{"id":"https://openalex.org/W2004183360","doi":"https://doi.org/10.1371/journal.pone.0061607","title":"Pre-Treatment with Amifostine Protects against Cyclophosphamide-Induced Disruption of Taste in Mice","display_name":"Pre-Treatment with Amifostine Protects against Cyclophosphamide-Induced Disruption of Taste in Mice","publication_year":2013,"publication_date":"2013-04-23","ids":{"openalex":"https://openalex.org/W2004183360","doi":"https://doi.org/10.1371/journal.pone.0061607","mag":"2004183360","pmid":"https://pubmed.ncbi.nlm.nih.gov/23626702","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3634019"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0061607","doi":"https://doi.org/10.1371/journal.pone.0061607","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0061607","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061607&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061607&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Nabanita Mukherjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nabanita Mukherjee","raw_affiliation_strings":["Department of Biology, University of Vermont, Burlington, Vermont, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Vermont, Burlington, Vermont, United States of America","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082843600","display_name":"Brittany L. Carroll","orcid":"https://orcid.org/0000-0002-4199-7762","observed_orcids":["https://orcid.org/0000-0002-4199-7762"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brittany L. Carroll","raw_affiliation_strings":["Department of Biology, University of Vermont, Burlington, Vermont, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Vermont, Burlington, Vermont, United States of America","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048430717","display_name":"Jeffrey L. Spees","orcid":"https://orcid.org/0000-0003-3560-3410","observed_orcids":["https://orcid.org/0000-0003-3560-3410"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffrey L. Spees","raw_affiliation_strings":["Department of Medicine, Stem Cell Core, Colchester, Vermont, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Stem Cell Core, Colchester, Vermont, United States of America","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084334256","display_name":"Eugene R. Delay","orcid":"https://orcid.org/0000-0002-2405-1182","observed_orcids":["https://orcid.org/0000-0002-2405-1182"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eugene R. Delay","raw_affiliation_strings":["Department of Biology, University of Vermont, Burlington, Vermont, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Vermont, Burlington, Vermont, United States of America","institution_ids":["https://openalex.org/I111236770"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048430717","https://openalex.org/A5084334256"],"corresponding_institution_ids":["https://openalex.org/I111236770"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":4.0951,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.92757555,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"4","first_page":"e61607","last_page":"e61607"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":0.322299987077713,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":0.322299987077713,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.3091000020503998,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.17350000143051147,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amifostine","display_name":"amifostine","score":0.996999979019165},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":1.0},{"id":"https://openalex.org/keywords/taste-buds","display_name":"taste buds","score":0.7730000019073486},{"id":"https://openalex.org/keywords/taste-sensitivity","display_name":"taste sensitivity","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.8970000147819519},{"id":"https://openalex.org/keywords/chemotherapy-side-effects","display_name":"chemotherapy side effects","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C2779387952","wikidata":"https://www.wikidata.org/wiki/Q251698","display_name":"Amifostine","level":3,"score":0.9649814367294312},{"id":"https://openalex.org/C8868529","wikidata":"https://www.wikidata.org/wiki/Q124794","display_name":"Taste","level":2,"score":0.7584196329116821},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5805127620697021},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5436869859695435},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4851863980293274},{"id":"https://openalex.org/C3454156","wikidata":"https://www.wikidata.org/wiki/Q1144241","display_name":"Side effect (computer science)","level":2,"score":0.45906785130500793},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.4470512270927429},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31394535303115845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2947499752044678},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1068916916847229},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004999","descriptor_name":"Amifostine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005247","descriptor_name":"Feeding Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005247","descriptor_name":"Feeding Behavior","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013649","descriptor_name":"Taste","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013650","descriptor_name":"Taste Buds","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013650","descriptor_name":"Taste Buds","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054799","descriptor_name":"Phospholipase C beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055697","descriptor_name":"Taste Perception","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D055697","descriptor_name":"Taste