{"id":"https://openalex.org/W2004183689","doi":"https://doi.org/10.1074/jbc.m610415200","title":"Inhibition of Hypoxia-inducible Factor (HIF) Hydroxylases by Citric Acid Cycle Intermediates","display_name":"Inhibition of Hypoxia-inducible Factor (HIF) Hydroxylases by Citric Acid Cycle Intermediates","publication_year":2006,"publication_date":"2006-12-21","ids":{"openalex":"https://openalex.org/W2004183689","doi":"https://doi.org/10.1074/jbc.m610415200","mag":"2004183689","pmid":"https://pubmed.ncbi.nlm.nih.gov/17182618"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m610415200","doi":"https://doi.org/10.1074/jbc.m610415200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m610415200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m610415200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108833842","display_name":"Peppi Koivunen","orcid":"https://orcid.org/0000-0002-2827-8229","observed_orcids":["https://orcid.org/0000-0002-2827-8229"]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Peppi Koivunen","raw_affiliation_strings":["Collagen Research Unit, University of Oulu, FIN-90014 Oulu, Finland; Biocenter Oulu, Departments of University of Oulu, FIN-90014 Oulu, Finland; Medical Biochemistry and Molecular Biology and, University of Oulu, FIN-90014 Oulu, Finland","Medical Biochemistry and Molecular Biology and, University of Oulu, FIN-90014 Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collagen Research Unit, University of Oulu, FIN-90014 Oulu, Finland; Biocenter Oulu, Departments of University of Oulu, FIN-90014 Oulu, Finland; Medical Biochemistry and Molecular Biology and, University of Oulu, FIN-90014 Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"Medical Biochemistry and Molecular Biology and, University of Oulu, FIN-90014 Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013560422","display_name":"Maija Hirsil\u00e4","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Maija Hirsil\u00e4","raw_affiliation_strings":["Collagen Research Unit, University of Oulu, FIN-90014 Oulu, Finland; Biocenter Oulu, Departments of University of Oulu, FIN-90014 Oulu, Finland; Medical Biochemistry and Molecular Biology and, University of Oulu, FIN-90014 Oulu, Finland","Biocenter Oulu, Departments of University of Oulu, FIN-90014 Oulu, Finland","Collagen Research Unit, University of Oulu, FIN-90014 Oulu, Finland","Medical Biochemistry and Molecular Biology and, University of Oulu, FIN-90014 Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collagen Research Unit, University of Oulu, FIN-90014 Oulu, Finland; Biocenter Oulu, Departments of University of Oulu, FIN-90014 Oulu, Finland; Medical Biochemistry and Molecular Biology and, University of Oulu, FIN-90014 Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"Biocenter Oulu, Departments of University of Oulu, FIN-90014 Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"Collagen Research Unit, University of Oulu, FIN-90014 Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"Medical Biochemistry and Molecular Biology and, University of Oulu, FIN-90014 Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108516719","display_name":"Anne Marja Remes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Anne M. Remes","raw_affiliation_strings":["Neurology, University of Oulu, FIN-90014 Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology, University of Oulu, FIN-90014 Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081402708","display_name":"Ilmo E. Hassinen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Ilmo E. Hassinen","raw_affiliation_strings":["Medical Biochemistry and Molecular Biology and, University of Oulu, FIN-90014 Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Biochemistry and Molecular Biology and, University of Oulu, FIN-90014 Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064900083","display_name":"Kari I. Kivirikko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Kari I. Kivirikko","raw_affiliation_strings":["Collagen Research Unit, University of Oulu, FIN-90014 Oulu, Finland; Biocenter Oulu, Departments of University of Oulu, FIN-90014 Oulu, Finland; Medical Biochemistry and Molecular Biology and, University of Oulu, FIN-90014 Oulu, Finland","Biocenter Oulu, Departments of