{"id":"https://openalex.org/W2004186306","doi":"https://doi.org/10.1371/journal.pone.0089722","title":"Elements Modulating the Prion Species Barrier and Its Passage Consequences","display_name":"Elements Modulating the Prion Species Barrier and Its Passage Consequences","publication_year":2014,"publication_date":"2014-03-07","ids":{"openalex":"https://openalex.org/W2004186306","doi":"https://doi.org/10.1371/journal.pone.0089722","mag":"2004186306","pmid":"https://pubmed.ncbi.nlm.nih.gov/24608126","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3946430"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0089722","doi":"https://doi.org/10.1371/journal.pone.0089722","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0089722","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089722&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089722&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017989541","display_name":"Juan Mar\u00eda Torres","orcid":"https://orcid.org/0000-0003-0443-9232","observed_orcids":["https://orcid.org/0000-0003-0443-9232"]},"institutions":[{"id":"https://openalex.org/I4210106474","display_name":"Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria","ror":"https://ror.org/011q66e29","country_code":"ES","type":"funder","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474"]},{"id":"https://openalex.org/I4388891844","display_name":"Centro de Investigaci\u00f3n en Sanidad Animal","ror":"https://ror.org/05m6hv760","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474","https://openalex.org/I4388891844"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Juan-Maria Torres","raw_affiliation_strings":["Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain","INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain","institution_ids":["https://openalex.org/I4388891844"]},{"raw_affiliation_string":"INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)","institution_ids":["https://openalex.org/I4210106474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068669818","display_name":"Juan Carlos Espinosa","orcid":"https://orcid.org/0000-0002-6719-9902","observed_orcids":["https://orcid.org/0000-0002-6719-9902"]},"institutions":[{"id":"https://openalex.org/I4210106474","display_name":"Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria","ror":"https://ror.org/011q66e29","country_code":"ES","type":"funder","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474"]},{"id":"https://openalex.org/I4388891844","display_name":"Centro de Investigaci\u00f3n en Sanidad Animal","ror":"https://ror.org/05m6hv760","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474","https://openalex.org/I4388891844"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan-Carlos Espinosa","raw_affiliation_strings":["Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain","INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain","institution_ids":["https://openalex.org/I4388891844"]},{"raw_affiliation_string":"INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)","institution_ids":["https://openalex.org/I4210106474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013693099","display_name":"Patricia Aguilar\u2010Calvo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106474","display_name":"Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria","ror":"https://ror.org/011q66e29","country_code":"ES","type":"funder","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474"]},{"id":"https://openalex.org/I4388891844","display_name":"Centro de Investigaci\u00f3n en Sanidad Animal","ror":"https://ror.org/05m6hv760","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474","https://openalex.org/I4388891844"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Patricia Aguilar-Calvo","raw_affiliation_strings":["Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain","INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain","institution_ids":["https://openalex.org/I4388891844"]},{"raw_affiliation_string":"INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)","institution_ids":["https://openalex.org/I4210106474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113559372","display_name":"Mar\u00eda Eugenia Herva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106474","display_name":"Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria","ror":"https://ror.org/011q66e29","country_code":"ES","type":"funder","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474"]},{"id":"https://openalex.org/I4388891844","display_name":"Centro de Investigaci\u00f3n en Sanidad Animal","ror":"https://ror.org/05m6hv760","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474","https://openalex.org/I4388891844"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda-Eugenia Herva","raw_affiliation_strings":["Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain","INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain","institution_ids":["https://openalex.org/I4388891844"]},{"raw_affiliation_string":"INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)","institution_ids":["https://openalex.org/I4210106474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079209784","display_name":"Aroa Rela\u00f1o-Gin\u00e9s","orcid":"https://orcid.org/0000-0002-3906-6360","observed_orcids":["https://orcid.org/0000-0002-3906-6360"]},"institutions":[{"id":"https://openalex.org/I4210106474","display_name":"Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria","ror":"https://ror.org/011q66e29","country_code":"ES","type":"funder","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474"]},{"id":"https://openalex.org/I4388891844","display_name":"Centro