Perception","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0061607","doi":"https://doi.org/10.1371/journal.pone.0061607","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0061607","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061607&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2632404","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3634019","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:europepmc.org:4654139","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5729964","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3634019","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3634019","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5729964","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5729964","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23626702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23626702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmid:29220848","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29220848","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a3e0456572154588a758672a4b7ed8ac","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a3e0456572154588a758672a4b7ed8ac","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 4, p e61607 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0061607","doi":"https://doi.org/10.1371/journal.pone.0061607","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0061607","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061607&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4991877263","display_name":"L-amino acid taste activation in mice.","funder_award_id":"0951016","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6409821001","display_name":"Factors Responsible for Cardiac Preservation Conferred by Adult Marrow Stem Cells","funder_award_id":"R01HL085210","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004183360.pdf","grobid_xml":"https://content.openalex.org/works/W2004183360.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W49248409","https://openalex.org/W136550933","https://openalex.org/W174629306","https://openalex.org/W175449331","https://openalex.org/W234547276","https://openalex.org/W1482416496","https://openalex.org/W1781576227","https://openalex.org/W1895143891","https://openalex.org/W1895775305","https://openalex.org/W1964574094","https://openalex.org/W1972744209","https://openalex.org/W1977383069","https://openalex.org/W1981940605","https://openalex.org/W1984363929","https://openalex.org/W1985590235","https://openalex.org/W1987545907","https://openalex.org/W1993903180","https://openalex.org/W2004604160","https://openalex.org/W2012571857","https://openalex.org/W2018623578","https://openalex.org/W2022101062","https://openalex.org/W2030774440","https://openalex.org/W2034780781","https://openalex.org/W2049819798","https://openalex.org/W2050597069","https://openalex.org/W2053468553","https://openalex.org/W2073213477","https://openalex.org/W2078846891","https://openalex.org/W2083647133","https://openalex.org/W2085616173","https://openalex.org/W2088376664","https://openalex.org/W2091166808","https://openalex.org/W2092830118","https://openalex.org/W2095673721","https://openalex.org/W2101620562","https://openalex.org/W2106125817","https://openalex.org/W2116585078","https://openalex.org/W2116653505","https://openalex.org/W2124546620","https://openalex.org/W2127390834","https://openalex.org/W2155482577","https://openalex.org/W2168284025","https://openalex.org/W2170363268","https://openalex.org/W2171035643","https://openalex.org/W2315881093","https://openalex.org/W2397848143","https://openalex.org/W2398674675","https://openalex.org/W2406477675","https://openalex.org/W2409287457","https://openalex.org/W2425455785","https://openalex.org/W2431009522","https://openalex.org/W3140738769","https://openalex.org/W6607107127"],"related_works":["https://openalex.org/W2773111043","https://openalex.org/W2931157775","https://openalex.org/W3174537227","https://openalex.org/W2980361768","https://openalex.org/W2757014446","https://openalex.org/W2078846891","https://openalex.org/W4392351783","https://openalex.org/W4416682379","https://openalex.org/W2771453238","https://openalex.org/W2908328511"],"abstract_inverted_index":{"Cyclophosphamide":[0],"(CYP),":[1],"a":[2,21,48,78],"commonly":[3],"prescribed":[4],"chemotherapy":[5,181],"drug,":[6],"has":[7],"multiple":[8],"adverse":[9],"side":[10],"effects":[11,17,197],"including":[12],"alteration":[13],"of":[14,23,36,44,81,100,128,136,143,154,162,174,198],"taste.":[15],"The":[16],"on":[18],"taste":[19,30,75,94,113,130,137,164,187,192],"are":[20,31],"cause":[22],"concern":[24],"for":[25,141,186],"patients":[26,176],"as":[27],"changes":[28,91],"in":[29,58,92,112,125],"often":[32],"associated":[33],"with":[34,120,177],"loss":[35,111,161],"appetite,":[37],"malnutrition,":[38],"poor":[39],"recovery":[40],"and":[41,62,96,132,157,189],"reduced":[42],"quality":[43],"life.":[45],"Amifostine":[46],"is":[47],"cytoprotective":[49],"agent":[50],"that":[51,98,118,148,172],"was":[52],"previously":[53],"shown":[54],"to":[55,69,74,89,105,180],"be":[56],"effective":[57],"preventing":[59],"chemotherapy-induced":[60,72],"mucositis":[61],"nephrotoxicity.":[63],"Here":[64],"we":[65],"determined":[66],"its":[67],"ability":[68],"protect":[70,190],"against":[71,109,160],"damage":[73],"buds":[76],"using":[77],"mouse":[79],"model":[80],"CYP":[82,106,167],"injury.":[83],"We":[84],"conducted":[85],"detection":[86],"threshold":[87],"tests":[88],"measure":[90],"sucrose":[93],"sensitivity":[95,185],"found":[97],"administration":[99,150],"amifostine":[101,121,149,178],"30":[102],"mins":[103],"prior":[104,179],"injection":[107],"protected":[108,159],"CYP-induced":[110,123,152],"sensitivity.":[114],"Morphological":[115],"studies":[116],"showed":[117,147],"pre-treatment":[119],"prevented":[122,151],"reduction":[124],"the":[126,134,144,191,195],"number":[127,135],"fungiform":[129],"papillae":[131],"increased":[133],"buds.":[138],"Immunohistochemical":[139],"assays":[140],"markers":[142],"cell":[145,155],"cycle":[146],"inhibition":[153],"proliferation":[156],"also":[158],"mature":[163],"cells":[165],"after":[166],"exposure.":[168],"Our":[169],"results":[170],"indicate":[171],"treatment":[173],"cancer":[175],"may":[182],"improve":[183],"their":[184],"stimuli":[188],"system":[193],"from":[194],"detrimental":[196],"chemotherapy.":[199]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}