosarcoma of the Limbs","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2004186414","doi":"https://doi.org/10.1179/joc.1996.8.6.472","mag":"2004186414","pmid":"https://pubmed.ncbi.nlm.nih.gov/8981189"},"language":"en","primary_location":{"id":"doi:10.1179/joc.1996.8.6.472","doi":"https://doi.org/10.1179/joc.1996.8.6.472","is_oa":false,"landing_page_url":"https://doi.org/10.1179/joc.1996.8.6.472","pdf_url":null,"source":{"id":"https://openalex.org/S127202688","display_name":"Journal of Chemotherapy","issn_l":"1120-009X","issn":["1120-009X","1973-9478"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008318243","display_name":"Giulia Bacci","orcid":"https://orcid.org/0009-0002-7213-2507","observed_orcids":["https://orcid.org/0009-0002-7213-2507"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Bacci","raw_affiliation_strings":["Sezione di Chemioterapia dei Tumori dell' Apparato Locomotore, Universit\u00e0 di Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sezione di Chemioterapia dei Tumori dell' Apparato Locomotore, Universit\u00e0 di Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101746409","display_name":"Stefano Ferrari","orcid":"https://orcid.org/0000-0001-6462-6000","observed_orcids":["https://orcid.org/0000-0001-6462-6000"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Ferrari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083948167","display_name":"Piero Picci","orcid":"https://orcid.org/0000-0002-8519-4101","observed_orcids":["https://orcid.org/0000-0002-8519-4101"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Picci","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086143046","display_name":"Carola Zolezzi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Zolezzi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038152327","display_name":"Franco Gherlinzoni","orcid":"https://orcid.org/0000-0003-4759-7257","observed_orcids":["https://orcid.org/0000-0003-4759-7257"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Gherlinzoni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025428966","display_name":"D Iantorno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Iantorno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"A. Cazzola","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Cazzola","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1773,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.78695935,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"8","issue":"6","first_page":"472","last_page":"478"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.8550000190734863},{"id":"https://openalex.org/keywords/serum-drug-levels","display_name":"serum drug concentration","score":0.8930000066757202},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.906000018119812},{"id":"https://openalex.org/keywords/limb-osteosarcoma","display_name":"limb osteosarcoma","score":0.8429999947547913},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.8999999761581421},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8700000047683716},{"id":"https://openalex.org/keywords/tumor-necrosis","display_name":"tumor necrosis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/histological-response","display_name":"histological response","score":0.6679999828338623},{"id":"https://openalex.org/keywords/telangiectatic-osteosarcoma","display_name":"telangiectatic osteosarcoma","score":0.8399999737739563},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.8690896034240723},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.8413476943969727},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.8164874315261841},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.7002800703048706},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6102946996688843},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5706593990325928},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5554375648498535},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.5398733615875244},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4352644979953766},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4252947270870209},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4172508418560028},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23241102695465088},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12191322445869446},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.051793575286865234}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005121","descriptor_name":"Extremities","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1179/joc.1996.8.6.472","doi":"https://doi.org/10.1179/joc.1996.8.6.472","is_oa":false,"landing_page_url":"https://doi.org/10.1179/joc.1996.8.6.472","pdf_url":null,"source":{"id":"https://openalex.org/S127202688","display_name":"Journal of Chemotherapy","issn_l":"1120-009X","issn":["1120-009X","1973-9478"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemotherapy","raw_type":"journal-article"},{"id":"pmid:8981189","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8981189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemotherapy (Florence, Italy)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W14799966","https://openalex.org/W1810454109","https://openalex.org/W1902222293","https://openalex.org/W1973948212","https://openalex.org/W1981956631","https://openalex.org/W2013612727","https://openalex.org/W2077746558","https://openalex.org/W2113211750","https://openalex.org/W2117852255","https://openalex.org/W2142136189","https://openalex.org/W2198846739","https://openalex.org/W2410506288"],"related_works":["https://openalex.org/W2137872977","https://openalex.org/W2401404931","https://openalex.org/W2031564407","https://openalex.org/W2153180030","https://openalex.org/W170676557","https://openalex.org/W2384299534","https://openalex.org/W1810454109","https://openalex.org/W2021276267","https://openalex.org/W1965417875","https://openalex.org/W2269550442"],"abstract_inverted_index":{"The":[0,217],"authors":[1,218],"investigated":[2],"the":[3,206],"influence":[4,225],"of":[5,92,97,104,118,144,151,168,200,236,249],"methotrexate":[6],"(MTX)":[7],"serum":[8,26,48,107,191,222],"concentration":[9],"on":[10],"(histologically":[11],"evaluated)":[12],"tumor":[13,58,68,73,81,86,148,163,186,215,227,242],"necrosis,":[14,164],"induced":[15],"by":[16],"a":[17,141,180,232],"primary":[18,233],"multiagent":[19],"chemotherapy,":[20],"including":[21,183],"MTX,":[22,240],"for":[23],"osteosarcoma.":[24,230],"MTX":[25,34,49,95,108,121,130,155,198,221,252],"peaks":[27,51,96,109,122,131,199,223],"in":[28,54,90,102,116,229,247],"151":[29],"patients,":[30],"preoperatively":[31],"treated":[32],"with":[33,56,66,94,106,120,140,146,153,251],"(8-12g/m2),":[35],"cisplatin":[36],"(120mg/m2)":[37],"and":[38,112,115,188,194,239],"Adriamycin":[39,238],"(60mg/m2),":[40],"were":[41,52,137,211],"analyzed.":[42],"Significantly":[43],"(p":[44,176],"<":[45,177],"0.01)":[46],"higher":[47],"mean":[50],"observed":[53,89],"patients":[55,65,93,105,152,169,250],"complete":[57,147,162,241],"necrosis":[59,69,74,82,87,228,243],"(MTX":[60],"773.8":[61],"mumol/l)":[62,76,136],"compared":[63,165],"to":[64,126,166],"90-99%":[67],"(639.8":[70],"mumol/l),":[71],"50-89%":[72],"(649.1":[75],"or":[77,256],"less":[78,98,204],"than":[79,99,158],"50%":[80],"(610":[83],"mumol/l).":[84],"Complete":[85],"was":[88],"9%":[91],"600":[100,111],"mumol/l,":[101],"27%":[103],"between":[110],"699":[113],"mumol/l":[114,160,202],"37%":[117],"those":[119],"ranging":[123],"from":[124],"700":[125,159,201,258],"799":[127],"mumol/l.":[128,259],"Higher":[129],"(800-899,":[132],"900-999,":[133],">":[134,255],"1000":[135],"not":[138,172],"associated":[139],"further":[142],"increase":[143],"cases":[145],"necrosis.":[149,216],"40%":[150,248],"an":[154],"peak":[156,253],"greater":[157],"had":[161],"15.5%":[167],"who":[170],"did":[171],"reach":[173],"this":[174],"value":[175],"0.002).":[178],"At":[179],"multivariant":[181],"analysis":[182],"age,":[184],"sex,":[185],"site":[187],"volume,":[189],"pretreatment":[190],"alkaline":[192],"phosphatase":[193],"lactic":[195],"dehydrogenase":[196],"levels,":[197],"and,":[203],"significantly,":[205],"histologic":[207],"type":[208],"(telangiectatic":[209],"osteosarcoma),":[210],"independent":[212],"factors":[213],"influencing":[214],"conclude":[219],"that":[220],"significantly":[224],"chemotherapy-induced":[226],"In":[231],"treatment":[234],"consisting":[235],"cisplatin,":[237],"can":[244],"be":[245],"obtained":[246],"concentrations":[254],"=":[257]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}