University of Oulu, FIN-90014 Oulu, Finland","Collagen Research Unit, University of Oulu, FIN-90014 Oulu, Finland","Medical Biochemistry and Molecular Biology and, University of Oulu, FIN-90014 Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collagen Research Unit, University of Oulu, FIN-90014 Oulu, Finland; Biocenter Oulu, Departments of University of Oulu, FIN-90014 Oulu, Finland; Medical Biochemistry and Molecular Biology and, University of Oulu, FIN-90014 Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"Biocenter Oulu, Departments of University of Oulu, FIN-90014 Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"Collagen Research Unit, University of Oulu, FIN-90014 Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"Medical Biochemistry and Molecular Biology and, University of Oulu, FIN-90014 Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002072250","display_name":"Johanna Myllyharju","orcid":"https://orcid.org/0000-0001-7772-1250","observed_orcids":["https://orcid.org/0000-0001-7772-1250"]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Johanna Myllyharju","raw_affiliation_strings":["Collagen Research Unit, University of Oulu, FIN-90014 Oulu, Finland; Biocenter Oulu, Departments of University of Oulu, FIN-90014 Oulu, Finland; Medical Biochemistry and Molecular Biology and, University of Oulu, FIN-90014 Oulu, Finland. Electronic address: johanna.myllyharju@oulu.fi","Biocenter Oulu, Departments of University of Oulu, FIN-90014 Oulu, Finland","Collagen Research Unit, University of Oulu, FIN-90014 Oulu, Finland","Medical Biochemistry and Molecular Biology and, University of Oulu, FIN-90014 Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collagen Research Unit, University of Oulu, FIN-90014 Oulu, Finland; Biocenter Oulu, Departments of University of Oulu, FIN-90014 Oulu, Finland; Medical Biochemistry and Molecular Biology and, University of Oulu, FIN-90014 Oulu, Finland. Electronic address: johanna.myllyharju@oulu.fi","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"Biocenter Oulu, Departments of University of Oulu, FIN-90014 Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"Collagen Research Unit, University of Oulu, FIN-90014 Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"Medical Biochemistry and Molecular Biology and, University of Oulu, FIN-90014 Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002072250"],"corresponding_institution_ids":["https://openalex.org/I98381234"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":7.1091,"has_fulltext":false,"cited_by_count":524,"citation_normalized_percentile":{"value":0.97808461,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"282","issue":"7","first_page":"4524","last_page":"4532"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia-inducible-factor","display_name":"hypoxia-inducible factor","score":0.9850000143051147},{"id":"https://openalex.org/keywords/fih","display_name":"FIH","score":0.8029999732971191},{"id":"https://openalex.org/keywords/citric-acid-cycle-intermediates","display_name":"citric acid cycle intermediates","score":0.9589999914169312},{"id":"https://openalex.org/keywords/fumarate","display_name":"fumarate","score":0.984000027179718},{"id":"https://openalex.org/keywords/succinic-acid","display_name":"succinic acid","score":1.0},{"id":"https://openalex.org/keywords/oxaloacetate","display_name":"oxaloacetate","score":0.968999981880188},{"id":"https://openalex.org/keywords/citrate","display_name":"citrate","score":0.996999979019165},{"id":"https://openalex.org/keywords/fumarate-hydratase-deficiency","display_name":"fumarate hydratase deficiency","score":0.8939999938011169},{"id":"https://openalex.org/keywords/succinate-dehydrogenase-deficiency","display_name":"succinate dehydrogenase deficiency","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hif-1alpha-stabilization","display_name":"HIF-1\u03b1 stabilization","score":0.9290000200271606},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8970000147819519},{"id":"https://openalex.org/keywords/erythropoietin","display_name":"erythropoietin","score":1.0},{"id":"https://openalex.org/keywords/p300-coactivator","display_name":"p300 