de Investigaci\u00f3n en Sanidad Animal","ror":"https://ror.org/05m6hv760","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474","https://openalex.org/I4388891844"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Aroa Rela\u00f1o-Gin\u00e9s","raw_affiliation_strings":["Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain","INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain","institution_ids":["https://openalex.org/I4388891844"]},{"raw_affiliation_string":"INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)","institution_ids":["https://openalex.org/I4210106474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001098349","display_name":"Ana Villa","orcid":"https://orcid.org/0000-0001-5419-3387","observed_orcids":["https://orcid.org/0000-0001-5419-3387"]},"institutions":[{"id":"https://openalex.org/I4210106474","display_name":"Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria","ror":"https://ror.org/011q66e29","country_code":"ES","type":"funder","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474"]},{"id":"https://openalex.org/I4388891844","display_name":"Centro de Investigaci\u00f3n en Sanidad Animal","ror":"https://ror.org/05m6hv760","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474","https://openalex.org/I4388891844"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Villa-Diaz","raw_affiliation_strings":["Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain","INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain","institution_ids":["https://openalex.org/I4388891844"]},{"raw_affiliation_string":"INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)","institution_ids":["https://openalex.org/I4210106474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044397066","display_name":"M\u00f3nica Morales","orcid":"https://orcid.org/0000-0001-9786-9076","observed_orcids":["https://orcid.org/0000-0001-9786-9076"]},"institutions":[{"id":"https://openalex.org/I4210106474","display_name":"Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria","ror":"https://ror.org/011q66e29","country_code":"ES","type":"funder","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474"]},{"id":"https://openalex.org/I4388891844","display_name":"Centro de Investigaci\u00f3n en Sanidad Animal","ror":"https://ror.org/05m6hv760","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474","https://openalex.org/I4388891844"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M\u00f3nica Morales","raw_affiliation_strings":["Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain","INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain","institution_ids":["https://openalex.org/I4388891844"]},{"raw_affiliation_string":"INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)","institution_ids":["https://openalex.org/I4210106474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101677711","display_name":"Beatriz Parra","orcid":"https://orcid.org/0000-0003-1169-4418","observed_orcids":["https://orcid.org/0000-0003-1169-4418"]},"institutions":[{"id":"https://openalex.org/I4210106474","display_name":"Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria","ror":"https://ror.org/011q66e29","country_code":"ES","type":"funder","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474"]},{"id":"https://openalex.org/I4388891844","display_name":"Centro de Investigaci\u00f3n en Sanidad Animal","ror":"https://ror.org/05m6hv760","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474","https://openalex.org/I4388891844"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Beatriz Parra","raw_affiliation_strings":["Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain","INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain","institution_ids":["https://openalex.org/I4388891844"]},{"raw_affiliation_string":"INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)","institution_ids":["https://openalex.org/I4210106474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075479684","display_name":"Elia Alamillo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106474","display_name":"Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria","ror":"https://ror.org/011q66e29","country_code":"ES","type":"funder","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474"]},{"id":"https://openalex.org/I4388891844","display_name":"Centro de Investigaci\u00f3n en Sanidad Animal","ror":"https://ror.org/05m6hv760","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474","https://openalex.org/I4388891844"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elia Alamillo","raw_affiliation_strings":["Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain","INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain","institution_ids":["https://openalex.org/I4388891844"]},{"raw_affiliation_string":"INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)","institution_ids":["https://openalex.org/I4210106474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048087932","display_name":"Alejandro Brun","orcid":"https://orcid.org/0000-0001-7865-538X","observed_orcids":["https://orcid.org/0000-0001-7865-538X"]},"institutions":[{"id":"https://openalex.org/I4210106474","display_name":"Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria","ror":"https://ror.org/011q66e29","country_code":"ES","type":"funder","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474"]},{"id":"https://openalex.org/I4388891844","display_name":"Centro