{"id":"https://openalex.org/W2004181810","doi":"https://doi.org/10.1002/jcp.1040860511","title":"Regulation of growth and morphological modulation of HeLa65 cells in monolayer culture by dibutyryl cyclic AMP, butyrate and their analogs","display_name":"Regulation of growth and morphological modulation of HeLa65 cells in monolayer culture by dibutyryl cyclic AMP, butyrate and their analogs","publication_year":1975,"publication_date":"1975-12-01","ids":{"openalex":"https://openalex.org/W2004181810","doi":"https://doi.org/10.1002/jcp.1040860511","mag":"2004181810","pmid":"https://pubmed.ncbi.nlm.nih.gov/172521"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.1040860511","doi":"https://doi.org/10.1002/jcp.1040860511","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.1040860511","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109874986","display_name":"Nimai K. Ghosh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nimai K. Ghosh","raw_affiliation_strings":["Division of Human Genetics and Departments of Medicine and Pharmacology, New York University Medical Center, New York, N. Y. 10016","New York University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Genetics and Departments of Medicine and Pharmacology, New York University Medical Center, New York, N. Y. 10016","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]},{"raw_affiliation_string":"New York University","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047021203","display_name":"Stephen I. Deutsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen I. Deutsch","raw_affiliation_strings":["Division of Human Genetics and Departments of Medicine and Pharmacology, New York University Medical Center, New York, N. Y. 10016","New York University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Genetics and Departments of Medicine and Pharmacology, New York University Medical Center, New York, N. Y. 10016","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]},{"raw_affiliation_string":"New York University","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113614860","display_name":"Martin J. Griffin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin J. Griffin","raw_affiliation_strings":["Oklahoma Medical Research Foundation, Oklahoma City, Okla. 73104","New York University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma Medical Research Foundation, Oklahoma City, Okla. 73104","institution_ids":["https://openalex.org/I30558944"]},{"raw_affiliation_string":"New York University","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111787597","display_name":"Rody P. Cox","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rody P. Cox","raw_affiliation_strings":["Division of Human Genetics and Departments of Medicine and Pharmacology, New York University Medical Center, New York, N. Y. 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Genetics and Departments of Medicine and Pharmacology, New York University Medical Center, New York, N. Y. 10016","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5230,"currency":"USD","value_usd":5230},"apc_paid":null,"fwci":1.9496,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.8490475,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"86","issue":"S2","first_page":"663","last_page":"672"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.2590000033378601,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.2590000033378601,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.17470000684261322,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.15649999678134918,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dibutyryl-camp","display_name":"dibutyryl cyclic AMP","score":0.9070000052452087},{"id":"https://openalex.org/keywords/butyrate","display_name":"butyrate","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.8090000152587891},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.8519999980926514},{"id":"https://openalex.org/keywords/cell-growth","display_name":"cell growth","score":0.8399999737739563},{"id":"https://openalex.org/keywords/cell-size","display_name":"cell size","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cell-shape","display_name":"cell shape","score":0.4169999957084656},{"id":"https://openalex.org/keywords/fatty-acid-analogs","display_name":"fatty acid analogs","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cytochalasin-b","display_name":"cytochalasin B","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-synthesis-inhibition","display_name":"protein synthesis inhibition","score":0.8289999961853027},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C2776979534","wikidata":"https://www.wikidata.org/wiki/Q193213","display_name":"Butyrate","level":3,"score":0.7551569938659668},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.6849707365036011},{"id":"https://openalex.org/C2779012151","wikidata":"https://www.wikidata.org/wiki/Q26998028","display_name":"Cytochalasin