coactivator","score":0.9369999766349792},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C165135838","wikidata":"https://www.wikidata.org/wiki/Q133895","display_name":"Citric acid cycle","level":3,"score":0.7045557498931885},{"id":"https://openalex.org/C111133373","wikidata":"https://www.wikidata.org/wiki/Q21132608","display_name":"Citrate synthase","level":3,"score":0.6419358849525452},{"id":"https://openalex.org/C2779032678","wikidata":"https://www.wikidata.org/wiki/Q159683","display_name":"Citric acid","level":2,"score":0.60905921459198},{"id":"https://openalex.org/C2781330172","wikidata":"https://www.wikidata.org/wiki/Q412837","display_name":"Succinate dehydrogenase","level":3,"score":0.5973140597343445},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5914349555969238},{"id":"https://openalex.org/C106302636","wikidata":"https://www.wikidata.org/wiki/Q21107515","display_name":"Fumarase","level":3,"score":0.5136329531669617},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5040665864944458},{"id":"https://openalex.org/C160450060","wikidata":"https://www.wikidata.org/wiki/Q104598479","display_name":"Hypoxia-inducible factors","level":3,"score":0.46462589502334595},{"id":"https://openalex.org/C2776441662","wikidata":"https://www.wikidata.org/wiki/Q2823314","display_name":"Tricarboxylic acid","level":4,"score":0.4370286464691162},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.4321436583995819},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3998816907405853},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.37192559242248535},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3172626495361328},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11981427669525146}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002952","descriptor_name":"Citric Acid Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002952","descriptor_name":"Citric Acid Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005649","descriptor_name":"Fumarate Hydratase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D005649","descriptor_name":"Fumarate Hydratase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005649","descriptor_name":"Fumarate Hydratase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011393","descriptor_name":"Procollagen-Proline Dioxygenase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011393","descriptor_name":"Procollagen-Proline Dioxygenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011393","descriptor_name":"Procollagen-Proline Dioxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011393","descriptor_name":"Procollagen-Proline Dioxygenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013385","descriptor_name":"Succinate Dehydrogenase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D013385","descriptor_name":"Succinate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013385","descriptor_name":"Succinate Dehydrogenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D050880","descriptor_name":"p300-CBP Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m610415200","doi":"https://doi.org/10.1074/jbc.m610415200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m610415200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:17182618","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17182618","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m610415200","doi":"https://doi.org/10.1074/jbc.m610415200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m610415200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W164548000","https://openalex.org/W1517438784","https://openalex.org/W1658332654","https://openalex.org/W1967291345","https://openalex.org/W1971502399","https://openalex.org/W1973092951","https://openalex.org/W1974567967","https://openalex.org/W1975918337","https://openalex.org/W1975984062","https://openalex.org/W1988073167","https://openalex.org/W1991346678","https://openalex.org/W1994303821","https://openalex.org/W2003305541","https://openalex.org/W2005729255","https://openalex.org/W2005868568","https://openalex.org/W2011562442","https://openalex.org/W2011810742","https://openalex.org/W2011874786","https://openalex.org/W2013221657","https://openalex.org/W2014868633","https://openalex.org/W2015715216","https://openalex.org/W2016160962","https://openalex.org/W2017575850","https://openalex.org/W2021932335