de Investigaci\u00f3n en Sanidad Animal","ror":"https://ror.org/05m6hv760","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474","https://openalex.org/I4388891844"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alejandro Brun","raw_affiliation_strings":["Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain","INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain","institution_ids":["https://openalex.org/I4388891844"]},{"raw_affiliation_string":"INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)","institution_ids":["https://openalex.org/I4210106474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052660860","display_name":"Joaqu\u0131\u0301n Castilla","orcid":"https://orcid.org/0000-0002-2216-1361","observed_orcids":["https://orcid.org/0000-0002-2216-1361"]},"institutions":[{"id":"https://openalex.org/I110594554","display_name":"Ikerbasque","ror":"https://ror.org/01cc3fy72","country_code":"ES","type":"other","lineage":["https://openalex.org/I110594554"]},{"id":"https://openalex.org/I4210106474","display_name":"Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria","ror":"https://ror.org/011q66e29","country_code":"ES","type":"funder","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474"]},{"id":"https://openalex.org/I4210112728","display_name":"CIC bioGUNE","ror":"https://ror.org/02x5c5y60","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210112728"]},{"id":"https://openalex.org/I4388891844","display_name":"Centro de Investigaci\u00f3n en Sanidad Animal","ror":"https://ror.org/05m6hv760","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474","https://openalex.org/I4388891844"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Joaqu\u00edn Castilla","raw_affiliation_strings":["Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain; CIC bioGUNE and IKERBASQUE, Basque Foundation for Science, Derio-Bilbao, Bizkaia, Spain","INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)","Ikerbasque - Basque Foundation for Science (Spain)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain; CIC bioGUNE and IKERBASQUE, Basque Foundation for Science, Derio-Bilbao, Bizkaia, Spain","institution_ids":["https://openalex.org/I110594554","https://openalex.org/I4210106474","https://openalex.org/I4210112728","https://openalex.org/I4388891844"]},{"raw_affiliation_string":"INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)","institution_ids":["https://openalex.org/I4210106474"]},{"raw_affiliation_string":"Ikerbasque - Basque Foundation for Science (Spain)","institution_ids":["https://openalex.org/I110594554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009016858","display_name":"Susana Molina","orcid":"https://orcid.org/0000-0001-7737-5562","observed_orcids":["https://orcid.org/0000-0001-7737-5562"]},"institutions":[{"id":"https://openalex.org/I4210106474","display_name":"Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria","ror":"https://ror.org/011q66e29","country_code":"ES","type":"funder","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474"]},{"id":"https://openalex.org/I4388891844","display_name":"Centro de Investigaci\u00f3n en Sanidad Animal","ror":"https://ror.org/05m6hv760","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210106474","https://openalex.org/I4388891844"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Susana Molina","raw_affiliation_strings":["Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain","INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain","institution_ids":["https://openalex.org/I4388891844"]},{"raw_affiliation_string":"INIA - Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria\r\nMadrid - Spain)","institution_ids":["https://openalex.org/I4210106474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113521780","display_name":"Steve A C Hawkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174729306","display_name":"Animal and Plant Health Agency","ror":"https://ror.org/0378g3743","country_code":"GB","type":"government","lineage":["https://openalex.org/I1326803253","https://openalex.org/I174729306","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steve A. C. Hawkins","raw_affiliation_strings":["Animal Health and Veterinary Laboratories Agency (AHVLA) New Haw, Addlestone, Surrey, United Kingdom","AHVLA - Animal Health and Veterinary Laboratories Agency (United Kingdom)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Health and Veterinary Laboratories Agency (AHVLA) New Haw, Addlestone, Surrey, United Kingdom","institution_ids":["https://openalex.org/I174729306"]},{"raw_affiliation_string":"AHVLA - Animal Health and Veterinary Laboratories Agency (United Kingdom)","institution_ids":["https://openalex.org/I174729306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042897654","display_name":"Olivier Andr\u00e9oletti","orcid":"https://orcid.org/0000-0002-7369-6016","observed_orcids":["https://orcid.org/0000-0002-7369-6016"]},"institutions":[{"id":"https://openalex.org/I176063091","display_name":"\u00c9cole Nationale V\u00e9t\u00e9rinaire de Toulouse","ror":"https://ror.org/03m3gzv89","country_code":"FR","type":"education","lineage":["https://openalex.org/I176063091","https://openalex.org/I205747304","https://openalex.org/I4210117091"]},{"id":"https://openalex.org/I4210146726","display_name":"Interactions h\u00f4tes-agents