B","level":3,"score":0.6283619403839111},{"id":"https://openalex.org/C2776095844","wikidata":"https://www.wikidata.org/wiki/Q903666","display_name":"Colcemid","level":3,"score":0.5736228823661804},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.5494522452354431},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.523710310459137},{"id":"https://openalex.org/C2776162396","wikidata":"https://www.wikidata.org/wiki/Q4983616","display_name":"Bucladesine","level":3,"score":0.5029646754264832},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43545931577682495},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.43166419863700867},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4231516718864441},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4208545684814453},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4133955240249634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40646228194236755},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33643198013305664},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.11199983954429626},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.09434366226196289},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002087","descriptor_name":"Butyrates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003078","descriptor_name":"Colchicine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003571","descriptor_name":"Cytochalasin B","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003994","descriptor_name":"Bucladesine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003994","descriptor_name":"Bucladesine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014631","descriptor_name":"Valerates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcp.1040860511","doi":"https://doi.org/10.1002/jcp.1040860511","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.1040860511","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:172521","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/172521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W229214304","https://openalex.org/W994937244","https://openalex.org/W1503465764","https://openalex.org/W1538213920","https://openalex.org/W1538334351","https://openalex.org/W1601102856","https://openalex.org/W1775749144","https://openalex.org/W1906197854","https://openalex.org/W1972416461","https://openalex.org/W1991293003","https://openalex.org/W1995074014","https://openalex.org/W1999736404","https://openalex.org/W2001336242","https://openalex.org/W2022415916","https://openalex.org/W2027152330","https://openalex.org/W2050036623","https://openalex.org/W2051823729","https://openalex.org/W2056030570","https://openalex.org/W2057365225","https://openalex.org/W2062145172","https://openalex.org/W2067839546","https://openalex.org/W2069161066","https://openalex.org/W2078160318","https://openalex.org/W2078653545","https://openalex.org/W2088867375","https://openalex.org/W2093342790","https://openalex.org/W2094986016","https://openalex.org/W2143002567","https://openalex.org/W3216705818"],"related_works":["https://openalex.org/W1942625845","https://openalex.org/W2919633601","https://openalex.org/W2013531793","https://openalex.org/W1970413801","https://openalex.org/W1969063819","https://openalex.org/W2045139726","https://openalex.org/W2343551627","https://openalex.org/W2064307579","https://openalex.org/W1497296083","https://openalex.org/W1992259146"],"abstract_inverted_index":{"N6-O2'-Dibutyryl":[0],"adenosine-3',5'":[1],"monophosphate":[2,33],"(DBcAMP)":[3],"markedly":[4],"altered":[5],"the":[6,106],"morphology":[7],"of":[8,46],"HeLa":[9,54],"cells":[10,55],"by":[11,30,99,104],"increasing":[12],"average":[13],"cell":[14,21],"size":[15],"with":[16,69,85,108],"an":[17,41],"increase":[18],"in":[19,53],"total":[20],"protein":[22,101],"and":[23,38,59,65,78,81],"RNA.":[24],"Such":[25],"effects":[26,72,96],"were":[27,73,82,97],"not":[28,83],"caused":[29,61],"adenosine":[31],"3',5'":[32],"(cAMP)":[34],"or":[35,89,103,110],"related":[36],"nucleosides":[37],"nucleotides.":[39],"Butyrate,":[40],"enzyme":[42],"catalyzed":[43],"hydrolysis":[44],"product":[45],"DBcAMP,":[47],"induced":[48],"a":[49],"jagged":[50],"spindle":[51],"shape":[52],"within":[56],"8":[57],"hours":[58],"then":[60],"them":[62],"to":[63],"enlarge":[64],"resemble":[66],"those":[67],"grown":[68],"DBcAMP.":[70],"These":[71,94],"specific":[74],"for":[75],"butyrate":[76],"(C4)":[77],"pentanoate":[79],"(C5)":[80],"observed":[84],"isomers,":[86],"substituted":[87],"analogs,":[88],"other":[90],"fatty":[91],"acid":[92],"derivatives.":[93],"morphological":[95],"prevented":[98],"blocking":[100],"synthesis":[102],"altering":[105],"cytoskeleton":[107],"Colcemide":[109],"cytochalasin":[111],"B.":[112]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