","https://openalex.org/W2040031153","https://openalex.org/W2042216712","https://openalex.org/W2048216460","https://openalex.org/W2055003799","https://openalex.org/W2057182894","https://openalex.org/W2057199368","https://openalex.org/W2059747280","https://openalex.org/W2068414886","https://openalex.org/W2077954885","https://openalex.org/W2101392425","https://openalex.org/W2118484233","https://openalex.org/W2135034560","https://openalex.org/W2136749294","https://openalex.org/W2144625075","https://openalex.org/W2145023430","https://openalex.org/W2153771223","https://openalex.org/W2169533924","https://openalex.org/W2340655074","https://openalex.org/W2946485412"],"related_works":["https://openalex.org/W2005917601","https://openalex.org/W2169533924","https://openalex.org/W2170559724","https://openalex.org/W7099807779","https://openalex.org/W3165574402","https://openalex.org/W1994250242","https://openalex.org/W2120370940","https://openalex.org/W2523411829","https://openalex.org/W2594625594","https://openalex.org/W2787255387"],"abstract_inverted_index":{"The":[0],"stability":[1],"and":[2,25,39,56,59,78,101,137,145,165,226,233,247],"transcriptional":[3,200],"activity":[4,201],"of":[5,46,67,75,91,98,103,111,116,120,132,140,180,202,210,245],"the":[6,44,107,199,211,223,231,240],"hypoxia-inducible":[7],"factors":[8],"(HIFs)":[9],"are":[10,17],"regulated":[11],"by":[12,19,42,193],"two":[13],"oxygen-dependent":[14],"events":[15],"that":[16,198,222],"catalyzed":[18],"three":[20,69,93],"HIF":[21,27,40,203],"prolyl":[22],"4-hydroxylases":[23],"(HIF-P4Hs)":[24],"one":[26],"asparaginyl":[28],"hydroxylase":[29],"(FIH).":[30],"We":[31],"have":[32],"studied":[33],"possible":[34],"links":[35],"between":[36],"metabolic":[37],"pathways":[38],"hydroxylases":[41],"analyzing":[43],"abilities":[45],"citric":[47],"acid":[48],"cycle":[49],"intermediates":[50],"to":[51],"inhibit":[52,239],"purified":[53],"human":[54],"HIF-P4Hs":[55,94,241],"FIH.":[57,85],"Fumarate":[58],"succinate":[60,79,183,227,234],"were":[61,152,176],"identified":[62],"as":[63],"in":[64,154,230],"vitro":[65],"inhibitors":[66],"all":[68,92],"HIF-P4Hs,":[70],"fumarate":[71,123,161,225],"having":[72],"K(i)":[73,96,115],"values":[74,97],"50-80":[76],"microM":[77,100],"350-460":[80],"microM,":[81],"whereas":[82],"neither":[83],"inhibited":[84,192],"Oxaloacetate":[86],"was":[87,190],"an":[88],"additional":[89],"inhibitor":[90,110],"with":[95,113,122,160,182,242],"400-1000":[99],"citrate":[102,105],"HIF-P4H-3,":[104],"being":[106],"most":[108],"effective":[109],"FIH":[112,189],"a":[114,129,158],"110":[117],"microM.":[118],"Culturing":[119],"cells":[121,181],"diethyl":[124,184],"or":[125,128,185],"dimethyl":[126,186],"ester,":[127,134],"high":[130,206],"concentration":[131],"monoethyl":[133],"stabilized":[135],"HIF-1alpha":[136],"increased":[138,224],"production":[139],"vascular":[141],"endothelial":[142],"growth":[143],"factor":[144],"erythropoietin.":[146],"Similar,":[147],"although":[148],"much":[149],"smaller,":[150],"changes":[151],"found":[153],"cultured":[155],"fibroblasts":[156],"from":[157],"patient":[159],"hydratase":[162],"(FH)":[163],"deficiency":[164],"upon":[166,178],"silencing":[167],"FH":[168,232],"using":[169],"small":[170],"interfering":[171],"RNA.":[172],"No":[173],"such":[174],"effects":[175,248],"seen":[177],"culturing":[179],"ester.":[187],"As":[188],"not":[191],"fumarate,":[194],"our":[195],"data":[196,217],"indicate":[197],"is":[204,214],"quite":[205],"even":[207],"when":[208],"binding":[209],"coactivator":[212],"p300":[213],"prevented.":[215],"Our":[216],"also":[218],"support":[219],"recent":[220],"suggestions":[221],"levels":[228],"present":[229],"dehydrogenase-deficient":[235],"tumors,":[236],"respectively,":[237],"can":[238],"consequent":[243],"stabilization":[244],"HIF-alphas":[246],"on":[249],"tumor":[250],"pathology.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":38},{"year":2020,"cited_by_count":26},{"year":2019,"cited_by_count":40},{"year":2018,"cited_by_count":26},{"year":2017,"cited_by_count":30},{"year":2016,"cited_by_count":28},{"year":2015,"cited_by_count":33},{"year":2014,"cited_by_count":30},{"year":2013,"cited_by_count":36},{"year":2012,"cited_by_count":32}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