pathog\u00e8nes","ror":"https://ror.org/041yk0b68","country_code":"FR","type":"facility","lineage":["https://openalex.org/I176063091","https://openalex.org/I205747304","https://openalex.org/I4210088668","https://openalex.org/I4210117091","https://openalex.org/I4210146726"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Andreoletti","raw_affiliation_strings":["UMR INRA-ENVT 1225, Interactions H\u00f4te Agent Pathog\u00e8ne, \u00c9cole Nationale V\u00e9t\u00e9rinaire de Toulouse, France","IHAP - Interactions h\u00f4tes-agents pathog\u00e8nes [Toulouse] (23, Chemin des Capelles 31076 Toulouse cedex - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR INRA-ENVT 1225, Interactions H\u00f4te Agent Pathog\u00e8ne, \u00c9cole Nationale V\u00e9t\u00e9rinaire de Toulouse, France","institution_ids":["https://openalex.org/I176063091","https://openalex.org/I4210146726"]},{"raw_affiliation_string":"IHAP - Interactions h\u00f4tes-agents pathog\u00e8nes [Toulouse] (23, Chemin des Capelles 31076 Toulouse cedex - France)","institution_ids":["https://openalex.org/I4210146726"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5017989541"],"corresponding_institution_ids":["https://openalex.org/I4210106474","https://openalex.org/I4388891844"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.3224,"has_fulltext":true,"cited_by_count":58,"citation_normalized_percentile":{"value":0.88729879,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"9","issue":"3","first_page":"e89722","last_page":"e89722"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bovine-spongiform-encephalopathy","display_name":"bovine spongiform encephalopathy","score":0.8999999761581421},{"id":"https://openalex.org/keywords/prion-disease","display_name":"prion disease","score":0.9269999861717224},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.527999997138977},{"id":"https://openalex.org/keywords/cellular-prion-protein","display_name":"cellular prion protein","score":0.859000027179718},{"id":"https://openalex.org/keywords/cross-species-transmission","display_name":"interspecies transmission","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C2781131914","wikidata":"https://www.wikidata.org/wiki/Q154666","display_name":"Bovine spongiform encephalopathy","level":4,"score":0.9376026391983032},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6877725124359131},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6821480989456177},{"id":"https://openalex.org/C3019804061","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"Prion protein","level":3,"score":0.575846791267395},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.5585372447967529},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5228450894355774},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5150020122528076},{"id":"https://openalex.org/C2776797465","wikidata":"https://www.wikidata.org/wiki/Q703961","display_name":"Transmissible spongiform encephalopathy","level":5,"score":0.5116682052612305},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.46058979630470276},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4287848174571991},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.42000776529312134},{"id":"https://openalex.org/C2776735649","wikidata":"https://www.wikidata.org/wiki/Q170102","display_name":"Scrapie","level":4,"score":0.28169864416122437},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2770760655403137},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22420671582221985},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016643","descriptor_name":"Encephalopathy, Bovine Spongiform","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017096","descriptor_name":"Prion Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pone.0089722","doi":"https://doi.org/10.1371/journal.pone.0089722","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0089722","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089722&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2931765","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3946430","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3946430","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3946430","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24608126","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24608126","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:digital.csic.es:10261/294060","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/294060","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:HAL:hal-02631177v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.inrae.fr/hal-02631177","pdf_url":"https://hal.inrae.fr/hal-02631177v1/file/2014_Torres_1.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.plosone.org/","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dnet:r2i2________::44beec321ed556078c7cbf3fce90e405","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.12792/4537","pdf_url":"http://hdl.handle.net/20.500.12792/4537","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.804.4365","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.804.4365","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/95/76/pone.0089722.PMC3946430.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:c89528df259e4d1b9e9b89ba0f1bf709","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c89528df259e4d1b9e9b89ba0f1bf709","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 3, p e89722 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0089722","doi":"https://doi.org/10.1371/journal.pone.0089722","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0089722","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089722&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4278422103","display_name":"Protecting the food chain from prions: shaping European priorities through basic and applied research","funder_award_id":"222887","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320309969","display_name":"Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria","ror":"https://ror.org/011q66e29"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004186306.pdf","grobid_xml":"https://content.openalex.org/works/W2004186306.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W53055727","https://openalex.org/W1557724928","https://openalex.org/W1563777667","https://openalex.org/W1829344915","https://openalex.org/W1968558040","https://openalex.org/W1979550663","https://openalex.org/W1983750916","https://openalex.org/W1991644458","https://openalex.org/W1996126760","https://openalex.org/W2000439710","https://openalex.org/W2000966908","https://openalex.org/W2005200706","https://openalex.org/W2013679718","https://openalex.org/W2014742609","https://openalex.org/W2016565903","https://openalex.org/W2021489997","https://openalex.org/W2022392367","https://openalex.org/W2026093694","https://openalex.org/W2049719457","https://openalex.org/W2053699160","https://openalex.org/W2057439911","https://openalex.org/W2065579355","https://openalex.org/W2070693268","https://openalex.org/W2083346670","https://openalex.org/W2100264046","https://openalex.org/W2104673642","https://openalex.org/W2112749271","https://openalex.org/W2115925208","https://openalex.org/W2120071129","https://openalex.org/W2121611717","https://openalex.org/W2129442923","https://openalex.org/W2130695464","https://openalex.org/W2133145715","https://openalex.org/W2134393699","https://openalex.org/W2143873953","https://openalex.org/W2144576624","https://openalex.org/W2150151638","https://openalex.org/W2151000339","https://openalex.org/W2155727218","https://openalex.org/W2162098088","https://openalex.org/W2303163021"],"related_works":["https://openalex.org/W2045406892","https://openalex.org/W2115187808","https://openalex.org/W2156464988","https://openalex.org/W2121218783","https://openalex.org/W146253285","https://openalex.org/W2134393699","https://openalex.org/W2560394536","https://openalex.org/W1965132458","https://openalex.org/W2112749271","https://openalex.org/W2081705989"],"abstract_inverted_index":{"The":[0,220],"specific":[1],"characteristics":[2,27],"of":[3,28,72,88,263],"Transmissible":[4],"Spongiform":[5,30],"Encephalopathy":[6,31],"(TSE)":[7],"strains":[8],"may":[9],"be":[10,96],"altered":[11],"during":[12],"passage":[13,202],"across":[14],"a":[15,125,131],"species":[16,39,133,198,253],"barrier.":[17,128],"In":[18,129],"this":[19],"study":[20],"we":[21,194],"investigated":[22],"the":[23,50,64,73,85,89,138,151,154,197,208,225,228,241,261],"biochemical":[24,86],"and":[25,43,45,175,200,212,244],"biological":[26],"Bovine":[29],"(BSE)":[32],"after":[33],"transmission":[34,127,156],"in":[35,46,56,84,107,186,190,240],"both":[36],"natural":[37,187],"host":[38,174,209,217],"(cattle,":[40],"sheep,":[41],"pigs":[42],"mice)":[44],"transgenic":[47,101,108,191],"mice":[48,102,109],"overexpressing":[49],"corresponding":[51],"cellular":[52],"prion":[53,155],"protein":[54],"(PrPC)":[55],"comparison":[57],"with":[58,122,182],"other":[59,216,235,252],"non-BSE":[60,139],"related":[61,140],"prions":[62,141,183],"from":[63],"same":[65],"species.":[66],"After":[67],"these":[68],"passages,":[69],"most":[70],"features":[71],"BSE":[74,229],"agent":[75,230],"remained":[76],"unchanged.":[77],"BSE-derived":[78,118],"agents":[79,119],"only":[80],"showed":[81],"slight":[82],"modifications":[83],"properties":[87,162,239],"accumulated":[90],"PrPSc,":[91],"which":[92],"were":[93,120,180],"demonstrated":[94],"to":[95,249,251],"reversible":[97],"upon":[98],"re-inoculation":[99],"into":[100],"expressing":[103,110],"bovine-PrPC.":[104],"Transmission":[105],"experiments":[106],"bovine,":[111],"porcine":[112],"or":[113,124,189],"human-PrP":[114],"revealed":[115],"that":[116,142,153,196,227],"all":[117],"transmitted":[121],"no":[123],"weak":[126],"contrast,":[130],"high":[132],"barrier":[134,157,199],"was":[135],"observed":[136,181],"for":[137,260,268],"harboured":[143],"an":[144,264],"identical":[145,178],"PrP":[146,168],"amino":[147,169],"acid":[148,170],"sequence,":[149],"supporting":[150],"theory":[152],"is":[158,231],"modulated":[159],"by":[160,167,207,215],"strain":[161],"(presumably":[163],"conformation-dependent)":[164],"rather":[165],"than":[166],"sequence":[171,211],"differences":[172],"between":[173],"donor.":[176],"As":[177],"results":[179,221],"propagated":[184],"either":[185],"hosts":[188],"mouse":[192],"models,":[193],"postulate":[195],"its":[201,238,247],"consequences":[203],"are":[204,258],"uniquely":[205],"governed":[206],"PrPC":[210],"not":[213],"influenced":[214],"genetic":[218],"factors.":[219],"presented":[222],"herein":[223],"reinforce":[224],"idea":[226],"highly":[232],"promiscuous,":[233],"infecting":[234],"species,":[236,243],"maintaining":[237],"new":[242],"even":[245],"increasing":[246],"capabilities":[248],"jump":[250],"including":[254],"humans.":[255],"These":[256],"data":[257],"essential":[259],"development":[262],"accurate":[265],"risk":[266],"assessment":[267],"BSE.":[269]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}